methylcellulose and Acne-Vulgaris

Rauvolfia serpentina (L). Benth. ex Kurz. (Apocynaceae) possessing antibacterial properties are widely used in modern herbal medicines. Curcuma longa L. (Zingiberaceae), a readily available antiseptic, possess antioxidant, antibacterial, blood purifying and antiinflammatory properties and used in various skin creams. Azadirachta indica A. Juss. (Meliaceae) possess astringent, antiviral, discutient, stimulant and antibacterial properties and works excellently well against acne and keeps the skin healthy.. Acne is the common skin problem that 85% of the teenagers face today. In this study, poly herbal anti-acne face wash gels were prepared using two polymers Carbopol and hydroxy propyl methyl cellulose (HPMC) along with the extracts of plants Rawvolfia serpentina, Curcuma longa, and Azadiracta indica.. The gel formulations were prepared in four different concentrations of 50, 100, 200 mg/ml as Gel-CRB 100, Gel-HPMC 50, Gel-HPMC 100, Gel-HPMC 200, respectively. The formulations were tested for the anti-acne activity by turbidimetric method.. RESULTS showed that the gels were non-irritant, stable and posses anti-acne activity. The efficacy when tested with a standard was almost same to that of Clindamycin gel.. From this study, Gel-HPMC 100 was proved to be stable and considered as an effective herbal formulation for acne treatment.

Topics: Acne Vulgaris; Acrylic Resins; Adolescent; Animals; Anti-Infective Agents, Local; Azadirachta; Curcuma; Drug Compounding; Excipients; Face; Gels; Humans; Hypromellose Derivatives; Methylcellulose; Nephelometry and Turbidimetry; Phytotherapy; Plant Preparations; Polyvinyls; Rats; Rats, Wistar; Rauwolfia; Skin; Treatment Outcome

Topics: Acne Vulgaris; Adjuvants, Pharmaceutic; Adolescent; Adult; Antibiosis; Drug Stability; Drug Storage; Female; Glycerol; Humans; Hydrogen-Ion Concentration; Male; Methylcellulose; Microscopy; Pharmaceutical Vehicles; Polyethylene Glycols; Polysorbates; Polyvinyl Alcohol; Povidone; Rheology; Rotation; Solvents; Staphylococcus; Suspensions; Technology, Pharmaceutical; Thiazoles; Viscosity