Page last updated: 2024-08-17

methylene blue and Malaria

methylene blue has been researched along with Malaria in 30 studies

*Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia. [MeSH]

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19906 (20.00)18.7374
1990's2 (6.67)18.2507
2000's5 (16.67)29.6817
2010's17 (56.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Becker, K; Davioud-Charvet, E; Friebolin, W; Furrer, J; Jannack, B; Lanzer, M; Oeser, T; Sanchez, CP; Wenzel, N; Yardley, V1
Barnard, L; Birkholtz, LM; Botha, M; Brunschwig, C; Burrows, JN; Chibale, K; Churchyard, A; Coetzer, TL; Denti, P; Egan, TJ; Laing, L; Lauterbach, S; Machado, M; Ndubi, F; Njogu, PM; Njoroge, M; Nondaba, S; Okombo, J; Prudêncio, M; Reader, J; Singh, K; Wiesner, L; Wilkinson, C; Wittlin, S; Yeates, C1
Bezuidenhout, B; Birkholtz, LM; Chibale, K; Churchyard, A; Coetzer, TL; Egan, TJ; Fontinha, D; Gibhard, L; Lauterbach, S; Mayoka, G; Njoroge, M; Okombo, J; Prudêncio, M; Reader, J; Sanches-Vaz, M; van der Watt, M; Wittlin, S; Yeates, C1
Chu, C; Fong, MY; Lau, YL; Lee, WC; Nosten, F; Renia, L; Russell, B; Sriprawat, K; Suwanarusk, R1
Adaramoye, OA; Ademowo, OG; Falade, CO; Nneji, CM1
McFee, RB1
Berman, J; Im-Erbsin, R; Li, Q; Obaldia, N; Ohrt, C; Xie, L1
Kiboi, DM; Mumo, RM; Mwangi, VI; Ng'ang'a, ZW; Omar, SA; Ozwara, HS1
Howland, RH1
Bezrukov, AV1
GRABENKO, IK1
Baerga-Ortiz, A; Coppens, I; Dinglasan, RR; Franke-Fayard, B; Fuentes-Caraballo, M; Jacobs-Lorena, M; Janse, CJ; Pastrana-Mena, R; Serrano, AE; Vega-Rodríguez, J1
Dubey, NK; Gupta, A; Pathak, S; Sankar, J1
Adler, H; Becker, K; Fritz-Wolf, K; Gromer, S; Kasozi, DM; Rahlfs, S; Schirmer, RH; Wittlin, S; Zocher, K1
Chen, MJ; Cheu, KW; Coghi, P; Guo, ZF; Guo, ZH; Haynes, RK; Li, KY; Monti, D; Tang, MM; Wong, HN1
Adjalley, SH; Eappen, AG; Eastman, RT; Ekland, EH; Fidock, DA; Hoffman, SL; Johnston, GL; Lee, MC; Li, T; Richman, A; Sim, BK1
Hempelmann, E; Krafts, K; Skórska-Stania, A1
Aldana, I; Bertani, S; Deharo, E; Garavito, G; Quiliano, M; Valentin, A1
Chan, HW; Chen, MJ; Cheu, KW; Coghi, P; Guo, ZF; Guo, ZH; Haynes, RK; Li, KY; Monti, D; Sinniah, K; Tang, MM; Witte, AB; Wong, HN1
FULTON, JD; VOLLER, A1
GURR, E1
GISELSSON, W1
Sörgel, F1
Arora, K; Srivastava, AK1
Burhenne, J; Haefeli, WE; Meissner, P; Mikus, G; Müller, O; Rengelshausen, J; Riedel, KD; Walter-Sack, I1
Atamna, H; Ginsburg, H; Pascarmona, G1
Atamna, H; Deharo, E; Ginsburg, H; Krugliak, M; Pescarmona, G; Shalmiev, G1
Houwen, B1
Donaldson, PT; Lillie, RD; Russo, A1
Barnes, MG; Polet, H1

Reviews

2 review(s) available for methylene blue and Malaria

ArticleYear
From methylene blue to chloroquine: a brief review of the development of an antimalarial therapy.
    Parasitology research, 2012, Volume: 111, Issue:1

    Topics: Antimalarials; Chloroquine; Drug Therapy; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Malaria; Methylene Blue

2012
Blood film preparation and staining procedures.
    Clinics in laboratory medicine, 2002, Volume: 22, Issue:1

    Topics: Eosine Yellowish-(YS); Erythrocytes; Humans; Malaria; Methylene Blue; Staining and Labeling

2002

Other Studies

28 other study(ies) available for methylene blue and Malaria

ArticleYear
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum.
    Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5

    Topics: Animals; Antimalarials; Biological Transport; Cell Line, Tumor; Chloroquine; Drug Resistance; Drug Therapy, Combination; Glutathione Reductase; Humans; In Vitro Techniques; Malaria; Mice; Mice, Inbred BALB C; Naphthalenes; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship

2008
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.
    Journal of medicinal chemistry, 2017, 02-23, Volume: 60, Issue:4

    Topics: Animals; Antimalarials; Benzimidazoles; Life Cycle Stages; Malaria; Male; Mice; Plasmodium berghei; Structure-Activity Relationship

2017
Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.
    Journal of medicinal chemistry, 2019, 01-24, Volume: 62, Issue:2

    Topics: Animals; Antimalarials; Benzimidazoles; Disease Models, Animal; Drug Design; ERG1 Potassium Channel; Half-Life; Hemeproteins; Life Cycle Stages; Malaria; Mice; Mice, Inbred C57BL; Plasmodium; Structure-Activity Relationship; Survival Rate

2019
Giemsa-stained wet mount based method for reticulocyte quantification: a viable alternative in resource limited or malaria endemic settings.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Azure Stains; Humans; Malaria; Methylene Blue; Reticulocyte Count; Reticulocytes

2013
Effect of chloroquine, methylene blue and artemether on red cell and hepatic antioxidant defence system in mice infected with Plasmodium yoelii nigeriensis.
    Parasitology research, 2013, Volume: 112, Issue:7

    Topics: Animals; Antimalarials; Antioxidants; Artemether; Artemisinins; Chloroquine; Erythrocytes; Liver; Malaria; Methylene Blue; Mice; Oxidative Stress; Plasmodium yoelii

2013
Malaria (Plasmodium).
    Disease-a-month : DM, 2013, Volume: 59, Issue:12

    Topics: Animals; Antimalarials; Culicidae; Disease Vectors; Drug Resistance; Drug Therapy, Combination; Endemic Diseases; Enzyme Inhibitors; Global Health; Humans; Malaria; Methylene Blue; Plasmodium falciparum; Plasmodium vivax; Public Health

2013
Efficacy of intravenous methylene blue, intravenous artesunate, and their combination in preclinical models of malaria.
    Malaria journal, 2014, Oct-21, Volume: 13

    Topics: Administration, Intravenous; Animals; Antimalarials; Aotidae; Artemisinins; Artesunate; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Macaca mulatta; Malaria; Male; Methylene Blue; Plasmodium berghei; Plasmodium cynomolgi; Rats; Rats, Sprague-Dawley; Treatment Outcome

2014
Methylene blue inhibits lumefantrine-resistant Plasmodium berghei.
    Journal of infection in developing countries, 2016, Jun-30, Volume: 10, Issue:6

    Topics: Animals; Antimalarials; Disease Models, Animal; Drug Resistance; Drug-Related Side Effects and Adverse Reactions; Enzyme Inhibitors; Ethanolamines; Female; Fluorenes; Lumefantrine; Malaria; Male; Methylene Blue; Mice; Parasitemia; Plasmodium berghei; Pyrimethamine; Survival Analysis; Treatment Outcome

2016
Methylene Blue: The Long and Winding Road from Stain to Brain: Part 1.
    Journal of psychosocial nursing and mental health services, 2016, Sep-01, Volume: 54, Issue:9

    Topics: Antipsychotic Agents; Brain; Histocytochemistry; History, 19th Century; History, 20th Century; Malaria; Methylene Blue

2016
Romanowsky staining, the Romanowsky effect and thoughts on the question of scientific priority.
    Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2017, Volume: 92, Issue:1

    Topics: Azure Stains; Coloring Agents; Eosine Yellowish-(YS); History, 19th Century; Humans; Malaria; Methylene Blue; Plasmodium; Staining and Labeling

2017
[Combined treatment of malaria with methylene blue and glucose].
    Vrachebnoe delo, 1946, Issue:5

    Topics: Combined Modality Therapy; Glucose; Humans; Malaria; Methylene Blue

1946
Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito.
    The Journal of biological chemistry, 2010, Aug-27, Volume: 285, Issue:35

    Topics: Animals; Drug Design; Enzyme Inhibitors; Eosine I Bluish; Female; Fluoresceins; Glutamate-Cysteine Ligase; Glutathione Disulfide; Glutathione Reductase; Malaria; Methylene Blue; Mice; Oocysts; Plasmodium berghei; Protozoan Proteins

2010
Death in an adolescent girl with methemoglobinemia and malaria.
    Journal of tropical pediatrics, 2012, Volume: 58, Issue:2

    Topics: Adolescent; Aniline Compounds; Diagnosis, Differential; Fatal Outcome; Female; Humans; Malaria; Methemoglobinemia; Methylene Blue; Occupational Exposure

2012
The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue.
    Redox report : communications in free radical research, 2011, Volume: 16, Issue:4

    Topics: Animals; Antimalarials; Crystallography, X-Ray; Cystic Fibrosis; Glutathione Reductase; Humans; Malaria; Methylene Blue; Mice; Oxidation-Reduction; Plasmodium falciparum; Pyocyanine; Wound Infection

2011
A partial convergence in action of methylene blue and artemisinins: antagonism with chloroquine, a reversal with verapamil, and an insight into the antimalarial activity of chloroquine.
    ChemMedChem, 2011, Sep-05, Volume: 6, Issue:9

    Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Synergism; Flavin-Adenine Dinucleotide; Homeostasis; Humans; Malaria; Methylene Blue; Oxidation-Reduction; Verapamil

2011
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Nov-22, Volume: 108, Issue:47

    Topics: Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Blotting, Southern; Dose-Response Relationship, Drug; Ethanolamines; Fluorenes; Genetic Vectors; Germ Cells, Plant; Green Fluorescent Proteins; Luciferases; Lumefantrine; Malaria; Methylene Blue; Naphthyridines; Plasmodium falciparum; Quinolines; Sexual Development

2011
The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine.
    Memorias do Instituto Oswaldo Cruz, 2012, Volume: 107, Issue:6

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Malaria; Male; Methylene Blue; Mice; Plasmodium berghei; Pyrimethamine; Quinine

2012
Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model--a unifying proposal for drug action.
    ChemMedChem, 2012, Volume: 7, Issue:12

    Topics: Antimalarials; Artemisinins; Chloroquine; Drug Interactions; Ferric Compounds; Flavin-Adenine Dinucleotide; Humans; Malaria; Methylene Blue; NAD; NADP; Oxidative Stress; Quinolines; Riboflavin

2012
EVALUATION OF IMMUNOFLUORESCENT AND DIRECT AGGLUTINATION METHODS FOR DETECTION OF SPECIFIC TOXOPLASMA ANTIBODIES.
    British medical journal, 1964, Nov-07, Volume: 2, Issue:5418

    Topics: Agglutination; Antibodies; Complement Fixation Tests; Filariasis; Fluorescent Antibody Technique; Humans; Leishmaniasis; Leishmaniasis, Visceral; Leptospirosis; Malaria; Methylene Blue; Sarcocystosis; Schistosomiasis; Serologic Tests; Statistics as Topic; Syphilis; Toxoplasma; Toxoplasmosis; Trypanosomiasis; Trypanosomiasis, African

1964
ROLE OF EOSIN IN ROMANOWSKY STAINING OF MALARIA NUCLEUS.
    Nature, 1964, Jun-06, Volume: 202

    Topics: Cell Nucleus; Coloring Agents; Eosine Yellowish-(YS); Malaria; Methylene Blue; Plasmodium; Research; Staining and Labeling

1964
[Manson's borax methylene blue solution in malaria cytology].
    Nordisk medicin, 1952, Mar-14, Volume: 47, Issue:11

    Topics: Borates; Coloring Agents; Humans; Malaria; Methylene Blue; Plasmodium; Staining and Labeling

1952
The return of Ehrlich's 'Therapia magna sterilisans' and other Ehrlich concepts?. Series of papers honoring Paul Ehrlich on the occasion of his 150th birthday.
    Chemotherapy, 2004, Volume: 50, Issue:1

    Topics: Antitreponemal Agents; Arsphenamine; Coloring Agents; Drug Resistance, Microbial; Helicobacter Infections; Helicobacter pylori; Humans; Malaria; Methylene Blue; Syphilis

2004
Antimalarial efficacy of methylene blue and menadione and their effect on glutathione metabolism of Plasmodium yoelii-infected albino mice.
    Parasitology research, 2005, Volume: 97, Issue:6

    Topics: Administration, Oral; Animals; Antifibrinolytic Agents; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glutathione; Liver; Malaria; Methylene Blue; Mice; Parasitemia; Plasmodium yoelii; Spleen; Suspensions; Vitamin K 3

2005
Quantification of cationic anti-malaria agent methylene blue in different human biological matrices using cation exchange chromatography coupled to tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Mar-01, Volume: 863, Issue:2

    Topics: Administration, Oral; Antimalarials; Calibration; Cation Exchange Resins; Chemical Fractionation; Chromatography, Ion Exchange; Enzyme Inhibitors; Humans; Malaria; Methylene Blue; Molecular Structure; Phenothiazines; Quality Control; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2008
Hexose-monophosphate shunt activity in intact Plasmodium falciparum-infected erythrocytes and in free parasites.
    Molecular and biochemical parasitology, 1994, Volume: 67, Issue:1

    Topics: Animals; Erythrocytes; Glucose; Glutamate Dehydrogenase; Humans; In Vitro Techniques; Kinetics; Malaria; Methylene Blue; NADP; Nucleic Acids; Oxidative Stress; Pentose Phosphate Pathway; Plasmodium falciparum

1994
Mode of antimalarial effect of methylene blue and some of its analogues on Plasmodium falciparum in culture and their inhibition of P. vinckei petteri and P. yoelii nigeriensis in vivo.
    Biochemical pharmacology, 1996, Mar-08, Volume: 51, Issue:5

    Topics: Animals; Antimalarials; Heme; Humans; Malaria; Male; Methylene Blue; Mice; Oxidation-Reduction; Pentose Phosphate Pathway; Plasmodium falciparum; Plasmodium yoelii; Tumor Cells, Cultured

1996
Lower azure B methylene blue ratios in Giemsa type blood and malaria stains.
    Stain technology, 1978, Volume: 53, Issue:1

    Topics: Azure Stains; Blood Cells; Chromatin; Lymphocytes; Malaria; Methylene Blue; Monocytes; Neutrophils; Phenothiazines; Plasmodium

1978
The influence of methylene blue on the pentose phosphate pathway in erythrocytes of monkeys infected with Plasmodium knowlesi.
    The Journal of laboratory and clinical medicine, 1969, Volume: 74, Issue:1

    Topics: Animals; Carbon Isotopes; Chloroquine; DNA; Erythrocytes; Glucose; Haplorhini; Isoleucine; Malaria; Methylene Blue; Orotic Acid; Pentosephosphates; Plasmodium; Protein Biosynthesis; Quinacrine; Quinine; RNA; Tritium

1969