methylcellulose and Peritoneal-Diseases

With the use of a rabbit surgical model, the ability of 1%, 2%, and 3% solutions of sodium carboxymethylcellulose to reduce postoperative uterine adhesions was determined. At all concentrations sodium carboxymethylcellulose was more effective than either 32% dextran 70 or heparinized lactated Ringer's solution. Neither the dextran nor Ringer's solution had a significant (p less than or equal to 0.05) effect. The beneficial effects of sodium carboxymethylcellulose were closely dose-dependent (correlation coefficient 0.97). Sodium carboxymethylcellulose is highly effective in reducing postoperative adhesions in laboratory animals, and additional studies are warranted to further define its efficacy and safety.

Topics: Animals; Autopsy; Carboxymethylcellulose Sodium; Dextrans; Dose-Response Relationship, Drug; Female; Isotonic Solutions; Methylcellulose; Microsurgery; Peritoneal Diseases; Postoperative Complications; Rabbits; Ringer's Lactate; Solutions; Tissue Adhesions; Uterus

Topics: Animals; Female; Male; Methylcellulose; Microscopy; Microscopy, Electron; Peritoneal Diseases; Peritoneum; Rats; Streptodornase and Streptokinase; Tissue Adhesions