methylcellulose and Colonic-Diseases

The present work was aimed at designing microsponge based colon specific drug delivery system containing paracetamol. Eudragit S-100 based microsponges containing drug in varying amounts were prepared using quasi-emulsion solvent diffusion method. The microsponges were prepared by optimizing various process parameters. DSC and FTIR studies indicated compatibility of the drug in various formulations. Shape and surface morphology of the microsponges were examined using scanning electron microscopy. The formulations were subjected to in vitro release studies and the results were evaluated kinetically and statistically. The in vitro release data showed a bi-phasic pattern with an initial burst effect. In the first hour drug release from microsponges was found to be between 18-30%. The cumulative percent release at the end of 12(th) hour was noted to be between 74-98%. The release kinetics showed that the data followed Higuchi model and the main mechanism of drug release was diffusion. The colon specific tablets were prepared by compressing the microsponges followed by coating with pectin: hydroxypropylmethyl cellulose (HPMC) mixture. In vitro release studies exhibited that compression coated colon specific tablet formulations started releasing the drug at 6(th) hour corresponding to the arrival time at proximal colon. The study presents a new approach for colon specific drug delivery.

Topics: Acetaminophen; Analgesics, Non-Narcotic; Calorimetry, Differential Scanning; Colon, Ascending; Colonic Diseases; Delayed-Action Preparations; Diffusion; Drug Compounding; Drug Delivery Systems; Hydrogen-Ion Concentration; Hypromellose Derivatives; Kinetics; Methylcellulose; Particle Size; Pectins; Pharmaceutic Aids; Polymethacrylic Acids; Solubility; Spectroscopy, Fourier Transform Infrared; Surface Properties; Tablets

Assessment of 3 different rectal contrast agents (water, methylcellulose, ultrasound gel) for their suitability for colorectal imaging in multislice CT (MS-CT).. 115 patients with colorectal diseases underwent MS-CT with varying, rectal contrast agents in a prospective study. Images were assessed by 2 independent CT-experienced radiologists. 6 criterias were evaluated, using a 5-point scale.. Methylcellulose (MC) proved to be significantly superior to ultrasound gel (US). Especially, differentiation of healthy and diseased bowel and bowel wall and lumen were aided, which was proven by quantitative analysis of attenuation values. Rectal distension is greater using MC or US than for water. More proximal parts of the colon could be better distended with water. The interobserver correlation was good (kappa 0.76).. Rectal filling with MC significantly improves diagnostic confidence in colorectal examinations. Ease of administration and lack of problems suggest its use as a clinical routine tool.

Topics: Adult; Aged; Aged, 80 and over; Colitis, Ulcerative; Colonic Diseases; Colorectal Neoplasms; Contrast Media; Crohn Disease; Female; Gels; Humans; Male; Methylcellulose; Middle Aged; Observer Variation; Prospective Studies; Radiography, Abdominal; Rectal Diseases; Tomography, X-Ray Computed; Water

Topics: Barium Sulfate; Cecum; Colon; Colonic Diseases; Colonic Neoplasms; Humans; Methods; Methylcellulose; Posture; Radiography

Topics: Barium Sulfate; Colonic Diseases; Contrast Media; Diverticulum, Colon; Enema; Humans; Methods; Methylcellulose; Muscles; Radiography; Water

Topics: Carboxylic Acids; Carboxymethylcellulose Sodium; Cardiovascular Agents; Colon; Colonic Diseases; Disease; Humans; Methylcellulose; Muscle Relaxants, Central; Muscle Spasticity