methylcellulose and Ulcer

methylcellulose has been researched along with Ulcer* in 2 studies

Other Studies

2 other study(ies) available for methylcellulose and Ulcer

ArticleYear
Sustained release enteric coated tablets of pantoprazole: formulation, in vitro and in vivo evaluation.
    Acta pharmaceutica (Zagreb, Croatia), 2013, Volume: 63, Issue:1

    In this study, an attempt was made to deliver pantoprazole in a sustained manner using delayed release tablets. The tablets were prepared by the wet granulation method using HPMC, cassava starch and polyvinyl pyrrolidine as polymers, Avicel PH 102 (MCC) as filler and potato starch as binder. The prepared tablets were evaluated for hardness, mass variation, friability and drug content uniformity, and the results were found to comply with official standards. The prepared tablets were coated using an enteric coating polymer such as cellulose acetate phthalate, Eudragit L100 and drug coat L100 by the dip coating method. The in vitro release was studied using pH 1.2 acidic buffer and pH 6.8 phosphate buffer and the study revealed that the prepared tablets were able to sustain drug release into the intestine. The anti-ulcer activity was evaluated by a water immersion stress induced ulcer model. The enteric coated pantoprazole tablets significantly reduced ulcer formation.

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Cellulose; Chemistry, Pharmaceutical; Delayed-Action Preparations; Excipients; Female; Hardness; Hydrogen-Ion Concentration; Lactose; Male; Methylcellulose; Pantoprazole; Polymers; Polymethacrylic Acids; Rats; Rats, Wistar; Starch; Tablets, Enteric-Coated; Ulcer

2013
A novel once daily microparticulate dosage form comprising lansoprazole to prevent nocturnal acid breakthrough in the case of gastro-esophageal reflux disease: preparation, pharmacokinetic and pharmacodynamic evaluation.
    Journal of microencapsulation, 2013, Volume: 30, Issue:6

    The objective of this study was to formulate and evaluate the lansoprazole (LPZ)-loaded microparticles to prevent nocturnal acid breakthrough in the case of gastro-esophageal reflux disease (GERD). The microparticulate delivery system was prepared by solvent evaporation method using Eudragit RS100 as a matrix polymer followed by enteric coated with Eudragit S100 and hydroxypropyl methylcellulose phthalate HP55 using spray drying method. The enteric coated microparticles were stable in gastric pH condition. In vivo pharmacokinetic and pharmacodynamic studies in male Wistar rats demonstrated that enteric coated microparticles sustained release of LPZ and promoted ulcer healing activity. In other words, the microparticulate dosage form provided effective drug concentration for a longer period as compared to conventional extended release dosage form, and showed sufficient anti-acid secretion activity to treat acid related disorders including the enrichment of nocturnal acid breakthrough event based on a once daily administration.

    Topics: Acids; Acrylic Resins; Animals; Anti-Ulcer Agents; Delayed-Action Preparations; Gastroesophageal Reflux; Lansoprazole; Male; Methylcellulose; Particle Size; Rats; Rats, Wistar; Stomach; Ulcer

2013