methylglucamine-iodoxamate and Chemical-and-Drug-Induced-Liver-Injury

A double-blind comparison of two recently introduced cholangiocholecystographic agents was carried out in 80 patients. Both agents proved to be equally effective in opacifying the gall-bladder and the bile ducts. The visualization of the bile ducts after cholecystectomy was slightly better after meglumine iotroxate administration. Both agents showed evidence of hepatic toxicity in mild or moderate degree. However, there were 3 cases in which adverse hepatotoxic reactions t meglumine iodoxamate have been observed. Careful observation of patients receiving this drug is advised.

Topics: Chemical and Drug Induced Liver Injury; Cholangiography; Cholecystography; Clinical Trials as Topic; Contrast Media; Double-Blind Method; Female; Humans; Iodipamide; Iodobenzoates; Liver Function Tests; Male; Radiographic Image Enhancement; Triiodobenzoic Acids