methylglyoxal-bis(butylamidinohydrazone) and Lung-Neoplasms

To prospectively examine the association between clonal hematopoiesis (CH) and subsequent risk of lung cancer.. Among 200,629 UK Biobank (UKBB) participants with whole-exome sequencing, CH was identified in a nested case-control study of 832 incident lung cancer cases and 3,951 controls (2006-2019) matched on age and year at blood draw, sex, race, and smoking status. A similar nested case-control study (141 cases/652 controls) was conducted among 27,975 participants with whole-exome sequencing in the Mass General Brigham Biobank (MGBB, 2010-2021). In parallel, we compared CH frequency in published data from 5,003 patients with solid tumor (2,279 lung cancer) who had pretreatment blood sequencing performed through Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets.. In UKBB, the presence of CH was associated with increased risk of lung cancer (cases: 12.5%. Independent of known risk factors, CH is associated with increased risk of lung cancer.

Topics: Case-Control Studies; Clonal Hematopoiesis; Hematopoiesis; Humans; Lung Neoplasms; Mutation; Risk Factors