methyldimethylaminoazobenzene has been researched along with Hyperplasia in 13 studies
Methyldimethylaminoazobenzene: A very potent liver carcinogen.
3-methyl-4'-dimethylaminoazobenzene : A member of the class of azobenzenes that is azobenzene in which one of the phenyl groups is substituted at position 3 by a methyl group, while the other is substituted at position 4 by a dimethylamino group. It is a potent liver carcinogen.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The chronobiology of ornithine decarboxylase (ODC) activity in livers was investigated in noninbred Sprague-Dawley rats fed for 5 months with a basal diet or diets with 3-methyl-4'-(dimethylamino)azobenzene (3-Me-DAB) that were oncogenic or caused bile duct hyperplasia (1-naphthylisothiocyanate) (NIT)." | 3.66 | Changes in th circadian rhythm of ornithine decarboxylase in rat liver during chemical hepatocarcinogenesis. ( Ferioli, ME; Fraschini, F; Majorino, G; Modena, D; Puerari, M; Scalabrino, G, 1981) |
| "Rats were dosed by gavage for 28 days with 25 mg/kg of 3'methyl-4-dimethylaminoazobenzene (3'M) followed by 4 days dosing with 0." | 1.28 | Studies on the hyperplastic responsiveness of binucleated rat hepatocytes. ( Bybee, A; Kelly, MD; Pritchard, NR; Styles, JA, 1990) |
| "Hepatocellular carcinomas were produced in 1 out of 8 male rats (13%) and in 1 out of 10 female rats (10%) receiving 3'-CH2OH-DAB." | 1.27 | Carcinogenic activities of hydroxymethyl derivatives of 4-(dimethylamino)azobenzene in the liver of rats, mice, and hamsters. ( Kawada, K; Koda, A; Konishi, Y; Mori, Y; Nagai, H; Niwa, T; Ojima, A; Toyoshi, K, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (92.31) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mori, Y | 1 |
| Niwa, T | 1 |
| Toyoshi, K | 1 |
| Nagai, H | 1 |
| Koda, A | 1 |
| Kawada, K | 1 |
| Ojima, A | 1 |
| Konishi, Y | 1 |
| Fiala, S | 2 |
| Trout, EC | 1 |
| Ostrander, H | 1 |
| Fiala, AE | 1 |
| Hasegawa, R | 2 |
| Tatematsu, M | 2 |
| Tsuda, H | 2 |
| Shirai, T | 1 |
| Hagiwara, A | 1 |
| Ito, N | 2 |
| Kuroda, K | 1 |
| Terao, K | 1 |
| Akao, M | 1 |
| Scalabrino, G | 1 |
| Ferioli, ME | 1 |
| Puerari, M | 1 |
| Modena, D | 1 |
| Fraschini, F | 1 |
| Majorino, G | 1 |
| Nakanishi, K | 1 |
| Pragani, B | 1 |
| Reuber, MD | 1 |
| Itabashi, M | 1 |
| Mochizuki, Y | 1 |
| Tsukada, H | 1 |
| Kodama, M | 1 |
| Ohki, T | 1 |
| Saitô, H | 1 |
| Nagata, C | 1 |
| Tagashira, Y | 1 |
| Styles, JA | 1 |
| Bybee, A | 1 |
| Pritchard, NR | 1 |
| Kelly, MD | 1 |
| Iwai, M | 1 |
| Okuno, T | 1 |
| Okanoue, T | 1 |
| Takino, T | 1 |
| Ibata, Y | 1 |
| Yamada, K | 1 |
| Tsukidate, K | 1 |
| Taki, T | 1 |
| Katayama, K | 1 |
| Sato, T | 1 |
| Sorof, S | 1 |
| Custer, RP | 1 |
13 other studies available for methyldimethylaminoazobenzene and Hyperplasia
| Article | Year |
|---|---|
Carcinogenic activities of hydroxymethyl derivatives of 4-(dimethylamino)azobenzene in the liver of rats, mice, and hamsters.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cricetinae; Dose-Response Relationship, Drug; Femal | 1984 |
gamma-Glutamyltransferase and the inhibition of azo dye-produced neoplasia by concomitant administration of disulfiram.
Topics: Animals; Disulfiram; gamma-Glutamyltransferase; Hyperplasia; Liver; Liver Neoplasms, Experimental; M | 1980 |
Induction of hyperplastic liver nodules in hepatectomized rats treated with 3'-methyl-4-dimethylaminoazobenzene, benzo[a]pyrene or phenobarbital before or after exposure to N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachloride; Hepatectomy; Hyp | 1982 |
Inhibitory effect of fumaric acid on 3-methyl-4'-(dimethylamino)-azobenzene-induced hepatocarcinogenesis in rats.
Topics: Animals; Diet; Drug Interactions; Fumarates; Hyperplasia; Liver; Liver Neoplasms; Male; Methyldimeth | 1983 |
Changes in th circadian rhythm of ornithine decarboxylase in rat liver during chemical hepatocarcinogenesis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Ducts; Carboxy-Lyases; Carcinogens; Circadian Rhythm; Hyperp | 1981 |
Route-dependent, organ-specific effects of carcinogens on induction of hyperplastic liver nodules in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Hyperplasia; Liver; Male; Methyldim | 1982 |
Inhibition of 3'-methyl-4-dimethylaminoazobenezene-induced hepatocarcinogenesis by portacaval shunt.
Topics: Animals; Biotransformation; Carcinoma, Hepatocellular; gamma-Glutamyltransferase; Glutathione; Hyper | 1978 |
Changes in peroxisomes in preneoplastic liver of rats induced by 3'-methyl-4-dimethylaminoazobenzene.
Topics: Animals; Carcinoma, Hepatocellular; Catalase; Cell Differentiation; Clofibrate; Enzyme Induction; Hy | 1977 |
Biphasic change of proton magnetic relaxation times during azo-dye hepatocarcinogenesis.
Topics: Animals; Body Water; Hyperplasia; Liver Neoplasms, Experimental; Magnetic Resonance Spectroscopy; Ma | 1978 |
Studies on the hyperplastic responsiveness of binucleated rat hepatocytes.
Topics: Animals; Butyrates; Cell Cycle; Cell Nucleus; Clofenapate; Hyperplasia; Liver; Male; Methyldimethyla | 1990 |
Biological significance of AFP-positive cells in rat livers with hyperplastic nodules induced by 3'-Me-DAB; combined immunocytochemical and radioautographical studies.
Topics: alpha-Fetoproteins; Animals; Autoradiography; Histocytochemistry; Hyperplasia; Liver; Liver Neoplasm | 1987 |
Time course of dolichol and dolichyl phosphate during chemical carcinogenesis in rat liver.
Topics: Acyl Coenzyme A; Animals; Diethylnitrosamine; Diterpenes; Dolichol Phosphates; Dolichols; Hepatectom | 1987 |
Elevated expression and cell cycle deregulation of a mitosis-associated target polypeptide of a carcinogen in hyperplastic and malignant rat hepatocytes.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Cell Cycle; Hyperplasia; Liver; Liver Neoplasms, Experiment | 1987 |