methylcellulose and Periodontal-Diseases

Eugenol is the principle chemical constituent of clove oil and has been used to cure dental problems for ages. Eugenol is an integral part of the dentist's kit due to its analgesic, local anesthetic, anti-inflammatory, and antibacterial effects. It is used in the form of a paste or mixture as dental cement, filler, and restorative material. This study reports the development and evaluation of controlled-release mucoadhesive tablets for gingival application, containing eugenol, which are prepared by taking carbopol 934 P and Hydroxypropyl methylcellulose (HPMC) K4M in the ratio of 1:2, 1:1, and 2:1. Incorporation of eugenol (10 mg) in a mucoadhesive formulation provides controlled release for a period of 8 hours, which is advantageous over conventional use. In vitro mucoadhesion measured as detachment force in grams and the formulations show good correlation in vivo. The release study indicates that increase in carbopol increases the release rate of eugenol from the formulation whereas HPMC retards it. Increased in vitro bioadhesion is related to HPMC content of the formulation. The release kinetics of eugenol in vitro correlates with the in vivo results. This indicates the increased potential of eugenol as antibacterial, local analgesic, and anaesthetic treatment.

Topics: Acrylates; Adhesiveness; Adult; Chromatography, Thin Layer; Delayed-Action Preparations; Eugenol; Female; Humans; Hypromellose Derivatives; Kinetics; Male; Methylcellulose; Mouth Mucosa; Periodontal Diseases; Shear Strength; Tablets; Viscosity

The aim of the study was to prepare and evaluate excipients with bioadhesive, properties obtained by means of lipophilic adjuvants which may be used as the active substance carriers providing prolonged contact with the oral mucosa. Light liquid paraffin, polyethylene, polydocanol and polymers with mucoadhesive properties: methylcellulose, pectin and gelatin have all been used in the study. The addition of paraffin to the excipients has been found to prolong the time of their washing down in water and in artificial saliva as well as to affect the rheological properties of the obtained formulations in comparison to standard preparations obtained on the basis of hydrophilic and lipophilic excipients. The analysis of rheological properties revealed that the flow curves of prepared formulations could be described on the basis of nonlinear models of Herschel-Bulkley and Ostwald-de Waele type.

Topics: Adjuvants, Pharmaceutic; Excipients; Gelatin; Humans; Methylcellulose; Mineral Oil; Mucous Membrane; Pectins; Periodontal Diseases; Polidocanol; Polyethylene; Polyethylene Glycols; Polymers; Rheology; Saliva, Artificial; Viscosity

Topics: Adult; Biguanides; Evaluation Studies as Topic; Female; Gingival Crevicular Fluid; Humans; Male; Methylcellulose; Middle Aged; Mouthwashes; Oral Hemorrhage; Periodontal Diseases; Periodontal Dressings; Postoperative Care; Wound Healing