methylcellulose has been researched along with Kidney-Diseases* in 4 studies
4 other study(ies) available for methylcellulose and Kidney-Diseases
| Article | Year |
|---|---|
Biopharmaceutical characterization of a novel sustained-release formulation of allopurinol with reduced nephrotoxicity.
The present study was aimed to develop a novel sustained-release formulation for allopurinol (ALP/SR) with the use of a pH-sensitive polymer, hydroxypropyl methylcellulose acetate succinate, to reduce nephrotoxicity. ALP/SR was evaluated in terms of crystallinity, the dissolution profile, pharmacokinetic behavior, and nephrotoxicity in a rat model of nephropathy. Under acidic conditions (pH1.2), sustained release behavior was seen for ALP/SR, although both crystalline ALP and ALP/SR exhibited rapid dissolution at neutral condition. After multiple oral administrations of ALP samples (10 mg-ALP/kg) for 4 days in a rat model of nephropathy, ALP/SR led to a low and sustained plasma concentration of ALP, as evidenced by half the maximum concentration of ALP and a 2.5-fold increase in the half-life of ALP compared with crystalline ALP, possibly due to suppressed dissolution behavior under acidic conditions. Repeated-dosing of ALP/SR resulted in significant reductions in plasma creatinine and blood urea nitrogen levels by 73% and 69%, respectively, in comparison with crystalline ALP, suggesting the low nephrotoxic risk of ALP/SR. From these findings, a strategic SR formulation approach might be an efficacious dosage option for ALP to avoid severe nephrotoxicity in patients with nephropathy. Topics: Administration, Oral; Allopurinol; Animals; Antineoplastic Agents; Blood Urea Nitrogen; Cisplatin; Creatinine; Delayed-Action Preparations; Drug Liberation; Gout Suppressants; Half-Life; Kidney; Kidney Diseases; Male; Methylcellulose; Rats, Sprague-Dawley | 2021 |
[Experimental kidney damage caused by cellulose derivatives in the electron microscope picture].
Topics: Electrons; Kidney; Kidney Diseases; Methylcellulose; Microscopy; Polysaccharides | 1963 |
[HISTOMORPHOLOGICAL RESEARCH ON EXPERIMENTAL SPLANCHNIC THESAURISMOSIS CONDUCTED ON ORGANS OF RATS TREATED WITH PARENTERALLY ADMINISTERED METHYLCELLULOSE].
Topics: Kidney Diseases; Leukopenia; Liver Diseases; Lung Diseases; Lymph Nodes; Lymphocytosis; Metabolic Diseases; Methylcellulose; Pathology; Rats; Research; Spleen; Toxicology | 1963 |
Anemia produced in the rat by methylcellulose. I. Repeated intraperitoneal injections of methylcellulose.
Topics: Anemia; Anemia, Hemolytic; Animals; Hypercholesterolemia; Injections, Intraperitoneal; Kidney Diseases; Methylcellulose; Rats; Splenomegaly | 1962 |