methyldimethylaminoazobenzene has been researched along with Cell Transformation, Neoplastic in 24 studies
Methyldimethylaminoazobenzene: A very potent liver carcinogen.
3-methyl-4'-dimethylaminoazobenzene : A member of the class of azobenzenes that is azobenzene in which one of the phenyl groups is substituted at position 3 by a methyl group, while the other is substituted at position 4 by a dimethylamino group. It is a potent liver carcinogen.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Activation of ras protooncogenes in 11 2-acetylaminofluorene (AAF)-induced hepatocellular carcinomas (HCCs) or liver cell lines and 9 3'-methyl-(dimethylamino)azobenzene (3'-Me-DAB)-induced HCCs in rats was examined using the NIH3T3 cell transfection assay and oligonucleotide hybridization analysis." | 7.68 | Low frequency of ras activation in 2-acetylaminofluorene- and 3'-methyl-4-(dimethylamino)azobenzene-induced rat hepatocellular carcinomas. ( Kitagawa, T; Lee, GH; Li, H; Liu, J; Nomura, K; Ohtake, K, 1991) |
| "Activation of ras protooncogenes in 11 2-acetylaminofluorene (AAF)-induced hepatocellular carcinomas (HCCs) or liver cell lines and 9 3'-methyl-(dimethylamino)azobenzene (3'-Me-DAB)-induced HCCs in rats was examined using the NIH3T3 cell transfection assay and oligonucleotide hybridization analysis." | 3.68 | Low frequency of ras activation in 2-acetylaminofluorene- and 3'-methyl-4-(dimethylamino)azobenzene-induced rat hepatocellular carcinomas. ( Kitagawa, T; Lee, GH; Li, H; Liu, J; Nomura, K; Ohtake, K, 1991) |
| "However, mutations and chromosomal aberrations were significantly induced by N-acetoxy-4-methylaminoazobenzene, an active metabolite of 4-dimethylaminoazobenzene or 3'-Me-DAB in the presence of liver microsomes." | 1.26 | Effect of 3'-methyl-4-dimethylaminoazobenzene in the induction of malignant transformation and of 8-azaguanine-resistant mutations and chromosomal aberrations in a diploid clone derived from normal rat liver cells in culture. ( Sato, J; Tokiwa, T, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (83.33) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hirano, T | 1 |
| Sakai, A | 1 |
| Ootsuyama, Y | 1 |
| Kasai, H | 1 |
| Liu, H | 1 |
| Higashi, K | 1 |
| Hiai, H | 1 |
| Miyazaki, M | 4 |
| Wahid, S | 3 |
| Matsuura, K | 1 |
| Tsunashima, M | 1 |
| Nakabayashi, H | 1 |
| Miyano, K | 2 |
| Sato, J | 7 |
| Yabe, T | 1 |
| Tokiwa, T | 3 |
| Nishiyama, S | 1 |
| Tanaka, T | 1 |
| Chiu, JF | 1 |
| Huang, DP | 1 |
| Burkhardt, AL | 1 |
| Cote, G | 1 |
| Schwartz, CE | 1 |
| Xue, L | 1 |
| Wen, J | 1 |
| Zhao, G | 1 |
| Ichihara, A | 1 |
| Stratil, P | 1 |
| Dolezalová, V | 1 |
| Nĕmecek, R | 1 |
| Simícková, M | 1 |
| Patel, NT | 2 |
| Folse, DS | 1 |
| Holoubek, V | 2 |
| Farber, E | 1 |
| Solt, D | 1 |
| Cameron, R | 1 |
| Laishes, B | 1 |
| Ogawa, K | 1 |
| Medline, A | 1 |
| Li, H | 1 |
| Lee, GH | 1 |
| Liu, J | 1 |
| Nomura, K | 1 |
| Ohtake, K | 1 |
| Kitagawa, T | 2 |
| Germain, L | 1 |
| Noël, M | 1 |
| Gourdeau, H | 1 |
| Marceau, N | 1 |
| Yeoh, G | 1 |
| Porter, I | 1 |
| Arcus, M | 1 |
| Douglas, A | 1 |
| Handa, Y | 2 |
| Suzuki, Y | 1 |
| Hishinuma, T | 1 |
| Degawa, M | 1 |
| Hashimoto, Y | 1 |
| Ueno, T | 1 |
| Takahashi, K | 1 |
| Matsuguchi, T | 1 |
| Ikejiri, K | 1 |
| Endo, H | 1 |
| Yamamoto, M | 1 |
| Xu, YD | 1 |
| Kim, YS | 1 |
| Cho, MY | 1 |
| Sugioka, Y | 1 |
| Fujii-Kuriyama, Y | 1 |
| Muramatsu, M | 1 |
24 other studies available for methyldimethylaminoazobenzene and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Chronic alcohol consumption prevents 8-hydroxyguanine accumulation in 3'-methyl-4-dimethylaminoazobenzene-treated mouse liver.
Topics: Alcohol Drinking; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA Damage; DNA Repair; Eth | 2009 |
Role of resistant Drh1 locus in chemical carcinogen-induced hepatocarcinogenesis in rats: analysis with a speed congenic strain.
Topics: Administration, Oral; Animals; Apoptosis; Carcinogens; Cell Cycle; Cell Transformation, Neoplastic; | 2005 |
Effect of 3'-methyl-4-dimethylaminoazobenzene on liver cells from adult rat in primary culture.
Topics: Animals; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome | 1982 |
In vitro transformation of adult rat liver cells by 3'-methyl-4-dimethylaminoazobenzene.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chromosomes; gamma-Glutamyltransferase; L | 1983 |
Expression of gamma-glutamyltranspeptidase in cultures of spontaneously and chemically transformed rat liver cells.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Epithelium; gamma-Glutamyltransferase; Li | 1983 |
Effect of 3'-methyl-N,N-dimethyl-4-aminoazobenzene in the presence or absence of liver microsomes on the liver cells having low tumor-producing capacity in culture.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Liver; Liver Neoplasms; Methyldimethylami | 1983 |
Effect of 3'-methyl-4-dimethylaminoazobenzene in the induction of malignant transformation and of 8-azaguanine-resistant mutations and chromosomal aberrations in a diploid clone derived from normal rat liver cells in culture.
Topics: Animals; Azaguanine; Cell Transformation, Neoplastic; Chromosome Aberrations; Clone Cells; Drug Resi | 1982 |
The alteration of gene expression in rat liver during chemical carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Gene Expression Regulation; Liver Neoplasms, | 1983 |
[The characteristics and significance of oncogenes expression in oval cells cultivated in vitro].
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Gene Expression; Genes, myc; Genes, ras; | 1998 |
Isozyme patterns of branched-chain amino acid transaminase during cellular differentiation and carcinogenesis.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Cell Differentiation; Cell Transformation, N | 1975 |
Relationship between alpha-fetoprotein positive cells and precancerous lesions in rat liver during 3'-methyl-4-dimethylaminoazobenzene carcinogenesis.
Topics: alpha-Fetoproteins; Animals; Cell Transformation, Neoplastic; Female; Fluorescent Antibody Technique | 1979 |
Release of repetitive nuclear RNA into the cytoplasm in liver of rats fed 3'-methyl-4-dimethylaminoazobenzene.
Topics: Animals; Base Sequence; Cell Nucleus; Cell Transformation, Neoplastic; Cytoplasm; Liver; Male; Methy | 1979 |
Protein composition of nuclear ribonucleoprotein particles isolated from liver of rats in the early stages of feeding of 3'-methyl-4-dimethylaminoazobenzene and from hepatoma induced by the same carcinogen.
Topics: Animals; Carcinoma, Hepatocellular; Cell Nucleus; Cell Transformation, Neoplastic; Electrophoresis, | 1977 |
Newer insights into the pathogenesis of liver cancer.
Topics: Aflatoxins; Animals; Cell Division; Cell Transformation, Neoplastic; Diethylnitrosamine; Dimethylnit | 1977 |
Low frequency of ras activation in 2-acetylaminofluorene- and 3'-methyl-4-(dimethylamino)azobenzene-induced rat hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Southern; Carcinoma, Hepatocellular; Cell Transformation, | 1991 |
Promotion of growth and differentiation of rat ductular oval cells in primary culture.
Topics: Animals; Cell Separation; Cell Transformation, Neoplastic; Dimethyl Sulfoxide; gamma-Glutamyltransfe | 1988 |
Transformation of cultured fetal rat liver cells by MDAB and phenobarbital. Morphological, biochemical and immunocytochemical characterization of cell lines.
Topics: Animals; Blotting, Northern; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Culture Te | 1989 |
Transformation of primary cultured and co-cultured adult rat liver cells by 3'-methyl-4-dimethylaminoazobenzene.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; DNA; Female; gamm | 1985 |
Promotion of 3'-methyl-4-dimethylaminoazobenzene-initiated adult rat liver cells to malignant state by phenobarbital in culture.
Topics: Animals; Cell Cycle; Cell Transformation, Neoplastic; Epithelium; gamma-Glutamyltransferase; Liver; | 1986 |
Malignant transformation of rat liver cells by N-benzoyloxy-3'-methyl-4-methylaminoazobenzene and its related compound.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; DNA | 1986 |
Reactivation of rat insulin-like growth factor II gene during hepatocarcinogenesis.
Topics: Animals; Blotting, Northern; Cell Transformation, Neoplastic; Female; Gene Expression Regulation; Ge | 1988 |
[Pathological study of hepatocarcinogenesis in rats induced by 3'-Me-DAB].
Topics: Animals; Cell Transformation, Neoplastic; Liver Neoplasms, Experimental; Male; Methyldimethylaminoaz | 1988 |
Surface properties of cell membrane in early stage of transformed cell. I. Early detection of transformed cell by concanavalin A. II. Properties of plasma membrane of transformed rat liver cell induced by 3'-Me DAB.
Topics: Animals; Cell Membrane; Cell Transformation, Neoplastic; Concanavalin A; Liver Neoplasms, Experiment | 1985 |
Changes in polypeptide pattern of rat liver cells during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aging; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver; L | 1985 |