methylcellulose and Diabetic-Retinopathy

We conducted a study to evaluate the shortterm effect on intraocular pressure (IOP) following extracapsular cataract extraction using either sodium hyaluronate 1% or hydroxypropyl methylcellulose 2%. In both groups a non-significant rise in IOP at day 1 was followed by a significant decline in IOP at day 3 to values below the pre-operative level (p < 0.05). At day 7 both groups had returned to pre-operative values. Post-operatively, spikes in intraocular pressure (> 25 mmHg) were seen equally in both groups. Patients with pre-operatively diagnosed open-angle glaucoma, high myopia and diabetic retinopathy are considered to be at high risk concerning post-operatively elevated IOP, but with small variation these patients followed the main trend.

Topics: Adult; Aged; Aged, 80 and over; Cataract Extraction; Diabetic Retinopathy; Female; Glaucoma, Open-Angle; Humans; Hyaluronic Acid; Hypromellose Derivatives; Intraocular Pressure; Lenses, Intraocular; Male; Methylcellulose; Middle Aged; Myopia; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Risk Factors

Topics: Contact Lenses; Corneal Diseases; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Epithelium, Corneal; Humans; Hyaluronic Acid; Laser Coagulation; Methylcellulose

Topics: Amnion; Contact Lenses; Corneal Diseases; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Epithelium, Corneal; Humans; Hyaluronic Acid; Laser Coagulation; Methylcellulose

To describe the effect of coupling solutions used during laser photocoagulation on the ocular surface of patients with noninsulin-dependent diabetes mellitus (NIDDM).. A prospective case-controlled study.. Ninety-two eyes of 46 NIDDM patients with clinically significant macular edema, poor metabolic control of diabetes, and peripheral neuropathy and 100 eyes of 50 normal control subjects were studied. The patients' eyes were assigned to argon green focal/grid laser photocoagulation using an applanation contact lens and one of the coupling fluids; 2% methocel, Thilo-Tears Gel, 1.4% sodium hyaluronate, or 0.9% simple saline. The control subjects received time-matched three-mirror contact lens fundus examinations. All subjects underwent corneal sensitivity measurements, Schirmer test, tear film breakup time, and corneal fluorescein staining before as well as 3 and 8 days after the laser procedures and contact lens examinations. Patients with corneal problems persisting after 8 days were followed longer.. Diabetic eyes assigned to 2% methocel and 1.4% sodium hyaluronate had significantly lower mean corneal sensitivities and break-up time values as well as significantly higher mean fluorescein staining scores at all examination points after laser photocoagulation. All diabetic eyes with aqueous deficiency assigned to 2% methocel and 1.4% sodium hyaluronate developed delayed corneal epithelial healing.. The use of viscous coupling solutions during applanation contact lens-aided laser procedures may be detrimental for the corneal epithelium in poorly controlled NIDDM patients with peripheral neuropathy and coexisting aqueous deficiency.

Topics: Adult; Aged; Case-Control Studies; Contact Lenses; Corneal Diseases; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Epithelium, Corneal; Female; Fluorescein; Fluorophotometry; Humans; Hyaluronic Acid; Laser Coagulation; Macular Edema; Male; Methylcellulose; Middle Aged; Ophthalmic Solutions; Prospective Studies; Tears; Wound Healing

Injection of 1% methylcellulose or 1% sodium hyaluronate (Healonid) was used to separate attached vitreous cortex and fibrovascular epiretinal membranes from the retina in 40 eyes undergoing closed microsurgery for severe diabetic eye disease. The viscodelamination technique was of great value in elevating vitreous cortex or sparsely vascularised epiretinal membranes, especially in eyes with combined traction and rhegmatogenous retinal detachment. However, bleeding from or tearing of the retina limited the usefulness of this technique in the surgery of highly vascularised and adherent membranes, as in eyes with table-top traction retinal detachment. Recurrent epiretinal membrane proliferation was seen in some eyes postoperatively.

Topics: Diabetic Retinopathy; Humans; Hyaluronic Acid; Methods; Methylcellulose; Microsurgery; Retina; Vitrectomy