methylcellulose and Lichen-Planus--Oral

Clinical morphological efficiency of local application of a new biopolymeric film was studied. The film was based on methylcellulose derivatives and contained shikonin (preparation of plant origin) and its esters isolated from Lithospermum erythrorhizon L. cell culture. Combined therapy of 30 patients (34-72 years) with erosive ulcerative lichen planus and leukoplakia of the buccal mucosa was carried out. Local application of the new drug led to more rapid pain relief, epithelialization of the inflammatory destructive foci in the buccal mucosa, and reduced the intensity of morphological signs of lesions in the studied patient population.

Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Biopolymers; Drugs, Chinese Herbal; Female; Humans; Inflammation; Leukoplakia, Oral; Lichen Planus, Oral; Male; Methylcellulose; Middle Aged; Mouth Mucosa; Naphthoquinones; Oral Ulcer

Patients often experience difficulties in applying topical steroids in orabase to the oral mucosa, particularly when large areas need to be covered. An aqueous hydrocortisone mouthwash solution has been developed, one that was anticipated to be more acceptable to patients. The solution contains hydrocortisone (0.3% w/v) in a 4.5% (w/v) 2-hydroxypropyl-beta-cyclodextrin solution. Hydroxypropylmethylcellulose (0.5% w/v) was used to increase the viscosity of the solution and to promote the hydrocortisonecyclodextrin complex. One hundred and two patients with aphthous ulceration, lichen planus, and other mucosal conditions used the mouthwash in an open clinical efficacy study. Most patients reported some or considerable improvement following a 2-week course of treatment with the mouthwash: 26 of 33 (78.8%) patients with aphthous ulceration were 'much better', as were 26 of 54 (48.1%) patients with lichen planus and 5 of 16 (31.3%) patients with other mucosal lesions. No serious side effects were reported. Aqueous mouthwash solutions offer a potential vehicle for topical steroid therapy of oral mucosal lesions.

Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; beta-Cyclodextrins; Chelating Agents; Chemistry, Pharmaceutical; Child; Cyclodextrins; Excipients; Female; Humans; Hydrocortisone; Hypromellose Derivatives; Lichen Planus, Oral; Male; Methylcellulose; Middle Aged; Mouth Diseases; Mouth Mucosa; Mouthwashes; Pharmaceutic Aids; Pharmaceutical Vehicles; Remission Induction; Stomatitis, Aphthous; Treatment Outcome; Viscosity