Compounds > methylglyoxal-bis(cyclopentylamidinohydrazone)

methylglyoxal-bis(cyclopentylamidinohydrazone) and Helicobacter-Infections

methylglyoxal-bis(cyclopentylamidinohydrazone) has been researched along with Helicobacter-Infections* in 1 studies

Other Studies

1 other study(ies) available for methylglyoxal-bis(cyclopentylamidinohydrazone) and Helicobacter-Infections

Article	Year
Growth inhibition of Helicobacter pylori by a polyamine synthesis inhibitor, methylglyoxal bis(cyclopentylamidinohydrazone). Letters in applied microbiology, 1997, Volume: 25, Issue:3 The anti-proliferative effect of methylglyoxal bis(cyclopentylamidino-hydrazone) (MGBCP), a multi-enzyme inhibitor of polyamine biosynthesis, on the growth of Helicobacter pylori was investigated. MGBCP inhibited the cell growth of H. pylori in a dose-dependent manner. The inhibition was partially reversed by the addition of spermidine. Synthesis of macromolecules, DNA, RNA and protein, was inhibited in the spermidine-depleted H. pylori cells. These findings suggest that MGBCP exhibits an anti-proliferative effect on H. pylori by suppression of macromolecule synthesis. Topics: Anti-Bacterial Agents; Bacterial Proteins; DNA, Bacterial; Enzyme Inhibitors; Helicobacter Infections; Helicobacter pylori; Humans; In Vitro Techniques; Mitoguazone; Polyamines; Putrescine; RNA, Bacterial; Spermidine	1997

Article

Year

Growth inhibition of Helicobacter pylori by a polyamine synthesis inhibitor, methylglyoxal bis(cyclopentylamidinohydrazone).

Letters in applied microbiology, 1997, Volume: 25, Issue:3

The anti-proliferative effect of methylglyoxal bis(cyclopentylamidino-hydrazone) (MGBCP), a multi-enzyme inhibitor of polyamine biosynthesis, on the growth of Helicobacter pylori was investigated. MGBCP inhibited the cell growth of H. pylori in a dose-dependent manner. The inhibition was partially reversed by the addition of spermidine. Synthesis of macromolecules, DNA, RNA and protein, was inhibited in the spermidine-depleted H. pylori cells. These findings suggest that MGBCP exhibits an anti-proliferative effect on H. pylori by suppression of macromolecule synthesis.

Topics: Anti-Bacterial Agents; Bacterial Proteins; DNA, Bacterial; Enzyme Inhibitors; Helicobacter Infections; Helicobacter pylori; Humans; In Vitro Techniques; Mitoguazone; Polyamines; Putrescine; RNA, Bacterial; Spermidine

1997