Compounds > methylglyoxal-bis(butylamidinohydrazone)

methylglyoxal-bis(butylamidinohydrazone) and Leukemia--Erythroblastic--Acute

methylglyoxal-bis(butylamidinohydrazone) has been researched along with Leukemia--Erythroblastic--Acute* in 1 studies

Other Studies

1 other study(ies) available for methylglyoxal-bis(butylamidinohydrazone) and Leukemia--Erythroblastic--Acute

Article	Year
Antitumor effect of methylglyoxal bis(butylamidinohydrazone), a new inhibitor of S-adenosylmethionine decarboxylase, against human erythroid leukemia K 562 cells. Cancer letters, 1986, Volume: 30, Issue:1 Methylglyoxal bis(butylamidinohydrazone) (MGBB) inhibited S-adenosylmethionine decarboxylase (SAMDC) activity competitively with S-adenosylmethionine (SAM) showing the Ki value of 1.8 X 10(-5) M. MGBB showed less SAMDC-stabilizing effect in rat liver in vivo than did methylglyoxal bis-(guanylhydrazone) (MGBG). MGBB inhibited the growth of human erythroid leukemia K 562 cells. Putrescine, spermidine and spermine concentrations in MGBB-treated cells were depressed to 56%, 58% and 88% of the values of control cells, respectively. [35S]Methionine incorporation into trichloroacetic acid-insoluble fraction was decreased in the inhibitor-treated cells. Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Line; Humans; Leukemia, Erythroblastic, Acute; Liver; Male; Mitoguazone; Polyamines; Rats; Rats, Inbred Strains	1986

Article

Year

Antitumor effect of methylglyoxal bis(butylamidinohydrazone), a new inhibitor of S-adenosylmethionine decarboxylase, against human erythroid leukemia K 562 cells.

Cancer letters, 1986, Volume: 30, Issue:1

Methylglyoxal bis(butylamidinohydrazone) (MGBB) inhibited S-adenosylmethionine decarboxylase (SAMDC) activity competitively with S-adenosylmethionine (SAM) showing the Ki value of 1.8 X 10(-5) M. MGBB showed less SAMDC-stabilizing effect in rat liver in vivo than did methylglyoxal bis-(guanylhydrazone) (MGBG). MGBB inhibited the growth of human erythroid leukemia K 562 cells. Putrescine, spermidine and spermine concentrations in MGBB-treated cells were depressed to 56%, 58% and 88% of the values of control cells, respectively. [35S]Methionine incorporation into trichloroacetic acid-insoluble fraction was decreased in the inhibitor-treated cells.

Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Line; Humans; Leukemia, Erythroblastic, Acute; Liver; Male; Mitoguazone; Polyamines; Rats; Rats, Inbred Strains

1986