methylmalonic acid has been researched along with Acquired Metabolic Diseases, Brain in 9 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Oxidative stress and excitotoxicity have been involved in the toxic pattern exerted by these organic acids." | 1.42 | The effect of WIN 55,212-2 suggests a cannabinoid-sensitive component in the early toxicity induced by organic acids accumulating in glutaric acidemia type I and in related disorders of propionate metabolism in rat brain synaptosomes. ( Colín-González, AL; Leipnitz, G; Paz-Loyola, AL; Ribeiro, CA; Santamaría, A; Seminotti, B; Serratos, IN; Souza, DO; Wajner, M, 2015) |
| "The influence of acute renal failure induced by gentamicin administration on the effects of MMA on mitochondrial respiratory chain complexes, citrate synthase, succinate dehydrogenase and creatine kinase activities in cerebral cortex and kidney of young rats were investigated." | 1.39 | Acute renal failure potentiates brain energy dysfunction elicited by methylmalonic acid. ( Ferreira, GC; Januário, SB; Mafioleti, RL; Malgarin, F; Pettenuzzo, LF; Scaini, G; Schuck, PF; Simon, KR; Streck, EL, 2013) |
| " In the present study we investigated the effect of chronic administration (from the 5th to the 28th day of life) of methylmalonic acid (MA) on the performance of adult rats in the Morris water maze task." | 1.32 | Ascorbic acid prevents water maze behavioral deficits caused by early postnatal methylmalonic acid administration in the rat. ( Dutra-Filho, CS; Netto, CA; Pettenuzzo, LF; Schuck, PF; Wajner, M; Wannmacher, CM; Wyse, AT, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tuncel, AT | 1 |
| Boy, N | 1 |
| Morath, MA | 1 |
| Hörster, F | 1 |
| Mütze, U | 1 |
| Kölker, S | 2 |
| Schuck, PF | 2 |
| Januário, SB | 1 |
| Simon, KR | 1 |
| Scaini, G | 1 |
| Mafioleti, RL | 1 |
| Malgarin, F | 1 |
| Pettenuzzo, LF | 3 |
| Streck, EL | 1 |
| Ferreira, GC | 1 |
| Colín-González, AL | 2 |
| Paz-Loyola, AL | 2 |
| Serratos, I | 1 |
| Seminotti, B | 2 |
| Ribeiro, CA | 2 |
| Leipnitz, G | 2 |
| Souza, DO | 2 |
| Wajner, M | 4 |
| Santamaría, A | 2 |
| Serratos, IN | 1 |
| Heringer, J | 1 |
| Valayannopoulos, V | 1 |
| Lund, AM | 1 |
| Wijburg, FA | 1 |
| Freisinger, P | 1 |
| Barić, I | 1 |
| Baumgartner, MR | 1 |
| Burgard, P | 1 |
| Burlina, AB | 1 |
| Chapman, KA | 1 |
| I Saladelafont, EC | 1 |
| Karall, D | 1 |
| Mühlhausen, C | 1 |
| Riches, V | 1 |
| Schiff, M | 1 |
| Sykut-Cegielska, J | 1 |
| Walter, JH | 1 |
| Zeman, J | 1 |
| Chabrol, B | 1 |
| Wyse, AT | 2 |
| Wannmacher, CM | 2 |
| Dutra-Filho, CS | 2 |
| Netto, CA | 2 |
| Capece, G | 1 |
| Giliberti, P | 1 |
| Militerni, R | 1 |
| Pignero, A | 1 |
| Heidenreich, R | 1 |
| Natowicz, M | 1 |
| Hainline, BE | 1 |
| Berman, P | 1 |
| Kelley, RI | 1 |
| Hillman, RE | 1 |
| Berry, GT | 1 |
1 review available for methylmalonic acid and Acquired Metabolic Diseases, Brain
| Article | Year |
|---|---|
Organic acidurias in adults: late complications and management.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Brain Diseases, Metabolic; Glutaryl-CoA Dehydrogenase; | 2018 |
8 other studies available for methylmalonic acid and Acquired Metabolic Diseases, Brain
| Article | Year |
|---|---|
Acute renal failure potentiates brain energy dysfunction elicited by methylmalonic acid.
Topics: Acute Kidney Injury; Animals; Brain; Brain Diseases, Metabolic; Dose-Response Relationship, Drug; Dr | 2013 |
Toxic synergism between quinolinic acid and organic acids accumulating in glutaric acidemia type I and in disorders of propionate metabolism in rat brain synaptosomes: Relevance for metabolic acidemias.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain; Brain Diseases, Metabolic; Disease Models, Ani | 2015 |
The effect of WIN 55,212-2 suggests a cannabinoid-sensitive component in the early toxicity induced by organic acids accumulating in glutaric acidemia type I and in related disorders of propionate metabolism in rat brain synaptosomes.
Topics: Acids, Acyclic; Amino Acid Metabolism, Inborn Errors; Animals; Benzoxazines; Brain; Brain Diseases, | 2015 |
Impact of age at onset and newborn screening on outcome in organic acidurias.
Topics: Adolescent; Adult; Age of Onset; Amino Acid Metabolism, Inborn Errors; Amino Acid Transport Disorder | 2016 |
Ascorbic acid prevents water maze behavioral deficits caused by early postnatal methylmalonic acid administration in the rat.
Topics: Animals; Animals, Newborn; Antioxidants; Ascorbic Acid; Brain Diseases, Metabolic; Corpus Striatum; | 2003 |
Evaluation of the effect of chronic administration of drugs on rat behavior in the water maze task.
Topics: Animals; Behavior, Animal; Brain; Brain Diseases, Metabolic; Cognition Disorders; Disease Models, An | 2003 |
[A case of metabolic encephalopathy caused by vitamin B 12-dependent methylmalonicoaciduria].
Topics: Amino Acid Metabolism, Inborn Errors; Brain Diseases, Metabolic; Female; Humans; Infant; Malonates; | 1981 |
Acute extrapyramidal syndrome in methylmalonic acidemia: "metabolic stroke" involving the globus pallidus.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Atrophy; Basal Ganglia Diseases; Brain Diseases, M | 1988 |