methyldimethylaminoazobenzene has been researched along with Hepatocellular Carcinoma in 38 studies
Methyldimethylaminoazobenzene: A very potent liver carcinogen.
3-methyl-4'-dimethylaminoazobenzene : A member of the class of azobenzenes that is azobenzene in which one of the phenyl groups is substituted at position 3 by a methyl group, while the other is substituted at position 4 by a dimethylamino group. It is a potent liver carcinogen.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Activation of ras protooncogenes in 11 2-acetylaminofluorene (AAF)-induced hepatocellular carcinomas (HCCs) or liver cell lines and 9 3'-methyl-(dimethylamino)azobenzene (3'-Me-DAB)-induced HCCs in rats was examined using the NIH3T3 cell transfection assay and oligonucleotide hybridization analysis." | 7.68 | Low frequency of ras activation in 2-acetylaminofluorene- and 3'-methyl-4-(dimethylamino)azobenzene-induced rat hepatocellular carcinomas. ( Kitagawa, T; Lee, GH; Li, H; Liu, J; Nomura, K; Ohtake, K, 1991) |
| "Activation of ras protooncogenes in 11 2-acetylaminofluorene (AAF)-induced hepatocellular carcinomas (HCCs) or liver cell lines and 9 3'-methyl-(dimethylamino)azobenzene (3'-Me-DAB)-induced HCCs in rats was examined using the NIH3T3 cell transfection assay and oligonucleotide hybridization analysis." | 3.68 | Low frequency of ras activation in 2-acetylaminofluorene- and 3'-methyl-4-(dimethylamino)azobenzene-induced rat hepatocellular carcinomas. ( Kitagawa, T; Lee, GH; Li, H; Liu, J; Nomura, K; Ohtake, K, 1991) |
| "The resistance to progression to hepatocellular carcinoma is affected solely by Drh2." | 2.42 | Genetic resistance to chemical hepatocarcinogenesis in the DRH rat strain. ( Denda, A; Hiai, H; Higashi, K; Higashi, T, 2004) |
| "Liver cancer was induced in rats by feeding 3'-MeDAB, and the changes in expression of IRS-1 and MAPK were analyzed in tumorous, non-tumorous and control liver." | 1.30 | Increased activity and expression of MAP kinase in HCC model rats induced by 3'-methyl-4-dimethylamino-azobenzene. ( Goldstein, BJ; Hashimoto, N; Kanatsuka, A; Saito, Y; Suzuki, Y; Tokita, K; Toyoda, M; Yokosuka, O, 1999) |
| "Carcinomas were found in the livers of both sham-operated and sialoadenectomized males that were 10 and 12 months old and were less frequent in sialoadenectomized males although the difference was significant only at the age of 12 months." | 1.29 | Inhibitory effect of sialoadenectomy on hepatocellular tumourigenesis in male mice induced by 3'-methyl-4-dimethylaminoazobenzene. ( Iishi, H; Tatsuta, M; Terada, N; Tsuji, M; Yamamoto, R, 1994) |
| "Hepatocellular carcinomas were produced in 1 out of 8 male rats (13%) and in 1 out of 10 female rats (10%) receiving 3'-CH2OH-DAB." | 1.27 | Carcinogenic activities of hydroxymethyl derivatives of 4-(dimethylamino)azobenzene in the liver of rats, mice, and hamsters. ( Kawada, K; Koda, A; Konishi, Y; Mori, Y; Nagai, H; Niwa, T; Ojima, A; Toyoshi, K, 1984) |
| "The fractions separated from the hepatoma were stimulated more than those of kidney by gamma-glutamyl group acceptor." | 1.26 | Higher transpeptidation activity and broad acceptor specificity of gamma-glutamyltransferases of tumors. ( Higashi, T; Nakashima, K; Naruse, A; Nomura, T; Tateishi, N, 1976) |
| "In well differentiated, slowly growing hepatomas, the concentration of GSH approached the level in normal adult rat liver." | 1.26 | Glutathione and gamma glutamyl transpeptidase in rat liver during chemical carcinogenesis. ( Fiala, AE; Fiala, S; Kettering, WG; Mohindru, A; Morris, HP, 1976) |
| "The urine of 90% of hepatoma-bearing rats contained AFP at the time of killing." | 1.26 | Excretion of alpha-foetoprotein in the urine of rats during exposure to 3'-methyl-4-dimethylaminoazobenzene. ( Boss, JH; Okon, E; Rosenmann, E; Zajicek, G, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (76.32) | 18.7374 |
| 1990's | 5 (13.16) | 18.2507 |
| 2000's | 4 (10.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HOFFMAN, J | 1 |
| KLEIN, A | 1 |
| MIHEYEV, T | 1 |
| POST, J | 1 |
| ARCOS, JC | 1 |
| GRIFFITH, GW | 1 |
| CUNNINGHAM, RW | 1 |
| HAWTREY, AO | 1 |
| SCHOEMAN, CA | 1 |
| DIJKSTRA, J | 1 |
| SCHIRREN, V | 1 |
| NOURSE, L | 1 |
| OLSON, KB | 1 |
| EDWARDS, CF | 1 |
| HEGGEN, GE | 1 |
| STEIN, AA | 1 |
| Higashi, K | 2 |
| Denda, A | 2 |
| Higashi, T | 2 |
| Hiai, H | 2 |
| Chen, QR | 1 |
| Xiang, J | 1 |
| Liao, B | 1 |
| Liu, QB | 1 |
| Che, LH | 1 |
| Xue, L | 1 |
| Zhao, GQ | 1 |
| Ando, N | 1 |
| Shimizu, M | 1 |
| Okuno, M | 1 |
| Matsushima-Nishiwaki, R | 1 |
| Tsurumi, H | 1 |
| Tanaka, T | 1 |
| Moriwaki, H | 1 |
| Mori, Y | 1 |
| Niwa, T | 1 |
| Toyoshi, K | 1 |
| Nagai, H | 1 |
| Koda, A | 1 |
| Kawada, K | 1 |
| Ojima, A | 1 |
| Konishi, Y | 2 |
| Blackburn, GR | 1 |
| Andrews, JP | 1 |
| Custer, RP | 1 |
| Sorof, S | 1 |
| Ogoshi, K | 1 |
| Yanagi, S | 1 |
| Moriyama, T | 1 |
| Arachi, H | 1 |
| Yamamoto, R | 1 |
| Iishi, H | 1 |
| Tatsuta, M | 1 |
| Tsuji, M | 1 |
| Terada, N | 1 |
| Kameda, H | 1 |
| Toyoda, M | 1 |
| Hashimoto, N | 1 |
| Tokita, K | 1 |
| Goldstein, BJ | 1 |
| Yokosuka, O | 1 |
| Kanatsuka, A | 1 |
| Suzuki, Y | 1 |
| Saito, Y | 1 |
| Yan, Y | 1 |
| Zeng, ZZ | 1 |
| Higashi, S | 1 |
| Onishi, S | 1 |
| Ueno, H | 1 |
| Kitagawa, Y | 1 |
| Kuroiwa, Y | 1 |
| Tateishi, N | 1 |
| Nomura, T | 1 |
| Naruse, A | 1 |
| Nakashima, K | 1 |
| Fiala, S | 2 |
| Mohindru, A | 1 |
| Kettering, WG | 1 |
| Fiala, AE | 1 |
| Morris, HP | 1 |
| Pragani, B | 1 |
| Reuber, MD | 1 |
| Onoé, T | 3 |
| Kaneko, A | 3 |
| Dempo, K | 2 |
| Ogawa, K | 1 |
| Minase, T | 1 |
| Ichihara, A | 1 |
| Boss, JH | 1 |
| Zajicek, G | 1 |
| Okon, E | 1 |
| Rosenmann, E | 1 |
| Smith, CJ | 1 |
| Kelleher, PC | 1 |
| Carruthers, C | 2 |
| Baumler, A | 2 |
| Neilson, A | 2 |
| Katayama, S | 1 |
| Yamaguchi, I | 1 |
| Nakano, Y | 1 |
| Fukuda, M | 1 |
| Kuroda, K | 1 |
| Akao, M | 1 |
| Harris, CL | 1 |
| Kerns, FT | 1 |
| St Clair, W | 1 |
| Pressman, D | 1 |
| Yoshida, Y | 2 |
| Yokoyama, S | 1 |
| Lambooy, JP | 1 |
| Itabashi, M | 1 |
| Mochizuki, Y | 1 |
| Tsukada, H | 1 |
| Frenkel, JK | 1 |
| Reddy, JK | 1 |
| Griffin, AC | 1 |
| Jacobs, MM | 1 |
| Patel, NT | 1 |
| Holoubek, V | 1 |
| Chisaka, N | 1 |
| Sato, K | 1 |
| Takaya, S | 1 |
| Imai, F | 1 |
| Hatayama, I | 1 |
| Ito, N | 1 |
| Martin, TJ | 1 |
| Hunt, NH | 1 |
| Boyd, H | 1 |
| Ellison, M | 1 |
| Michelangeli, VP | 1 |
| Atkins, D | 1 |
| Li, H | 1 |
| Lee, GH | 1 |
| Liu, J | 1 |
| Nomura, K | 1 |
| Ohtake, K | 1 |
| Kitagawa, T | 1 |
| Adamson, RH | 1 |
2 reviews available for methyldimethylaminoazobenzene and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Genetic resistance to chemical hepatocarcinogenesis in the DRH rat strain.
Topics: Animals; Carcinoma, Hepatocellular; DNA Adducts; Hepatectomy; Hepatocytes; Immunity, Innate; Liver N | 2004 |
Hormone receptors and cyclic nucleotide metabolism in cancer cells.
Topics: Adenocarcinoma; Adenoma; Adenylyl Cyclases; Animals; Calcitonin; Carcinoma, Hepatocellular; Cell Mem | 1976 |
36 other studies available for methyldimethylaminoazobenzene and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Responses of the liver to injury. Nuclear DNA changes during evolution of 3'-methyl-4-dimethylaminoazobenzene hepatomas.
Topics: Carcinoma, Hepatocellular; DNA; Liver Neoplasms; Methyldimethylaminoazobenzene | 1961 |
Fine stuctural alterations in cell particles during chemical carcinogenesis. II. Further evidence for their involvement in the mechanism of carcinogenesis. The swelling of rat liver mitochondria during feeding of amino azo dyes.
Topics: Animals; Azo Compounds; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Coloring Agents; Liv | 1960 |
THE EFFECT OF SHORT-TERM FEEDING EXPERIMENTS WITH 3'-METHYL-4-DIMETHYLAMINOAZOBENZENE OF RAT-LIVER MITOCHONDRIAL FUNCTION.
Topics: Carcinoma, Hepatocellular; Citrates; Citric Acid Cycle; Glutamates; Hydroxybutyrates; Isocitrate Deh | 1964 |
ANALYSIS OF THE LIVERS AND TUMORS FOR FOURTEEN TRACE ELEMENTS OF RATS FED 3'-METHYL-4-DIMETHYLAMINOAZOBENZENE (3'-ME-DAB).
Topics: Carcinoma; Carcinoma, Hepatocellular; Copper; Dietary Proteins; Histocytochemistry; Iron; Liver; Liv | 1964 |
[Evolutive characters of oval cells in experimental hepatocarcinogenesis].
Topics: Animals; Carcinoma, Hepatocellular; Cholangiocarcinoma; Hepatocytes; Immunohistochemistry; Liver; Li | 2007 |
Expression of retinoid X receptor alpha is decreased in 3'-methyl-4-dimethylaminoazobenzene-induced hepatocellular carcinoma in rats.
Topics: Adenoma; Animals; beta Catenin; Blotting, Western; Carcinoma, Hepatocellular; Cell Nucleus; Cyclin D | 2007 |
Carcinogenic activities of hydroxymethyl derivatives of 4-(dimethylamino)azobenzene in the liver of rats, mice, and hamsters.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cricetinae; Dose-Response Relationship, Drug; Femal | 1984 |
Early events during liver carcinogenesis involving two carcinogen:protein complexes.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cytosol; Ethionine; Female; | 1981 |
Accumulation of aluminum in cancers of the liver, stomach, duodenum and mammary glands of rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aluminum; Animals; Carcinoma, Hepatocellular; Copper; Disease Mode | 1994 |
Inhibitory effect of sialoadenectomy on hepatocellular tumourigenesis in male mice induced by 3'-methyl-4-dimethylaminoazobenzene.
Topics: Adenoma; Animals; Animals, Newborn; Carcinoma; Carcinoma, Hepatocellular; Liver Neoplasms; Male; Met | 1994 |
[Establishment of an estrogen receptor positive 3'-methyl-4-dimethylaminoazobenzene induced hepatoma cell line of rat and investigation of hormonal therapy].
Topics: Animals; Carcinoma, Hepatocellular; Castration; Cell Division; Estradiol; Estrogen Antagonists; Live | 1996 |
Increased activity and expression of MAP kinase in HCC model rats induced by 3'-methyl-4-dimethylamino-azobenzene.
Topics: Animals; Blotting, Northern; Blotting, Western; Carcinoma, Hepatocellular; Insulin Receptor Substrat | 1999 |
Resistance of DRH strain rats to chemical carcinogenesis of liver: genetic analysis of later progression stage.
Topics: Animals; Carcinoma, Hepatocellular; Chromosome Mapping; Crosses, Genetic; Disease Progression; Femal | 2002 |
Change in intracellular pH of rat liver during azo-dye carcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Growth; Hydrogen-Ion Concentra | 1976 |
Higher transpeptidation activity and broad acceptor specificity of gamma-glutamyltransferases of tumors.
Topics: Amino Acids; Animals; Animals, Newborn; Carcinoma, Hepatocellular; Cattle; Enzyme Activation; Female | 1976 |
Glutathione and gamma glutamyl transpeptidase in rat liver during chemical carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Chloramphenicol; gamma-Glutamyltransferas | 1976 |
Inhibition of 3'-methyl-4-dimethylaminoazobenezene-induced hepatocarcinogenesis by portacaval shunt.
Topics: Animals; Biotransformation; Carcinoma, Hepatocellular; gamma-Glutamyltransferase; Glutathione; Hyper | 1978 |
Alpha-Fetoprotein and early histological changes of hepatic tissue in DAB-hepatocarcinogenesis.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Fetal Proteins; Liver; Liver Neoplasms; Meth | 1975 |
Isozyme patterns of branched-chain amino acid transaminase during cellular differentiation and carcinogenesis.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Cell Differentiation; Cell Transformation, N | 1975 |
Excretion of alpha-foetoprotein in the urine of rats during exposure to 3'-methyl-4-dimethylaminoazobenzene.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Female; Liver Neoplasms; Methyldimethylamino | 1977 |
Induction of hepatomas secreting large amounts of alpha-fetoprotein.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Liver Neoplasms; Methyldimethylaminoazobenze | 1977 |
A distinctive antigen present in liver carcinomas induced by 3'-methyl-p-dimethylaminoazobenzene.
Topics: Adenoma, Bile Duct; alpha-Fetoproteins; Animals; Antibodies, Neoplasm; Antigens, Neoplasm; Carcinoma | 1977 |
[Proceedings: Differentation of LDH pI isozyme in 3'-MeDAB-induced liver neoplasms].
Topics: Animals; Carcinoma, Hepatocellular; Isoenzymes; L-Lactate Dehydrogenase; Liver Neoplasms; Methyldime | 1975 |
Effect of Capsella bursa-pastoris on liver catalase activity in rats fed 3'-methyl-4-(dimethylamino)azobenzene.
Topics: Animals; Carcinoma, Hepatocellular; Catalase; China; Japan; Liver; Liver Neoplasms; Male; Methyldime | 1975 |
RNA sulfurtransferase activity in rat liver and chemically induced hepatomas.
Topics: Animals; Carcinoma, Hepatocellular; Histocytochemistry; Liver; Liver Neoplasms; Male; Methyldimethyl | 1975 |
Binding of the azocarcinogen 3'-methyl-p-dimethylaminoazobenzene to cellular components of normal rat liver and azocarcinogen-induced hepatomas.
Topics: Adenoma, Bile Duct; Animals; Binding Sites; Carcinoma, Hepatocellular; Cell Membrane; Cell Nucleus; | 1975 |
Some properties and electrophoretic patterns of rat liver esterases in relation to hepatocarcinogenesis by 3'-methyl-4-(dimethylamino) azobenzene.
Topics: Acetates; Animals; Carcinoma, Hepatocellular; Cholinesterases; Cysteine; Electrophoresis, Cellulose | 1976 |
Influence of riboflavin antagonists on azo dye hepatoma induction in the rat.
Topics: Animals; Carcinoma, Hepatocellular; Flavins; Liver Neoplasms; Male; Methyldimethylaminoazobenzene; N | 1976 |
Changes in peroxisomes in preneoplastic liver of rats induced by 3'-methyl-4-dimethylaminoazobenzene.
Topics: Animals; Carcinoma, Hepatocellular; Catalase; Cell Differentiation; Clofibrate; Enzyme Induction; Hy | 1977 |
Induction of liver tumours by 3'-methyl-dimethylaminoazobenzene (3'-Me-DAB) in rats chronically infected with Toxoplasma or Besnoitia.
Topics: Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Chronic Disease; Diet; Liver Neoplasms; Male | 1977 |
Effects of selenium on azo dye hepatocarcinogenesis.
Topics: Animals; Benz(a)Anthracenes; Carcinoma, Hepatocellular; Liver Neoplasms; Male; Methyldimethylaminoaz | 1977 |
Protein composition of nuclear ribonucleoprotein particles isolated from liver of rats in the early stages of feeding of 3'-methyl-4-dimethylaminoazobenzene and from hepatoma induced by the same carcinogen.
Topics: Animals; Carcinoma, Hepatocellular; Cell Nucleus; Cell Transformation, Neoplastic; Electrophoresis, | 1977 |
Appearance of intestinal type of tumor cells in hepatoma tissue induced by 3'-methyl-4-dimethylaminoazobenzene.
Topics: Alkaline Phosphatase; Animals; Carcinoma, Hepatocellular; Cytoplasmic Granules; Intestines; Isoenzym | 1978 |
Different deviation patterns of carbohydrate-metabolizing enzymes in primary rat hepatomas induced by different chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carbohydrate Metabolism; Carcinogens; Carcinoma, Hepatocellular; Cel | 1978 |
Low frequency of ras activation in 2-acetylaminofluorene- and 3'-methyl-4-(dimethylamino)azobenzene-induced rat hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Southern; Carcinoma, Hepatocellular; Cell Transformation, | 1991 |
Induction of hepatocellular carcinoma in nonhuman primates by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Carcinogens, Environmental; Carcinoma, Hepatocellular; C | 1989 |