methylcellulose has been researched along with Fissure-in-Ano* in 1 studies
1 other study(ies) available for methylcellulose and Fissure-in-Ano
| Article | Year |
|---|---|
In vitro and ex vivo studies on diltiazem hydrochloride-loaded microsponges in rectal gels for chronic anal fissures treatment.
Diltiazem hydrochloride, topically applied at 2% concentration, is considered effective for the treatment of chronic anal fissures, although it involves several side effects among which anal pruritus and postural hypotension. To test the hypothesis that a sustained delivery system of diltiazem hydrochloride may be helpful for the treatment of chronic anal fissures, in the present study we evaluated the potential of gels containing diltiazem hydrochloride entrapped in microsponges. Such microsponges were based on Eudragit RS 100 and the effect of some formulation variables was assessed by a 2 Topics: Acrylic Resins; Administration, Rectal; Animals; Chronic Disease; Diltiazem; Drug Delivery Systems; Drug Liberation; Fissure in Ano; Gels; Methylcellulose; Mucous Membrane; Poloxamer; Swine | 2019 |