methylcellulose and Eye-Injuries

Solutions of flexible macromolecules are used in ophthalmic surgery for insertion of intraocular lens, during corneal transplantation, in cataract, corneal, glaucoma, trauma, and vitreo-retinal surgery. Polymeric materials used in formulating these solutions include hyaluronic acid, chondroitin sulfate, polyacrylamide, collagen, and mixtures of some of these materials. Although the physical properties of these materials have been studied extensively, the long-term effects resulting from transitory increases in intraocular pressure and loss of even a small number of corneal endothelial cells are still unknown. The purpose of this paper is to review the literature that is available on these topics.

Topics: Acrylic Resins; Animals; Biocompatible Materials; Chondroitin Sulfates; Collagen; Eye Injuries; Hyaluronic Acid; Intraocular Pressure; Methylcellulose; Ophthalmologic Surgical Procedures; Rheology; Time Factors; Viscosity

Topics: Anesthesia, General; Bandages; Cornea; Corneal Injuries; Double-Blind Method; Eye Injuries; Humans; Intraoperative Complications; Methylcellulose; Ointment Bases; Ointments; Ophthalmic Solutions; Paraffin; Pharmaceutic Aids

Intrastromal injection of viscoelastic (2% methylcellulose or healon) will facilitate the separation of deep stroma during dissection of recipient stroma. Full thickness lamellar keratoplasty was performed on a smooth graft bed which approached Descemet's membrane. 21 cases with bullous keratopathy were treated and followed up for six months, post-operatively. The symptoms were controlled in all cases and 13 cases were relieved from blindness with corrected visual acuities over 0.05. The safety, efficacy and reoperability of full thickness lamellar keratoplasty with viscodelamination of cornea for treatment of bullous keratopathy make it a promising technique.

Topics: Adolescent; Adult; Aged; Aphakia, Postcataract; Corneal Diseases; Corneal Transplantation; Eye Injuries; Female; Humans; Male; Methylcellulose; Middle Aged; Visual Acuity

Since 1976 I have used a solution of hydroxypropyl methylcellulose to prevent corneal endothelial damage during intraocular lens implantation. The substance is inexpensive, readily available, and can be easily dissolved. This paper describes preparation of a 2% solution.

Topics: Corneal Injuries; Eye Injuries; Humans; Hypromellose Derivatives; Lenses, Intraocular; Methods; Methylcellulose; Osmolar Concentration; Solutions

The authors' study of the viscosities of various concentrations of sodium hyaluronate, chondroitin sulfate, and methylcellulose revealed that sodium hyaluronate and methylcellulose are pseudoplastic fluids in contrast to chondroitin sulfate, which is a Newtonian fluid. Pseudoplastic fluids are ideal for maintaining the anterior chamber, since they are more viscous at rest. Intermediate viscosity preparations of these three agents used as a thin endothelial coating gave excellent protection from intraocular lens abrasion. A highly viscous agent, eg, sodium hyaluronate 1%, in a thin layer produced extensive endothelial cell damage because it transmitted excessive shear force to the endothelium. A highly viscous agent, sodium hyaluronate 1% in a thick layer produced a physical barrier to compression with little endothelial damage. A low-viscosity agent, balanced salt solution provided insufficient protection against intraocular lens abrasion.

Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Chondroitin; Chondroitin Sulfates; Cornea; Eye Injuries; Hyaluronic Acid; Hydrogen-Ion Concentration; Lenses, Intraocular; Methylcellulose; Viscosity

Topics: Corneal Injuries; Eye Injuries; Humans; Lenses, Intraocular; Methylcellulose

Topics: Animals; Ciliary Body; Eye Injuries; Glaucoma; Hemorrhage; Intraocular Pressure; Methylcellulose; Rabbits; Rupture

Topics: Acrylic Resins; Adolescent; Adult; Aged; Child; Child, Preschool; Eye Diseases; Eye Injuries; Eye Neoplasms; Eye, Artificial; Female; Follow-Up Studies; Glaucoma; Humans; Male; Melanoma; Methods; Methylcellulose; Middle Aged; Nystagmus, Pathologic; Ophthalmic Solutions; Ophthalmologic Surgical Procedures; Pemphigus; Postoperative Complications; Silicones; Suture Techniques; Trachoma

Topics: Animals; Anterior Chamber; Cranial Nerve Injuries; Dogs; Epinephrine; Eye; Eye Injuries; Glaucoma; Injections; Intraocular Pressure; Iris; Isoflurophate; Methylcellulose; Nitrogen Mustard Compounds; Rabbits; Sympathomimetics; Synaptic Transmission