methyldimethylaminoazobenzene has been researched along with Condition, Preneoplastic in 39 studies
Methyldimethylaminoazobenzene: A very potent liver carcinogen.
3-methyl-4'-dimethylaminoazobenzene : A member of the class of azobenzenes that is azobenzene in which one of the phenyl groups is substituted at position 3 by a methyl group, while the other is substituted at position 4 by a dimethylamino group. It is a potent liver carcinogen.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Drug resistance was not induced by chronic administration of the tumor promoters phenobarbital, choline-deficient diet, phorbol, nor with 2,3,7,8-tetrachlorodibenzo-p-dioxin, but was induced to a variable extent by three hepatotoxins (ethanol, methotrexate, carbon tetrachloride)." | 1.27 | Pleiotropic drug resistance in hepatocytes induced by carcinogens administered to rats. ( Carr, BI, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (76.92) | 18.7374 |
| 1990's | 9 (23.08) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fiala, S | 1 |
| Trout, EC | 1 |
| Ostrander, H | 1 |
| Fiala, AE | 1 |
| Tamano, S | 1 |
| Tsuda, H | 3 |
| Fukushima, S | 1 |
| Masui, T | 1 |
| Hosoda, K | 2 |
| Ito, N | 4 |
| Schwartz, CE | 1 |
| Gabryelak, T | 1 |
| Smith, CJ | 1 |
| Taylor, JM | 1 |
| Chiu, JF | 2 |
| Gotoh, M | 2 |
| Mochizuki, Y | 3 |
| Sawada, N | 2 |
| Tsukada, H | 3 |
| Hino, O | 1 |
| Kitagawa, T | 3 |
| Simícková, M | 2 |
| Dolezalová, V | 2 |
| Nĕmecek, R | 2 |
| Ishii, K | 1 |
| Okudaira, M | 1 |
| Shibata, H | 1 |
| Okabe, H | 1 |
| Furukawa, K | 1 |
| Nomura, M | 1 |
| Nakachiyama, M | 1 |
| Hida, T | 1 |
| Ohtaki, Y | 1 |
| Sudo, K | 1 |
| Aizawa, T | 1 |
| Aburada, M | 1 |
| Miyamoto, KI | 1 |
| de Camargo, JL | 1 |
| Asamoto, M | 1 |
| Tagawa, Y | 1 |
| Wada, S | 1 |
| Nagase, S | 1 |
| Ogasawara, H | 1 |
| Hiramoto, J | 1 |
| Takahashi, M | 1 |
| Shirahama, K | 1 |
| Furusaka, A | 1 |
| Hiyane, S | 1 |
| Nakada, T | 1 |
| Nagayama, K | 1 |
| Tanaka, T | 1 |
| Yan, Y | 2 |
| Higashi, K | 2 |
| Yamamura, K | 1 |
| Fukamachi, Y | 2 |
| Abe, T | 2 |
| Gotoh, S | 2 |
| Sugiura, T | 1 |
| Hirano, T | 1 |
| Higashi, T | 3 |
| Ichiba, M | 1 |
| Denda, A | 1 |
| Kitayama, W | 1 |
| Konishi, Y | 1 |
| Miura, M | 1 |
| Ikemura, K | 1 |
| Kitagawa, Y | 1 |
| Kuroiwa, Y | 1 |
| Stratil, P | 1 |
| Sugano, H | 1 |
| Itabashi, M | 1 |
| Toh, BH | 1 |
| Cauchi, MN | 1 |
| Cook, PC | 1 |
| Muller, HK | 1 |
| Smith, LD | 2 |
| Emerson, RL | 1 |
| Nixon, LK | 1 |
| Kojima, S | 1 |
| Ishii, N | 1 |
| Shiki, Y | 1 |
| Kubodera, A | 1 |
| Blunck, JM | 1 |
| Crowther, CE | 1 |
| Farber, E | 1 |
| Solt, D | 1 |
| Cameron, R | 1 |
| Laishes, B | 1 |
| Ogawa, K | 1 |
| Medline, A | 1 |
| Boyd, H | 1 |
| Martin, TJ | 1 |
| Chai, KJ | 1 |
| Kim, JS | 1 |
| Lee, HK | 1 |
| Dong, JM | 1 |
| Kilianska, Z | 1 |
| Fukuda, K | 1 |
| Mack, DO | 1 |
| Reed, VL | 1 |
| Scoazec, JY | 3 |
| Hassan, N | 1 |
| Feldmann, G | 3 |
| Kamata, Y | 1 |
| Hasegawa, R | 1 |
| Shirai, T | 2 |
| Kurata, Y | 1 |
| Masuda, A | 1 |
| Iwai, M | 1 |
| Okuno, T | 1 |
| Okanoue, T | 1 |
| Takino, T | 1 |
| Ibata, Y | 1 |
| Moreau, A | 2 |
| Bernuau, D | 1 |
| Hirose, K | 1 |
| Hirose, M | 1 |
| Fukui, R | 1 |
| Sekiyama, M | 1 |
| Yoshimoto, F | 1 |
| Tateishi, N | 1 |
| Sakamoto, Y | 1 |
| Carr, BI | 1 |
| Ueno, T | 1 |
| Takahashi, K | 1 |
| Matsuguchi, T | 1 |
| Ikejiri, K | 1 |
| Endo, H | 1 |
| Yamamoto, M | 1 |
| Maurice, M | 1 |
| Tamura, S | 1 |
| Suzuki, Y | 1 |
| Kikuchi, K | 1 |
| Hatayama, I | 1 |
| Sato, K | 1 |
| Hirai, R | 1 |
| Tsuiki, S | 1 |
| Sugioka, Y | 1 |
| Fujii-Kuriyama, Y | 1 |
| Muramatsu, M | 1 |
| Aquino, TM | 1 |
| Porta, EA | 1 |
| Sablan, HM | 1 |
| Dorado, RD | 1 |
39 other studies available for methyldimethylaminoazobenzene and Condition, Preneoplastic
| Article | Year |
|---|---|
gamma-Glutamyltransferase and the inhibition of azo dye-produced neoplasia by concomitant administration of disulfiram.
Topics: Animals; Disulfiram; gamma-Glutamyltransferase; Hyperplasia; Liver; Liver Neoplasms, Experimental; M | 1980 |
Dose and sex dependent effects of 2-acetylaminofluorene, 3'-methyl-4-dimethylaminoazobenzene and DL-ethionine in induction of gamma-glutamyl transpeptidase-positive liver cell foci in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; E | 1983 |
The expression of alpha-fetoprotein and albumin genes in rat liver during chemical carcinogenesis.
Topics: alpha-Fetoproteins; Animals; Kinetics; Liver; Liver Neoplasms, Experimental; Methyldimethylaminoazob | 1982 |
Matrical inclusions of peroxisomes induced by clofibrate in preneoplastic hepatocytes of rats fed 3'-methyl-4-dimethyl-aminoazobenzene.
Topics: Animals; Clofibrate; Inclusion Bodies; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobe | 1982 |
Existence of a practical threshold dose for the hepatocarcinogen 3'-methyl-4-(dimethyl-amino) azobenzene in rat liver.
Topics: Adenosine Triphosphatases; Animals; Liver; Liver Neoplasms, Experimental; Male; Methyldimethylaminoa | 1981 |
Correlation of deoxycytidylate deaminase activity with cell proliferation during hepatocarcinogenesis and tumour growth in transplantable rat hepatomas.
Topics: Aflatoxins; Animals; Cell Division; DCMP Deaminase; Liver; Liver Neoplasms, Experimental; Methyldime | 1980 |
Inhibitory effects of autologous hepatic tumor suspension on the development of liver cell carcinoma in rats.
Topics: Animals; Antigens, Neoplasm; Liver Cirrhosis; Liver Neoplasms, Experimental; Male; Methyldimethylami | 1983 |
Hepatocytes with extraperoxisomal catalase in rats fed 3'-methyl-4-dimethylaminoazobenzene.
Topics: Animals; Catalase; Clofibrate; Enzyme Activation; Histocytochemistry; Liver Neoplasms, Experimental; | 1982 |
Gomisin A, a lignan component of Schizandora fruits, inhibits development of preneoplastic lesions in rat liver by 3'-methyl-4-dimethylamino-azobenzene.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Cell Nucleus; Cyclooctanes; Dioxoles; Drugs, Chinese | 1994 |
Modifying effects of chemicals on the development of liver preneoplastic placental glutathione S-transferase positive foci in analbuminemic and Sprague-Dawley rats.
Topics: Acetylglucosaminidase; Animals; Butylated Hydroxyanisole; Carcinogens; Clofibrate; Diethylnitrosamin | 1993 |
Hepatocyte growth factor stimulates DNA synthesis in rat preneoplastic hepatocytes but not in liver carcinoma cells.
Topics: Animals; Bromodeoxyuridine; DNA; Hepatocyte Growth Factor; Humans; Immunohistochemistry; Liver Neopl | 1998 |
Different responses other than the formation of DNA-adducts between the livers of carcinogen-resistant rats (DRH) and carcinogen-sensitive rats (Donryu) to 3'-methyl-4-dimethylaminoazobenzene administration.
Topics: Animals; Carcinogens; DNA Adducts; DNA Damage; Drug Resistance; Gene Expression; Gene Expression Reg | 1998 |
Genetic properties for the suppression of development of putative preneoplastic glutathione S-transferase placental form-positive foci in the liver of carcinogen-resistant DRH strain rats.
Topics: Animals; Blotting, Northern; Body Weight; Cell Division; Crosses, Genetic; Diethylnitrosamine; DNA; | 1999 |
Change in intracellular pH of rat liver during azo-dye carcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Growth; Hydrogen-Ion Concentra | 1976 |
Relationship between alpha-fetoprotein positive cells and precancerous lesions in rat liver during 3'-methyl-4-dimethylaminoazobenzene carcinogenesis.
Topics: alpha-Fetoproteins; Animals; Cell Transformation, Neoplastic; Female; Fluorescent Antibody Technique | 1979 |
Enhancing effect of phenobarbital on the development of enzyme-altered islands and hepatocellular carcinomas initiated by 3'-methyl-4-(dimethylamino) azobenzene or diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Drug Synergism; Liver; Liver Neoplasms, Expe | 1978 |
Changes in peroxisomes in preneoplastic liver of rats induced by 3'-methyl-4-dimethylaminoazobenzene.
Topics: Animals; Carcinoma, Hepatocellular; Catalase; Cell Differentiation; Clofibrate; Enzyme Induction; Hy | 1977 |
Increased expression of actin-like contractile protein in preneoplastic and neoplastic lesions in rat liver.
Topics: Actins; Animals; Contractile Proteins; Fluorescent Antibody Technique; Hepatectomy; Liver Neoplasms; | 1977 |
Effect of hepatocarcinogens on the adenine purine nucleotide cycle during the initiation phase of carcinogenesis.
Topics: 2-Acetylaminofluorene; Adenylosuccinate Lyase; Adenylosuccinate Synthase; AMP Deaminase; Animals; Ca | 1979 |
Radiorespirometric analysis of glucose metabolism in the rat during feeding with 3'-methyl-4-(dimethylamino) azobenzene. -Radiorespirometry using [1-14C]glucose-.
Topics: Animals; Breath Tests; Carbon Radioisotopes; DNA, Neoplasm; Glucose; Glucosephosphate Dehydrogenase; | 1979 |
Enhancement of azo dye carcinogenesis by dietary sodium sulphate.
Topics: Acetanilides; Animals; Azo Compounds; Body Weight; Diet; Drug Synergism; Liver; Liver Cirrhosis; Liv | 1975 |
Newer insights into the pathogenesis of liver cancer.
Topics: Aflatoxins; Animals; Cell Division; Cell Transformation, Neoplastic; Diethylnitrosamine; Dimethylnit | 1977 |
Changes in catecholamine- and glucagon-responsive adenylate cyclase activity in preneoplastic rat liver.
Topics: Adenylyl Cyclases; Animals; Enzyme Activation; Epinephrine; Glucagon; Isoproterenol; Kinetics; Liver | 1976 |
Expressions of c-fos and c-myc genes during 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB)-induced rat hepatocarcinoma.
Topics: Animals; Blotting, Southern; DNA; Female; Gene Expression; Genes, fos; Genes, myc; Liver Neoplasms, | 1992 |
The appearance of hepatoma-associated chromosomal non-histone proteins in rat liver after a single dose of 3'-MDAB followed by treatment of phenobarbital.
Topics: alpha-Fetoproteins; Animals; Biomarkers, Tumor; Cell Nucleus; Chromatin; Chromosomal Proteins, Non-H | 1990 |
Retinyl acetate inhibition of 3'-methyl-4-dimethyl-aminoazobenzene induced hepatic neoplasia.
Topics: Adenylosuccinate Lyase; Animals; Diterpenes; Female; gamma-Glutamyltransferase; Liver; Liver Neoplas | 1990 |
Bile canalicular alterations in hepatocyte nodules induced by 3'-methyl-4-dimethylaminoazobenzene in the rat: morphological clues on their pathogenesis and relevance to the neoplastic process.
Topics: Animals; Bile Canaliculi; Bile Ducts, Intrahepatic; Liver; Liver Neoplasms, Experimental; Male; Meth | 1990 |
The prevention of chemical hepatocarcinogenesis in rats by combining active and passive immunization with alpha-fetoprotein.
Topics: Adenoma, Bile Duct; alpha-Fetoproteins; Animals; Antibodies; Antibody Formation; Antibody Specificit | 1985 |
Effect of timing of partial hepatectomy on the induction of preneoplastic liver foci in rats given hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; gamma-Glutamyltransferase; Hepatectomy; Hexachlorocyclohexane; Liver | 1986 |
Biological significance of AFP-positive cells in rat livers with hyperplastic nodules induced by 3'-Me-DAB; combined immunocytochemical and radioautographical studies.
Topics: alpha-Fetoproteins; Animals; Autoradiography; Histocytochemistry; Hyperplasia; Liver; Liver Neoplasm | 1987 |
Cellular expression of alpha-fetoprotein gene and its relation to albumin gene expression during rat azo-dye hepatocarcinogenesis.
Topics: Albumins; alpha-Fetoproteins; Animals; Cell Division; Liver; Liver Neoplasms, Experimental; Male; Me | 1989 |
Promoting effects of phenobarbital and 3'-methyl-4-dimethylaminoazobenzene on the appearance of gamma-glutamyltranspeptidase positive foci in rat liver pretreated with varying doses of diethylnitrosamine.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Ex | 1985 |
Decreased induction of gamma-glutamyltransferase activity by 3'-methyl-4-dimethylaminoazobenzene in the liver of rats given carcinogen-containing diet for several generations.
Topics: Animals; Animals, Newborn; Drug Resistance; Enzyme Induction; Female; gamma-Glutamyltransferase; Glu | 1986 |
Pleiotropic drug resistance in hepatocytes induced by carcinogens administered to rats.
Topics: 2-Acetylaminofluorene; Adaptation, Physiological; Animals; Carcinogens; Drug Resistance; gamma-Gluta | 1987 |
Reactivation of rat insulin-like growth factor II gene during hepatocarcinogenesis.
Topics: Animals; Blotting, Northern; Cell Transformation, Neoplastic; Female; Gene Expression Regulation; Ge | 1988 |
Analysis of hepatocyte plasma membrane polarity during rat azo dye hepatocarcinogenesis using monoclonal antibodies directed against domain-associated antigens.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Antigens, Neoplasm; Antigens, Surface; Cell D | 1988 |
Tyrosine protein kinase in preneoplastic and neoplastic rat liver.
Topics: Affinity Labels; Animals; Antibodies; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Methy | 1988 |
Changes in polypeptide pattern of rat liver cells during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aging; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver; L | 1985 |
Effects of selenium supplementation on hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Liver; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Org | 1985 |