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methyldimethylaminoazobenzene and Hyperplasia

methyldimethylaminoazobenzene has been researched along with Hyperplasia in 13 studies

Methyldimethylaminoazobenzene: A very potent liver carcinogen.
3-methyl-4'-dimethylaminoazobenzene : A member of the class of azobenzenes that is azobenzene in which one of the phenyl groups is substituted at position 3 by a methyl group, while the other is substituted at position 4 by a dimethylamino group. It is a potent liver carcinogen.

Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.

Research Excerpts

ExcerptRelevanceReference
"The chronobiology of ornithine decarboxylase (ODC) activity in livers was investigated in noninbred Sprague-Dawley rats fed for 5 months with a basal diet or diets with 3-methyl-4'-(dimethylamino)azobenzene (3-Me-DAB) that were oncogenic or caused bile duct hyperplasia (1-naphthylisothiocyanate) (NIT)."3.66Changes in th circadian rhythm of ornithine decarboxylase in rat liver during chemical hepatocarcinogenesis. ( Ferioli, ME; Fraschini, F; Majorino, G; Modena, D; Puerari, M; Scalabrino, G, 1981)
"Rats were dosed by gavage for 28 days with 25 mg/kg of 3'methyl-4-dimethylaminoazobenzene (3'M) followed by 4 days dosing with 0."1.28Studies on the hyperplastic responsiveness of binucleated rat hepatocytes. ( Bybee, A; Kelly, MD; Pritchard, NR; Styles, JA, 1990)
"Hepatocellular carcinomas were produced in 1 out of 8 male rats (13%) and in 1 out of 10 female rats (10%) receiving 3'-CH2OH-DAB."1.27Carcinogenic activities of hydroxymethyl derivatives of 4-(dimethylamino)azobenzene in the liver of rats, mice, and hamsters. ( Kawada, K; Koda, A; Konishi, Y; Mori, Y; Nagai, H; Niwa, T; Ojima, A; Toyoshi, K, 1984)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-199012 (92.31)18.7374
1990's1 (7.69)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mori, Y1
Niwa, T1
Toyoshi, K1
Nagai, H1
Koda, A1
Kawada, K1
Ojima, A1
Konishi, Y1
Fiala, S2
Trout, EC1
Ostrander, H1
Fiala, AE1
Hasegawa, R2
Tatematsu, M2
Tsuda, H2
Shirai, T1
Hagiwara, A1
Ito, N2
Kuroda, K1
Terao, K1
Akao, M1
Scalabrino, G1
Ferioli, ME1
Puerari, M1
Modena, D1
Fraschini, F1
Majorino, G1
Nakanishi, K1
Pragani, B1
Reuber, MD1
Itabashi, M1
Mochizuki, Y1
Tsukada, H1
Kodama, M1
Ohki, T1
Saitô, H1
Nagata, C1
Tagashira, Y1
Styles, JA1
Bybee, A1
Pritchard, NR1
Kelly, MD1
Iwai, M1
Okuno, T1
Okanoue, T1
Takino, T1
Ibata, Y1
Yamada, K1
Tsukidate, K1
Taki, T1
Katayama, K1
Sato, T1
Sorof, S1
Custer, RP1

Other Studies

13 other studies available for methyldimethylaminoazobenzene and Hyperplasia

ArticleYear
Carcinogenic activities of hydroxymethyl derivatives of 4-(dimethylamino)azobenzene in the liver of rats, mice, and hamsters.
    Experimental pathology, 1984, Volume: 26, Issue:1

    Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cricetinae; Dose-Response Relationship, Drug; Femal

1984
gamma-Glutamyltransferase and the inhibition of azo dye-produced neoplasia by concomitant administration of disulfiram.
    Journal of the National Cancer Institute, 1980, Volume: 64, Issue:2

    Topics: Animals; Disulfiram; gamma-Glutamyltransferase; Hyperplasia; Liver; Liver Neoplasms, Experimental; M

1980
Induction of hyperplastic liver nodules in hepatectomized rats treated with 3'-methyl-4-dimethylaminoazobenzene, benzo[a]pyrene or phenobarbital before or after exposure to N-2-fluorenylacetamide.
    Gan, 1982, Volume: 73, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachloride; Hepatectomy; Hyp

1982
Inhibitory effect of fumaric acid on 3-methyl-4'-(dimethylamino)-azobenzene-induced hepatocarcinogenesis in rats.
    Journal of the National Cancer Institute, 1983, Volume: 71, Issue:4

    Topics: Animals; Diet; Drug Interactions; Fumarates; Hyperplasia; Liver; Liver Neoplasms; Male; Methyldimeth

1983
Changes in th circadian rhythm of ornithine decarboxylase in rat liver during chemical hepatocarcinogenesis.
    Journal of the National Cancer Institute, 1981, Volume: 66, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Ducts; Carboxy-Lyases; Carcinogens; Circadian Rhythm; Hyperp

1981
Route-dependent, organ-specific effects of carcinogens on induction of hyperplastic liver nodules in rats.
    Toxicology letters, 1982, Volume: 14, Issue:3-4

    Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Hyperplasia; Liver; Male; Methyldim

1982
Inhibition of 3'-methyl-4-dimethylaminoazobenezene-induced hepatocarcinogenesis by portacaval shunt.
    Tumori, 1978, Apr-30, Volume: 64, Issue:2

    Topics: Animals; Biotransformation; Carcinoma, Hepatocellular; gamma-Glutamyltransferase; Glutathione; Hyper

1978
Changes in peroxisomes in preneoplastic liver of rats induced by 3'-methyl-4-dimethylaminoazobenzene.
    Cancer research, 1977, Volume: 37, Issue:4

    Topics: Animals; Carcinoma, Hepatocellular; Catalase; Cell Differentiation; Clofibrate; Enzyme Induction; Hy

1977
Biphasic change of proton magnetic relaxation times during azo-dye hepatocarcinogenesis.
    British journal of cancer, 1978, Volume: 38, Issue:2

    Topics: Animals; Body Water; Hyperplasia; Liver Neoplasms, Experimental; Magnetic Resonance Spectroscopy; Ma

1978
Studies on the hyperplastic responsiveness of binucleated rat hepatocytes.
    Carcinogenesis, 1990, Volume: 11, Issue:7

    Topics: Animals; Butyrates; Cell Cycle; Cell Nucleus; Clofenapate; Hyperplasia; Liver; Male; Methyldimethyla

1990
Biological significance of AFP-positive cells in rat livers with hyperplastic nodules induced by 3'-Me-DAB; combined immunocytochemical and radioautographical studies.
    Gastroenterologia Japonica, 1987, Volume: 22, Issue:2

    Topics: alpha-Fetoproteins; Animals; Autoradiography; Histocytochemistry; Hyperplasia; Liver; Liver Neoplasm

1987
Time course of dolichol and dolichyl phosphate during chemical carcinogenesis in rat liver.
    Biochimica et biophysica acta, 1987, Oct-17, Volume: 921, Issue:3

    Topics: Acyl Coenzyme A; Animals; Diethylnitrosamine; Diterpenes; Dolichol Phosphates; Dolichols; Hepatectom

1987
Elevated expression and cell cycle deregulation of a mitosis-associated target polypeptide of a carcinogen in hyperplastic and malignant rat hepatocytes.
    Cancer research, 1987, Jan-01, Volume: 47, Issue:1

    Topics: 2-Acetylaminofluorene; Adenoma; Animals; Cell Cycle; Hyperplasia; Liver; Liver Neoplasms, Experiment

1987