Page last updated: 2024-08-23

methyldopa and Parkinson Disease

methyldopa has been researched along with Parkinson Disease in 97 studies

Research

Studies (97)

Timeframe	Studies, this research(%)	All Research%
pre-1990	85 (87.63)	18.7374
1990's	4 (4.12)	18.2507
2000's	3 (3.09)	29.6817
2010's	5 (5.15)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Jin, H; Ren, J; Wu, F; Yu, J; Zhang, W; Zhang, Y; Zhou, Y	1
Barbe, MT; Christensen, MS; Florin, E; Herz, DM; Reck, C; Siebner, HR; Timmermann, L; Tittgemeyer, M; Tscheuschler, MK	1
Muhlack, S; Müller, T	1
Antonini, A; Bareggi, SR; Bondiolotti, G; Natuzzi, F	1
Bengel, G; Ebersbach, G; Ehret, R; Jugel, C; Klostermann, F; Muhlack, S; Müller, T	1
Arstrand, K; Dizdar, N; Kågedal, B	1
GRODEN, BM	1
CLARK, WG; MARKHAM, CH; WINTERS, WD	1
Dean, RT; Hume, PM; Morris, JG; Rodgers, KJ	1
Jankovic, J	1
Travenets, IA	1
Aebert, K	1
Da Prada, M; Haefely, WE; Keller, HH; Kettler, R; Pieri, L	1
Fahn, S; Reches, A	1
Adam, WR; Campbell, DJ; Funder, JW; Mendelsohn, FA	1
Reilly, DK; Rivera-Calimlim, L; Van Dyke, D	1
Montgomery, EB; Rosenblum, AM	1
Kerr, FW; Muenter, MD; Sharpless, NS; Tyce, GM	1
Rausing, A; Rosén, U	1
Davidson, L; Hornykiewicz, O; Lloyd, KG	1
Sjönell, G	1
Feuerstein, C; Gavend, M; Pellat, J; Perret, J; Serre, F; Tanche, M	2
Asmus, PA; Freed, CR	1
Marsden, CD; Mindham, RH; Parkes, JD	1
Feigenson, JS; McDowell, FH; Sweet, RD	1
Katzman, R; Wade, LA	1
McDowell, FH; Sweet, RD	2
Nevsímal, O; Roth, B; Vymazal, J	1
Calne, DB; Fermaglich, J	1
Collin, C; Eckernäs, SA; Grahnén, A; Ling-Andersson, A; Nilsson, M; Tiger, G	1
Ikarashi, Y; Maruyama, Y	1
Carlsson, A; Carlsson, M; Svensson, A	1
Davoudi, H; Durso, R; Feldman, RG; Szabo, G	1
Bennett, JP; Landow, E; Turk, M	1
Bazan, E; de Yebenes, JG; Mena, MA; Muradas, V; Reiriz, J	1
Nutt, JG	1
Jenner, P; Marion, MH; Marsden, CD; Quinn, NP; Stocchi, F	1
Hardie, RJ; Lees, AJ; Stern, GM	1
Chase, TN; Fermaglich, J	1
Hornykiewicz, O	1
Cotzias, GC; Gellene, R; Papavasiliou, PS	1
Crawford, JP	1
Böszörményi, Z; Villeneuve, A	1
Chang, CP	1
Curzon, G	1
Hartmann-von Monakow, K	1
Gershon, S; Wallach, MB	1
Delesie, R; Fahn, S; Prasad, AL	1
Axelrod, J; Weinshilboum, R	1
Bédard, P; Larochelle, L; Parent, A; Poirier, LJ	1
Dinapoli, RP; Muenter, MD; Sharpless, NS; Tyce, GM	2
Muenter, MD; Sharpless, NS; Tyce, GM	2
Horvath, TB; Meares, RA	1
Bell, MA; Cotzias, GC; Düby, SE; Fehling, C; Papavasiliou, PS; Steck, AJ	1
Duvoisin, RC; Yahr, MD	1
Allen, JG; Calne, DB; Davies, CA; Reid, JL; Vakil, SD	1
Chase, TN; Ng, LK; Watanabe, AM	1
Calne, DB; Hilson, A; Rao, SK; Vakil, SD	1
Gibberd, FB; Small, E	1
Presthus, J	1
Mones, RJ	1
Calne, DB; George, CF; Reid, JL; Vakil, SD	1
Chase, TN; Colburn, RW; Kopin, IJ; Ng, LK	1
Mars, H	1
Kofman, OS	1
Bartholini, G; Constantinidis, J; de Ajuriaguerra, J; Eisenring, JJ; Geissbühler, F; Tissot, R; Yanniotis, G	1
Duvoisin, RC; Marsden, CD	1
Bell, MA; Mena, I; Potter, DW	1
Fahn, S	1
Degkwitz, R	1
Calne, DB; Gawler, J; Hilson, A; Pallis, CA; Petrie, A; Rao, S; Reid, JL; Thomas, PK; Vakil, SD	1
Sutherland, JM	1
Calne, DB; Petrie, A; Rao, S; Reid, JL; Vakil, SD	1
Curzon, G; Kantamaneni, BD; Trigwell, J	1
Muenter, MD; Owen, CA; Sharpless, NS; Tyce, GM	1
Eisenring, JJ; Gaillard, JM; Geissbühler, F; Krassoievitch, M; Tissot, R; Yanniotis, G	1
Chase, TN; Watanabe, AM	1
Barrera, ER; Bennett, S; Mars, H	1
Chase, TN; Ng, LK	1
Constantinidis, J; Eisenring, JJ; Geissbühler, F; Krassoievitch, M; Tissot, R; Yanniotis, G	1
Dankova, J; Davidson, L; Hornykiewicz, O; Lloyd, K	1
Krall, J; Mars, H	1
Bartholini, G; Pletscher, A	1
Fermaglich, J; O'Doherty, DS	1
Barrett, RE; Duvoisin, RC; Mendoza, MR; Schear, MJ; Yahr, MD	1
Lee, JE; McDowell, F; Sweet, RD	1
Cotzias, GC	1
Bruck, J; Gerstenbrand Gründig, E; Prosenz, P	1
Chase, TN	1
Ernst, AM	1
Bruck, J; Gerstenbrand, F; Gnad, H; Gründig, E; Prosenz, P; Simanyi, M	1

Reviews

12 review(s) available for methyldopa and Parkinson Disease

Article	Year
Parkinson's disease and movement disorders: moving forward. The Lancet. Neurology, 2008, Volume: 7, Issue:1 Topics: Dopamine Agonists; Humans; Methyldopa; Movement Disorders; Parkinson Disease; Tetrahydronaphthalenes; Thiophenes	2008
The pharmacology of Parkinson's disease: basic aspects and recent advances. Experientia, 1984, Nov-15, Volume: 40, Issue:11 Topics: Animals; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Brain; Bromocriptine; Carbidopa; Corpus Striatum; Dopamine; Ergolines; Humans; Kidney; Kinetics; Levodopa; Lisuride; Liver; Methyldopa; Norepinephrine; Parkinson Disease; Pergolide; Receptors, Dopamine; Selegiline; Serotonin; Stereotyped Behavior; Substantia Nigra; Tyramine	1984
Is aldosterone secretion under dopaminergic control? Circulation research, 1981, Volume: 49, Issue:6 Topics: Aldosterone; Bromocriptine; Chlorpromazine; Dopamine; Dopamine Antagonists; Edema; Humans; Levodopa; Methyldopa; Metoclopramide; Parkinson Disease; Sulpiride	1981
The case for and concerns about continuous dopamine stimulation in Parkinson's disease. Journal of neural transmission. Supplementum, 1988, Volume: 27 Topics: Administration, Oral; Animals; Delayed-Action Preparations; Dopamine; Drug Tolerance; Humans; Infusion Pumps; Levodopa; Methyldopa; Parkinson Disease; Stimulation, Chemical	1988
Parkinson's disease: from brain homogenate to treatment. Federation proceedings, 1973, Volume: 32, Issue:2 Topics: Animals; Brain; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Dose-Response Relationship, Drug; Globus Pallidus; Homovanillic Acid; Humans; Methyldopa; Parkinson Disease; Phenylacetates; Receptors, Drug; Substantia Nigra; Tyrosine 3-Monooxygenase	1973
The biochemistry of dyskinesias. International review of neurobiology, 1967, Volume: 10 Topics: Acetylcholine; Animals; Catecholamines; Cats; Copper; Dihydroxyphenylalanine; Dogs; Hepatolenticular Degeneration; Humans; Huntington Disease; Manganese Poisoning; Melanins; Metals; Methyldopa; Movement Disorders; Parkinson Disease; Phenothiazines; Rabbits; Rats; Reserpine; Serotonin; Telencephalon; Tremorine	1967
Catecholamines. The New England journal of medicine, 1972, Aug-03, Volume: 287, Issue:5 Topics: Adrenal Medulla; Affective Symptoms; Animals; Brain; Catechol O-Methyltransferase; Catecholamines; Dihydroxyphenylalanine; Dopamine beta-Hydroxylase; Humans; Hypertension; Methyldopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nerve Endings; Neurons; Parkinson Disease; Receptors, Drug; Sympathetic Nervous System; Sympathomimetics; Synaptic Transmission; Tyrosine; Tyrosine 3-Monooxygenase	1972
Drug therapy of parkinsonism. The New England journal of medicine, 1972, Jul-06, Volume: 287, Issue:1 Topics: Amantadine; Amitriptyline; Amphetamine; Antiparkinson Agents; Dihydroxyphenylalanine; Drug Antagonism; Drug Synergism; Humans; Imipramine; Methyldopa; Monoamine Oxidase Inhibitors; Parasympatholytics; Parkinson Disease; Phenothiazines	1972
Augmenting the action of levodopa. Postgraduate medical journal, 1972, Volume: 48, Issue:565 Topics: Amantadine; Antacids; Apomorphine; Carboxy-Lyases; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Dopamine beta-Hydroxylase; Drug Synergism; Humans; Methyldopa; Monoamine Oxidase Inhibitors; Parasympatholytics; Parkinson Disease	1972
[Other trials with drug therapy in parkinsonism]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1973, Oct-10, Volume: 93, Issue:28 Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Dihydroxyphenylalanine; Disulfiram; Drug Evaluation; Drug Therapy, Combination; Humans; Imipramine; Methyldopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Picolinic Acids; Rats; Serine; Time Factors; Tryptophan; Tyrosine	1973
[l-dopa treatment of Parkinson's syndrome and mechanism of action of neuroleptics]. Medizinische Klinik, 1969, Aug-15, Volume: 64, Issue:33 Topics: Acetylcholine; Basal Ganglia; Butyrophenones; Chorea; Dihydroxyphenylalanine; Dopamine; Extrapyramidal Tracts; Humans; Methyldopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Parkinson Disease, Secondary; Phenothiazines; Reserpine; Tranquilizing Agents; Xanthenes	1969
Parkinson's syndrome: aetiological factors and certain clinical features. Australian and New Zealand journal of medicine, 1971, Volume: 1 Topics: Adult; Aged; Brain Injuries; Butyrophenones; Female; Humans; Intracranial Arteriosclerosis; Male; Methyldopa; Middle Aged; Parkinson Disease; Parkinson Disease, Postencephalitic; Parkinson Disease, Secondary; Phenothiazines; Reserpine	1971

Trials

15 trial(s) available for methyldopa and Parkinson Disease

Article	Year
Elevation of total homocysteine levels in patients with Parkinson's disease treated with duodenal levodopa/carbidopa gel. Journal of neural transmission (Vienna, Austria : 1996), 2011, Volume: 118, Issue:9 Topics: Aged; Antiparkinson Agents; Carbidopa; Drug Combinations; Duodenum; Female; Gels; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Male; Methyldopa; Middle Aged; Parkinson Disease	2011
Psychiatric symptoms during l-dopa therapy for Parkinson's disease and their relationship to physical disability. Psychological medicine, 1976, Volume: 6, Issue:1 Topics: Aged; Amantadine; Carbidopa; Clinical Trials as Topic; Depression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Interview, Psychological; Levodopa; Male; Mental Status Schedule; Methyldopa; Middle Aged; Parkinson Disease; Placebos; Recurrence; Trihexyphenidyl	1976
Comparative multiple-dose pharmacokinetics of controlled-release levodopa products. European neurology, 1992, Volume: 32, Issue:6 Topics: Adult; Antiparkinson Agents; Carbidopa; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Humans; Levodopa; Male; Metabolic Clearance Rate; Methyldopa; Neurologic Examination; Parkinson Disease	1992
Methyldopa or methyldopahydrazine as levodopa synergists. Lancet (London, England), 1973, Jun-02, Volume: 1, Issue:7814 Topics: Carbidopa; Dihydroxyphenylalanine; Drug Synergism; Humans; Hydrazines; Methyldopa; Parkinson Disease	1973
Modification of Parkinsonism--chronic treatment with L-dopa. The New England journal of medicine, 1969, Feb-13, Volume: 280, Issue:7 Topics: Adult; Aged; Agranulocytosis; Aromatic Amino Acid Decarboxylase Inhibitors; Blood Urea Nitrogen; Blood-Brain Barrier; Chronic Disease; Dihydroxyphenylalanine; Dopamine; Feeding and Eating Disorders; Female; Humans; Huntington Disease; Male; Manganese; Mental Processes; Methyldopa; Middle Aged; Movement Disorders; Nausea; Neurologic Manifestations; Parkinson Disease; Phenylacetates; Placebos; Thyroid Function Tests; Tyrosine; Vomiting	1969
Treatment of drug-induced dyskinesias. Lancet (London, England), 1970, Feb-14, Volume: 1, Issue:7642 Topics: Aged; Dihydroxyphenylalanine; Humans; Methyldopa; Middle Aged; Movement Disorders; Parkinson Disease; Reserpine	1970
Levodopa in Parkinsonism: potentiation of central effects with a peripheral inhibitor. The New England journal of medicine, 1972, Jan-06, Volume: 286, Issue:1 Topics: Administration, Oral; Adult; Biotransformation; Brain; Carbon Monoxide Poisoning; Cerebral Palsy; Child; Clinical Trials as Topic; Dihydroxyphenylalanine; Dopamine; Drug Synergism; Female; Humans; Hydrazines; Male; Methyldopa; Neurologic Examination; Neuromuscular Diseases; Parkinson Disease; Phenylacetates; Pyridoxine; Time Factors	1972
Plasma concentration of levodopa in Parkinsonism before and after inhibition of peripheral decarboxylase. Journal of the neurological sciences, 1972, Volume: 17, Issue:1 Topics: Carboxy-Lyases; Clinical Trials as Topic; Dihydroxyphenylalanine; Humans; Hydrazines; Male; Methyldopa; Movement Disorders; Parkinson Disease	1972
Parkinson's disease. Modification by 5-hydroxytryptophan. Neurology, 1972, Volume: 22, Issue:5 Topics: 5-Hydroxytryptophan; Adult; Aged; Brain; Carboxy-Lyases; Clinical Trials as Topic; Drug Synergism; Evaluation Studies as Topic; Extrapyramidal Tracts; Female; Humans; Hydrazines; Hydroxyindoleacetic Acid; Male; Methyldopa; Middle Aged; Parkinson Disease; Phenylacetates; Placebos; Serotonin	1972
3-O-Methyldopa, L-dopa, and trihexyphenidyl in the treatment of Parkinson's disease. Mayo Clinic proceedings, 1973, Volume: 48, Issue:3 Topics: Aged; Clinical Trials as Topic; Dihydroxyphenylalanine; Disability Evaluation; Drug Interactions; Female; Humans; Male; Methyldopa; Middle Aged; Parkinson Disease; Time Factors; Trihexyphenidyl	1973
Interaction between levodopa and methyldopa. British medical journal, 1973, Apr-14, Volume: 2, Issue:5858 Topics: Blood Pressure; Clinical Trials as Topic; Dihydroxyphenylalanine; Drug Synergism; Humans; Methyldopa; Parkinson Disease	1973
Evaluation of alpha methyl dopa and alpha methyl dopa hydrazine with L-dopa therapy. New York state journal of medicine, 1974, Volume: 74, Issue:1 Topics: Adult; Aged; Carbidopa; Clinical Trials as Topic; Dihydroxyphenylalanine; Drug Evaluation; Drug Therapy, Combination; Humans; Hydrazines; Methyldopa; Middle Aged; Parkinson Disease	1974
Idiopathic Parkinsonism treated with an extracerebral decarboxylase inhibitor in combination with levodopa. British medical journal, 1971, Sep-25, Volume: 3, Issue:5777 Topics: Adult; Aged; Aromatic Amino Acid Decarboxylase Inhibitors; Clinical Trials as Topic; Dihydroxyphenylalanine; Drug Synergism; Female; Humans; Hydrazines; Male; Methyldopa; Middle Aged; Nausea; Parkinson Disease; Vomiting	1971
Action of L- -methyldopa-hydrazine on the blood pressure of patients receiving levodopa. British journal of pharmacology, 1972, Volume: 44, Issue:1 Topics: Adult; Aged; Blood Pressure; Dihydroxyphenylalanine; Dopamine; Female; Humans; Hydrazines; Hypotension; Male; Methyldopa; Middle Aged; Parkinson Disease; Pulse	1972
Methyldopahydrazine as an adjunct to L-dopa therapy in parkinsonism. Neurology, 1972, Volume: 22, Issue:4 Topics: Adolescent; Adult; Aged; Blood Pressure; Brain; Child; Dihydroxyphenylalanine; Dopamine; Evaluation Studies as Topic; Female; Gastrointestinal Diseases; Heart; Humans; Hydrazines; Hydroxyindoleacetic Acid; Male; Methyldopa; Middle Aged; Motor Skills; Parkinson Disease; Phenylacetates; Serotonin	1972

Other Studies

70 other study(ies) available for methyldopa and Parkinson Disease

Article	Year
Novel inhibitors of human DOPA decarboxylase extracted from Euonymus glabra Roxb. ACS chemical biology, 2014, Apr-18, Volume: 9, Issue:4 Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Cells, Cultured; Dopa Decarboxylase; Dose-Response Relationship, Drug; Enzyme Activation; Euonymus; Humans; Inhibitory Concentration 50; Models, Molecular; Parkinson Disease	2014
Dopamine replacement modulates oscillatory coupling between premotor and motor cortical areas in Parkinson's disease. Cerebral cortex (New York, N.Y. : 1991), 2014, Volume: 24, Issue:11 Topics: Aged; Antiparkinson Agents; Bayes Theorem; Brain Waves; Case-Control Studies; Deep Brain Stimulation; Electroencephalography; Electromyography; Female; Fourier Analysis; Humans; Image Processing, Computer-Assisted; Levodopa; Magnetic Resonance Imaging; Male; Methyldopa; Middle Aged; Motor Cortex; Muscle, Skeletal; Neural Pathways; Oxygen; Parkinson Disease; Time Factors	2014
Levodopa-related cysteinyl-glycine and cysteine reduction with and without catechol-O-methyltransferase inhibition in Parkinson's disease patients. Journal of neural transmission (Vienna, Austria : 1996), 2014, Volume: 121, Issue:6 Topics: Aged; Analysis of Variance; Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase; Catechols; Chromatography, Reverse-Phase; Cysteine; Dipeptides; Drug Delivery Systems; Female; Humans; Levodopa; Male; Methyldopa; Middle Aged; Nitriles; Parkinson Disease; Time Factors	2014
Levodopa and 3-OMD levels in Parkinson patients treated with Duodopa. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2010, Volume: 20, Issue:10 Topics: Antiparkinson Agents; Drug Therapy, Combination; Duodenum; Female; Home Infusion Therapy; Homocysteine; Humans; Infusions, Parenteral; Levodopa; Male; Methyldopa; Parkinson Disease	2010
Analysis of L-dopa in human serum. BioTechniques, 2002, Volume: 33, Issue:5 Topics: Antiparkinson Agents; Chromatography, Affinity; Edetic Acid; Formates; Humans; Hydrogen-Ion Concentration; Levodopa; Methyldopa; Parkinson Disease; Reference Standards	2002
Parkinsonism occurring with methyldopa treatment. British medical journal, 1963, Apr-13, Volume: 1, Issue:5336 Topics: Antihypertensive Agents; Humans; Methyldopa; Parkinson Disease; Parkinsonian Disorders	1963
EFFECT OF ALPHA-METHYL DOPA AND RESERPINE IN HUNTINGTON'S CHOREA, PARKINSON'S DISEASE AND OTHER MOVEMENT DISORDERS. Life sciences (1962), 1963, Volume: 9 Topics: Adolescent; Chorea; Dystonia Musculorum Deformans; Dystonic Disorders; Genetic Diseases, X-Linked; Humans; Huntington Disease; Methyldopa; Movement Disorders; Parkinson Disease; Parkinsonian Disorders; Reserpine; Selective Serotonin Reuptake Inhibitors; Serotonin; Torticollis; Tremor	1963
Evidence for L-dopa incorporation into cell proteins in patients treated with levodopa. Journal of neurochemistry, 2006, Volume: 98, Issue:4 Topics: Aged; Antiparkinson Agents; Chromatography, High Pressure Liquid; Erythrocytes; Female; Humans; Hydrolysis; Levodopa; Lymphocytes; Male; Methyldopa; Parkinson Disease; Proteins	2006
[On the problem of the metabolism of dopamine in the brain of patients with parkinsonism]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1966, Volume: 66, Issue:10 Topics: Brain; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Humans; Methyldopa; Parkinson Disease	1966
[What success does L-Dopa have in the treatment of parkinsonian akinesia?]. Deutsche medizinische Wochenschrift (1946), 1967, Mar-17, Volume: 92, Issue:11 Topics: Aged; Biperiden; Blood-Brain Barrier; Desipramine; Dihydroxyphenylalanine; Dopa Decarboxylase; Female; Humans; Infusions, Parenteral; Male; Methyldopa; Middle Aged; Parasympatholytics; Parkinson Disease	1967
Catechol-O-methyltransferase and Parkinson's disease. Advances in neurology, 1984, Volume: 40 Topics: Animals; Brain; Catechol O-Methyltransferase; Corpus Striatum; Levodopa; Male; Methyldopa; Parkinson Disease; Propiophenones; Rats; Rats, Inbred Strains	1984
"On-off" phenomenon in Parkinson's disease. The New England journal of medicine, 1984, Jul-19, Volume: 311, Issue:3 Topics: Animals; Carbidopa; Humans; Levodopa; Methyldopa; Parkinson Disease	1984
Catechol-O-methyltransferase activity: a determinant of levodopa response. Clinical pharmacology and therapeutics, 1980, Volume: 28, Issue:2 Topics: Aged; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Erythrocytes; Female; Humans; Kidney; Levodopa; Liver; Male; Methyldopa; Middle Aged; Parkinson Disease; Time Factors	1980
Exacerbation of parkinsonism by methyldopa. JAMA, 1980, Dec-19, Volume: 244, Issue:24 Topics: Acute Disease; Aged; Female; Humans; Hypertension; Methyldopa; Parkinson Disease; Parkinson Disease, Secondary	1980
Dopamine conjugate in cerebrospinal fluid. Journal of neurochemistry, 1980, Volume: 34, Issue:1 Topics: Animals; Dogs; Dopamine; Humans; Methyldopa; Parkinson Disease	1980
Black cartilage after therapy with levodopa and methyldopa. Archives of pathology & laboratory medicine, 1994, Volume: 118, Issue:5 Topics: Aged; Aged, 80 and over; Cartilage, Articular; Dose-Response Relationship, Drug; Female; Humans; Intervertebral Disc; Levodopa; Male; Methyldopa; Microscopy, Electron; Parkinson Disease; Pigmentation; Ribs; Time Factors	1994
The neurochemistry of Parkinson's disease: effect of L-dopa therapy. The Journal of pharmacology and experimental therapeutics, 1975, Volume: 195, Issue:3 Topics: Aged; Brain; Catechol O-Methyltransferase; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Female; Homovanillic Acid; Humans; Levodopa; Male; Methyldopa; Middle Aged; Monoamine Oxidase; Parkinson Disease; Tyrosine 3-Monooxygenase	1975
[Alphamethyldopa and levodopa interaction]. Lakartidningen, 1979, Nov-07, Volume: 76, Issue:45 Topics: Aged; Drug Interactions; Female; Humans; Levodopa; Methyldopa; Parkinson Disease	1979
Plasma O-methyldopa in levodopa-induced dyskinesias. A bioclinical investigation. Acta neurologica Scandinavica, 1977, Volume: 56, Issue:6 Topics: Aged; Benserazide; Carbidopa; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Methyldopa; Middle Aged; Parkinson Disease	1977
Brain tissue and plasma assay of L-DOPA and alpha-methyldopa metabolites by high performance liquid chromatography with electrochemical detection. Journal of neurochemistry, 1979, Volume: 32, Issue:1 Topics: Animals; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Humans; Hypothalamus; Male; Methyldopa; Parkinson Disease; Rats	1979
Does O-methyl-dopa play a role in levodopa-induced dyskinesias? Acta neurologica Scandinavica, 1977, Volume: 56, Issue:1 Topics: Adult; Aged; Benserazide; Carbidopa; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Methyldopa; Middle Aged; Parkinson Disease	1977
Piribedil: its synergistic effect in multidrug regimens for parkinsonism. Neurology, 1976, Volume: 26, Issue:5 Topics: Aged; Amantadine; Drug Synergism; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Methyldopa; Middle Aged; Movement Disorders; Parasympatholytics; Parkinson Disease; Piperazines; Piribedil	1976
3-O-methyldopa uptake and inhibition of L-dopa at the blood-brain barrier. Life sciences, 1975, Jul-01, Volume: 17, Issue:1 Topics: Animals; Biological Availability; Biological Transport, Active; Blood-Brain Barrier; Brain; Cerebral Cortex; Corpus Striatum; Diffusion; Hypothalamus; Kinetics; Levodopa; Male; Mesencephalon; Methyldopa; Parkinson Disease; Rats	1975
Five years' treatment of Parkinson's disease with levodopa. Therapeutic results and survival of 100 patients. Annals of internal medicine, 1975, Volume: 83, Issue:4 Topics: Adult; Aged; Carbidopa; Female; Follow-Up Studies; Humans; Levodopa; Male; Methyldopa; Middle Aged; Parkinson Disease	1975
[Experiences in the treatment of Parkinsonism using a combination of L-dopa and alpha-methyldopa-hydrazine]. Ceskoslovenska neurologie a neurochirurgie, 1976, Volume: 39, Issue:2 Topics: Adult; Aged; Drug Combinations; Drug Evaluation; Drug Synergism; Humans; Hydrazines; Levodopa; Methyldopa; Middle Aged; Parkinson Disease	1976
Gout induced by L-dopa and decarboxylase inhibitors. Postgraduate medical journal, 1976, Volume: 52, Issue:606 Topics: Aged; Carbidopa; Carboxy-Lyases; Gout; Humans; Levodopa; Male; Methyldopa; Middle Aged; Parkinson Disease	1976
Identification of O-methyldopa in the ventricular fluid of patients with Parkinson's disease. Biological mass spectrometry, 1992, Volume: 21, Issue:8 Topics: Cerebral Ventricles; Chromatography, High Pressure Liquid; Chromatography, Liquid; Electrochemistry; Humans; Indicators and Reagents; Methyldopa; Parkinson Disease; Serotonin; Spectrometry, Mass, Fast Atom Bombardment	1992
Synergistic interactions between muscarinic antagonists, adrenergic agonists and NMDA antagonists with respect to locomotor stimulatory effects in monoamine-depleted mice. Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 343, Issue:6 Topics: Adrenergic alpha-Agonists; Animals; Atropine; Biperiden; Clonidine; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism; Ketamine; Male; Methyldopa; Mice; Mice, Neurologic Mutants; Motor Activity; N-Methylaspartate; Parasympatholytics; Parkinson Disease; Piperazines	1991
Magnitude of response to levodopa in Parkinson disease as it relates to peripheral and central measurements of levodopa and associated metabolites. Clinical neuropharmacology, 1989, Volume: 12, Issue:5 Topics: Aged; Carbidopa; Drug Combinations; Homovanillic Acid; Humans; Levodopa; Male; Methyldopa; Middle Aged; Parkinson Disease	1989
Continuous oral administration of L-dihydroxyphenylalanine (L-DOPA) solution to patients with advanced Parkinson's disease. Clinical neuropharmacology, 1989, Volume: 12, Issue:4 Topics: Administration, Oral; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Injections, Intravenous; Levodopa; Methyldopa; Parkinson Disease	1989
Pharmacokinetics of L-dopa in patients with Parkinson's disease. Advances in neurology, 1987, Volume: 45 Topics: Biotransformation; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Disability Evaluation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Humans; Kinetics; Levodopa; Methyldopa; Parkinson Disease; Receptors, Dopamine; Receptors, Dopamine D2; Tiapamil Hydrochloride	1987
Repeated levodopa infusions in fluctuating Parkinson's disease: clinical and pharmacokinetic data. Clinical neuropharmacology, 1986, Volume: 9, Issue:2 Topics: Drug Administration Schedule; Drug Interactions; Female; Humans; Infusions, Parenteral; Kinetics; Levodopa; Male; Methyldopa; Middle Aged; Parkinson Disease; Time Factors	1986
Pharmacokinetics of levodopa and motor fluctuations. Advances in neurology, 1987, Volume: 45 Topics: Administration, Oral; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Kinetics; Levodopa; Methyldopa; Motor Skills; Parkinson Disease	1987
DOPA in Parkinson's disease. Lancet (London, England), 1969, Apr-26, Volume: 1, Issue:7600 Topics: Animals; Dihydroxyphenylalanine; Humans; Methyldopa; Parkinson Disease; Parkinson Disease, Postencephalitic	1969
Dopa in Parkinson's disease. Lancet (London, England), 1969, May-10, Volume: 1, Issue:7602 Topics: Dihydroxyphenylalanine; Humans; Methyldopa; Parkinson Disease; Tranquilizing Agents	1969
[Methyldopa and levodopa]. Zhonghua yi xue za zhi, 1974, Volume: 7 Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Humans; Hypertension; Methyldopa; Parkinson Disease	1974
[Specific therapy of extrapyramidal-motor syndromes]. Bibliotheca psychiatrica et neurologica, 1969, Volume: 139 Topics: Analgesics; Athetosis; Chorea; Datura stramonium; Dihydroxyphenylalanine; Dystonia Musculorum Deformans; Extrapyramidal Tracts; Female; Humans; Huntington Disease; Methyldopa; Movement Disorders; Myoclonus; Parasympatholytics; Parkinson Disease; Parkinson Disease, Postencephalitic; Phenothiazines; Physical Therapy Modalities; Phytotherapy; Plants, Medicinal; Plants, Toxic; Pregnancy; Pyridoxine; Reserpine; Scopolamine; Stereotaxic Techniques; Tranquilizing Agents	1969
A neuropsychopharmacological comparison of d-amphetamine, L-dopa and cocaine. Neuropharmacology, 1971, Volume: 10, Issue:6 Topics: Animals; Behavior, Animal; Cats; Cocaine; Cortical Synchronization; Dextroamphetamine; Dihydroxyphenylalanine; Electroencephalography; Female; Hair; Humans; Hydrazines; Male; Methyldopa; Paranoid Disorders; Parkinson Disease; Phenethylamines; Reticular Formation; Salivation; Sleep, REM; Stereoisomerism	1971
A reliable and simple method for simultaneous determination of DOPA and 3-O-methyldopa in plasma and brain. Analytical biochemistry, 1972, Volume: 46, Issue:2 Topics: Antiparkinson Agents; Brain Chemistry; Carbon Isotopes; Chromatography, Ion Exchange; Cold Temperature; Dihydroxyphenylalanine; Edetic Acid; Epinephrine; Ferricyanides; Humans; Hydrazines; Hydrogen-Ion Concentration; Iodine; Methods; Methyldopa; Norepinephrine; Oxidation-Reduction; Parkinson Disease; Perchlorates; Periodic Acid; Spectrometry, Fluorescence	1972
[Control of motor activity in relation to monoaminergic mechanisms]. Revue canadienne de biologie, 1972, Volume: 31 Topics: Animals; Brain; Catatonia; Cerebellum; Corpus Striatum; Dopamine; Dopamine Antagonists; Haplorhini; Humans; Mesencephalon; Methyldopa; Methyltyrosines; Motor Activity; Parkinson Disease; Phenothiazines; Red Nucleus; Reserpine; Substantia Nigra; Tremor	1972
Dopa, 3-O-methyldopa, and metabolites in urine during oral L-3-O-methyldopa therapy. Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:5 Part 1 Topics: Administration, Oral; Autoanalysis; Catecholamines; Dealkylation; Decarboxylation; Dihydroxyphenylalanine; Fluorometry; Homovanillic Acid; Humans; Lactates; Male; Methoxyhydroxyphenylglycol; Methyldopa; Parkinson Disease; Vanilmandelic Acid	1974
3-O-Methyldopa in Parkinson's disease. Advances in neurology, 1974, Volume: 5 Topics: Antiparkinson Agents; Drug Antagonism; Drug Therapy, Combination; Humans; Levodopa; Methyldopa; Parkinson Disease; Time Factors; Trihexyphenidyl	1974
The "on-off" response to chronic L-DOPA treatment of Parkinsonism. Advances in neurology, 1974, Volume: 5 Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Confusion; Dietary Proteins; Enzyme Inhibitors; Female; Gait; Humans; Levodopa; Male; Methyldopa; Movement Disorders; Muscle Cramp; Parkinson Disease; Time Factors	1974
The relevance of the neurophysiological concepts of excitation and inhibition to clinical psychiatry. The Australian and New Zealand journal of psychiatry, 1973, Volume: 7, Issue:2 Topics: Acoustic Stimulation; Adolescent; Adult; Aged; Alcohol Amnestic Disorder; Anxiety; Arousal; Dihydroxyphenylalanine; Electroencephalography; Galvanic Skin Response; Habituation, Psychophysiologic; Humans; Hysteria; Mental Disorders; Methyldopa; Middle Aged; Obsessive-Compulsive Disorder; Parkinson Disease; Personality Inventory; Schizophrenia; Schizophrenia, Paranoid	1973
The action of L(-)-dopa on baroreflexes in Parkinsonism. Clinical science, 1972, Volume: 43, Issue:6 Topics: Adult; Aged; Aromatic Amino Acid Decarboxylase Inhibitors; Blood Pressure; Dihydroxyphenylalanine; Female; Humans; Hydrazines; Male; Methyldopa; Middle Aged; Parkinson Disease; Posture; Pressoreceptors; Reflex; Valsalva Maneuver	1972
L-dopa in Parkinsonism. A possible mechanism of action. Neurology, 1972, Volume: 22, Issue:7 Topics: Amines; Animals; Basal Ganglia; Brain; Carbon Isotopes; Cerebral Cortex; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Frontal Lobe; Hydroxydopamines; Methyldopa; Norepinephrine; Parkinson Disease; Rats; Serotonin; Tritium; Tyrosine; Urea	1972
Modification of levodopa effect by systemic decarboxylase inhibition. Archives of neurology, 1973, Volume: 28, Issue:2 Topics: Arrhythmias, Cardiac; Carboxy-Lyases; Dihydroxyphenylalanine; Dopamine; Drug Synergism; Electrocardiography; Humans; Hydrazines; Methyldopa; Parkinson Disease	1973
A therapeutic paradox? Combined treatment of Parkinson's disease with levodopa and methyldopa. Archives of neurology, 1973, Volume: 29, Issue:2 Topics: Dihydroxyphenylalanine; Drug Synergism; Evaluation Studies as Topic; Female; Follow-Up Studies; Humans; Male; Methyldopa; Middle Aged; Muscle Rigidity; Parkinson Disease; Tremor	1973
[Treatment of Parkinson's syndrome with L-dopa and its methylated derivatives: 3-OMD and 4-OMD associated with a decarboxylase inhibitor. Clinical and biochemical study]. Schweizerische medizinische Wochenschrift, 1973, Oct-20, Volume: 103, Issue:42 Topics: Aged; Benserazide; Carboxy-Lyases; Depression; Dihydroxyphenylalanine; Drug Evaluation; Drug Therapy, Combination; Humans; Hydrazines; Methyldopa; Middle Aged; Paralysis; Parkinson Disease; Sleep Wake Disorders; Time Factors	1973
Reversal of reserpine-induced bradykinesia by alpha-methyldopa--new light on its modus operandi. Brain research, 1974, May-10, Volume: 71, Issue:1 Topics: Animals; Carbidopa; Chlorpromazine; Dihydroxyphenylalanine; Disease Models, Animal; Disulfiram; Dose-Response Relationship, Drug; Drug Synergism; Methyldopa; Mice; Movement Disorders; Parkinson Disease; Phenoxybenzamine; Pimozide; Reserpine	1974
Ergometry in the clinical evaluation of Parkinsonism. Archives of physical medicine and rehabilitation, 1974, Volume: 55, Issue:6 Topics: Allied Health Personnel; Circadian Rhythm; Computers; Dietary Proteins; Dihydroxyphenylalanine; Hand; Humans; Mathematics; Methods; Methyldopa; Neurologic Examination; Parkinson Disease; Pressure; Time Factors; Work	1974
"On-off" phenomenon with levodopa therapy in Parkinsonism. Clinical and pharmacologic correlations and the effect of intramuscular pyridoxine. Neurology, 1974, Volume: 24, Issue:5 Topics: Adult; Carbidopa; Dihydroxyphenylalanine; Drug Synergism; Evaluation Studies as Topic; Female; Homovanillic Acid; Humans; Hydrazines; Injections, Intramuscular; Male; Methyldopa; Middle Aged; Movement Disorders; Parkinson Disease; Pyridoxine	1974
A method for the determination of dopa and 3-O-methyldopa in the plasma of Parkinsonian patients. Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 37 Topics: Chromatography, Ion Exchange; Dihydroxyphenylalanine; Ferricyanides; Hot Temperature; Humans; Iodine; Kinetics; Methods; Methyldopa; Oxidation-Reduction; Parkinson Disease; Spectrometry, Fluorescence	1972
3-methoxy-4-hydroxyphenylalanine (3-O-methyldopa) in plasma during oral L-dopa therapy of patients with Parkinson's disease. Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 37 Topics: Administration, Oral; Aluminum; Buffers; Chromatography; Chromatography, Ion Exchange; Dihydroxyphenylalanine; Fasting; Humans; Hydrogen-Ion Concentration; Kinetics; Methods; Methyldopa; Parkinson Disease; Phenylacetates; Spectrometry, Fluorescence	1972
[Therapy of parkinsonian syndromes and plasmatic DOPA levels. Effects of L-DOPA and 3-OMD, administered alone or combined, with or without a decarboxylase inhibitor]. Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research, 1972, Volume: 17, Issue:1 Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Drug Combinations; Drug Synergism; Humans; Methyldopa; Parkinson Disease; Phenylacetates; Time Factors	1972
Plasma 3-0-methyldopa in L-dopa therapy of Parkinson's disease. Mayo Clinic proceedings, 1972, Volume: 47, Issue:6 Topics: Dihydroxyphenylalanine; Fasting; Humans; Methyldopa; Parkinson Disease; Phenylacetates; Time Factors	1972
Levadopa and pyridoxine. JAMA, 1972, Mar-27, Volume: 219, Issue:13 Topics: Animals; Brain; Carboxy-Lyases; Decarboxylation; Dihydroxyphenylalanine; Drug Interactions; Humans; Hydrazines; Injections, Intraperitoneal; Methyldopa; Mice; Parkinson Disease; Propionates; Pyridoxine	1972
Central monoamine metabolism in Parkinson's disease. Archives of neurology, 1972, Volume: 27, Issue:6 Topics: Adult; Aged; Dihydroxyphenylalanine; Dopamine; Evaluation Studies as Topic; Female; Humans; Hydroxyindoleacetic Acid; Male; Methyldopa; Middle Aged; Parkinson Disease; Phenylacetates; Probenecid; Serotonin	1972
[Parkinsonism and plasma metabolism of dihydroxyphenylalanine administered with an inhibitor of decarboxylase]. Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 33, Issue:1 Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Humans; Hydrazines; Hydrochloric Acid; Methyldopa; Parkinson Disease; Phenylacetates; Sodium Hydroxide	1971
L-DOPA treatment in Parkinson's disease: effect on dopamine and related substances in discrete brain regions. Experientia, 1971, Sep-15, Volume: 27, Issue:9 Topics: Brain; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Humans; Methyldopa; Parkinson Disease; Phenylacetates	1971
L-dopa and cardiac arrhythmias. The New England journal of medicine, 1971, Dec-16, Volume: 285, Issue:25 Topics: Arrhythmias, Cardiac; Dihydroxyphenylalanine; Humans; Hydrazines; Methyldopa; Parkinson Disease; Propionates	1971
[Dopa metabolism in relation to the therapy of Parkinson's syndrome]. Actualites pharmacologiques, 1971, Volume: 24 Topics: Animals; Brain; Carboxy-Lyases; Dihydroxyphenylalanine; Humans; Methyldopa; Mice; Myocardium; Parkinson Disease; Rats	1971
Synergism of levodopa by alpha methyldopa. Transactions of the American Neurological Association, 1971, Volume: 96 Topics: Aged; Dihydroxyphenylalanine; Drug Synergism; Female; Humans; Male; Methyldopa; Middle Aged; Parkinson Disease	1971
Modification of L-dopa therapy of Parkinsonism by alpha-methyldopa hydrazine (MK-486). Transactions of the American Neurological Association, 1971, Volume: 96 Topics: Dihydroxyphenylalanine; Drug Synergism; Humans; Hydrazines; Methyldopa; Parkinson Disease	1971
Alpha-methyldopa as an adjunct to levodopa treatment of Parkinson's disease. Transactions of the American Neurological Association, 1971, Volume: 96 Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Drug Synergism; Humans; Methyldopa; Parkinson Disease	1971
Levodopa in the treatment of Parkinsonism. JAMA, 1971, Dec-27, Volume: 218, Issue:13 Topics: Animals; Apomorphine; Aromatic Amino Acid Decarboxylase Inhibitors; Brain; Dihydroxyphenylalanine; Dopamine; Esters; Humans; Hydrazines; Manganese Poisoning; Methylation; Methyldopa; Mice; Movement; Parkinson Disease; Parkinson Disease, Secondary; Phenylacetates	1971
[Metabolic changes in extrapyramidal syndromes and preliminary therapeutic consequences]. Fortschritte der Neurologie, Psychiatrie, und ihrer Grenzgebiete, 1965, Volume: 33, Issue:12 Topics: Aged; Amino Acids; Chorea; Extrapyramidal Tracts; Female; Humans; Injections, Intravenous; Male; Methyldopa; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease	1965
Cerebrospinal fluid monoamine metabolites and peripheral decarboxylase inhibitors in parkinsonism. Neurology, 1970, Volume: 20, Issue:12 Topics: 5-Hydroxytryptophan; Adult; Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Drug Synergism; Female; Humans; Hydrazines; Hydroxyindoleacetic Acid; Methyldopa; Middle Aged; Parkinson Disease; Phenylacetates	1970
Mode of action of apomorphine and dexamphetamine on gnawing compulsion in rats. Psychopharmacologia, 1967, Volume: 10, Issue:4 Topics: Animals; Apomorphine; Chemistry, Pharmaceutical; Compulsive Behavior; Dextroamphetamine; Dihydroxyphenylalanine; Dopamine; Extrapyramidal Tracts; Humans; Iproniazid; Male; Methyldopa; Parkinson Disease; Phenethylamines; Psychopharmacology; Rats	1967
[The effect of the administration of amino acids, especially of L-dopa and alpha-methyldopa, on the composition of cerebrospinal fluid in extrapyramidal syndromes. II. Alterations of cerebrospinal fluid in patients with Parkinson's disease and chorea fol Deutsche Zeitschrift fur Nervenheilkunde, 1969, Volume: 196, Issue:3 Topics: Alanine Transaminase; Amino Acids; Aspartate Aminotransferases; Chorea; Humans; Methyldopa; Parkinson Disease; Valine	1969