Page last updated: 2024-08-23

methyldopa and Acute Liver Injury, Drug-Induced

methyldopa has been researched along with Acute Liver Injury, Drug-Induced in 108 studies

Research

Studies (108)

Timeframe	Studies, this research(%)	All Research%
pre-1990	85 (78.70)	18.7374
1990's	5 (4.63)	18.2507
2000's	3 (2.78)	29.6817
2010's	14 (12.96)	24.3611
2020's	1 (0.93)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Ding, D; Fang, H; Kelly, R; Liu, Z; Shi, Q; Tong, W	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Andrade, RJ; Björnsson, ES; Lucena, MI; Medina-Caliz, I	1
Baraty, B; Kalantar, J; Kashkooli, S	1
Ahrens, W; Bonkovsky, HL; deLemos, AS; Foureau, DM; Jacobs, C; Russo, MW	1
Aoyagi, T; Baba, M; Furuya, K; Goto, R; Hattori, A; Koizumi, T; Sadaoka, K; Sekiya, C; Shimamura, T; Yamashita, K	1
Ali, T; Le, V; Rizvi, S; Srinivasan, N	1
Monostory, K; Ozsvár, Z; Solymossi, Z	1
Ben Salem, C; Bouraoui, K; Hmouda, H; Slim, R	1
Boitnott, JK; Maddrey, WC	3
FORTIER, J; MORIN, Y; TURMEL, L	1
Fernández-Marcote Menor, EM; Pérez-Bedmar Delgado, J	1
Phadnis, SV; Sangay, MR; Sanusi, FA	1
Kolts, BE; Langfitt, M	1
Homberg, JC	1
Ariel, I; Mosseri, M; Shalev, O; Stalnikowicz, R	1
Orozco López, P; Pujol Fernández, C; Román Martínez, J; Sorribes Puelles, R; Trilla Soler, M	1
Salaspuro, M	1
Bengtsson, L; Brodén, G	1
Maddrey, WC	1
Wright, R	1
Seeff, LB	1
de Bruin, CD; Jordans, JG; Seeverens, H	1
Breland, BD; Hicks, GS	1
Balázs, M; Kovách, G	2
Beaugrand, M; Ferrier, JP; Gavillon, C	2
Arranto, AJ; Sotaniemi, EA	2
Piercy, WN; Smith, GN	1
Belkahia, CH; Ben Khelifa, H; Ben Mami, N; Daghfous, R; el Aidli, S; Lakhal, M; Loueslati, MH; Sakka, T	1
Cardwell, MS; Thomas, LA	1
Puppala, AR; Steinheber, FU	1
Bano, KA; Haider, Z; Uddin, F	1
Furhoff, AK	1
Dybing, E; Gillette, JR; Mitchell, JR; Nelson, SD; Sasame, HA	1
Oldershausen v, HF	1
Olsson, R	1
Thaler, H	1
Dybing, E; Mitchell, JR	1
Dybing, E; Nelson, SD	1
Buffet, C; Chaput, JC; Etienne, P; Labayle, D; Lenoir, C	1
Campbell, JA; Clain, D; Gitlin, N; Kirsch, RE; Saunders, SJ; Seggie, J; Terblanche, J	1
Dybing, E	3
Rotermund, HM	1
Ahlqvist, J; Ahokas, JT; Hokkanen, OT; Pelkonen, RO; Sotaniemi, EA	1
Heissmeyer, HH	1
Granlien, M; Ostergaard Kristensen, HP	1
Lauterburg, BH; Mitchell, JR	1
Dybing, E; McMurtry, RJ; Mitchell, JR; Nelson, SD; Thorgeirsson, SS	1
Drèze, C	1
Micci, D; Rosenthal, WS; Thomas, E; Zapiach, L	1
Deutsch, DJ; Gutman, SI; Rodman, JS	1
Bhuta, S; Rosenthal, WS; Thomas, E	1
Miller, AC; Reid, WM	1
Cholette, A; Lapointe, G	1
Bonkowsky, HL; Brisbane, J	1
Bonnet-Eymard, JH; Fournet, J; Pellat, J; Thery, JP	1
Diñeiro, A; Huberman, ED; Malamud, SW; Valicenti, P	1
Thomas, E	1
Zimmerman, HJ	1
Bianchi, L; De Groote, J; Desmet, V; Gedigk, P; Korb, G; Popper, H; Poulsen, H; Scheuer, PJ; Schmid, M; Thaler, H; Wepler, W	1
Lowell, D; Sataline, L	1
Mirada Canals, A; Monteagudo Jimenez, M; Rodriguez Moreno, C; Sole Villa, J	1
de Préville, G; Nicolas, P; Picaud, A; Walter, P	1
Abe, T; Arai, T; Ichikawa, K; Nagamine, T; Saeki, S; Sakurai, S; Takagi, H; Takahashi, H; Takezawa, J; Yamada, S	1
Denton, WT; Lee, WM	1
Alvarez, E; Colombato, LO; Guma, C; Lami, G; Miyashiro, R; Olmos, M	1
Mijch, A; Stanley, P	1
Hattori, N; Kobayashi, K; Matsushita, E; Morimoto, H; Tanaka, N	1
Oka, H; Yamada, H; Yoshiba, M; Yoshikawa, Y	1
Kenna, JG; Neuberger, J; Nouri Aria, K; Williams, R	1
Bien, E	1
Hirota, N; Kimura, K; Minakami, H; Ohkusa, T; Tamada, T	1
Fujimura, M; Funada, H; Harada, M; Koshino, T; Matsuda, T; Nakamura, S; Otake, S; Otsuka, M; Ueda, M	1
Eliastam, M; Holmes, AW	1
Peters, RL; Schweitzer, IL	1
Wong, ML	1
Benton, P; Brown, RC; Matthews, HL; Smith, PG; Toghill, PJ	2
Finlayson, NC	1
Fossati, C	1
Goldstein, GB; Lam, KC; Mistilis, SP	1
Connell, AM; Hoyumpa, AM	1
Barret, O; Brouillard, RP	1
Gall, EA; Keith, TA; Rehman, OU	1
Markoff, N	1
Mackie, IJ	1
Knauer, M; Tysell, JE	1
Rosenthal, WS; Wolff, FW; Zarday, Z	1
Stenbaek, O	1
Miller, JP	1
Popper, H; Schaffner, F	1
Conn, HO; Elkington, SG; Schreiber, WM	1

Reviews

17 review(s) available for methyldopa and Acute Liver Injury, Drug-Induced

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug-induced liver injury with autoimmune features. Seminars in liver disease, 2014, Volume: 34, Issue:2 Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Antihypertensive Agents; Autoantibodies; Autoimmunity; Chemical and Drug Induced Liver Injury; Cytokines; Diagnosis, Differential; Drug Hypersensitivity; Female; Hepatitis, Autoimmune; HLA Antigens; Humans; Hydralazine; Hypergammaglobulinemia; Liver; Liver Function Tests; Male; Methyldopa; Minocycline; Nitrofurantoin; Time Factors; Young Adult	2014
[Autoimmunity induced by drugs. Immunological characteristics and etiopathogenic hypotheses]. Presse medicale (Paris, France : 1983), 1984, Dec-15, Volume: 13, Issue:45 Topics: Animals; Autoimmune Diseases; Cardiac Glycosides; Chemical and Drug Induced Liver Injury; Drug Combinations; Humans; Iproniazid; Lymphocytes; Methimazole; Methyldopa; Penicillamine; Plant Extracts; Pyrazoles; T-Lymphocytes; Ticrynafen	1984
Drug-related acute and chronic hepatitis. Clinics in gastroenterology, 1980, Volume: 9, Issue:1 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Fever; Halothane; Humans; Isoniazid; Liver; Male; Methyldopa; Middle Aged; Necrosis; Oxyphenisatin Acetate; Phenytoin	1980
Drug-induced chronic hepatitis. Springer seminars in immunopathology, 1980, Volume: 3, Issue:3 Topics: Allopurinol; Chemical and Drug Induced Liver Injury; Cholestasis; Chronic Disease; Female; Granuloma; Hepatitis; Humans; Indoles; Liver Cirrhosis; Methyldopa; Nitrofurantoin; Oxyphenisatin Acetate; Phenylbutazone	1980
Drug-induced chronic liver disease, with emphasis on chronic active hepatitis. Seminars in liver disease, 1981, Volume: 1, Issue:2 Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Dantrolene; Diagnosis, Differential; Fat Necrosis; Female; Hepatitis, Viral, Human; Humans; Liver Cirrhosis, Biliary; Male; Methotrexate; Methyldopa; Middle Aged; Nitrofurantoin; Oxyphenisatin Acetate; Perhexiline	1981
[Hepatitis-like liver disorders caused by infections, poisoning and drugs]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1976, Volume: 82 Pt 1 Topics: Alcoholism; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cytomegalovirus Infections; Halothane; Hepatitis; Humans; Infectious Mononucleosis; Isoniazid; Liver Diseases; Methyldopa; Rickettsia Infections; Virus Diseases; Yellow Fever	1976
Drug-induced chronic liver disease. Gastroenterology, 1977, Volume: 72, Issue:6 Topics: Chemical and Drug Induced Liver Injury; Chronic Disease; Halothane; Humans; Indoles; Isoniazid; Methyldopa; Oxyphenisatin Acetate; Phenothiazines	1977
Metabolic activation of methyldopa and other catechols. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1978, Issue:1 Topics: Animals; Biotransformation; Catechols; Chemical and Drug Induced Liver Injury; Erythrocytes; Estradiol Congeners; Humans; Hydroxylation; Methyldopa; Microsomes, Liver; Oxidation-Reduction	1978
[Drug-induced active hepatitis (author's transl)]. La Nouvelle presse medicale, 1979, Jun-02, Volume: 8, Issue:24 Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Indoles; Isoniazid; Male; Methyldopa; Oxyphenisatin Acetate; Prognosis	1979
Drug-induced chronic hepatitis and cirrhosis. Progress in liver diseases, 1979, Volume: 6 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Female; Halothane; Hepatitis; Humans; Isoniazid; Liver Cirrhosis; Male; Methyldopa; Necrosis; Oxyphenisatin Acetate	1979
Metabolic activation: biochemical basis for many drug-induced liver injuries. Progress in liver diseases, 1976, Volume: 5 Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Hydrazines; Isoniazid; Liver; Methyldopa; Necrosis; Pharmaceutical Preparations; Phenacetin; Thiophenes	1976
[Toxic hepatitis induced by cardiovascular agents]. Nihon rinsho. Japanese journal of clinical medicine, 1985, Volume: 43, Issue:6 Topics: Adult; Aged; Ajmaline; Anti-Arrhythmia Agents; Antihypertensive Agents; Cardiovascular Agents; Chemical and Drug Induced Liver Injury; Diuretics; Humans; Male; Methyldopa; Procaine; Quinidine; Warfarin	1985
[Prevention and therapy of severe toxic hepatitis]. Nihon rinsho. Japanese journal of clinical medicine, 1985, Volume: 43, Issue:6 Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Halothane; Humans; Isoniazid; Methyldopa; Perfusion; Plasma Exchange; Prognosis	1985
[Possibilities of liver damage by foreign substances]. Die Pharmazie, 1985, Volume: 40, Issue:11 Topics: Aminopyrine; Animals; Antimetabolites; Carcinogens; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Galactosamine; Halothane; Humans; Isoniazid; Membranes; Methyldopa; Nucleic Acids; Oxidation-Reduction; Pharmaceutical Preparations; Prostaglandin-Endoperoxide Synthases; Protein Biosynthesis	1985
The adverse effects of drugs on the liver. The British journal of clinical practice, 1973, Volume: 27, Issue:8 Topics: Acetaminophen; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Contraceptives, Oral; Drug Interactions; Halothane; Humans; Hyperbilirubinemia; Methyldopa; Phenothiazines; Tetracycline	1973
[Liver damage due to drugs. I]. La Clinica terapeutica, 1974, Jan-15, Volume: 68, Issue:1 Topics: Arsenicals; Chemical and Drug Induced Liver Injury; Chloramphenicol; Cholestasis; Coumarins; Drug-Related Side Effects and Adverse Reactions; Erythromycin; Halothane; Humans; Imipramine; Liver; Methotrexate; Methyldopa; Nicotinic Acids; Oxacillin; Phenylbutazone; Testosterone; Tetracycline	1974

Other Studies

91 other study(ies) available for methyldopa and Acute Liver Injury, Drug-Induced

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology, 2011, Volume: 7, Issue:12 Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Models, Biological; Predictive Value of Tests	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Setting up criteria for drug-induced autoimmune-like hepatitis through a systematic analysis of published reports. Hepatology communications, 2022, Volume: 6, Issue:8 Topics: Adalimumab; Chemical and Drug Induced Liver Injury; Diclofenac; Female; Hepatitis A; Hepatitis, Autoimmune; Humans; Imatinib Mesylate; Infliximab; Interferons; Methyldopa; Methylprednisolone; Minocycline; Nitrofurantoin	2022
α-Methyldopa-induced hepatitis during the postpartum period. BMJ case reports, 2014, Feb-27, Volume: 2014 Topics: Adult; Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Methyldopa; Postpartum Period; Pre-Eclampsia; Pregnancy	2014
[Case Report; A case of subacute fulminant hepatitis induced by methyldopa]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2015, Mar-10, Volume: 104, Issue:3 Topics: Adult; Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Hypertension; Liver Transplantation; Methyldopa; Tomography, X-Ray Computed	2015
Alpha-methyldopa hepatotoxicity in pregnancy. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2009, Volume: 19, Issue:2 Topics: Adult; Anti-Inflammatory Agents; Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hypertension; Jaundice; Liver Function Tests; Methyldopa; Prednisone; Pregnancy; Pregnancy Complications, Cardiovascular; Treatment Outcome	2009
[Methyldopa-induced acute reactive hepatitis in pregnancy, drug-metabolizing capacity of the liver]. Orvosi hetilap, 2010, Mar-14, Volume: 151, Issue:11 Topics: Adrenergic alpha-Agonists; Adult; Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Blood Pressure; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Drug Administration Schedule; Female; Humans; Hypertension, Pregnancy-Induced; Methyldopa; Nifedipine; Oxidoreductases, N-Demethylating; Pregnancy; Pregnancy Complications, Cardiovascular; Transaminases; Treatment Outcome	2010
Hepatotoxicity of alpha-methyldopa in pregnancy. Journal of clinical pharmacy and therapeutics, 2010, Volume: 35, Issue:3 Topics: Acute Disease; Adult; Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Hypertension, Pregnancy-Induced; Methyldopa; Pregnancy	2010
Severe hepatitis from methyldopa. Gastroenterology, 1975, Volume: 68, Issue:2 Topics: Adult; Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Fatal Outcome; Female; Humans; Hypertension; Liver; Methyldopa; Middle Aged; Treatment Outcome	1975
METHYLDOPA: CLINICAL STUDIES IN ARTERIAL HYPERTENSION. The American journal of the medical sciences, 1964, Volume: 248 Topics: Cardiac Output; Chemical and Drug Induced Liver Injury; Drug Therapy; Hemodynamics; Hepatitis; Humans; Hydrochlorothiazide; Hypertension; Hyperthyroidism; Kidney; Methyldopa; Pharmacology; Placebos; Reserpine; Toxicology	1964
[Methyldopa-induced acute toxic hepatitis]. Revista espanola de enfermedades digestivas, 2005, Volume: 97, Issue:11 Topics: Adult; Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Methyldopa; Treatment Outcome	2005
Alpha-methyldopa-induced acute hepatitis in pregnancy. The Australian & New Zealand journal of obstetrics & gynaecology, 2006, Volume: 46, Issue:3 Topics: Adult; Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Humans; Hypertension; Methyldopa; Pregnancy; Pregnancy Complications, Cardiovascular; Prenatal Diagnosis	2006
Drugs and the liver. Comprehensive therapy, 1984, Volume: 10, Issue:12 Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cholestasis; Cimetidine; Fatty Liver; Female; Hepatic Artery; Hepatic Veins; Humans; Ketoconazole; Liver; Liver Diseases; Liver Neoplasms; Methyldopa; Necrosis; Nitrofurantoin; Peliosis Hepatis; Portal Vein; Valproic Acid; Verapamil	1984
Methyldopa-induced immune hemolytic anemia and chronic active hepatitis. Archives of internal medicine, 1983, Volume: 143, Issue:3 Topics: Aged; Anemia, Hemolytic; Chemical and Drug Induced Liver Injury; Humans; Male; Methyldopa; Prednisone	1983
[Carbamazepine and methyldopa: a hepatotoxic combination?]. Medicina clinica, 1983, Jun-11, Volume: 81, Issue:1 Topics: Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Interactions; Female; Humans; Methyldopa; Middle Aged	1983
[Drug-induced liver damage; new aspects on its mechanism]. Duodecim; laaketieteellinen aikakauskirja, 1980, Volume: 96, Issue:5 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chlorpromazine; Contraceptives, Oral; Drug-Related Side Effects and Adverse Reactions; Estrogens; Female; Halothane; Humans; Isoniazid; Liver; Methyldopa; Oxyphenisatin Acetate	1980
Biliary carcinoma associated with methyldopa therapy. Acta chirurgica Scandinavica. Supplementum, 1980, Volume: 500 Topics: Adult; Aged; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Common Bile Duct Neoplasms; Female; Hepatic Duct, Common; Humans; Liver; Male; Methyldopa; Middle Aged; Models, Theoretical; Retrospective Studies	1980
Myocarditis and methyldopa. Acta medica Scandinavica, 1982, Volume: 211, Issue:3 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Male; Methyldopa; Middle Aged; Myocarditis; Pneumonia	1982
Hepatitis and hemolytic anemia associated with methyldopa therapy. Drug intelligence & clinical pharmacy, 1982, Volume: 16, Issue:6 Topics: Anemia, Hemolytic; Chemical and Drug Induced Liver Injury; Humans; Liver; Male; Methyldopa; Middle Aged	1982
Chronic aggressive hepatitis after methyldopa treatment. Case report with electron-microscopic study. Hepato-gastroenterology, 1981, Volume: 28, Issue:4 Topics: Bile Canaliculi; Cell Membrane; Cell Nucleus; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Humans; Hypertension; Liver; Methyldopa; Middle Aged; Mitochondria, Liver; Necrosis	1981
[Chronic hepatitis with elevated level of endoplasmic anti-reticulum antibodies: alpha-methyldopa or tienilic acid?]. Gastroenterologie clinique et biologique, 1981, Volume: 5, Issue:8-9 Topics: Chemical and Drug Induced Liver Injury; Female; Glycolates; Humans; Methyldopa; Ticrynafen	1981
Morphologic alterations in patients with alpha-methyldopa-induced liver damage after short- and long-term exposure. Scandinavian journal of gastroenterology, 1981, Volume: 16, Issue:7 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Humans; Liver; Liver Function Tests; Male; Methyldopa; Middle Aged; Necrosis; Time Factors	1981
Histologic follow-up of alpha-methyldopa-induced liver injury. Scandinavian journal of gastroenterology, 1981, Volume: 16, Issue:7 Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Humans; Liver; Liver Function Tests; Methyldopa; Middle Aged; Time Factors	1981
[High levels of endoplasmic reticulum antibody titer in a case of alpha-methyldopa-induced chronic active hepatitis (author's transl)]. Gastroenterologie clinique et biologique, 1980, Volume: 4, Issue:3 Topics: Aged; Autoantibodies; Chemical and Drug Induced Liver Injury; Chronic Disease; Endoplasmic Reticulum; Female; Humans; Liver; Methyldopa	1980
[Aggressive chronic hepatitis during methyldopa therapy]. Orvosi hetilap, 1980, Mar-23, Volume: 121, Issue:12 Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Humans; Liver; Methyldopa; Middle Aged	1980
Methyldopa hepatotoxicity in pregnancy: a case report. American journal of obstetrics and gynecology, 1995, Volume: 172, Issue:1 Pt 1 Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Hypertension; Methyldopa; Pregnancy; Pregnancy Complications; Pregnancy Complications, Cardiovascular; Transaminases	1995
[Methyldopa-induced hepatitis: 3 case reports]. La Tunisie medicale, 1994, Volume: 72, Issue:1 Topics: Adverse Drug Reaction Reporting Systems; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Costs; Drug Utilization; Female; Humans; Methyldopa; Middle Aged	1994
Acute reactive hepatitis in pregnancy induced by alpha-methyldopa. Obstetrics and gynecology, 1997, Volume: 90, Issue:4 Pt 2 Topics: Adult; alpha-Fetoproteins; Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Hypertension; Methyldopa; Pregnancy; Pregnancy Complications, Cardiovascular	1997
Editorial: Methyldopa hepatitis. Lancet (London, England), 1976, Aug-07, Volume: 2, Issue:7980 Topics: Chemical and Drug Induced Liver Injury; Humans; Methyldopa	1976
Fulminant hepatic failure associated with methyldopa. The American journal of gastroenterology, 1977, Volume: 68, Issue:6 Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Hepatic Encephalopathy; Humans; Liver; Methyldopa; Necrosis; Neutrophils	1977
Liver function profile in patients taking methyldopa. JPMA. The Journal of the Pakistan Medical Association, 1978, Volume: 28, Issue:8 Topics: Chemical and Drug Induced Liver Injury; Humans; Hypertension; Liver Function Tests; Methyldopa; Prospective Studies	1978
Adverse reactions with methyldopa--a decade's reports. Acta medica Scandinavica, 1978, Volume: 203, Issue:5 Topics: Adult; Age Factors; Aged; Chemical and Drug Induced Liver Injury; Drug Eruptions; Drug Hypersensitivity; Female; Fever; Gastrointestinal Diseases; Hemolysis; Humans; Hypertension; Liver; Male; Methyldopa; Middle Aged; Sex Factors	1978
Oxidation of alpha-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: possible mechanism of methyldopa hepatitis. Molecular pharmacology, 1976, Volume: 12, Issue:6 Topics: Animals; Catecholamines; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Glutathione; In Vitro Techniques; Kinetics; Male; Methyldopa; Microsomes, Liver; Oxidation-Reduction; Oxygen; Proteins; Quinones; Rats; Superoxides	1976
Liver damage due to antihypertensive drugs. Acta medica Scandinavica. Supplementum, 1979, Volume: 628 Topics: Antihypertensive Agents; Benzothiadiazines; Chemical and Drug Induced Liver Injury; Diuretics; Female; Humans; Hydralazine; Liver; Liver Function Tests; Male; Methyldopa; Prognosis; Sodium Chloride Symporter Inhibitors	1979
Acute structural hepatic alteration due to poisons. Acta pharmacologica et toxicologica, 1977, Volume: 41 Suppl 2 Topics: Acetaminophen; Acute Disease; Amanita; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Methane; Methyldopa; Mushroom Poisoning; Oxyphenisatin Acetate; Tetracycline	1977
The role of metabolic activation for drug-induced liver injuries. Acta pharmacologica et toxicologica, 1977, Volume: 41 Suppl 2 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Furosemide; Humans; Isoniazid; Liver; Methyldopa	1977
Patterns of hepatic injury induced by methyldopa. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1979, Jan-20, Volume: 55, Issue:3 Topics: Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis; Chronic Disease; Female; Hepatomegaly; Humans; Jaundice; Liver; Liver Function Tests; Male; Methyldopa; Middle Aged; Necrosis; Time Factors	1979
Activation of alpha-methyldopa, paracetamol and furosemide by human liver microsomes. Acta pharmacologica et toxicologica, 1977, Volume: 41, Issue:1 Topics: Acetaminophen; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Furosemide; Humans; Methyldopa; Microsomes, Liver	1977
[Drug-induced chronic aggressive hepatitis]. Medizinische Klinik, 1977, Dec-16, Volume: 72, Issue:50 Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Halothane; Humans; Isoniazid; Methyldopa; Oxyphenisatin Acetate; Prognosis; Salicylates; Sulfonamides	1977
[Alpha-methyldopa hepatitis]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1977, Nov-10, Volume: 97, Issue:31 Topics: Chemical and Drug Induced Liver Injury; Humans; Liver; Methyldopa	1977
Hepatic injury and drug metabolism in patients with alpha-methyldopa-induced liver damage. European journal of clinical pharmacology, 1977, Dec-28, Volume: 12, Issue:6 Topics: Adult; Aged; Antipyrine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Female; Half-Life; Humans; Liver; Male; Methyldopa; Middle Aged; Pharmaceutical Preparations; Time Factors	1977
[Clinical aspects of chronic hepatitis. Diagnosis and differential diagnosis]. ZFA. Zeitschrift fur Allgemeinmedizin, 1978, Mar-10, Volume: 54, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Chronic Disease; Diagnosis, Differential; Female; Hepatitis; Humans; Isoniazid; Liver Cirrhosis; Male; Methyldopa; Oxyphenisatin Acetate	1978
[Methyldopa hepatitis in 2 sisters]. Ugeskrift for laeger, 1978, Apr-24, Volume: 140, Issue:17 Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Methyldopa; Middle Aged	1978
Drug-induced liver injury. Hospital practice, 1978, Volume: 13, Issue:9 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Halothane; Humans; Isoniazid; Liver; Methyldopa; Mice	1978
[Adverse effects of methyldopa during a 10-year period]. Lakartidningen, 1977, May-25, Volume: 74, Issue:21 Topics: Anemia, Hemolytic; Chemical and Drug Induced Liver Injury; Depression; Diarrhea; Drug Hypersensitivity; Female; Fever; Humans; Hypertension; Male; Methyldopa	1977
[Liver involvement in mehtyldopa therapy]. Revue medicale de Liege, 1977, Aug-01, Volume: 32, Issue:15 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Methyldopa; Middle Aged	1977
Spectrum of methyldopa liver injury. The American journal of gastroenterology, 1977, Volume: 68, Issue:2 Topics: Acute Disease; Adult; Aged; Chemical and Drug Induced Liver Injury; Chronic Disease; Drug Hypersensitivity; Female; Humans; Hypertension; Liver; Male; Methyldopa; Middle Aged	1977
Methyldopa Hepatitis. A report of six cases and review of the literature. The American journal of medicine, 1976, Volume: 60, Issue:7 Topics: Adrenal Cortex Hormones; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Humans; Iatrogenic Disease; Liver; Male; Methyldopa; Middle Aged; Prognosis	1976
Methyldopa-induced liver injury. Rapid progression to fatal postnecrotic cirrhosis. Archives of pathology & laboratory medicine, 1976, Volume: 100, Issue:3 Topics: Adrenal Cortex Hormones; Chemical and Drug Induced Liver Injury; Female; Humans; Hypertension; Liver; Methyldopa; Middle Aged	1976
Methyldopa-induced granulomatous hepatitis. JAMA, 1976, May-03, Volume: 235, Issue:18 Topics: Biopsy, Needle; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Granuloma; Humans; Hypertension; Liver; Methyldopa; Middle Aged	1976
[Hepatitis in aged persons]. L'union medicale du Canada, 1976, Volume: 105, Issue:9 Topics: Aged; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Humans; Methyldopa; Middle Aged	1976
Colitis and hepatitis caused by methyldopa. JAMA, 1976, Oct-04, Volume: 236, Issue:14 Topics: Acute Disease; Administration, Oral; Chemical and Drug Induced Liver Injury; Colitis; Drug Hypersensitivity; Humans; Hypertension; Male; Methyldopa; Middle Aged	1976
[Hepatitis following methyldopa]. La Nouvelle presse medicale, 1976, Dec-11, Volume: 5, Issue:42 Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Hypertension; Methyldopa; Middle Aged	1976
[Hepatitis induced by methyldopa. Actualization with reference to a case]. Revista clinica espanola, 1976, Oct-31, Volume: 143, Issue:2 Topics: Chemical and Drug Induced Liver Injury; Humans; Hypertension; Methyldopa	1976
Methyldopa liver injury. The Journal of the Association of Physicians of India, 1976, Volume: 24, Issue:12 Topics: Chemical and Drug Induced Liver Injury; Humans; Liver; Methyldopa	1976
Liver disease caused by medicinal agents. The Medical clinics of North America, 1975, Volume: 59, Issue:4 Topics: Adrenal Cortex Hormones; Analgesics; Chemical and Drug Induced Liver Injury; Cholestasis; Contraceptive Agents; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Fatty Liver; Halothane; Humans; Isoniazid; Jaundice; Liver; Liver Cirrhosis; Metabolism, Inborn Errors; Methotrexate; Methoxyflurane; Methyldopa; Necrosis; Novobiocin	1975
[Rules for the histological evaluation of drug-induced liver lesions]. Deutsche medizinische Wochenschrift (1946), 1975, Aug-29, Volume: 100, Issue:35 Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Contraceptives, Oral; Female; Granuloma; Halothane; Humans; Liver; Liver Diseases; Methyldopa; Necrosis; Oxyphenisatin Acetate	1975
Delayed hepatotoxicity from methyldopa. Connecticut medicine, 1975, Volume: 39, Issue:12 Topics: Adult; Chemical and Drug Induced Liver Injury; Cholecystitis; Cholelithiasis; Cholestasis; Humans; Male; Methyldopa; Time Factors	1975
[Drug induced liver injury. Chemical liver necrosis caused by formation of reactive metabolites]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Feb-10, Volume: 96, Issue:4 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Isoniazid; Liver; Methyldopa; Necrosis	1976
Methyldopa-induced granulomatous hepatitis. DICP : the annals of pharmacotherapy, 1991, Volume: 25, Issue:11 Topics: Aged; Blood Chemical Analysis; Chemical and Drug Induced Liver Injury; Female; Granuloma; Humans; Hypertension; Methyldopa	1991
[Fatal toxic hepatitis in pregnancy. A discussion of the role of methyldopa]. Journal de gynecologie, obstetrique et biologie de la reproduction, 1990, Volume: 19, Issue:2 Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Hypertension; Methyldopa; Pregnancy; Pregnancy Complications; Pregnancy Complications, Cardiovascular	1990
[A male case of methyldopa-induced liver injury with positive lupus cell preparation]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1985, Volume: 82, Issue:9 Topics: Chemical and Drug Induced Liver Injury; Humans; Liver; Male; Methyldopa; Middle Aged; Neutrophils	1985
Chronic hepatitis and indolent cirrhosis due to methyldopa: the bottom of the iceberg? Journal of the South Carolina Medical Association (1975), 1989, Volume: 85, Issue:2 Topics: Adult; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Humans; Liver Cirrhosis; Male; Methyldopa; Middle Aged	1989
[Hepatic lesions induced by drugs. Report of 26 cases]. Acta gastroenterologica Latinoamericana, 1987, Volume: 17, Issue:2 Topics: Adult; Aged; Biopsy; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Estrogens; Female; Humans; Indomethacin; Ketoconazole; Liver; Male; Methyldopa; Middle Aged; Penicillins	1987
Methyldopa: an often overlooked cause of fever and transient hepatocellular dysfunction. The Medical journal of Australia, 1986, May-26, Volume: 144, Issue:11 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Fever; Humans; Liver Diseases; Liver Function Tests; Male; Methyldopa; Middle Aged	1986
Antibody mediated hepatocyte injury in methyl dopa induced hepatotoxicity. Gut, 1985, Volume: 26, Issue:11 Topics: Aged; Antibody-Dependent Cell Cytotoxicity; Antigens, Surface; Chemical and Drug Induced Liver Injury; Cytotoxicity Tests, Immunologic; Female; Fluorescent Antibody Technique; Humans; Liver; Liver Diseases; Male; Methyldopa; Middle Aged	1985
[Hepatic injury caused by methyldopa in a pre-eclamptic patient]. Nihon Sanka Fujinka Gakkai zasshi, 1986, Volume: 38, Issue:1 Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Methyldopa; Pre-Eclampsia; Pregnancy	1986
[A case of autoimmune hemolytic anemia, interstitial pneumonia and liver injury occurred during one month's medication of small dose of alpha-methyldopa]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 1985, Volume: 26, Issue:10 Topics: Aged; Anemia, Hemolytic, Autoimmune; Chemical and Drug Induced Liver Injury; Humans; Male; Methyldopa; Prednisolone; Pulmonary Fibrosis	1985
Hepatitis, arthritis and lupus cell phenomena caused by methyldopa. The American journal of digestive diseases, 1971, Volume: 16, Issue:11 Topics: Antibodies, Antinuclear; Arthritis; Biopsy; Chemical and Drug Induced Liver Injury; Female; Guanethidine; Humans; Hypertension; Immunoglobulin G; Jaundice; Liver; Methyldopa; Neutrophils	1971
Acute submassive hepatic necrosis due to methyldopa. A case demonstrating possible initiation of chronic liver disease. Gastroenterology, 1974, Volume: 66, Issue:6 Topics: Alanine Transaminase; Aspartate Aminotransferases; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Coombs Test; Electrocardiography; Female; Humans; Hydrochlorothiazide; Hypertension; Liver; Methyldopa; Middle Aged; Necrosis; Neutrophils; Reserpine	1974
Hepatocellular damage due to methyldopa. The Medical journal of Malaya, 1971, Volume: 25, Issue:3 Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Cirrhosis; Methyldopa	1971
Methyldopa liver damage. British medical journal, 1974, Aug-31, Volume: 3, Issue:5930 Topics: Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Autopsy; Bilirubin; Chemical and Drug Induced Liver Injury; Eosinophils; Female; Humans; Hypertension; Jaundice; Liver; Liver Diseases; Male; Methyldopa; Middle Aged; Necrosis; Organ Size; Recurrence	1974
Drug-induced active chronic hepatitis. The American journal of digestive diseases, 1973, Volume: 18, Issue:3 Topics: Adult; Aged; Biopsy; Cathartics; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Humans; Indoles; Ketones; Liver; Liver Function Tests; Methyldopa; Middle Aged; Necrosis; Phenols	1973
Methyldopa hepatitis. Report of three cases. The American journal of digestive diseases, 1973, Volume: 18, Issue:3 Topics: Biopsy; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Hepatic Encephalopathy; Hepatitis A; Humans; Hypertension; Liver; Methyldopa; Middle Aged; Necrosis; Serologic Tests	1973
Methyldopa associated hepatitis. JAMA, 1973, May-07, Volume: 224, Issue:6 Topics: Chemical and Drug Induced Liver Injury; Coombs Test; Female; Humans; Hypertension; Liver Function Tests; Methyldopa; Middle Aged	1973
Methyldopa-induced submassive hepatic necrosis. JAMA, 1973, Jun-04, Volume: 224, Issue:10 Topics: Alanine Transaminase; Aspartate Aminotransferases; Autopsy; Biopsy; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Female; Humans; Jaundice; L-Lactate Dehydrogenase; Liver; Liver Function Tests; Methyldopa; Middle Aged; Necrosis	1973
[New forms of toxic hepatitis. II]. Hippokrates, 1973, Volume: 44, Issue:4 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Methyldopa; Pemoline	1973
Proceedings: Liver damage in patients taking methyldopa. Gut, 1974, Volume: 15, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Liver; Liver Diseases; Methyldopa	1974
Drug-induced hepatitis? The Medical journal of Australia, 1971, Jul-10, Volume: 2, Issue:2 Topics: Chemical and Drug Induced Liver Injury; Chlorothiazide; Humans; Male; Methyldopa; Middle Aged	1971
Hepatitis induced by methyldopa (aldomet). Report of a case and a review of the literature. The American journal of digestive diseases, 1971, Volume: 16, Issue:9 Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Biopsy; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Hypertension; Liver; Liver Function Tests; Methyldopa	1971
Severe liver toxicity after methyldopa. New York state journal of medicine, 1967, Jul-01, Volume: 67, Issue:13 Topics: Adult; Chemical and Drug Induced Liver Injury; Humans; Hypertension; Liver; Male; Methyldopa	1967
[Liver injuries caused by methyldopa]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1970, Jun-15, Volume: 90, Issue:12 Topics: Chemical and Drug Induced Liver Injury; Humans; Hypertension; Liver; Methyldopa	1970
Febrile reaction to methlydopa with hepatotoxicity. Virginia medical monthly, 1970, Volume: 97, Issue:3 Topics: Chemical and Drug Induced Liver Injury; Fever; Humans; Hypertension; Liver; Liver Function Tests; Male; Methyldopa; Middle Aged	1970
[Hepatitis: caused by viruses, alcohol and drugs]. Die Medizinische Welt, 1969, Apr-12, Volume: 20, Issue:15 Topics: Alcoholism; Aminosalicylic Acids; Anesthetics; Chemical and Drug Induced Liver Injury; Hepatitis A; Humans; Methyldopa; Monoamine Oxidase Inhibitors; Muscles; Phenothiazines; Sulfonamides	1969
Hepatic injury caused by L-alpha-methyldopa. Circulation, 1969, Volume: 40, Issue:4 Topics: Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypersensitivity; Hepatitis A; Humans; Hypertension; Liver Diseases; Male; Methyldopa; Sulfobromophthalein	1969