methylcellulose and Diverticulum--Colon

Topics: Adult; Animals; Blood Cell Count; Blood Sedimentation; Cecum; Child; Chronic Disease; Colonic Diseases, Functional; Constipation; Diarrhea; Diet; Diverticulum, Colon; Female; Fruit; Gastrointestinal Motility; Humans; Intestines; Male; Methylcellulose; Milk; Pain; Parasympatholytics; Psychotherapy; Sigmoidoscopy; Stress, Psychological; Syndrome

Thirty patients with diverticular disease confirmed by barium enema examination were entered into a three-month double-blind trial of two tablets of methylcellulose (Celevac) daily or two placebo tablets daily. As these tablets were indistinguishable it was possible to cross over nine of the patients and follow them for a further three-month period. The placebo effect was sufficient for 11 patients who completed the trial on placebo to show a small mean improvement. A greater mean clinical improvement was shown, however, by the 16 patients who completed the trial on methylcellulose and in those who were crossed over, most of the improvement occurred during the time the patients were on methylcellulose.

Topics: Aged; Clinical Trials as Topic; Diverticulum, Colon; Drug Evaluation; Female; Humans; Male; Methylcellulose; Middle Aged; Placebos; Tablets

Double-contrast barium enema has a reduced sensitivity in patients with severe sigmoid diverticulosis. Therefore a carboxy methyl cellulose enema was employed after the conventional double-contrast examination in 15 patients with sigmoid diverticulosis. A significant increase in lumen diameter and a superior removal of barium residue from the diverticula facilitated the interpretation of the sigmoid loops.. The addition of methyl cellulose enema to double-contrast barium imaging improves diagnostic imaging in diverticulosis by expanding the lumen and emptying the diverticula.

Topics: Aged; Aged, 80 and over; Barium Sulfate; Colon, Sigmoid; Contrast Media; Diverticulum, Colon; Drug Evaluation; Enema; Female; Humans; Male; Methylcellulose; Middle Aged; Radiography; Sensitivity and Specificity; Sigmoid Diseases

Topics: Colon, Sigmoid; Diverticulum, Colon; Humans; Methylcellulose; Pressure; Rectum; Sigmoidoscopy

Topics: Diverticulum, Colon; Edible Grain; Humans; Intestinal Obstruction; Methylcellulose; Resins, Plant

Six patients with diverticular disorder confirmed by barium-enema examination were given a six-month course of methylcellulose (Celevac) tablets; their rectal and rectosigmoid colonic pressures were measured before and afterwards. Open-tipped, fluid-filled, narrow-bore polyethylene tubes were used for pressure measurements and care was taken to site the tubes similarly in all patients before and after treatment. After methylcellulose treatment the mean rectosigmoid pressures had fallen to the same range as the mean rectal pressures, a highly significant reduction. Methylcellulose significantly reduces rectosigmoid pressures in diverticular disease.

Topics: Aged; Colon; Diverticulum, Colon; Female; Gastrointestinal Motility; Humans; Male; Manometry; Methylcellulose; Pressure; Rectum

Topics: Barium Sulfate; Colonic Diseases; Contrast Media; Diverticulum, Colon; Enema; Humans; Methods; Methylcellulose; Muscles; Radiography; Water