methylcellulose and Eye-Diseases

Topics: Adrenal Cortex Hormones; Aloe; Anesthetics, Local; Anti-Bacterial Agents; Antiviral Agents; Chymotrypsin; Epinephrine; Eye Diseases; Glycosides; Heparin; Humans; Imidazoles; Methylcellulose; Miotics; Mydriatics; Ointments; Ophthalmic Solutions; Phytotherapy; Plants, Medicinal; Sulfonamides

A total of 120 patients who were all anaesthetized for more than 90 minutes were given eye protection with paraffin-based oculentum simplex, Ph. Nord. 63, in one eye, and water-based four per cent methylcellulose in the other. Anaesthesia was conducted with halothane, or thiopentone an meperidine, or by a neurolept technique. Peri-ocular oedema and reaction in the conjunctiva resembling conjunctivitis was less pronounced after methylcellulose. When both paraffin-based ointment and halothane anaesthesia were used, there were signs of drug interaction, as the patients' conjunctivae were now distinctly red. In all three types of anaesthesia, methylcellulose produces a firm gluing of the eyelids with the result that the eye is not dried out and the eye is protected mechanically so that foreign bodies and corneal abrasions are avoided. There were no untoward effects of methylcellulose. It is concluded that methylcellulose four per cent provides better eye protection than paraffin during general anaesthesia.

Topics: Adolescent; Adult; Aged; Anesthesia, General; Child; Child, Preschool; Edema; Eye Diseases; Female; Humans; Infant; Infant, Newborn; Male; Methylcellulose; Middle Aged; Ointments; Paraffin; Vision Disorders

In a double blind trial 47 anaesthetized patients were given eye protection with the paraffin-based neutral eye ointment Ph. Nord. 63 in one eye and the water-based Methyl cellulose (MC) 4% in the other. Twenty-four hours later the eyes were vital-stained with rose bengal/fluorescein. No unintended effects of the ointments were found and no injury to the eyes were seen. Compared with the paraffin-based ointment the MC ointment produced a more firm adhesion of the eyelids. A water-based 4% MC ointment is therefore as alternative to the fat-based neutral eye ointment.

Topics: Adolescent; Adult; Aged; Anesthesia, General; Child; Double-Blind Method; Eye Diseases; Female; Humans; Male; Methylcellulose; Middle Aged; Ointments

The aim of the study was in vitro evaluation of piroxicam solid dispersions containing hydroxypropyl methylcellulose acetate succinate (HPMCAS-LF, -HF) as a carrier. Binary (piroxicam-HPMCAS) and ternary (piroxicam-HPMCAS-Carbopol 940) solid dispersions were prepared by spray-drying method. The morphological characteristics were investigated by scanning electron microscopy. X-ray diffraction and differential scanning calorimetry were employed to study physical and chemical properties. In vitro release was studied using a flow-through cell technique. Studies of dissolution rate of piroxicam from solid dispersions were carried out in comparison with corresponding physical mixtures and drug alone. The dissolution profiles depend on the presence of Carbopol 940 in solid dispersions.

Topics: Acrylic Resins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Drug Carriers; Excipients; Eye; Eye Diseases; Humans; Methylcellulose; Microscopy, Electron, Scanning; Ophthalmic Solutions; Particle Size; Piroxicam; Surface Properties; Transition Temperature; X-Ray Diffraction

We examined 2% hydroxypropylmethylcellulose prepared for clinical intraocular surgical procedures in various laboratories. Each sample contained a variety of particulate debris of botanical origin, although in varying amounts. The identified material was also seen in a sample of the raw material from which all the clinical material had been prepared. Our conclusion is that filtration methods, which are the physical methods used to purify the product, are at worst ineffective and at best inadequate. Until proper laboratory and clinical studies confirm an acceptable level of adverse reactions, we recommend that this material not be used clinically.

Topics: Anterior Eye Segment; Costs and Cost Analysis; Drug Contamination; Eye Diseases; Humans; Hypromellose Derivatives; Intraoperative Period; Methylcellulose; Osmolar Concentration

This article reports a new concept in the treatment of tear film abnormalities. Solubilization of an artifical tear insert provides a continuous flow of polymer into the tear film in place of intermittent drop therapy. The physiochemical properties of succinylated collagen were studied in vitro and compared favorably with presently available tear substitutes. The use of this polymer as a solid solubilizable insert was evaluated in normal patients. It was found to be comfortable, resulted in no blurring of vision, and prolonged the tear film breakup time.

Topics: Cellulose; Collagen; Drug Combinations; Edetic Acid; Eye Diseases; Humans; Methylcellulose; Ophthalmic Solutions; Polymers; Polyvinyl Alcohol; Povidone; Solubility; Tears; Thimerosal; Time Factors; Viscosity

Topics: Benzalkonium Compounds; Boric Acids; Evaluation Studies as Topic; Eye Diseases; Humans; Hypersensitivity; Imidazoles; Methylcellulose; Naphazoline; Ophthalmic Solutions; Vasoconstrictor Agents

Topics: Avitaminosis; Collagen Diseases; Contact Lenses, Hydrophilic; Eye Diseases; Humans; Keratoconjunctivitis; Methylcellulose; Polyvinyl Alcohol; Stevens-Johnson Syndrome; Tears; Trachoma

Topics: Cornea; Edema; Eye Diseases; Glycerol; Humans; Methylcellulose; Ointments; Ophthalmic Solutions; Sodium Chloride; Sulfacetamide; Visual Acuity; Zea mays

Topics: Adolescent; Adult; Age Factors; Aged; Child; Cocaine; Cornea; Eye Diseases; Eyelids; Female; Fluorescent Dyes; Humans; Intraocular Pressure; Lacrimal Apparatus; Male; Methylcellulose; Middle Aged; Sex Factors; Staining and Labeling; Tears; Time Factors

Topics: Acrylic Resins; Adolescent; Adult; Aged; Child; Child, Preschool; Eye Diseases; Eye Injuries; Eye Neoplasms; Eye, Artificial; Female; Follow-Up Studies; Glaucoma; Humans; Male; Melanoma; Methods; Methylcellulose; Middle Aged; Nystagmus, Pathologic; Ophthalmic Solutions; Ophthalmologic Surgical Procedures; Pemphigus; Postoperative Complications; Silicones; Suture Techniques; Trachoma

Topics: Asian People; Eye Diseases; Eyelids; Humans; Methylcellulose; Ophthalmic Solutions

Topics: Adrenal Cortex Hormones; Eye Diseases; Methylcellulose; Neomycin; Prednisolone; Sympathomimetics