methylcellulose and Glaucoma--Open-Angle

Comparison of the effect of mitomycin C (MMC) versus bevacizumab-methylcellulose mixture (BMM) on combined phacoemulsification and non-penetrating deep sclerectomy surgery on the intraocular pressure in patients with open-angle glaucoma was made.. The current study is a controlled, randomized, double-blind clinical trial. Thirty-eight patients were enrolled, with a total of 40 eyes, and underwent a combined phacoemulsification and non-penetrating deep sclerectomy surgery from 2016 to 2017. MMC with concentration of 0.2 mg/mL for 2 min was used for 20 eyes before separating the scleral flap, and 0.3 mL of BMM (bevacizumab 1.25 mg incorporated into 2% methylcellulose) was injected subconjunctivally following surgery. The success rate of surgery was categorized as complete, relative and failure. Fisher's exact, Mann-Whitney U and Chi-square tests were employed to data analysis. A p value < 0.05 was supposed significant.. Patients had the same distribution in terms of age, sex, type of glaucoma and type of cataract. Patients were followed up for a mean of 6 months. The mean intraocular pressure before surgery in the MMC group was 24.85 ± 2.83 mmHg with 3.2 ± 0.523 anti-glaucoma drugs, which reached 13.75 ± 3.552 mmHg with 0.15 ± 0.489 anti-glaucoma drugs at the latest visit. The average intraocular pressure before surgery in the BMM group was 24.45 ± 2.48 mmHg with 2.9 ± 0.641 anti-glaucoma drugs, which reached 15.40 ± 3.267 mmHg with 0.25 ± 0.55 anti-glaucoma drug at the last follow-up. The intraocular pressure was notably lower in the MMC group than BMM group 6 months after surgery. There was not a significant difference from the aspect of success rate and failure rate among the two groups at the 6-month follow-up (p = 0.135).. Based on the results of this study, MMC and bevacizumab-methylcellulose both seem to be effective in the success of combined phacoemulsification and non-penetrating deep sclerectomy surgery, but MMC decreases intraocular pressure in patients at 6 months post-surgery.

Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Bevacizumab; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Methylcellulose; Middle Aged; Mitomycin; Phacoemulsification; Sclera; Sclerostomy; Visual Acuity

We conducted a study to evaluate the shortterm effect on intraocular pressure (IOP) following extracapsular cataract extraction using either sodium hyaluronate 1% or hydroxypropyl methylcellulose 2%. In both groups a non-significant rise in IOP at day 1 was followed by a significant decline in IOP at day 3 to values below the pre-operative level (p < 0.05). At day 7 both groups had returned to pre-operative values. Post-operatively, spikes in intraocular pressure (> 25 mmHg) were seen equally in both groups. Patients with pre-operatively diagnosed open-angle glaucoma, high myopia and diabetic retinopathy are considered to be at high risk concerning post-operatively elevated IOP, but with small variation these patients followed the main trend.

Topics: Adult; Aged; Aged, 80 and over; Cataract Extraction; Diabetic Retinopathy; Female; Glaucoma, Open-Angle; Humans; Hyaluronic Acid; Hypromellose Derivatives; Intraocular Pressure; Lenses, Intraocular; Male; Methylcellulose; Middle Aged; Myopia; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Risk Factors

To characterize a new animal model of moderate chronic hyperpressure obtained by obstruction of the iridocorneal angle (ICA) in the minipig.. Intraocular hyperpressure was induced in one eye (left) using an injection of methylcellulose (4%) in the anterior chamber of six healthy adult minipigs. Intraocular pressure (IOP) was measured before injection and at D+60 and D+180. The clinical condition thus created was regularly assessed with the following procedures: fundus photography, electroretinography (ERG) to evaluate retinal function, scanning laser ophthalmoscopy (SLO) angiography to measure the arteriovenous filling times (AVFT). Optical microscopy was also performed to evaluate iridocorneal angle and inner retinal layers.. In all instances the injection produced a significant increase in the IOP accompanied by a mydriasis, as well as a significant increase in the AVFT and reduction (abolition in some cases) in the i-wave of the ERG. Fundus examination also revealed a blurred aspect and reduction in the calibre of the retinal blood vessels. Similarly, all experimental eyes showed, at optical microscopy, obstruction of the ICA as well a significant loss of of retinal ganglion cells.. Our results suggest that the above pathophysiological processes, triggered by the induced hyperpressure, share many similarities with human chronic open-angle glaucoma. Consequently, our model, which is very easy to create, could be used to test new therapeutic agents such as neuroprotective drugs.

Topics: Animals; Disease Models, Animal; Electroretinography; Fluorescein Angiography; Glaucoma, Open-Angle; Methylcellulose; Ocular Hypertension; Swine; Swine, Miniature

Topics: False Positive Reactions; Glaucoma, Open-Angle; Humans; Laser Therapy; Methylcellulose; Tonometry, Ocular; Trabeculectomy