methylcellulose and Corneal-Ulcer

To compare the efficacy of two forms of eye care (hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients.. Randomised-controlled trial.. University affiliated, tertiary referral hospital.. One hundred ten patients with a reduced or absent blink reflex were followed through until they regained consciousness, were discharged from the facility during study enrolment, died or developed a positive corneal ulcer or eye infection.. All patients received standard eye cleansing every 2 h. In addition to this, group one ( n=60) received a treatment combining hypromellose drops and Lacri-Lube (HL) to each eye every 2 h. Group two ( n=50) had polyethylene covers only placed over the eye to create a moisture chamber.. Corneal ulceration was determined using corneal fluorescein stains and mobile slit lamp evaluation, performed daily. No patients had corneal ulceration in the polyethylene cover group, but 4 patients had corneal ulceration in the HL group.. Polyethylene covers are as effective as HL in reducing the incidence of corneal damage in intensive care patients.

Topics: Australia; Bandages; Chlorobutanol; Consciousness Disorders; Corneal Ulcer; Drug Combinations; Female; Humans; Hypromellose Derivatives; Intensive Care Units; Lanolin; Male; Methylcellulose; Middle Aged; Mineral Oil; Ophthalmic Solutions; Petrolatum; Polyethylene; Statistics, Nonparametric

Thermosensitive. The effect of different polymer combinations on parameters like gelation time and temperature, rheological properties, texture, spreading coefficients, mucoadhesion, conjunctival irritation potential,. Both gelation time and temperature were significantly dependent on the concentrations of poloxamer 407 and additive polymers (chitosan and methyl cellulose), where it ranged from <10 s to several minutes. Mechanical properties investigated through texture analysis (hardness, adhesiveness, and cohesiveness) were dependent on composition. Promising spreading-ability, mucoadhesion, transcorneal permeation of L-carnosine, high ocular tolerability, and enhanced corneal epithelium wound healing were recorded for poloxamer 407/chitosan systems.

Topics: Administration, Topical; Animals; Carnosine; Chemistry, Pharmaceutical; Chitosan; Cornea; Corneal Ulcer; Delayed-Action Preparations; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Liberation; Gels; Methylcellulose; Poloxamer; Rabbits; Rheology; Temperature; Wound Healing

Corneal lesions cause significant pain and visual impairment and, in many cases, are unresponsive to conventional treatments. Platelet lysate (PL) is an haemoderivative rich in growth factors (GFs) that are released by platelets after freeze-thawing destruction of platelet rich plasma (PRP). The aim of the present work was to develop thermosensitive and mucoadhesive eyedrops to maintain and prolong the contact of platelet lysate (PL) with cornea ulcers. A sterile vehicle based on chondroitin sulphate sodium (CS) and hydroxypropylmethyl cellulose (HPMC) was developed. An extemporaneous loading of the vehicle with PL was performed and the obtained formulation was able to quickly thermogelify at about 32 °C and was characterized by good mucoadhesive properties. ELISA evidenced that the growth factor PDGF AB was compatible with the vehicle and stable in the formulation up to 15 days of storage at 2-8 °C. In vitro wound healing and proliferation test (performed using rabbit corneal epithelial cells (RCE)) showed that the formulation enhanced cell growth and put in evidence a synergistic effect of CS and PL in stimulating cell proliferation. The overall results indicate that PL loaded in thermosensitive and mucoadhesive eyedrops can be profitably employed to treat corneal lesions.

Topics: Adhesiveness; Animals; Biological Products; Blood Platelets; Cell Extracts; Cell Line; Cell Proliferation; Chemistry, Pharmaceutical; Chondroitin Sulfates; Corneal Ulcer; Drug Carriers; Enzyme-Linked Immunosorbent Assay; Epithelium, Corneal; Gels; Humans; Hypromellose Derivatives; Methylcellulose; Ophthalmic Solutions; Platelet-Derived Growth Factor; Rabbits; Rheology; Temperature; Wound Healing

Topics: Bandages; Chlorobutanol; Consciousness Disorders; Corneal Ulcer; Drug Combinations; Humans; Hypromellose Derivatives; Intensive Care Units; Lanolin; Methylcellulose; Mineral Oil; Ophthalmic Solutions; Petrolatum; Polyethylene

Topics: Blepharoplasty; Blepharoptosis; Corneal Neovascularization; Corneal Opacity; Corneal Ulcer; Disease Progression; Dry Eye Syndromes; Ectropion; Humans; Hypromellose Derivatives; Male; Methylcellulose; Middle Aged; Ophthalmic Solutions; Pantothenic Acid; Postoperative Care; Tangier Disease

A series of recurrent corneal erosions secondary to map-dot-fingerprint dystrophy is presented. Erosions were closely related to the Hudson-Stahli line, and this may be a factor in pathogenesis. Traumatic abrasions did not demonstrate such localisation, evidence that trauma is not a primary cause. A trial of management with therapeutic contact lenses versus topical medication was performed. Therapeutic contact lenses were shown to be inferior and had a high complication rate. Recurrent erosion is often considered an indication for therapeutic contact lenses, but this is questioned and great caution recommended in such use.

Topics: Administration, Topical; Adult; Cellulose; Contact Lenses; Corneal Dystrophies, Hereditary; Corneal Ulcer; Drug Combinations; Female; Humans; Hypromellose Derivatives; Male; Methylcellulose; Middle Aged; Recurrence

Topics: Adolescent; Age Factors; Atropine; Conjunctiva; Contact Lenses; Corneal Ulcer; Drug Combinations; Eyelids; Humans; Male; Methylcellulose; Neomycin; Ophthalmic Solutions; Phenytoin; Polymyxins; Seizures; Sex Factors; Stevens-Johnson Syndrome; Time Factors; Tyrothricin; Vision Disorders