methylcellulose and Xerostomia

Topics: Carboxymethylcellulose Sodium; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Glycerol; Humans; Male; Methylcellulose; Mouthwashes; Oral Hygiene; Prospective Studies; Random Allocation; Saliva, Artificial; Sorbitol; Xerostomia

The aim of this investigation was to describe and to compare the effectiveness of a CMC- and a mucin-containing saliva substitute. 22 post-radiation patients, 17 Sjögren's Syndrome patients and 3 patients with xerostomia of unknown origin used a CMC- and a mucin-containing saliva substitute, each for 1 week in an arbitrary sequence. Neither the patient, the assistant, nor the physician were aware of the substitute being used. Each patient had to complete a questionnaire at 3 different intervals during the trial. One of the conclusions of this study is that mucin-containing substitutes are preferred by patients when compared to CMC-containing substitutes.

Topics: Adolescent; Adult; Aged; Carboxymethylcellulose Sodium; Double-Blind Method; Female; Humans; Male; Methylcellulose; Middle Aged; Mouthwashes; Mucins; Radiation Injuries; Saliva, Artificial; Sjogren's Syndrome; Xerostomia

The stimulatory effect of a recently introduced saliva substitute (Saliment) on the parotid salivary secretion was experimentally investigated in 10 healthy individuals without signs or symptoms of xerostomia and in 11 patients with xerostomia due to Sjögren's syndrome. Further, in 15 patients with Sjögren's syndrome, the effect of Saliment on the sensation of xerostomia was examined in a double-blind clinical study with cross-over. The use of Saliment was followed by a significant stimulation in the parotid salivary secretion (P less than 0.01) and the subjection sensation of xerostomia was significantly reduced (P less than 0.01).

Topics: Adolescent; Adult; Aged; Carboxymethylcellulose Sodium; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Glycerol; Humans; Male; Methylcellulose; Middle Aged; Parotid Gland; Saliva; Secretory Rate; Sjogren's Syndrome; Sorbitol; Time Factors; Xerostomia

This investigation was carried out to try the application of pilocarpine hydrochloride (PC) solid dispersion as sustained release dosage form. Four preparations of PC with ethylcellulose and/or hydroxypropylmethylcellulose phthalate were prepared by the organic solvent method. The preparation D including PC: ethylcellulose: hydroxypropylmethylcellulose phthalate (1:9:10 at weight ratio) showed the best sustained release behavior in dissolution test among four preparations. The preparation D was examined by powder X-ray diffractometry and differential scanning calorimetry, and confirmed to be solid dispersion. Saliva secretory effect of preparation D was examined in healthy male volunteers, and its effect for Xerostomia was showed.

Topics: Cellulose; Delayed-Action Preparations; Dosage Forms; Humans; Hypromellose Derivatives; Male; Methylcellulose; Pilocarpine; Saliva; Stimulation, Chemical; Xerostomia

Salivary gland hypofunction is a common sequela of Sjögren's syndrome and irradiation treatment of tumors in head and neck region. The aim of the present study was to evaluate the therapeutic effect of a recently developed hydroxy-propyl-methyl-cellulose (HPMC) containing artificial saliva and to compare it with that of the carboxy-methyl-cellulose (CMC) based saliva substitute. The therapeutic effects of both preparations were assessed by means of self-administered questionnaires which had to be completed before and after the use of each type of artificial saliva after one week treatment. We found significant improvement in symptoms of nocturnal discomfort and difficulty in speech, and results were better in case of HPMC based artificial saliva. The retention time in oral cavity and the frequency of daily administration also were better in case of HPMC containing preparation. It is concluded that the use of HPMC containing artificial saliva can be recommended in the treatment of salivary hypofunction.

Topics: Aged; Carboxymethylcellulose Sodium; Female; Humans; Male; Methylcellulose; Middle Aged; Saliva, Artificial; Salivary Glands; Xerostomia

Sjögren's syndrome is a complex disease state with multisystem manifestations. Two forms of the disease, primary and secondary, are recognized; the secondary form is more easily diagnosed because of its association with an already established rheumatic or autoimmune disease. Treatment consists of measures to prevent damage from ocular and oral dryness (sicca complex) and to minimize systemic manifestations.

Topics: Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Female; Humans; Male; Methylcellulose; Prednisone; Salivary Glands; Sjogren's Syndrome; Xerophthalmia; Xerostomia

In this investigation, the subjective impressions of patients, suffering from severe xerostomia, have been recorded after symptomatic treatment with different CMC- and mucin-containing artificial saliva over 3 years. A total number of 137 patients divided into 3 groups participated. Group I (40 patients) used CMC-containing artificial saliva, group II (61 patients) alternately used CMC- and mucin-containing artificial saliva and group III (36 patients) used mucin-containing artificial saliva. From this study it is concluded that artificial saliva containing mucins proved to be of benefit to patients suffering from xerostomia.

Topics: Adult; Aged; Carboxymethylcellulose Sodium; Consumer Behavior; Evaluation Studies as Topic; Female; Humans; Male; Methylcellulose; Middle Aged; Mouthwashes; Mucins; Saliva, Artificial; Xerostomia

Topics: Carboxymethylcellulose Sodium; Drug Combinations; Female; Fluorides; Humans; Methylcellulose; Middle Aged; Minerals; Saliva; Sjogren's Syndrome; Sodium Fluoride; Xerostomia

Topics: Adult; Female; Humans; Male; Methylcellulose; Middle Aged; Pharyngeal Neoplasms; Radiotherapy; Rhinitis, Atrophic; Saliva; Salivary Gland Diseases; Xerostomia

Topics: Acetylcysteine; Adolescent; Adult; Aged; Arthritis, Rheumatoid; Child; Child, Preschool; Cornea; Female; Humans; Keratoconjunctivitis; Lacrimal Apparatus; Male; Methylcellulose; Middle Aged; Mucus; Salivary Glands; Sarcoidosis; Tears; Xerostomia