methylmalonic acid has been researched along with Acrania in 9 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of folic acid in the primary prevention of neural tube defects (NTDs) is well established." | 7.69 | Elevated midtrimester serum methylmalonic acid levels as a risk factor for neural tube defects. ( Adams, MJ; Cheek, JE; Haddow, JE; Henry, JP; Khoury, MJ; Knight, GJ; Scanlon, KS; Stabler, SP; Stevenson, RE; Sylvester, GC, 1995) |
| "Mandatory fortification of flour with folic acid has reduced the number of neural tube defects in North America." | 5.13 | Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial. ( Brouwer, IA; Clarke, R; Katan, MB; Verhoef, P; Winkels, RM, 2008) |
| "Although early epidemiologic studies showed a protective effect of adequate maternal folic acid (FA) status against neural tube defects (NTDs), the role of adequate vitamin B-12 nutrition in the putative reduction of NTD frequency has remained uncertain." | 4.85 | Vitamin B-12 and neural tube defects: the Canadian experience. ( Cole, DE; Ray, JG; Thompson, MD, 2009) |
| "The role of folic acid in the primary prevention of neural tube defects (NTDs) is well established." | 3.69 | Elevated midtrimester serum methylmalonic acid levels as a risk factor for neural tube defects. ( Adams, MJ; Cheek, JE; Haddow, JE; Henry, JP; Khoury, MJ; Knight, GJ; Scanlon, KS; Stabler, SP; Stevenson, RE; Sylvester, GC, 1995) |
| " We considered whether homocysteine metabolism via the enzyme methionine synthase, which requires both folate and B12, could be the critical defect in folate-related neural tube defects." | 3.69 | Homocysteine metabolism in pregnancies complicated by neural-tube defects. ( Conley, MR; Kirke, PN; Lee, YJ; McPartlin, JM; Mills, JL; Scott, JM; Weir, DG, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Winkels, RM | 1 |
| Brouwer, IA | 1 |
| Clarke, R | 1 |
| Katan, MB | 1 |
| Verhoef, P | 1 |
| Thompson, MD | 1 |
| Cole, DE | 1 |
| Ray, JG | 1 |
| Luo, X | 1 |
| Zhang, L | 1 |
| Wei, H | 1 |
| Liu, W | 1 |
| Wang, M | 1 |
| Ning, Q | 1 |
| Song, YZ | 1 |
| Li, BX | 1 |
| Hao, H | 1 |
| Xin, RL | 1 |
| Zhang, T | 1 |
| Zhang, CH | 1 |
| Kobayashi, K | 1 |
| Wang, ZN | 1 |
| Zheng, XY | 1 |
| Adams, MJ | 1 |
| Khoury, MJ | 1 |
| Scanlon, KS | 1 |
| Stevenson, RE | 1 |
| Knight, GJ | 1 |
| Haddow, JE | 1 |
| Sylvester, GC | 1 |
| Cheek, JE | 1 |
| Henry, JP | 1 |
| Stabler, SP | 1 |
| Mills, JL | 1 |
| McPartlin, JM | 1 |
| Kirke, PN | 1 |
| Lee, YJ | 1 |
| Conley, MR | 1 |
| Weir, DG | 1 |
| Scott, JM | 1 |
| Norberg, B | 1 |
| Chanarin, I | 1 |
| Deacon, R | 1 |
| Lumb, M | 1 |
| Perry, J | 1 |
| Evans, MI | 1 |
| Schulman, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Bread Trial: a Demonstration Trial to Show Effects of Fortification of Food With Both Folic Acid and Vitamin B12[NCT00353353] | 150 participants (Anticipated) | Interventional | 2006-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for methylmalonic acid and Acrania
| Article | Year |
|---|---|
Vitamin B-12 and neural tube defects: the Canadian experience.
Topics: Adult; Biological Availability; Biomarkers; Canada; Female; Flour; Folic Acid; Food, Fortified; Huma | 2009 |
Cobalamin and folate: recent developments.
Topics: Anemia, Megaloblastic; Female; Folic Acid; Humans; Methylation; Methylmalonic Acid; Nervous System D | 1992 |
In utero treatment of fetal metabolic disorders.
Topics: Adrenal Hyperplasia, Congenital; Female; Fetal Diseases; Humans; Metabolism, Inborn Errors; Methylma | 1991 |
1 trial available for methylmalonic acid and Acrania
| Article | Year |
|---|---|
Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial.
Topics: Aged; Aging; Bread; Double-Blind Method; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocyst | 2008 |
5 other studies available for methylmalonic acid and Acrania
| Article | Year |
|---|---|
Methylmalonic acid in amniotic fluid and maternal urine as a marker for neural tube defects.
Topics: Adult; Amniotic Fluid; Biomarkers; Female; Folic Acid; Humans; Methylmalonic Acid; Neural Tube Defec | 2004 |
Selective screening for inborn errors of metabolism and secondary methylmalonic aciduria in pregnancy at high risk district of neural tube defects: a human metabolome study by GC-MS in China.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; China; Female; Gas | 2008 |
Elevated midtrimester serum methylmalonic acid levels as a risk factor for neural tube defects.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Gas Chromatography-Mass Spectrometry; Humans; Methy | 1995 |
Homocysteine metabolism in pregnancies complicated by neural-tube defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Analysis of Variance; Female; Folic Acid; | 1995 |
Turn of tide for oral vitamin B12 treatment.
Topics: Administration, Oral; Aged; Biological Availability; Biomarkers; England; Female; Homocysteine; Huma | 1999 |