methylcellulose has been researched along with Herpes-Genitalis* in 2 studies
1 trial(s) available for methylcellulose and Herpes-Genitalis
| Article | Year |
|---|---|
Topical polyriboinosinic-polyribocytidylic acid complex in the treatment of recurrent genital herpes.
Polyriboinosinic-polyribocytidylic acid complexed with poly-l-lysine and carboxymethylcellulose [poly(ICLC)] is a potent interferon inducer when given parenterally to humans. Topical application in animal models has shown beneficial antiviral and clinical effects. In a randomized, double-blinded, placebo-controlled trial of topical poly(ICLC) in recurrent genital herpes simplex virus infection, five clinical and two virological parameters were followed. Fifty-seven men and women, with 78 recurrences of genital herpes, were stratified by sex. No clinical or antiviral differences between poly(ICLC) and placebo groups in either stratum were found. Further analysis of male subgroups by age and size of lesions showed no changes in the rapidity of healing or viral shedding. Topics: Administration, Topical; Adult; Carboxymethylcellulose Sodium; Clinical Trials as Topic; Double-Blind Method; Female; Herpes Genitalis; Humans; Male; Methylcellulose; Peptides; Poly I-C; Polylysine; Recurrence | 1982 |
1 other study(ies) available for methylcellulose and Herpes-Genitalis
| Article | Year |
|---|---|
Treatment of experimental genital herpes with liposomal interferon.
The therapeutic effect of genetically engineered interferon (reaferon) in the treatment of genital herpes in male guinea pigs was studied. The disease was induced in the animals by application of culture liquid containing herpes simplex virus type 2 (HSV-2) to the scarified skin of the penis. The affected sites were treated once daily, for 7 days, with different reaferon preparations 1-3 days after the symptoms of the disease had appeared. Reaferon preparations were most effective in the treatment of experimentally induced genital herpes when incorporated into liposomes, had a less pronounced therapeutic effect when mixed with 3% deoxymethylcellulose to form a hydrocolloid, and were least effective in aqueous solution. Incorporation of the antiviral agents acyclovir and Biolf-62 into liposomes also showed improved effectiveness, in comparison with the free compounds, in the treatment of genital herpes in guinea pigs. Topics: Acyclovir; Animals; Drug Carriers; Ganciclovir; Guinea Pigs; Herpes Genitalis; Interferon alpha-2; Interferon Type I; Interferon-alpha; Liposomes; Male; Methylcellulose; Recombinant Proteins | 1991 |