methylcellulose and Peptic-Ulcer

Topics: Adolescent; Adult; Aged; Carboxymethylcellulose Sodium; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Female; Humans; Magnesium Oxide; Male; Methylcellulose; Middle Aged; Papaverine; Peptic Ulcer; Phenobarbital

To examine the effects of a pepsin inhibitor, pepstatin-A, a long acting H2-receptor blocker, loxtidine, exogenous pepsin and exogenous acid against indomethacin-induced antral ulceration in the rat.. Indomethacin (60 mg/kg s.c.) caused antral ulceration in fasted/re-fed rats over a period of 4 h. Ulceration was prevented in a dose-dependent manner by treatment with pepstatin-A (0.1-1 mg.kg hourly) or loxtidine (3 mg/kg) given orally. Acidified methylcellulose (1 mL hourly per os) enhanced damage and also prevented protection by loxtidine (3 mg/kg per os). The protection by pepstatin-A was not altered by treatment with acidified methylcellulose but was reversed by treatment with a 10-fold excess of pepsin.. These studies suggest that mucosal degradation by pepsin, rather than direct damage by luminal acid, was the major factor in the development of indomethacin-induced antral ulceration in the rat.

Topics: Animals; Disease Models, Animal; Drug Interactions; Female; Gastric Mucosa; Indomethacin; Methylcellulose; Pepsin A; Pepstatins; Peptic Ulcer; Pyloric Antrum; Rats; Time Factors

Topics: Animals; Gastric Mucosa; Guinea Pigs; Intestinal Mucosa; Intestine, Small; Methylcellulose; Peptic Ulcer; Sodium

Topics: Antacids; Carboxymethylcellulose Sodium; Humans; Methylcellulose; Muscle Relaxants, Central; Peptic Ulcer

Topics: Carboxylic Acids; Carboxymethylcellulose Sodium; Methylcellulose; Parasympatholytics; Peptic Ulcer; Stomach Ulcer

Topics: Carboxymethylcellulose Sodium; Humans; Methylcellulose; Peptic Ulcer