methylazoxymethanol acetate has been researched along with Pregnancy in 234 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 51 (21.79) | 18.7374 |
| 1990's | 64 (27.35) | 18.2507 |
| 2000's | 55 (23.50) | 29.6817 |
| 2010's | 53 (22.65) | 24.3611 |
| 2020's | 11 (4.70) | 2.80 |
| Authors | Studies |
|---|---|
| D'Addario, C; Di Bartolomeo, M; Di Martino, S; Di Marzo, V; Drago, F; Iannotti, FA; Micale, V; Piscitelli, F; Ruda-Kucerova, J; Stark, T; Wotjak, CT | 1 |
| Grace, AA; Zhu, X | 1 |
| Chen, GY; Chen, L; Cheng, Y; Du, Y; Li, XS | 1 |
| Kopciuch, D; Kus, K; Murawiecka, P; Nowakowska, E; Paczkowska, A; Ratajczak, P; Słodzińska, I; Zaprutko, T | 1 |
| Gzielo, K; Holuj, M; Litwa, E; Nikiforuk, A; Popik, P; Potasiewicz, A; Socha, L | 1 |
| Babinska, Z; Bucolo, C; D'Addario, C; Di Bartolomeo, M; Di Marco, R; Di Marzo, V; Drago, F; Drazanova, E; Fedotova, J; Giurdanella, G; Iannotti, FA; Kratka, L; Mechoulam, R; Micale, V; Pekarik, V; Piscitelli, F; Platania, CBM; Ruda-Kucerova, J; Salomone, S; Starcuk, Z; Stark, T; Sulcova, A; Wotjak, CT | 1 |
| Boley, AM; Carless, MA; Donegan, JJ; Glenn, JP; Lodge, DJ | 1 |
| Bienertova-Vasku, J; Horska, K; Hruska, P; Kucera, J; Kuruczova, D; Micale, V; Ruda-Kucerova, J | 1 |
| Hu, LB; Huang, J; Ling, Y; Shen, HW; Xu, L; Zhang, XQ | 1 |
| Minami, S; Ueda, S; Yamaguchi, T | 1 |
| Bilecki, W; Chmelova, M; Gawlińska, K; Latusz, J; Maćkowiak, M | 1 |
| Gálosi, R; Kállai, J; Kállai, V; Karádi, Z; László, K; Lénárd, L; Ollmann, T; Péczely, L; Petykó, Z; Szabó, I; Tóth, A | 1 |
| Elefant, F; Gao, WJ; Gulchina, Y; Snyder, MA; Xu, SJ | 1 |
| Gomes, FV; Grace, AA; Zhu, X | 1 |
| Gill, KM; Grace, AA; Miller, SA | 1 |
| Bator, E; Głowacka, U; Latusz, J; Maćkowiak, M; Mudlaff, K; Radaszkiewicz, A | 1 |
| Azizi, M; Kashani, IR; Mokhtari, T; Nadji, SA; Omidi, N; Pasbakhsh, P; Pourabdollah, M; Sadr, M; Zendehdel, A | 1 |
| Gao, WJ; Han, G; Snyder, MA; Wang, MJ; Xing, B | 1 |
| Fenton, AA; Levy, ERJ; O'Reilly, KC; Patino, AV; Perica, MI | 1 |
| Huang, H; Huo, C; Liu, X; Ye, H; Zhao, J; Zhao, T | 1 |
| Aivaliotis, M; Chalkiadaki, K; Chatzaki, E; Kyriazidis, E; Sidiropoulou, K; Stavroulaki, V; Velli, A; Vouvoutsis, V | 1 |
| Holuj, M; Nikiforuk, A; Piotrowska, D; Popik, P; Potasiewicz, A; Wojcik, M; Zajda, K | 1 |
| Babinska, Z; Bari, M; D'Addario, C; Di Bartolomeo, M; Di Marco, R; Di Marzo, V; Drago, F; Drazanova, E; Giurdanella, G; Iannotti, FA; Maccarrone, M; Mechoulam, R; Micale, V; Pekarik, V; Piscitelli, F; Ruda-Kucerova, J; Salomone, S; Starcuk, Z; Stark, T; Sulcova, A; Wotjak, CT | 1 |
| Donegan, JJ; Lodge, DJ; Perez, SM | 1 |
| Lin, JR; Nakagawasai, O; Nemoto, W; Odaira, T; Onogi, H; Sakuma, W; Srivastava, LK; Takahashi, K; Tan-No, K | 1 |
| Drago, F; Drazanova, E; Kratka, L; Kuchar, M; Maryska, M; Micale, V; Ruda-Kucerova, J; Starcuk, Z; Stark, T | 1 |
| Battaglia, GS; Cagnoli, C; Cipelletti, B; Colciaghi, F; de Curtis, M; Locatelli, D; Nobili, P; Zambon, S | 1 |
| Lodge, DJ | 1 |
| Du, Y; Grace, AA | 3 |
| Bellaire, M; Ewing, SG; Grace, AA; Zimmerman, EC | 1 |
| Abbah, J; Braga, MF; Juliano, SL | 1 |
| Barry, JM; Duffy, BA; Gimi, B; Jenks, KR; Lucas, MM; Robbins, AA; Scott, RC | 1 |
| Chen, L; Lodge, DJ; Perez, SM | 1 |
| Gomes, FV; Grace, AA; Guimarães, FS | 1 |
| Jellett, AP; Jenks, K; Lucas, M; Scott, RC | 1 |
| Goda, SA; Hunt, MJ; Kasicki, S; Olszewski, M; Piasecka, J; Rejniak, K; Whittington, MA | 1 |
| Bellinger, SA; Kleven, GA | 1 |
| Kohlhaas, KL; Robb, HM; Roderwald, VA; Rueter, LE | 1 |
| Aguilar, DD; Carless, MA; Giuffrida, A; Lodge, DJ; Neary, JL; Perez, SM | 1 |
| Giermaziak, W; Kus, K; Murawiecka, P; Nowakowska, E; Ratajczak, P; Słodzińska, I | 1 |
| Amchova, P; Babinska, Z; Drago, F; Micale, V; Ruda-Kucerova, J; Stark, T; Sulcova, A | 1 |
| Gao, WJ; Li, YC; Xing, B | 1 |
| Fenton, AA; O'Reilly, KC; Perica, MI | 1 |
| Akbari, M; Beyer, C; Eqlimi, E; Mortezaee, K; Omidi, A; Ragerdi Kashani, I; Zendedel, A | 1 |
| Aloe, L; Di Fausto, V; Fiore, M; Iannitelli, A | 1 |
| Grace, AA; Lodge, DJ | 4 |
| Behrens, MM; Grace, AA; Lodge, DJ | 1 |
| Hazane, F; Jay, TM; Krebs, MO; Le Pen, G | 1 |
| Burton, CL; Coppa-Hopman, R; Featherstone, RE; Fletcher, PJ; Kapur, S; Rizos, Z; Sinyard, J | 1 |
| Hirata, K; Kadowaki, T; Nakamura, A; Sakakibara, S; Ueda, S; Yoshimoto, K | 1 |
| Basso, AM; Chin, CL; Curzon, P; Day, M; Fox, GB; O'Connor, EM; Rueter, LE; Schwartz, AJ | 1 |
| Jay, TM; Krebs, MO; Le Pen, G | 1 |
| Cotel, MC; Edgar, DM; Jones, MW; McCarthy, AP; O'Neill, MJ; Phillips, KG; Tricklebank, M; Wafford, KA | 1 |
| Aras, S; Cook, JM; Gill, KM; Grace, AA; Lodge, DJ | 1 |
| Collingridge, GL; Cotel, MC; O'Neill, MJ; Sanderson, TM; Sher, E; Tricklebank, MD | 1 |
| Doisy, ET; Jürgen Wenzel, H; Schwartzkroin, PA; Tschuluun, N | 1 |
| Bahn, S; Cheng, TM; Collingridge, GL; Fitzjohn, SM; Guest, PC; Harris, LW; Holmes, E; Hradetzky, E; Lakics, V; Malik, N; O'Neill, MJ; Rahmoune, H; Sanderson, TM; Schoeffmann, S; Sher, E; Sherwood, JL; Tricklebank, MD; Tsang, TM | 1 |
| de Groot, D; Fox, DA; Grandjean, P; Paule, MG | 1 |
| Schwartzkroin, PA; Wenzel, HJ | 1 |
| Imai, H; Sugioka, K; Terashima, T; Yamamoto, T | 1 |
| Beekhuijzen, M; Emmen, H; Lensen, J; Zmarowski, A | 1 |
| Adelman, AE; Gao, WJ; Snyder, MA | 1 |
| Belujon, P; Grace, AA; Patton, MH | 2 |
| Asher, A; Lodge, DJ; Perez, SM; Shah, A | 1 |
| Baraban, SC; Calcagnotto, ME; Paredes, MF | 1 |
| Baraban, SC; Barbaro, NM; Smyth, MD | 1 |
| Baraban, SC; Colmers, WF; Pentney, AR | 1 |
| Loupe, PS; Schloss, J; Schroeder, SR; Tessel, RE | 1 |
| Darmanto, W; Funahashi, A; Inouye, M | 1 |
| Gierdalski, M; Hasling, TA; Jablonska, B; Juliano, SL | 1 |
| Bigl, V; Rossner, S | 1 |
| Garbossa, D; Vercelli, A | 1 |
| Bassanini, S; Battaglia, G; Cattabeni, F; Di Luca, M; Pagliardini, S; Saglietti, L; Setola, V | 1 |
| Bassanini, S; Battaglia, G; Cattabeni, F; Di Luca, M; Gardoni, F; Pagliardini, S; Setola, V | 1 |
| Reitzenstein, J; Wallace, CS; Withers, GS | 1 |
| Jablonska, B; Juliano, SL; Noctor, SC; Palmer, SL; Smith, AL | 1 |
| Feldon, J; Jongen-Rêlo, AL; Leng, A; Lüber, M; Pothuizen, HH; Weber, L | 1 |
| Bae, YC; Cho, JH; Choi, BJ; Choi, IS; Jung, SC; Kim, JH; Lee, MG | 1 |
| Gourevitch, R; Jay, TM; Krebs, MO; Le Pen, G; Rocher, C | 1 |
| Aloe, L; Fiore, M; Grace, AA; Korf, J; Stampachiacchiere, B | 1 |
| Cortez, MA; McKerlie, C; Serbanescu, I; Snead, OC | 1 |
| Didriksen, M; Flagstad, P; Glenthøj, BY | 1 |
| Arnfred, S; Cumming, P; Gjedde, A; Hansen, AK; Hemmingsen, R; Jelsing, J; Olsen, AK; Pakkenberg, B | 1 |
| Grace, AA; Lavin, A; Moore, HM | 1 |
| Katleba, K; Schwartzkroin, PA; Tschuluun, N; Wenzel, JH | 1 |
| Feldon, J; Jongen-Rêlo, AL; Leng, A; Pothuizen, HH | 1 |
| Eguchi, M; Ueda, S; Watabe, Y; Yoshimoto, K | 1 |
| Cho, JH; Choi, BJ; Choi, IS; Lee, MG | 1 |
| Corfas, G; Gierdalski, M; Juliano, SL; Sardi, SP | 1 |
| Didriksen, M; Flagstad, P; Leist, M; Michael-Titus, AT; Penschuck, S | 1 |
| Baraban, SC; Paredes, M; Pleasure, SJ | 1 |
| Geyer, MA; Ghajarnia, M; Grace, AA; Jentsch, JD; Moore, H | 1 |
| Hazane, F; Hoareau, C; Krebs, MO; Le Pen, G | 1 |
| Davis, J; Elmore, A; Guenther, B; Johnson, K; Marcus, J; Maronpot, RR; Ryan, L | 1 |
| Goto, Y; Grace, AA | 1 |
| Gourevitch, R; Hazane, F; Hoareau, C; Jay, TM; Krebs, MO; Le Pen, G | 1 |
| Bassanini, S; Battaglia, G; Caccia, S; Chimenti, S; Gagliardi, B; Guiso, G; Marchi, N; Noé, F; Ravizza, T; Rizzi, M; Vezzani, A | 1 |
| Featherstone, RE; Fletcher, PJ; Kapur, S; Nobrega, JN; Rizos, Z | 1 |
| Fonnum, F; Mehl, A; Schanke, TM; Torvik, A | 1 |
| Baraban, SC; Harrington, EP; Möddel, G; Najm, IM | 1 |
| Chessel, A; Garcia, R; Krebs, MO; Le Pen, G; Léna, I | 1 |
| Juliano, SL; Poluch, S | 1 |
| Bassanini, S; Battaglia, G; Cipolla, M; Finardi, A; Hallene, K; Janigro, D; Santaguida, S | 1 |
| Falsig, J; Geist, MA; Leist, M; Podhorna, J; Volbracht, C | 1 |
| Juliano, SL; Schaefer, AW | 1 |
| Juliano, S; Poluch, S; Schaefer, A | 1 |
| Matsutani, T | 1 |
| Carman, AB; Coyle, JT; Johnston, MV | 1 |
| Hallman, H; Jonsson, G | 2 |
| Coyle, JT; Johnston, MV | 2 |
| Carman-Young, A; Coyle, JT; Haddad, R; Johnston, MV | 1 |
| Fleshman, JW; Jones, EG; Valentino, KL | 1 |
| Floeter, MK; Jones, EJ | 1 |
| Beaulieu, M; Coyle, JT | 1 |
| Abbracchio, MP; Balduini, W; Cattabeni, F; Lombardelli, G | 1 |
| Fleshman, JW; Floeter, MK; Jones, EG; Valentino, KL; Yurkewicz, L | 1 |
| Dumas, RM; Fernandez, K; Haddad, RK; Vorhees, CV | 1 |
| Kameyama, Y | 1 |
| Cheema, SS; Lauder, JM | 1 |
| Abbracchio, MP; Balduini, W; Banfi, S; Cattabeni, F; Coen, E; Dorigotti, L; Ragusa, C | 1 |
| Cannon-Spoor, HE; Freed, WJ | 1 |
| Fujii, T; Hanada, S; Hayasaka, I; Nakatsuka, T | 1 |
| Fabregues, I; Ferrer, I; Palacios, G | 1 |
| Eiden, LE; Latker, CH; Zatz, M | 1 |
| Matsumoto, J; Sano, K | 1 |
| Dambska, M; Haddad, R; Kozlowski, PB; Lee, MH; Shek, J | 1 |
| Kalter, H; Ormsby, I; Warkany, J | 1 |
| Eiden, LE; Latker, C; Zatz, M | 1 |
| Matsutani, T; Nagayoshi, M; Tamaru, M; Tsukada, Y | 1 |
| Singh, SC | 3 |
| Emmett, MR; Wood, JA; Wood, PL | 1 |
| de Feo, MR; Mecarelli, O; Ricci, GF | 1 |
| Loupe, PS; Schroeder, SR; Tessel, RE | 2 |
| Barone, S; Crofton, KM; Goldey, ES; O'Callaghan, JP; Stanton, ME | 1 |
| Archer, T | 1 |
| Gavin, CE; Gerken, LA; Kates, B; Rodier, PM | 1 |
| Berdel, B; Bobiński, M; Dambska, M; Kozłowski, PB; Maciejewska, B; Moryś, J; Narkiewicz, O; Wisniewski, HM | 1 |
| Ciani, E; Contestabile, A | 1 |
| Cattabeni, F; Cinquanta, M; Di Luca, M | 1 |
| Ferguson, SA; Holson, RR; Paule, MG; Racey, FD | 1 |
| Gavin, CE; Hoffman, GE; Kates, B; Rodier, PM | 1 |
| Balduini, W; Cattabeni, F; Cimino, M; De Graan, PN; Di Luca, M; Gispen, WH; Merazzi, F | 1 |
| Arrowood, JW; Ferguson, SA; Holson, RR; Schultetus, RS | 1 |
| Baraban, SC; Schwartzkroin, PA | 2 |
| Balduini, W; Cattabeni, F; Lombardelli, G; Peruzzi, G | 3 |
| Caputi, A; Cattabeni, FN; Cimino, M; Di Luca, M; Pastorino, L; Rurale, S | 1 |
| Barindelli, S; Buxbaum, JD; Caputi, A; Cattabeni, F; Cimino, M; Di Luca, M; Pastorino, L | 1 |
| Ichinowatari, N; Kodama, Y; Matsutani, T; Shimizu, K; Watanabe, M | 1 |
| Contestabile, A; Vandi, M; Virgili, M | 1 |
| Fujimiya, M; Funahashi, A; Kimura, H; Maeda, T | 1 |
| Germano, IM; Sperber, EF | 1 |
| Hagino, Y; Kaichi, Y; Kodama, Y; Nonaka, R; Watanabe, M | 1 |
| Ben-Ari, Y; Chevassus-au-Louis, N; Khrestchatisky, M; Rafiki, A; Represa, A | 1 |
| Koch, T; Korf, J; Talamini, LM; Ter Horst, GJ | 1 |
| Hagino, Y; Kodama, Y; Nonaka, R; Watanabe, M | 2 |
| Ben-Ari, Y; Chevassus-Au-Louis, N; Jorquera, I; Rafiki, A; Represa, A | 1 |
| Ben-Ari, Y; Chevassus-Au-Louis, N; Congar, P; Gaïarsa, JL; Represa, A | 1 |
| Delhaye-Bouchaud, N; Doughty, ML; Mariani, J | 1 |
| Avanzini, G; Battaglia, G; Cattabeni, F; Colacitti, C; Di Luca, M; Franceschetti, S; Sancini, G; Spreafico, R | 1 |
| Avanzini, G; Battaglia, G; Colacitti, C; Di Luca, M; Franceschetti, S; Sancini, G; Spreafico, R | 1 |
| Ben-Ari, Y; Chevassus-au-Louis, N; Vergnes, M | 1 |
| Ahuja, S; Germano, IM; Moshé, SL; Sperber, EF | 1 |
| Caputi, A; Cattabeni, F; Cimino, M; Di Luca, M; Gardoni, F; Pastorino, L | 1 |
| Avanzini, G; Battaglia, G; Caputi, A; Cattabeni, F; Colacitti, C; DeBiasi, S; Di Luca, M; Franceschetti, S; Frassoni, C; Sancini, G; Spreafico, R | 1 |
| Aloe, L; Angelucci, F; Fiore, M; Koch, T; Korf, J; Talamini, L | 1 |
| Ben-Ari, Y; Chevassus-Au-Louis, N; Jorquera, I; Represa, A | 1 |
| Baraban, SC; Hochman, DW; Schwartzkroin, PA; Wenzel, HJ | 1 |
| Ellenbroek, B; Koch, T; Korf, J; Talamini, LM | 1 |
| Beck, M; Bigl, V; Mendla, K; Rossner, S; Schliebs, R; Stahl, T | 1 |
| Juliano, SL; McLaughlin, DF; Noctor, SC; Palmer, SL | 1 |
| Bigl, V; Brückner, MK; Rossner, S | 1 |
| Aloe, L; Amendola, T; Antonelli, A; Fiore, M; Korf, J; Westenbroek, C | 1 |
| Baraban, SC; Castro, PA; Cooper, EC; Lowenstein, DH | 1 |
| Tsukada, Y | 1 |
| Funahashi, A; Inouye, M; Yamamura, H | 1 |
| Matsutani, T; Nagata, Y; Ogita, K; Shimizu, J; Tamaru, M; Yoneda, Y | 1 |
| Kinuya, M; Mamiya, G; Ohtakeno, S; Watanabe, H; Watanabe, M | 1 |
| Davies, P; Minger, SL | 2 |
| Cattabeni, F; Cimino, M; Di Luca, M; Naus, CC; Wood, GR | 1 |
| Catalano, A; Huang, PH | 1 |
| Evrard, P; Gadisseux, JF; Gressens, P; Kadhim, HJ; Richelme, C | 1 |
| Asano, Y; Nishida, A; Okaniwa, A | 1 |
| Ambrogini, P; Cecchini, T; Ciaroni, S; Del Grande, P; Minelli, G | 1 |
| Ashwell, KW | 1 |
| Katsukura, T; Matsutani, T; Nagata, Y; Shimizu, J; Tamaru, M | 1 |
| Kates, B; Muhs, A; Rodier, PM; White, WA | 1 |
| Fujii, T | 1 |
| Balduini, W; Cattabeni, F; Elsner, J; Lombardelli, G; Peruzzi, G | 1 |
| Cattabeni, F; Cimino, M; De Graan, PN; Di Luca, M; Gispen, WH; Oestreicher, AB | 1 |
| Hashimoto, Y; Mizutani, M | 1 |
| Agnati, LF; Cattabeni, F; Cimino, M; Fuxe, K; Lombardelli, G; Peruzzi, G; Pich, EM; Zoli, M | 1 |
| Kinuya, M; Mamiya, G; Matsutani, T; Nagayoshi, M; Tatsunuma, T; Tsukada, Y; Watanabe, M | 1 |
| Battelli, F; Cecchini, T; Ciaroni, S; Del Grande, P | 1 |
| Johansson, P | 1 |
| Batshaw, ML; Hyman, SL; Mercugliano, M | 1 |
| Gragnola, TG; Robertson, RT; Yu, J | 1 |
| Abbracchio, MP; Cattabeni, F; Cimino, M; Cocchi, D; Di Luca, M; Mennuni, L; Rosi, F; Zaratin, P | 1 |
| Ashwell, KW; Webster, WS | 1 |
| Barnabei, O; Contestabile, A; Virgili, M | 1 |
| Hirata, Y; Matsutani, T; Nagayoshi, M; Tamaru, M | 1 |
| Ambach, G; Bardosi, A; Hann, P | 1 |
| Björklund, H; Dahl, D; Eriksdotter-Nilsson, M; Jonsson, G | 1 |
| Cagiano, R; Cuomo, V; De Salvia, M; Racagni, G; Renna, G | 1 |
| Kawashima, K; Nakaura, S; Omori, Y; Takanaka, A; Tanaka, S; Usami, M; Yamaguchi, M | 1 |
| Abbracchio, MP; Balduini, W; Cattabeni, F; Cecchini, T; Cimino, M; Gazzanelli, GC; Lombardelli, G; Peruzzi, G | 1 |
| Yasuda, K | 1 |
| Archer, T; Jonsson, G; Minor, BG; Mohammed, AK; Söderberg, U; Sundström, E | 1 |
| Ashwell, K | 3 |
| Hirabayashi, K; Hirata, Y; Matsutani, T; Nagayoshi, M; Shimizu, J; Sugimoto, S; Tamaru, M | 1 |
| Archer, T; Jonsson, G; Mohammed, AK; Söderberg, U | 1 |
| Chen, S; Hillman, DE | 1 |
| Amenta, F; Bossoni, G; Carpi, C; Cavallotti, C; De Rossi, M | 1 |
| Ambach, G; Bardosi, A; Friede, RL | 1 |
| Autuono, PG; Coyle, JT; Pevsner, J; Sanberg, PR | 1 |
| Matsutani, T; Nomura, M; Tsukada, Y | 1 |
8 review(s) available for methylazoxymethanol acetate and Pregnancy
| Article | Year |
|---|---|
Developmental pathways of motor dysfunction.
Topics: Animals; Brain; Disease Models, Animal; Female; Guinea Pigs; Methylazoxymethanol Acetate; Mice; Motor Skills Disorders; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 2015 |
Hippocampal dysfunction and disruption of dopamine system regulation in an animal model of schizophrenia.
Topics: Animals; Disease Models, Animal; Dopamine; Female; Gestational Age; Hippocampus; Humans; Methylazoxymethanol Acetate; Neural Pathways; Nucleic Acid Synthesis Inhibitors; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Schizophrenia; Signal Transduction | 2008 |
Are developmental dysplastic lesions epileptogenic?
Topics: Animals; Carcinogens; Disease Models, Animal; Epilepsy; Female; Humans; Malformations of Cortical Development; Methylazoxymethanol Acetate; Mice; Mice, Knockout; Phosphotransferases; Pregnancy; Rats; Tuberous Sclerosis | 2012 |
Amyloid precursor protein processing in vivo--insights from a chemically-induced constitutive overactivation of protein kinase C in Guinea pig brain.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Brain Diseases; Disease Models, Animal; Endopeptidases; Enzyme Activation; Female; Guinea Pigs; Isoenzymes; Methylazoxymethanol Acetate; Microcephaly; Mutation; Peptide Hydrolases; Pregnancy; Protein Kinase C; Protein Processing, Post-Translational | 2003 |
Protein kinase C-dependent phosphorylation in prenatally induced microencephaly.
Topics: Animals; Female; Methylazoxymethanol Acetate; Microcephaly; Phosphorylation; Pregnancy; Protein Kinase C; Rats | 1994 |
[Neurochemical approaches to the higher nervous activity (author's transl)].
Topics: Animals; Brain; Discrimination Learning; Dopamine; Female; Growth Hormone; Higher Nervous Activity; Humans; Hypothyroidism; Learning; Male; Methylazoxymethanol Acetate; Microcephaly; Phenylketonurias; Pregnancy; Protein Deficiency; Rats; Serotonin | 1977 |
Cycasin.
Topics: Animals; Animals, Newborn; Azo Compounds; Carcinogens; Cricetinae; Cycasin; Drug Evaluation, Preclinical; Female; Humans; Kidney Neoplasms; Lethal Dose 50; Liver Neoplasms; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Mice; Neoplasms, Experimental; Pregnancy; Rats; Species Specificity | 1976 |
[Integrative assessment of the developmental pharmacology and developmental toxicology, with special reference to the brain].
Topics: Animals; Brain; Cell Division; Cisplatin; Female; Humans; Methylazoxymethanol Acetate; Neuropharmacology; Nimustine; Pregnancy; Prenatal Exposure Delayed Effects; Toxicology | 1991 |
226 other study(ies) available for methylazoxymethanol acetate and Pregnancy
| Article | Year |
|---|---|
Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia.
Topics: Animals; Disease Models, Animal; Female; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Schizophrenia | 2022 |
Use of prepubertal environment enrichment to prevent dopamine dysregulation in a neurodevelopmental rat model of schizophrenia risk.
Topics: Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Female; Male; Methylazoxymethanol Acetate; Pregnancy; Rats; Schizophrenia | 2022 |
A Network Analysis of Epigenetic and Transcriptional Regulation in a Neurodevelopmental Rat Model of Schizophrenia With Implications for Translational Research.
Topics: Adult; Animals; Disease Models, Animal; Epigenesis, Genetic; Female; Hippocampus; Humans; Male; Methylazoxymethanol Acetate; MicroRNAs; Neurodevelopmental Disorders; Neurotoxins; Prefrontal Cortex; Pregnancy; Proto-Oncogene Mas; Rats; Rats, Sprague-Dawley; RNA, Messenger; Schizophrenia; Sequence Analysis, RNA; Transcription, Genetic; Translational Research, Biomedical | 2020 |
Memory deterioration based on the tobacco smoke exposure and methylazoxymethanol acetate administration vs. aripiprazole, olanzapine and enrichment environment conditions.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Behavior, Animal; Cognition; Disease Models, Animal; Female; Male; Methylazoxymethanol Acetate; Morris Water Maze Test; Neurotoxins; Olanzapine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Schizophrenia; Spatial Memory; Tobacco Smoke Pollution; Treatment Outcome | 2020 |
Social dysfunction in the neurodevelopmental model of schizophrenia in male and female rats: Behavioural and biochemical studies.
Topics: Animals; Disease Models, Animal; Female; Male; Methylazoxymethanol Acetate; Neurotoxins; Oxytocin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Oxytocin; Schizophrenia; Schizophrenic Psychology; Social Behavior; Vocalization, Animal | 2020 |
Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment.
Topics: Animals; Antipsychotic Agents; Brain; Cannabidiol; Cerebrovascular Circulation; Disease Models, Animal; Female; Gene Expression Regulation; Haloperidol; Magnetic Resonance Imaging; Male; Methylazoxymethanol Acetate; Models, Molecular; Molecular Dynamics Simulation; Pregnancy; Prenatal Exposure Delayed Effects; Puberty; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Schizophrenia | 2020 |
Developmental alterations in the transcriptome of three distinct rodent models of schizophrenia.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Female; Gene Expression Profiling; Growth and Development; Hippocampus; Malnutrition; Methylazoxymethanol Acetate; Poly I-C; Pregnancy; Rats; Rats, Sprague-Dawley; Schizophrenia | 2020 |
Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: Untargeted proteomics approach in adipose tissue.
Topics: Adipose Tissue; Animals; Antipsychotic Agents; Disease Models, Animal; Female; Haloperidol; Intra-Abdominal Fat; Methylazoxymethanol Acetate; Olanzapine; Pregnancy; Prenatal Exposure Delayed Effects; Proteomics; Rats; Rats, Sprague-Dawley; Risperidone; Schizophrenia; Signal Transduction; TOR Serine-Threonine Kinases | 2021 |
Diminished excitatory synaptic transmission correlates with impaired spatial working memory in neurodevelopmental rodent models of schizophrenia.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Excitatory Postsynaptic Potentials; Female; Male; Memory, Short-Term; Methylazoxymethanol Acetate; Mice; Mice, Inbred C57BL; Neurodevelopmental Disorders; Prefrontal Cortex; Pregnancy; Pyramidal Cells; Schizophrenia; Schizophrenic Psychology; Social Isolation; Spatial Memory; Synaptic Transmission | 2021 |
Effects of methylazoxymethanol-induced micrencephaly on parvalbumin-positive GABAergic interneurons in the rat rostral basolateral amygdala.
Topics: Animals; Basolateral Nuclear Complex; Carcinogens; Female; GABAergic Neurons; Interneurons; Male; Methylazoxymethanol Acetate; Microcephaly; Parvalbumins; Pregnancy; Rats; Rats, Sprague-Dawley | 2021 |
Prenatal MAM treatment altered fear conditioning following social isolation: Relevance to schizophrenia.
Topics: Age Factors; Animals; Behavior, Animal; Conditioning, Classical; Fear; Female; Male; Methylazoxymethanol Acetate; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Proteome; Rats, Wistar; Schizophrenia; Social Isolation; Teratogens | 2021 |
The MAM-E17 schizophrenia rat model: Comprehensive behavioral analysis of pre-pubertal, pubertal and adult rats.
Topics: Aging; Animals; Anxiety; Disease Models, Animal; Exploratory Behavior; Female; Hippocampus; Male; Methylazoxymethanol Acetate; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Prepulse Inhibition; Rats, Wistar; Rotarod Performance Test; Schizophrenia; Schizophrenic Psychology | 2017 |
Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cognition Disorders; Disease Models, Animal; Epigenesis, Genetic; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Gene Expression Regulation, Developmental; In Vitro Techniques; Male; Methylazoxymethanol Acetate; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Prefrontal Cortex; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2017 |
The methylazoxymethanol acetate rat model: molecular and epigenetic effect in the developing prefrontal cortex: An Editorial Highlight for 'Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM
Topics: Animals; Disease Models, Animal; Epigenesis, Genetic; Female; Methylazoxymethanol Acetate; Neurotoxins; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Schizophrenia | 2017 |
Impaired contextual fear-conditioning in MAM rodent model of schizophrenia.
Topics: Action Potentials; Amphetamine; Animals; Central Nervous System Stimulants; Conditioning, Classical; Disease Models, Animal; Dopaminergic Neurons; Fear; Female; Learning Disabilities; Locomotion; Male; Methylazoxymethanol Acetate; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Schizophrenia; Time Factors; Ventral Tegmental Area | 2018 |
Adolescent Social Isolation Affects Schizophrenia-Like Behavior in the MAM-E17 Model of Schizophrenia.
Topics: Age Factors; Animals; Carcinogens; Disease Models, Animal; Embryo, Mammalian; Female; Gene Expression Regulation, Developmental; Glutamate Decarboxylase; Interpersonal Relations; Locomotion; Methylazoxymethanol Acetate; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Sensory Gating; Social Isolation; Statistics, Nonparametric | 2018 |
Therapeutic effect of perinatal exogenous melatonin on behavioral and histopathological changes and antioxidative enzymes in neonate mouse model of cortical malformation.
Topics: Animals; Animals, Newborn; Antioxidants; Carcinogens; Catalase; Disease Models, Animal; Exploratory Behavior; Female; Gene Expression Regulation, Developmental; Glutathione Peroxidase; Intermediate Filaments; Malformations of Cortical Development; Malondialdehyde; Maze Learning; Melatonin; Methylazoxymethanol Acetate; Mice; Mice, Inbred BALB C; Nitroprusside; Pregnancy; Prenatal Exposure Delayed Effects; Superoxide Dismutase; Tryptamines | 2018 |
Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β.
Topics: Amino Acids; Animals; Antipsychotic Agents; Bridged Bicyclo Compounds, Heterocyclic; Dendritic Spines; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Glycogen Synthase Kinase 3 beta; Learning Disabilities; Methylazoxymethanol Acetate; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Schizophrenia; Tissue Culture Techniques | 2018 |
Sub-circuit alterations in dorsal hippocampus structure and function after global neurodevelopmental insult.
Topics: Animals; Disease Models, Animal; Epilepsy; Female; Hippocampus; Male; Membrane Potentials; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Long-Evans; Schizophrenia; Synapses | 2018 |
Abnormalities in behaviour, histology and prefrontal cortical gene expression profiles relevant to schizophrenia in embryonic day 17 MAM-Exposed C57BL/6 mice.
Topics: Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hypertrophy; Lateral Ventricles; Male; Methylazoxymethanol Acetate; Mice; Mice, Inbred C57BL; Motor Activity; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Prepulse Inhibition; Schizophrenia; Schizophrenic Psychology; Sex Characteristics; Social Behavior; Transcriptome | 2018 |
Development of the MAM model of schizophrenia in mice: Sex similarities and differences of hippocampal and prefrontal cortical function.
Topics: Animals; Auditory Perception; Disease Models, Animal; Fear; Female; Hippocampus; Long-Term Potentiation; Male; Memory; Methylazoxymethanol Acetate; Mice; Mice, Inbred C57BL; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Prepulse Inhibition; Proteome; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Sex Characteristics | 2019 |
Evaluation of ultrasonic vocalizations in a neurodevelopmental model of schizophrenia during the early life stages of rats.
Topics: Animals; Disease Models, Animal; Female; Male; Methylazoxymethanol Acetate; Pregnancy; Rats; Schizophrenia; Social Behavior; Ultrasonics; Vocalization, Animal | 2019 |
Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia.
Topics: Amides; Animals; Arachidonic Acids; Cannabidiol; Disease Models, Animal; Endocannabinoids; Ethanolamines; Female; Glycerides; Hippocampus; Interpersonal Relations; Male; Methylazoxymethanol Acetate; Motor Activity; Oleic Acids; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Puberty; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Recognition, Psychology; RNA, Messenger; Schizophrenia | 2019 |
Effect of estrous cycle on schizophrenia-like behaviors in MAM exposed rats.
Topics: Amphetamine; Animals; Behavior, Animal; Disease Models, Animal; Estrous Cycle; Female; Hippocampus; Methylazoxymethanol Acetate; Parvalbumins; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Schizophrenia; Sensory Gating | 2019 |
Prenatal treatment with methylazoxymethanol acetate as a neurodevelopmental disruption model of schizophrenia in mice.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Behavior, Animal; Clozapine; Disease Models, Animal; Female; Haloperidol; Hippocampus; Methylazoxymethanol Acetate; Mice; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Prepulse Inhibition; Risperidone; Schizophrenia | 2019 |
Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats.
Topics: Animals; Behavior Observation Techniques; Cerebrovascular Circulation; Circle of Willis; Disease Models, Animal; Dronabinol; Female; Hippocampus; Humans; Magnetic Resonance Angiography; Male; Methylazoxymethanol Acetate; Neurogenesis; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Schizophrenia; Sensorimotor Cortex | 2019 |
Targeting PSD95-nNOS interaction by Tat-N-dimer peptide during status epilepticus is neuroprotective in MAM-pilocarpine rat model.
Topics: Animals; Disease Models, Animal; Disks Large Homolog 4 Protein; Female; Methylazoxymethanol Acetate; Neuroprotective Agents; Nitric Oxide Synthase Type I; Peptides; Pilocarpine; Pregnancy; Protein Binding; Random Allocation; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2019 |
The MAM rodent model of schizophrenia.
Topics: Animals; Brain; Clinical Protocols; Disease Models, Animal; Female; Fetal Development; Male; Methylazoxymethanol Acetate; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Schizophrenia | 2013 |
Peripubertal diazepam administration prevents the emergence of dopamine system hyperresponsivity in the MAM developmental disruption model of schizophrenia.
Topics: Amphetamine; Animals; Anxiety; Central Nervous System Sensitization; Diazepam; Dopaminergic Neurons; Female; Male; Maze Learning; Methylazoxymethanol Acetate; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Schizophrenia; Ventral Tegmental Area | 2013 |
Abnormal stress responsivity in a rodent developmental disruption model of schizophrenia.
Topics: Age Factors; Animals; Corticosterone; Female; Immobility Response, Tonic; Male; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Schizophrenia; Stress, Psychological; Vocalization, Animal | 2013 |
Targeted disruption of layer 4 during development increases GABAA receptor neurotransmission in the neocortex.
Topics: Animals; Disease Models, Animal; Female; Ferrets; Inhibitory Postsynaptic Potentials; Malformations of Cortical Development; Methylazoxymethanol Acetate; Miniature Postsynaptic Potentials; Neocortex; Pregnancy; Protein Subunits; Pyramidal Cells; Receptors, GABA-A; Teratogens | 2014 |
Enrichment and training improve cognition in rats with cortical malformations.
Topics: Animals; Avoidance Learning; Behavior, Animal; Choice Behavior; Cognition; Conditioning, Psychological; Female; Magnetic Resonance Imaging; Male; Malformations of Cortical Development; Maze Learning; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 2013 |
Alterations in dopamine system function across the estrous cycle of the MAM rodent model of schizophrenia.
Topics: Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Estrous Cycle; Female; Humans; Male; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Sprague-Dawley; Schizophrenia; Signal Transduction; Vaginal Smears | 2014 |
Effects of pubertal cannabinoid administration on attentional set-shifting and dopaminergic hyper-responsivity in a developmental disruption model of schizophrenia.
Topics: Amphetamine; Animals; Attention; Benzoxazines; Cannabinoids; Central Nervous System Stimulants; Disease Models, Animal; Dopaminergic Neurons; Executive Function; Female; Male; Methylazoxymethanol Acetate; Morpholines; Motor Activity; Naphthalenes; Neuropsychological Tests; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Schizophrenia; Schizophrenic Psychology; Ventral Tegmental Area | 2014 |
Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cognition; Cognition Disorders; Disease Models, Animal; Epilepsy; Female; Flurothyl; Hippocampus; Malformations of Cortical Development; Maze Learning; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Rats, Sprague-Dawley; Seizures; Survival Analysis; Valproic Acid | 2015 |
Aberrant high frequency oscillations recorded in the rat nucleus accumbens in the methylazoxymethanol acetate neurodevelopmental model of schizophrenia.
Topics: Animals; Antipsychotic Agents; Brain Waves; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials; Excitatory Amino Acid Antagonists; Female; Male; Methylazoxymethanol Acetate; Neurotoxins; Nucleus Accumbens; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Schizophrenia | 2015 |
Nicotinic modulation of auditory evoked potential electroencephalography in a rodent neurodevelopmental model of schizophrenia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Evoked Potentials, Auditory; Female; Gene Expression Regulation; Indoles; Male; Methylazoxymethanol Acetate; Neurodevelopmental Disorders; Nicotine; Pregnancy; Quinuclidines; Rats; Rats, Sprague-Dawley; Schizophrenia | 2015 |
Schizophrenia-Like Phenotype Inherited by the F2 Generation of a Gestational Disruption Model of Schizophrenia.
Topics: Animals; Disease Models, Animal; DNA Methylation; Dopaminergic Neurons; Female; Hippocampus; Male; Methylation; Methylazoxymethanol Acetate; Parvalbumins; Phenotype; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Schizophrenia; Transcription Factors; Ventral Tegmental Area | 2016 |
Biochemical and cognitive impairments observed in animal models of schizophrenia induced by prenatal stress paradigm or methylazoxymethanol acetate administration.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Cognition Disorders; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Escape Reaction; Female; Gestational Age; Male; Maze Learning; Methylazoxymethanol Acetate; Motor Activity; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Schizophrenia | 2015 |
Amygdala Hyperactivity in MAM Model of Schizophrenia is Normalized by Peripubertal Diazepam Administration.
Topics: Action Potentials; Administration, Oral; Amygdala; Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Conditioning, Psychological; Diazepam; Disease Models, Animal; Fear; Female; Hippocampus; Male; Maze Learning; Methylazoxymethanol Acetate; Neurons; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Schizophrenia | 2016 |
Reactivity to addictive drugs in the methylazoxymethanol (MAM) model of schizophrenia in male and female rats.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Disease Models, Animal; Female; Male; Methamphetamine; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Sprague-Dawley; Schizophrenia; Sex Characteristics | 2017 |
GSK3β Hyperactivity during an Early Critical Period Impairs Prefrontal Synaptic Plasticity and Induces Lasting Deficits in Spine Morphology and Working Memory.
Topics: Age Factors; Animals; Animals, Newborn; Female; Glycogen Synthase Kinase 3 beta; In Vitro Techniques; Long-Term Potentiation; Memory, Short-Term; Methylazoxymethanol Acetate; Neuronal Plasticity; Neurons; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Protein Synthesis Inhibitors; Rats; Signal Transduction | 2016 |
Loss of Parvalbumin in the Hippocampus of MAM Schizophrenia Model Rats Is Attenuated by Peripubertal Diazepam.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Diazepam; Disease Models, Animal; Down-Regulation; Drug Administration Schedule; Female; Gestational Age; Hippocampus; Interneurons; Methylazoxymethanol Acetate; Parvalbumins; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Schizophrenia; Schizophrenic Psychology; Sexual Maturation | 2016 |
Memory deficits with intact cognitive control in the methylazoxymethanol acetate (MAM) exposure model of neurodevelopmental insult.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Executive Function; Female; Hippocampus; Hyperkinesis; Male; Memory Disorders; Methylazoxymethanol Acetate; Prefrontal Cortex; Pregnancy; Rats; Rats, Long-Evans; Schizophrenia; Spatial Memory | 2016 |
Prenatal transplantation of epidermal neural crest stem cells in malformation of cortical development mouse model.
Topics: Animals; Calcium-Binding Proteins; Cell- and Tissue-Based Therapy; Cells, Cultured; Cerebral Cortex; Chemokine CXCL12; Chick Embryo; Corpus Callosum; Disease Models, Animal; DNA-Binding Proteins; Doublecortin Domain Proteins; Doublecortin Protein; Epithelial Cells; Female; Glial Fibrillary Acidic Protein; Hair Follicle; Homeodomain Proteins; Methylazoxymethanol Acetate; Mice; Mice, Inbred BALB C; Microfilament Proteins; Microtubule-Associated Proteins; Nerve Tissue Proteins; Nestin; Neural Crest; Neural Stem Cells; Neurogenesis; Neuropeptides; Nuclear Proteins; Pregnancy; Receptors, CXCR4; Tissue Culture Techniques | 2017 |
Clozapine or Haloperidol in rats prenatally exposed to methylazoxymethanol, a compound inducing entorhinal-hippocampal deficits, alter brain and blood neurotrophins' concentrations.
Topics: Alkylating Agents; Animals; Antipsychotic Agents; Body Weight; Brain Chemistry; Clozapine; Entorhinal Cortex; Female; Granulocytes; Haloperidol; Hippocampus; Methylazoxymethanol Acetate; Nerve Growth Factors; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2008 |
A loss of parvalbumin-containing interneurons is associated with diminished oscillatory activity in an animal model of schizophrenia.
Topics: Analysis of Variance; Animals; Behavior, Animal; Biological Clocks; Conditioning, Psychological; Disease Models, Animal; Electroencephalography; Evoked Potentials; Fear; Female; Glutamate Decarboxylase; Hippocampus; Interneurons; Male; Methylazoxymethanol Acetate; Neural Inhibition; Neurotoxins; Parvalbumins; Prefrontal Cortex; Pregnancy; Rats; Schizophrenia; Spectrum Analysis | 2009 |
Behavioral perturbations after prenatal neurogenesis disturbance in female rat.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavioral Symptoms; Female; Inhibition, Psychological; Interpersonal Relations; Male; Maze Learning; Methylazoxymethanol Acetate; Motor Activity; Neurogenesis; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Recognition, Psychology; Reflex, Startle; Teratogens | 2009 |
Gestational treatment with methylazoxymethanol (MAM) that disrupts hippocampal-dependent memory does not alter behavioural response to cocaine.
Topics: Alkylating Agents; Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Hippocampus; Learning; Maze Learning; Memory; Methylazoxymethanol Acetate; Motor Activity; Organ Size; Pregnancy; Rats; Rats, Sprague-Dawley; Reinforcement Schedule | 2009 |
Regeneration of 5-HT fibers in hippocampal heterotopia of methylazoxymethanol-induced micrencephalic rats after neonatal 5,7-DHT injection.
Topics: 5,6-Dihydroxytryptamine; Age Factors; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Creatinine; Female; Hippocampus; Immunohistochemistry; Male; Methylazoxymethanol Acetate; Microcephaly; Nerve Fibers, Unmyelinated; Nerve Regeneration; Neurons; Periventricular Nodular Heterotopia; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Serotonin | 2010 |
Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophrenia.
Topics: Animals; Brain; Disease Models, Animal; Female; Hyperkinesis; Memory, Short-Term; Methylazoxymethanol Acetate; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Schizophrenia; Schizophrenic Psychology; Sensory Gating | 2009 |
Structural abnormalities revealed by magnetic resonance imaging in rats prenatally exposed to methylazoxymethanol acetate parallel cerebral pathology in schizophrenia.
Topics: Age Factors; Animals; Animals, Newborn; Brain Mapping; Cerebral Cortex; Cerebral Ventricles; Corpus Callosum; Diffusion Magnetic Resonance Imaging; Female; Hippocampus; Magnetic Resonance Imaging; Male; Methylazoxymethanol Acetate; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2011 |
Effect of antipsychotics on spontaneous hyperactivity and hypersensitivity to MK-801-induced hyperactivity in rats prenatally exposed to methylazoxymethanol.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dizocilpine Maleate; Female; Hyperkinesis; Methylazoxymethanol Acetate; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Schizophrenia | 2011 |
Divergent activation of ventromedial and ventrolateral dopamine systems in animal models of amphetamine sensitization and schizophrenia.
Topics: Action Potentials; Amphetamine; Animals; Central Nervous System Stimulants; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Dyskinesia, Drug-Induced; Female; Male; Methylazoxymethanol Acetate; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Schizophrenia; Ventral Tegmental Area | 2012 |
Differential effects of NMDA antagonists on high frequency and gamma EEG oscillations in a neurodevelopmental model of schizophrenia.
Topics: Animals; Biphenyl Compounds; Brain Waves; Cerebral Cortex; Cross-Over Studies; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Male; Methylazoxymethanol Acetate; Pregnancy; Propionates; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2012 |
A novel α5GABA(A)R-positive allosteric modulator reverses hyperactivation of the dopamine system in the MAM model of schizophrenia.
Topics: Allosteric Regulation; Amphetamine; Animals; Benzodiazepines; Diazepam; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Female; GABA Agonists; Hippocampus; Humans; Hyperkinesis; Imidazoles; Male; Methylazoxymethanol Acetate; Neurotoxins; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Schizophrenia; Ventral Tegmental Area | 2011 |
Alterations in hippocampal excitability, synaptic transmission and synaptic plasticity in a neurodevelopmental model of schizophrenia.
Topics: Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; Female; Hippocampus; Male; Methylazoxymethanol Acetate; Neuronal Plasticity; Organ Culture Techniques; Pregnancy; Rats; Rats, Sprague-Dawley; Schizophrenia; Synaptic Transmission | 2012 |
Initiation of epileptiform activity in a rat model of periventricular nodular heterotopia.
Topics: Action Potentials; Animals; Disease Models, Animal; Epilepsy; Female; Hippocampus; In Vitro Techniques; Lysine; Male; Methylazoxymethanol Acetate; Neocortex; Neurons; Periventricular Nodular Heterotopia; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Teratogens | 2011 |
The methylazoxymethanol acetate (MAM-E17) rat model: molecular and functional effects in the hippocampus.
Topics: Animals; Disease Models, Animal; Female; Frontal Lobe; Gene Expression Regulation; Hippocampus; Humans; Male; Metabolomics; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Proteomics; Rats; Schizophrenia; Synaptic Transmission | 2012 |
Gestational methylazoxymethanol acetate administration alters proteomic and metabolomic markers of hippocampal glutamatergic transmission.
Topics: Animals; Female; Hippocampus; Humans; Male; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Schizophrenia; Synaptic Transmission | 2012 |
Developmental origins of adult diseases and neurotoxicity: epidemiological and experimental studies.
Topics: Adolescent; Adult; Age Factors; Animals; Child; Child Behavior; Child Development; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Humans; Lead; Lead Poisoning, Nervous System, Adult; Lead Poisoning, Nervous System, Childhood; Male; Maternal Exposure; Mercury Poisoning, Nervous System; Methylazoxymethanol Acetate; Methylmercury Compounds; Mice; Nervous System; Neurotoxicity Syndromes; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Risk Assessment; Risk Factors; Toxicity Tests | 2012 |
Characterization of heterotopic cell clusters in the hippocampus of the rat after prenatal treatment of methylazoxymethanol acetate.
Topics: Animals; Brain; Cerebral Cortex; Female; Hippocampus; Male; Methylazoxymethanol Acetate; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar | 2012 |
Differential performance of Wistar Han and Sprague Dawley rats in behavioral tests: differences in baseline behavior and reactivity to positive control agents.
Topics: Animals; Behavior, Animal; Brain; Chlorpromazine; Control Groups; Dizocilpine Maleate; Female; Learning; Male; Memory; Methylazoxymethanol Acetate; Motor Activity; Neurotoxicity Syndromes; Neurotoxins; Nitriles; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reflex, Startle; Species Specificity | 2012 |
Gestational methylazoxymethanol exposure leads to NMDAR dysfunction in hippocampus during early development and lasting deficits in learning.
Topics: Age Factors; Animals; Female; Hippocampus; Learning; Memory Disorders; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2013 |
Disruption of prefrontal cortical-hippocampal balance in a developmental model of schizophrenia: reversal by sulpiride.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Female; Hippocampus; Long-Term Potentiation; Male; Methylazoxymethanol Acetate; Prefrontal Cortex; Pregnancy; Rats; Rats, Sprague-Dawley; Schizophrenia; Sulpiride | 2013 |
Hippocampal deep brain stimulation reverses physiological and behavioural deficits in a rodent model of schizophrenia.
Topics: Action Potentials; Amphetamine; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Deep Brain Stimulation; Disease Models, Animal; Dopaminergic Neurons; Female; Hippocampus; Hyperkinesis; Male; Mental Disorders; Methylazoxymethanol Acetate; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Schizophrenia; Ventral Tegmental Area | 2013 |
Role of the prefrontal cortex in altered hippocampal-accumbens synaptic plasticity in a developmental animal model of schizophrenia.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Female; Hippocampus; Male; Methylazoxymethanol Acetate; Neural Pathways; Neuronal Plasticity; Neurons; Neurotoxins; Nucleus Accumbens; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Schizophrenia; Synapses | 2014 |
Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy.
Topics: Animals; Carrier Proteins; Choristoma; Disease Models, Animal; Epilepsy; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Membrane Proteins; Membrane Transport Proteins; Methylazoxymethanol Acetate; Nervous System Malformations; Neural Inhibition; Neurons; Organic Anion Transporters; Patch-Clamp Techniques; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Synapses | 2002 |
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Carbamazepine; Disease Models, Animal; Electroencephalography; Epilepsy; Ethosuximide; Female; Hippocampus; In Vitro Techniques; Lamotrigine; Methylazoxymethanol Acetate; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Triazines; Valproic Acid | 2002 |
NPY sensitivity and postsynaptic properties of heterotopic neurons in the MAM model of malformation-associated epilepsy.
Topics: Abnormalities, Drug-Induced; Animals; Electrophysiology; Epilepsy; Excitatory Postsynaptic Potentials; Female; Hippocampus; Histocytochemistry; Membrane Potentials; Methylazoxymethanol Acetate; Neocortex; Neuropeptide Y; Potassium Channel Blockers; Potassium Channels; Pregnancy; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Teratogens | 2002 |
Kinetic assessment of the effects of task difficulty, microencephaly, and a response manipulandum alteration on the rate of fixed-ratio discrimination acquisition.
Topics: Animals; Behavior, Animal; Discrimination Learning; Female; Kinetics; Methylazoxymethanol Acetate; Microcephaly; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Task Performance and Analysis; Teratogens | 2002 |
Cortical fiber distribution in the somatosensory cortex of rats following prenatal exposure to X-irradiation.
Topics: Abnormalities, Radiation-Induced; Animals; Cerebral Cortex; Female; Male; Maternal Exposure; Methylamines; Methylazoxymethanol Acetate; Microcephaly; Nerve Fibers; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Somatosensory Cortex; Teratogens | 1997 |
A radialization factor in normal cortical plate restores disorganized radial glia and disrupted migration in a model of cortical dysplasia.
Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Brain; Bromodeoxyuridine; Cell Count; Cell Movement; Cerebral Cortex; Ciliary Neurotrophic Factor; Coculture Techniques; Female; Ferrets; Fluorescent Dyes; Image Processing, Computer-Assisted; Methylazoxymethanol Acetate; Models, Neurological; Neuroglia; Organ Culture Techniques; Pregnancy; Teratogens | 2003 |
Experimentally-induced microencephaly: effects on cortical neurons.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Corpus Callosum; Female; Methylazoxymethanol Acetate; Microcephaly; Neurons; Pregnancy; Rats; Rats, Wistar | 2003 |
Neurogenesis in cerebral heterotopia induced in rats by prenatal methylazoxymethanol treatment.
Topics: Animals; Brain Diseases; Bromodeoxyuridine; Cerebral Cortex; Choristoma; Disease Models, Animal; Female; Methylazoxymethanol Acetate; Microscopy, Confocal; Morphogenesis; Neurons; Phenotype; Pregnancy; Rats; Rats, Sprague-Dawley | 2003 |
The NMDA receptor complex is altered in an animal model of human cerebral heterotopia.
Topics: Animals; Animals, Newborn; Autoradiography; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Membrane; Cerebral Cortex; Choristoma; Cloning, Molecular; Disease Models, Animal; Disks Large Homolog 4 Protein; Female; Hippocampus; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Matched-Pair Analysis; Membrane Proteins; Methylazoxymethanol Acetate; Microscopy, Confocal; Nerve Tissue Proteins; Peptide Fragments; Phosphorylation; Pregnancy; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Subcellular Fractions | 2003 |
Diminished experience-dependent neuroanatomical plasticity: evidence for an improved biomarker of subtle neurotoxic damage to the developing rat brain.
Topics: Animals; Biomarkers; Brain; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Male; Maternal Exposure; Methylazoxymethanol Acetate; Neuronal Plasticity; Pregnancy; Rats; Rats, Long-Evans | 2003 |
GABAA receptors reorganize when layer 4 in ferret somatosensory cortex is disrupted by methylazoxymethanol (MAM).
Topics: Animals; Autoradiography; Female; Ferrets; Immunohistochemistry; Methylazoxymethanol Acetate; Nerve Fibers; Neurons, Afferent; Pregnancy; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Thalamus | 2004 |
The prenatal methylazoxymethanol acetate treatment: a neurodevelopmental animal model for schizophrenia?
Topics: Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Body Weight; Brain; Cognition; Disease Models, Animal; Dose-Response Relationship, Radiation; Embryo, Mammalian; Emotions; Female; Inhibition, Psychological; Male; Methylazoxymethanol Acetate; Motor Activity; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Protein Synthesis Inhibitors; Rats; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Sex Factors | 2004 |
Excitability of CA1 neurons in the model of malformation-associated epilepsy.
Topics: Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Epilepsy; Evoked Potentials; Female; GABA Antagonists; Hippocampus; Male; Methylazoxymethanol Acetate; Neurons; Potassium Acetate; Pregnancy; Rats; Rats, Sprague-Dawley | 2004 |
Working memory deficits in adult rats after prenatal disruption of neurogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Drug Administration Schedule; Female; Hippocampus; Male; Maze Learning; Memory Disorders; Methylazoxymethanol Acetate; Organ Size; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
Impaired brain development in the rat following prenatal exposure to methylazoxymethanol acetate at gestational day 17 and neurotrophin distribution.
Topics: Age Factors; Animals; Brain; Female; Gestational Age; Male; Methylazoxymethanol Acetate; Nerve Growth Factors; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred F344; Time Factors | 2004 |
Refractory atypical absence seizures in rat: a two hit model.
Topics: Animals; Anticholesteremic Agents; Brain; Disease Models, Animal; Drug Resistance; Electroencephalography; Epilepsy, Absence; Female; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Protein Synthesis Inhibitors; Rats; Rats, Long-Evans; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2004 |
Cognitive deficits caused by late gestational disruption of neurogenesis in rats: a preclinical model of schizophrenia.
Topics: Animals; Association Learning; Cognition Disorders; Conditioning, Operant; Disease Models, Animal; Exploratory Behavior; Female; Maze Learning; Methylazoxymethanol Acetate; Nervous System; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; Rats; Rats, Wistar; Recognition, Psychology; Reversal Learning; Schizophrenia; Swimming; Teratogens | 2005 |
A volumetric screening procedure for the Göttingen minipig brain.
Topics: Algorithms; Anatomy, Cross-Sectional; Animals; Brain; Cell Count; Disease Models, Animal; Female; Methylazoxymethanol Acetate; Nervous System Malformations; Pilot Projects; Pregnancy; Prenatal Exposure Delayed Effects; Swine; Swine, Miniature; Teratogens | 2005 |
Prenatal disruption of neocortical development alters prefrontal cortical neuron responses to dopamine in adult rats.
Topics: Animals; Animals, Newborn; Dopamine; Drug Interactions; Electric Stimulation; Female; Male; Membrane Potentials; Methylazoxymethanol Acetate; Neurons; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Protein Synthesis Inhibitors; Rats; Rats, Inbred F344 | 2005 |
Initiation and spread of epileptiform discharges in the methylazoxymethanol acetate rat model of cortical dysplasia: functional and structural connectivity between CA1 heterotopia and hippocampus/neocortex.
Topics: Abnormalities, Drug-Induced; Animals; Bicuculline; Biotin; Brain Diseases; Dextrans; Electrophysiology; Epilepsy; Female; Fluorescent Dyes; GABA Antagonists; Hippocampus; Immunohistochemistry; Methylazoxymethanol Acetate; Neocortex; Neural Pathways; Potassium; Pregnancy; Rats; Rats, Sprague-Dawley; Teratogens | 2005 |
Effects of prenatal methylazoxymethanol acetate (MAM) treatment in rats on water maze performance.
Topics: Analysis of Variance; Animals; Behavior, Animal; Female; Gestational Age; Inhibition, Psychological; Male; Maze Learning; Memory; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Reaction Time; Sex Factors; Spatial Behavior; Visual Perception; Water | 2005 |
Degeneration of monoaminergic fibers in the aged micrencephalic rat.
Topics: Aging; Animals; Biogenic Monoamines; Brain Chemistry; Brain Injuries; Chromatography, High Pressure Liquid; Female; Immunohistochemistry; Male; Methylazoxymethanol Acetate; Nerve Degeneration; Nerve Fibers; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Time Factors | 2005 |
Pilocarpine-induced seizure susceptibility in rats following prenatal methylazoxymethanol treatment.
Topics: Animals; Disease Susceptibility; Female; Immunohistochemistry; Maternal Exposure; Methylazoxymethanol Acetate; Pilocarpine; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures; Teratogens | 2005 |
Endogenous neuregulin restores radial glia in a (ferret) model of cortical dysplasia.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Female; Ferrets; In Vitro Techniques; Methylazoxymethanol Acetate; Neuregulins; Neuroglia; Pregnancy; Prenatal Exposure Delayed Effects; Teratogens | 2005 |
Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Female; Gene Expression; Hippocampus; Immunohistochemistry; Methylazoxymethanol Acetate; Motor Activity; Neurons; Parvalbumins; Phencyclidine; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Schizophrenia; Time Factors | 2006 |
Embryonic and early postnatal abnormalities contributing to the development of hippocampal malformations in a rodent model of dysplasia.
Topics: Animals; Animals, Newborn; Cell Differentiation; Cell Movement; Cell Proliferation; Cerebral Cortex; Choristoma; Disease Models, Animal; Epilepsy; Female; Hippocampus; Methylazoxymethanol Acetate; Nervous System Malformations; Neuroglia; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Stem Cells; Teratogens | 2006 |
A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia.
Topics: Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Brain; Central Nervous System Stimulants; Cognition Disorders; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Gait Disorders, Neurologic; Methylazoxymethanol Acetate; Neurons; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred F344; Schizophrenia | 2006 |
Postnatal effect of embryonic neurogenesis disturbance on reelin level in organotypic cultures of rat hippocampus.
Topics: Animals; Animals, Newborn; Cell Adhesion Molecules, Neuronal; Extracellular Matrix Proteins; Female; Hippocampus; Male; Methylazoxymethanol Acetate; Mitosis; Nerve Tissue Proteins; Neurons; Organ Culture Techniques; Pregnancy; Rats; Rats, Sprague-Dawley; Reelin Protein; Serine Endopeptidases | 2006 |
Application of magnetic resonance imaging in developmental neurotoxicity testing: a pilot study.
Topics: Animals; Animals, Newborn; Body Weight; Dose-Response Relationship, Drug; Female; Hippocampus; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Methylazoxymethanol Acetate; Neurotoxicity Syndromes; Organ Size; Pilot Projects; Pregnancy; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley | 2006 |
Alterations in medial prefrontal cortical activity and plasticity in rats with disruption of cortical development.
Topics: Action Potentials; Age Factors; Animals; Animals, Newborn; Cell Proliferation; Dopamine; Electric Stimulation; Electroencephalography; Female; Hippocampus; Male; Methylazoxymethanol Acetate; Neuronal Plasticity; Neurotoxins; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred F344; Time Factors | 2006 |
Peri-pubertal maturation after developmental disturbance: a model for psychosis onset in the rat.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Brain; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Inhibition, Psychological; Interpersonal Relations; Maze Learning; Methylazoxymethanol Acetate; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Psychotic Disorders; Rats; Recognition, Psychology; Reflex, Startle; Time Factors | 2006 |
Determinants of drug brain uptake in a rat model of seizure-associated malformations of cortical development.
Topics: Animals; Anticonvulsants; Astrocytes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Capillary Permeability; Choristoma; Disease Models, Animal; Drug Resistance; Endothelial Cells; Epilepsy; Female; Hippocampus; Male; Matched-Pair Analysis; Methylazoxymethanol Acetate; Ondansetron; Pregnancy; Rats; RNA, Messenger; Seizures; Serum Albumin | 2006 |
Gestational methylazoxymethanol acetate treatment impairs select cognitive functions: parallels to schizophrenia.
Topics: Animals; Atrophy; Brain; Brain Damage, Chronic; Cognition Disorders; Discrimination Learning; Disease Models, Animal; Female; Learning Disabilities; Male; Methylazoxymethanol Acetate; Neuropsychological Tests; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; Rats; Reinforcement, Psychology; Schizophrenia; Teratogens | 2007 |
The effect of trichlorfon and methylazoxymethanol on the development of guinea pig cerebellum.
Topics: Acetylcholinesterase; Acetyltransferases; Animals; Animals, Newborn; Carboxy-Lyases; Cerebellum; Female; Gestational Age; Guinea Pigs; Injections, Subcutaneous; Methylazoxymethanol Acetate; Microscopy, Electron; Pregnancy; Trichlorfon | 2007 |
Altered glutamate receptor - transporter expression and spontaneous seizures in rats exposed to methylazoxymethanol in utero.
Topics: Amino Acid Transport System X-AG; Amygdala; Animals; Cerebral Cortex; Choristoma; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Female; Hippocampus; Immunohistochemistry; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Seizures; Teratogens; Vesicular Glutamate Transport Protein 2 | 2007 |
Alterations in prefrontal glutamatergic and noradrenergic systems following MK-801 administration in rats prenatally exposed to methylazoxymethanol at gestational day 17.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Male; Methylazoxymethanol Acetate; Microdialysis; Motor Activity; Norepinephrine; Nucleus Accumbens; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2007 |
A normal radial glial scaffold is necessary for migration of interneurons during neocortical development.
Topics: Animals; Cell Communication; Cell Movement; Female; Ferrets; gamma-Aminobutyric Acid; Immunophenotyping; Interneurons; Methylazoxymethanol Acetate; Neocortex; Neuroglia; Organ Culture Techniques; Pregnancy; Teratogens | 2007 |
Early cerebrovascular and parenchymal events following prenatal exposure to the putative neurotoxin methylazoxymethanol.
Topics: Abnormalities, Drug-Induced; Animals; Aquaporin 1; Brain; Cerebral Arteries; Cerebral Cortex; Disease Models, Animal; Female; Methylazoxymethanol Acetate; Neovascularization, Physiologic; Nervous System Malformations; Neurotoxins; Pokeweed Mitogens; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Teratogens; Vascular Endothelial Growth Factor A | 2007 |
Wide spectrum modulation by KP-544 in models relevant for neuronal survival.
Topics: Animals; Astrocytes; Cell Death; Cell Survival; Cerebellum; Cyclohexanols; Disease Models, Animal; Drug Synergism; Female; Male; Methylazoxymethanol Acetate; Nerve Growth Factor; Neurites; Neurons; Neuroprotective Agents; Neurotoxins; PC12 Cells; Pregnancy; Pyrimidines; Rats; Schizophrenia | 2007 |
Migration of transplanted neural progenitor cells in a ferret model of cortical dysplasia.
Topics: Amino Acids; Analysis of Variance; Animals; Animals, Newborn; Cell Culture Techniques; Cell Movement; Cell Proliferation; Disease Models, Animal; Embryo, Mammalian; Female; Ferrets; Malformations of Cortical Development; Methylazoxymethanol Acetate; Mice; Nerve Tissue Proteins; Neurons; Organ Culture Techniques; Pregnancy; Prenatal Exposure Delayed Effects; Stem Cell Transplantation; Stem Cells | 2008 |
Reelin is essential for neuronal migration but not for radial glial elongation in neonatal ferret cortex.
Topics: Animals; Animals, Newborn; Antimetabolites; Antimitotic Agents; Bromodeoxyuridine; Cell Adhesion Molecules, Neuronal; Cell Line; Cell Movement; Cell Size; Cerebral Cortex; Coculture Techniques; Extracellular Matrix Proteins; Female; Ferrets; Fluorescent Dyes; Genotype; Humans; Methylazoxymethanol Acetate; Nerve Tissue Proteins; Neuroglia; Neurons; Organ Culture Techniques; Pregnancy; Reelin Protein; Reverse Transcriptase Polymerase Chain Reaction; Serine Endopeptidases | 2008 |
A neurochemical study of experimental microencephalic rat.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Biogenic Amines; Brain; Brain Chemistry; Cytarabine; DNA; Female; Learning; Methylazoxymethanol Acetate; Myelin Proteins; Nerve Tissue Proteins; Organ Size; Phosphoric Diester Hydrolases; Pregnancy; Rats; Rats, Inbred Strains; Time Factors; Tryptophan; Tryptophan Hydroxylase | 1984 |
Effects of fetal treatment with methylazoxymethanol acetate at various gestational dates on the neurochemistry of the adult neocortex of the rat.
Topics: Age Factors; Animals; Azo Compounds; Brain Chemistry; Cerebral Cortex; Choline O-Acetyltransferase; Female; Gestational Age; Glutamate Decarboxylase; Methylazoxymethanol Acetate; Norepinephrine; Organ Size; Pregnancy; Rats; Serotonin; Tyrosine 3-Monooxygenase | 1981 |
Effects of prenatal methylazoxymethanol treatment on the development of central monoamine neurons.
Topics: Animals; Azo Compounds; Brain; Cell Differentiation; Dopamine; Female; Methylazoxymethanol Acetate; Neurons; Neurotransmitter Agents; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Serotonin | 1981 |
Development of central neurotransmitter systems.
Topics: Animals; Animals, Newborn; Brain; Catecholamines; Cerebral Cortex; Dopamine; Female; Fetus; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Macaca mulatta; Methylazoxymethanol Acetate; Neurons; Neurotransmitter Agents; Norepinephrine; Pregnancy; Rats | 1981 |
Neurotransmitter chemistry of lissencephalic cortex induced in ferrets by fetal treatment with methylazoxymethanol acetate.
Topics: Animals; Azo Compounds; Carnivora; Cerebral Cortex; Choline O-Acetyltransferase; Female; Ferrets; Fetus; Glutamate Decarboxylase; Methylazoxymethanol Acetate; Organ Specificity; Pregnancy; Synaptic Transmission; Tyrosine 3-Monooxygenase | 1982 |
Monoamine neurotransmitter metabolism in microencephalic rat brain after prenatal methylazoxymethanol treatment.
Topics: Abnormalities, Drug-Induced; Animals; Azo Compounds; Biogenic Amines; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Female; Hippocampus; Methylazoxymethanol Acetate; Microcephaly; Neurotransmitter Agents; Pregnancy; Rats; Rats, Inbred Strains | 1984 |
Adjustment of connectivity in rat neocortex after prenatal destruction of precursor cells of layers II-IV.
Topics: Animals; Azacitidine; Azo Compounds; Cerebral Cortex; Efferent Pathways; Female; Methylazoxymethanol Acetate; Neurons; Pregnancy; Rats; Rats, Inbred Strains | 1981 |
Connections made by transplants to the cerebral cortex of rat brains damaged in utero.
Topics: Afferent Pathways; Animals; Animals, Newborn; Axonal Transport; Cerebral Cortex; Efferent Pathways; Female; Fetus; Horseradish Peroxidase; Methylazoxymethanol Acetate; Pregnancy; Rats; Transplantation, Homologous | 1984 |
Fetally-induced noradrenergic hyperinnervation of cerebral cortex results in persistent down-regulation of beta-receptors.
Topics: Animals; Azo Compounds; Cerebral Cortex; Desipramine; Dihydroalprenolol; Female; Hydroxydopamines; Kinetics; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Neurons; Norepinephrine; Oxidopamine; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, beta | 1982 |
Loss of intrinsic striatal neurons after methylazoxymethanol acetate treatment in pregnant rats.
Topics: Adenylyl Cyclases; Animals; Azo Compounds; Corpus Striatum; Female; Kainic Acid; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1984 |
Effects of cytotoxic deletions of somatic sensory cortex in fetal rats.
Topics: Animals; Axons; Brain Mapping; Cerebral Cortex; Dendrites; Female; Methylazoxymethanol Acetate; Neurons; Pregnancy; Pyramidal Tracts; Rats; Rats, Inbred Strains; Somatosensory Cortex; Synapses; Thalamus | 1984 |
Pervasive hyperactivity and long-term learning impairments in rats with induced micrencephaly from prenatal exposure to methylazoxymethanol.
Topics: Animals; Azo Compounds; Body Weight; Brain; Disease Models, Animal; Female; Humans; Hyperkinesis; Intellectual Disability; Learning Disabilities; Male; Methylazoxymethanol Acetate; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Spatial Behavior | 1984 |
Factors in manifestation of developmental abnormalities of the central nervous system by environmental agents.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Animals; Brain; Cell Differentiation; Environmental Pollutants; Female; Humans; Methylazoxymethanol Acetate; Mice; Pregnancy | 1983 |
Infrapyramidal mossy fibers in the hippocampus of methylazoxymethanol acetate-induced microcephalic rats.
Topics: Animals; Female; Hippocampus; Methylazoxymethanol Acetate; Microcephaly; Nerve Fibers; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 1983 |
Methylazoxymethanol microencephaly in rats: neurochemical characterization and behavioral studies with the nootropic oxiracetam.
Topics: Abnormalities, Drug-Induced; Animals; Azo Compounds; Behavior, Animal; Cognition; Female; Learning; Methylazoxymethanol Acetate; Microcephaly; Pregnancy; Pyrrolidines; Rats; Rats, Inbred Strains | 1984 |
Hyperactivity induced by prenatal administration of methylazoxymethanol: association with altered performance on conditioning tasks in rats.
Topics: Alkylating Agents; Animals; Avoidance Learning; Azo Compounds; Body Weight; Conditioning, Operant; Female; Methylazoxymethanol Acetate; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; Rats; Rats, Inbred Strains | 1984 |
Effects of prenatal treatment with methylazoxymethanol acetate on growth, development, reproductive performance, learning ability and behavior in the rat offspring.
Topics: Abnormalities, Drug-Induced; Analysis of Variance; Animals; Azo Compounds; Behavior, Animal; Body Weight; Brain; Carcinogens; Female; Fetus; Learning; Male; Methylazoxymethanol Acetate; Motor Activity; Organ Size; Pregnancy; Rats; Rats, Inbred Strains; Reproduction | 1982 |
An autoradiographic study of methyl-azoxy-methanol acetate-induced cortical malformation.
Topics: Animals; Autoradiography; Cell Movement; Cerebral Cortex; Female; Methylazoxymethanol Acetate; Neurons; Pregnancy; Rats; Time Factors | 1982 |
The effect of methylazoxymethanol acetate (MAM) on the developing rat retina.
Topics: Animals; Azo Compounds; Female; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Microscopy, Electron; Photoreceptor Cells; Pregnancy; Rats; Rats, Inbred Strains; Retina; Retinal Diseases | 1982 |
The sleep-wakefulness cycle and spindle bursts during paradoxical sleep in microencephalic rats induced by prenatal administration of methylazoxymethanol (MAM) acetate.
Topics: Animals; Azo Compounds; Brain; Female; Male; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Inbred Strains; Sleep; Sleep, REM; Wakefulness | 1982 |
Telencephalic cytoarchitectonics in the brains of rats with graded degrees of micrencephaly.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Cerebral Cortex; Dendrites; Dose-Response Relationship, Drug; Female; Hippocampus; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Pregnancy; Rats; Telencephalon | 1982 |
Congenital malformations of the central nervous system and transplacental carcinogenesis: modification of ethylnitrosourea-induced brain tumors in rats by pretreatment with methylazoxymethanol.
Topics: Animals; Azo Compounds; Brain Neoplasms; Ethylnitrosourea; Female; Methylazoxymethanol Acetate; Microcephaly; Neoplasms, Experimental; Nervous System Neoplasms; Nitrosourea Compounds; Pregnancy; Rats; Rats, Inbred Strains | 1982 |
Retinal toxicity of methylazoxymethanol acetate is developmentally specific.
Topics: Aging; Animals; Animals, Newborn; Azo Compounds; Cell Differentiation; Female; Methylazoxymethanol Acetate; Photoreceptor Cells; Pregnancy; Rats; Retina; Rosette Formation | 1981 |
Elevated monoamine levels in the cerebral hemispheres of microencephalic rats treated prenatally with methylazoxymethanol or cytosine arabinoside.
Topics: Animals; Azo Compounds; Biogenic Amines; Brain; Cytarabine; DNA; Dopamine; Female; Fetus; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Norepinephrine; Pregnancy; Rats; Serotonin; Tryptophan Hydroxylase | 1980 |
Deformed dendrites and reduced spine numbers on ectopic neurones in the hippocampus of rats exposed to methylazoxymethanol-acetate. A Golgi-Cox study.
Topics: Animals; Azo Compounds; Cell Count; Dendrites; Female; Hippocampus; Methylazoxymethanol Acetate; Neurons; Pregnancy; Rats; Time Factors | 1980 |
Involvement of granule, basket and stellate neurons but not Purkinje or Golgi cells in cerebellar cGMP increases in vivo.
Topics: Amino Acid Oxidoreductases; Amino Acids; Animals; Cerebellum; Cyclic GMP; Cytoplasmic Granules; Female; Golgi Apparatus; Harmaline; Immunohistochemistry; Methylazoxymethanol Acetate; Mice; Mice, Neurologic Mutants; N-Methylaspartate; Neurons; Nitric Oxide Synthase; Pregnancy; Purkinje Cells | 1994 |
Seizure susceptibility in immature rats with micrencephaly induced by prenatal exposure to methylazoxymethanol acetate.
Topics: Age Factors; Animals; Bicuculline; Body Weight; Brain; Disease Models, Animal; Female; Humans; Infant, Newborn; Kainic Acid; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Wistar; Seizures | 1995 |
FR discrimination training effects in SHR and microencephalic rats.
Topics: Animals; Brain; Discrimination Learning; Female; Food; Hippocampus; Hypertension; Male; Methylazoxymethanol Acetate; Microcephaly; Organ Size; Pregnancy; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Reinforcement Schedule; Teratogens | 1995 |
Developmental neurotoxicity: evaluation of testing procedures with methylazoxymethanol and methylmercury.
Topics: Alkylating Agents; Animals; Brain; Cognition; Dose-Response Relationship, Drug; Female; Fetus; Glial Fibrillary Acidic Protein; Hearing; Male; Methylazoxymethanol Acetate; Methylmercury Compounds; Motor Activity; Organ Size; Pregnancy; Rats; Reflex, Startle | 1994 |
Behavioural retardation in the neuropathology of mental retardation.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Dihydroxyphenylalanine; Dopamine Agents; Female; Haloperidol; Intellectual Disability; Learning; Male; Mercury Poisoning; Methylazoxymethanol Acetate; Metoclopramide; Mice; Motor Activity; Organotin Compounds; Pregnancy; Rats; Rats, Sprague-Dawley | 1993 |
Patterns of growth deficiency in rats exposed in utero to undernutrition, ethanol, or the neuroteratogen methylazoxymethanol (MAM).
Topics: Age Factors; Animals; Birth Weight; Brain; DNA Damage; Dwarfism; Ethanol; Female; Fetal Growth Retardation; Growth Disorders; Hypothalamo-Hypophyseal System; Male; Methylazoxymethanol Acetate; Nerve Tissue Proteins; Neurons; Nutrition Disorders; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Rats; Receptors, Corticotropin-Releasing Hormone; Sexual Maturation; Somatostatin; Weight Loss | 1994 |
The insular claustrum in the methylazoxymethanol acetate (MAM) treated rats shows two different populations of neurons.
Topics: Animals; Basal Ganglia; Basal Ganglia Diseases; Female; Methylazoxymethanol Acetate; Microcephaly; Neurons; Pregnancy; Pregnancy, Animal; Rats; Rats, Wistar | 1994 |
Immunohistochemical localization of calbindin-D28K in telencephalic regions of microencephalic rats.
Topics: Animals; Calbindin 1; Calbindins; Cerebral Cortex; Female; Hippocampus; Immunohistochemistry; Methylazoxymethanol Acetate; Microcephaly; Neurons; Pregnancy; Rats; Rats, Wistar; S100 Calcium Binding Protein G; Telencephalon | 1994 |
Behavioral effects of methylazoxymethanol-induced micrencephaly.
Topics: Alkylating Agents; Animals; Arousal; Association Learning; Behavior, Animal; Brain; Cerebral Cortex; Conditioning, Classical; Discrimination Learning; Dose-Response Relationship, Drug; Female; Male; Methamphetamine; Methylazoxymethanol Acetate; Motor Activity; Organ Size; Orientation; Pregnancy; Prenatal Exposure Delayed Effects; Problem Solving; Rats; Rats, Sprague-Dawley | 1993 |
Changes in the reproductive system following acute prenatal exposure to ethanol or methylazoxymethanol in the rat: I. Effects on immunoreactive LHRH cell number.
Topics: Animals; Body Weight; Brain; Cell Count; Cell Division; Ethanol; Female; Gonadotropin-Releasing Hormone; Methylazoxymethanol Acetate; Neurons; Organ Size; Pilot Projects; Pituitary Gland; Pregnancy; Rats; Teratogens | 1994 |
Selective alteration in B-50/GAP-43 phosphorylation in brain areas of animals characterized by cognitive impairment.
Topics: Animals; Avoidance Learning; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Cognition Disorders; Female; GAP-43 Protein; Hippocampus; In Situ Hybridization; Membrane Glycoproteins; Methylazoxymethanol Acetate; Nerve Tissue Proteins; Neuronal Plasticity; Phosphorylation; Pregnancy; Rats; Rats, Sprague-Dawley | 1993 |
Decreased dominance in a limited access test but normal maternal behavior in micrencephalic rats.
Topics: Animals; Birth Weight; Brain; Female; Litter Size; Male; Maternal Behavior; Methylazoxymethanol Acetate; Microcephaly; Organ Size; Pregnancy; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal; Social Dominance; Teratogens | 1995 |
Flurothyl seizure susceptibility in rats following prenatal methylazoxymethanol treatment.
Topics: Animals; Convulsants; Epilepsy, Tonic-Clonic; Female; Flurothyl; Hippocampus; Male; Methylazoxymethanol Acetate; Mice; Myoclonus; Pregnancy; Prenatal Exposure Delayed Effects; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures; Teratogens | 1996 |
Effect of prenatal treatment with methylazoxymethanol on carbachol-, norepinephrine- and glutamate-stimulated phosphoinositide metabolism in the neonatal, young, and adult offspring.
Topics: Animals; Animals, Newborn; Carbachol; Cerebral Cortex; Drug Interactions; Female; Gestational Age; Glutamic Acid; In Vitro Techniques; Male; Methylazoxymethanol Acetate; Mitosis; Norepinephrine; Phosphatidylinositols; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1995 |
Electrophysiology of CA1 pyramidal neurons in an animal model of neuronal migration disorders: prenatal methylazoxymethanol treatment.
Topics: Action Potentials; Animals; Cell Movement; Evoked Potentials; Female; Male; Methylazoxymethanol Acetate; Microcephaly; Potassium Chloride; Pregnancy; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synapses | 1995 |
Differential translocation of protein kinase C isozymes in rats characterized by a chronic lack of LTP induction and cognitive impairment.
Topics: Animals; Cognition Disorders; Enzyme Induction; Female; Isoenzymes; Long-Term Potentiation; Methylazoxymethanol Acetate; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Synapses | 1996 |
Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive up-regulation of protein kinase C.
Topics: Alkylating Agents; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Female; Hippocampus; Membrane Proteins; Methylazoxymethanol Acetate; Organ Culture Techniques; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Synaptosomes | 1997 |
5-Hydroxytryptamine1B and alpha 2 adrenaline receptors in the brain of rats prenatally treated with methylazoxymethanol.
Topics: Alkylating Agents; Animals; Autoreceptors; Biogenic Monoamines; Brain; Female; Methylazoxymethanol Acetate; Microcephaly; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Adrenergic, alpha-2; Receptors, Serotonin | 1997 |
Ischemic and excitotoxic damage to brain slices from normal and microencephalic rats.
Topics: Animals; Brain; Brain Ischemia; Female; Methylazoxymethanol Acetate; Models, Biological; Neurotoxins; Nucleic Acid Synthesis Inhibitors; Pregnancy; Radioligand Assay; Rats; Rats, Wistar | 1997 |
Effects of neuroleptic and anticonvulsant drugs on repeated acquisition learning in microencephalic and normal rats.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Brain; Clozapine; Conditioning, Operant; Female; Learning; Methylazoxymethanol Acetate; Microcephaly; Organ Size; Pregnancy; Rats; Rats, Sprague-Dawley; Teratogens; Thioridazine | 1997 |
Abnormal development of serotonin nerve fibers in the visual cortex in rats with methylazoxymethanol-induced microcephaly.
Topics: Animals; Female; Immunohistochemistry; Male; Methylazoxymethanol Acetate; Microcephaly; Nerve Fibers; Neuronal Plasticity; Pregnancy; Rats; Rats, Wistar; Serotonin; Teratogens; Visual Cortex | 1998 |
Transplacentally induced neuronal migration disorders: an animal model for the study of the epilepsies.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Brain Mapping; Cell Movement; Disease Models, Animal; Electroencephalography; Epilepsy; Female; Gestational Age; Hippocampus; Litter Size; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Neurons; Organ Size; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures | 1998 |
Effect of chronic amitriptyline administration on serotonergic receptors in rats with methylazoxymethanol-induced microencephaly.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alkylating Agents; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Cerebral Cortex; Female; Ketanserin; Kinetics; Male; Methylazoxymethanol Acetate; Microcephaly; Pregnancy; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1998 |
Glutamate receptors in dysplasic cortex: an in situ hybridization and immunohistochemistry study in rats with prenatal treatment with methylazoxymethanol.
Topics: Animals; Brain Diseases; Cerebral Cortex; Choristoma; Female; Hippocampus; Immunohistochemistry; In Situ Hybridization; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, Glutamate; RNA, Messenger | 1998 |
Methylazoxymethanol acetate-induced abnormalities in the entorhinal cortex of the rat; parallels with morphological findings in schizophrenia.
Topics: Animals; Disease Models, Animal; Entorhinal Cortex; Female; Frontal Lobe; Gestational Age; Gyrus Cinguli; Hippocampus; Immunohistochemistry; Isoenzymes; Male; Methylazoxymethanol Acetate; Occipital Lobe; Pregnancy; Prenatal Exposure Delayed Effects; Protein Kinase C; Rats; Rats, Wistar; Schizophrenia | 1998 |
Effects of prenatal methylazoxymethanol treatment on striatal dopaminergic systems in rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Autoradiography; Brain; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Homovanillic Acid; Kinetics; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Methylazoxymethanol Acetate; Microdialysis; Nerve Tissue Proteins; Piperazines; Potassium Chloride; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Reference Values; Synapses; Teratogens; Tritium | 1998 |
Neocortex in the hippocampus: an anatomical and functional study of CA1 heterotopias after prenatal treatment with methylazoxymethanol in rats.
Topics: Animals; Animals, Newborn; Brain Mapping; Bromodeoxyuridine; Cell Movement; Choristoma; Female; Hippocampus; In Situ Hybridization; Methylazoxymethanol Acetate; Mitosis; Neocortex; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar | 1998 |
Neuronal migration disorders: heterotopic neocortical neurons in CA1 provide a bridge between the hippocampus and the neocortex.
Topics: Action Potentials; Animals; Cell Movement; Electric Stimulation; Electrophysiology; Female; Hippocampus; Methylazoxymethanol Acetate; Neocortex; Nerve Net; Patch-Clamp Techniques; Pregnancy; Pyramidal Cells; Rats; Rats, Wistar; Teratogens | 1998 |
Quantitative analysis of cerebellar lobulation in normal and agranular rats.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Cerebellar Diseases; Cerebellum; Female; Male; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Radiation Injuries, Experimental; Rats; Rats, Wistar | 1998 |
Altered connections between neocortical and heterotopic areas in methylazoxymethanol-treated rat.
Topics: Animals; Axonal Transport; Brain; Brain Diseases; Choristoma; Disease Models, Animal; Female; Functional Laterality; Gestational Age; Humans; Methylazoxymethanol Acetate; Neocortex; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Teratogens | 1998 |
Dysplastic neocortex and subcortical heterotopias in methylazoxymethanol-treated rats: an intracellular study of identified pyramidal neurones.
Topics: Animals; Cell Movement; Cerebral Ventricles; Choristoma; Culture Techniques; Drug Administration Schedule; Electric Stimulation; Embryo, Mammalian; Evoked Potentials; Female; Hippocampus; Injections, Intraperitoneal; Intracellular Fluid; Maternal Exposure; Maternal-Fetal Exchange; Membrane Potentials; Methylazoxymethanol Acetate; Microelectrodes; Neocortex; Neurons; Pregnancy; Pyramidal Cells; Rats; Synaptic Transmission; Time Factors | 1998 |
Decreased seizure threshold and more rapid rate of kindling in rats with cortical malformation induced by prenatal treatment with methylazoxymethanol.
Topics: Abnormalities, Drug-Induced; Animals; Cerebral Cortex; Electroencephalography; Female; Hippocampus; Kindling, Neurologic; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Reaction Time; Seizures | 1998 |
Evidence of enhanced kindling and hippocampal neuronal injury in immature rats with neuronal migration disorders.
Topics: Animals; Animals, Newborn; Cell Count; Cerebral Cortex; Electric Stimulation; Epilepsy; Female; Hippocampus; Kindling, Neurologic; Methylazoxymethanol Acetate; Mitosis; Neurons; Pregnancy; Rats | 1998 |
CaMKII-dependent phosphorylation of NR2A and NR2B is decreased in animals characterized by hippocampal damage and impaired LTP.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Enzyme Activation; Female; Gene Expression; Hippocampus; In Situ Hybridization; Long-Term Potentiation; Methylazoxymethanol Acetate; Nerve Degeneration; Neurons; Organ Culture Techniques; Phosphorylation; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Serine; Synapses; Threonine; Tyrosine | 1999 |
Prenatal methylazoxymethanol treatment in rats produces brain abnormalities with morphological similarities to human developmental brain dysgeneses.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Cerebral Ventricles; Choristoma; Embryonic and Fetal Development; Female; Hippocampus; Humans; Immunohistochemistry; Injections, Intraperitoneal; Methylazoxymethanol Acetate; Microscopy, Electron; Neurons; Neurotoxins; Pregnancy; Rats; Rats, Sprague-Dawley | 1999 |
Prenatal methylazoxymethanol acetate alters behavior and brain NGF levels in young rats: a possible correlation with the development of schizophrenia-like deficits.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Brain; Disease Models, Animal; Exploratory Behavior; Female; Methylazoxymethanol Acetate; Nerve Growth Factors; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Schizophrenia; Social Behavior; Substance P | 1999 |
Abnormal connections in the malformed cortex of rats with prenatal treatment with methylazoxymethanol may support hyperexcitability.
Topics: Abnormalities, Drug-Induced; Animals; Cerebral Cortex; Embryo, Mammalian; Female; Hippocampus; Methylazoxymethanol Acetate; Neocortex; Neural Pathways; Pregnancy; Rats; Rats, Wistar; Teratogens | 1999 |
Characterization of heterotopic cell clusters in the hippocampus of rats exposed to methylazoxymethanol in utero.
Topics: 4-Aminopyridine; Animals; Bicuculline; Brain Diseases; Choristoma; Convulsants; Electrophysiology; Epilepsy; Female; Hippocampus; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Synapses | 2000 |
The distribution of serotonergic nerves in microencephalic rats treated prenatally with methylazoxymethanol.
Topics: Animals; Autoradiography; Binding Sites; Brain; Carrier Proteins; Cerebellum; Cerebral Cortex; Female; Hippocampus; Membrane Glycoproteins; Membrane Transport Proteins; Methylazoxymethanol Acetate; Microcephaly; Nerve Tissue Proteins; Neurons; Nucleus Accumbens; Paroxetine; Pregnancy; Prenatal Exposure Delayed Effects; Raphe Nuclei; Rats; Rats, Wistar; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Thalamus | 2000 |
Impaired sensory gating and attention in rats with developmental abnormalities of the mesocortex. Implications for schizophrenia.
Topics: Acoustic Stimulation; Animals; Attention; Cerebral Cortex; Female; Habituation, Psychophysiologic; Methylazoxymethanol Acetate; Noise; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Sensation; Sensation Disorders | 2000 |
Constitutive overactivation of protein kinase C in guinea pig brain increases alpha-secretory APP processing without decreasing beta-amyloid generation.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Carcinogens; Endopeptidases; Enzyme Activation; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Guinea Pigs; Hippocampus; Methylazoxymethanol Acetate; Microcephaly; Models, Animal; Neocortex; Peptide Fragments; Phorbol Esters; Pregnancy; Protein Kinase C; Protein Synthesis Inhibitors; RNA, Messenger | 2000 |
Disruption of layers 3 and 4 during development results in altered thalamocortical projections in ferret somatosensory cortex.
Topics: Animals; Behavior, Animal; Bromodeoxyuridine; Cell Count; Cell Differentiation; Cell Movement; Electrodes, Implanted; Female; Ferrets; Fluorescent Dyes; Methylazoxymethanol Acetate; Mitosis; Morphogenesis; Neural Pathways; Physical Stimulation; Pregnancy; Prenatal Exposure Delayed Effects; Somatosensory Cortex; Teratogens; Thalamus | 2001 |
Developmentally induced microencephalopathy in guinea pigs--embryonic glial cell activation marks selective neuronal death.
Topics: Amyloid beta-Protein Precursor; Animals; Antimetabolites; Astrocytes; Bromodeoxyuridine; Cell Death; Female; Genes, Immediate-Early; Guinea Pigs; Methylazoxymethanol Acetate; Microglia; Neocortex; Neurons; Pregnancy; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun | 2001 |
Bromodeoxyuridine and methylazoxymethanol exposure during brain development affects behavior in rats: consideration for a role of nerve growth factor and brain derived neurotrophic factor.
Topics: Animals; Antimetabolites; Behavior, Animal; Brain; Brain Chemistry; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Choline O-Acetyltransferase; Female; Male; Maze Learning; Mental Disorders; Methylazoxymethanol Acetate; Nerve Growth Factor; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptor, Nerve Growth Factor; Teratogens | 2001 |
Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cerebral Cortex; Choristoma; Delayed Rectifier Potassium Channels; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Hippocampus; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Methylazoxymethanol Acetate; Patch-Clamp Techniques; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Pregnancy; Prenatal Exposure Delayed Effects; Pyramidal Cells; Rats; RNA, Messenger; Shab Potassium Channels; Shal Potassium Channels; Somatosensory Cortex; Tetraethylammonium | 2001 |
Histological and neurochemical effects of fetal treatment with methylazoxymethanol on rat neocortex in adulthood.
Topics: Acetylcholine; Age Factors; Animals; Azo Compounds; Brain; Cerebral Cortex; Choline O-Acetyltransferase; Dopamine beta-Hydroxylase; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Methylazoxymethanol Acetate; Neurons; Norepinephrine; Organ Size; Pregnancy; Rats; Receptors, Neurotransmitter; Tyrosine 3-Monooxygenase | 1979 |
Redirected perforant and commissural of connections of eutopic and ectopic neurons in the hippocampus of methylazoxymethanol-acetate treated rats.
Topics: Animals; Axons; Azo Compounds; Female; Hippocampus; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Neurons; Pregnancy; Rats | 1978 |
Ectopic neurones in the hippocampus of the postnatal rat exposed to methylazoxymethanol during foetal development.
Topics: Age Factors; Animals; Azo Compounds; Cell Movement; Female; Guanine; Hippocampus; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Neurons; Pregnancy; Rats | 1977 |
Developmental alteration of serotonin neurons in the raphe nucleus of rats with methylazoxymethanol-induced microcephaly.
Topics: Animals; Cerebral Cortex; Female; Immunohistochemistry; Methylazoxymethanol Acetate; Microcephaly; Nerve Degeneration; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Raphe Nuclei; Rats; Rats, Wistar; Serotonin | 1992 |
Cholinergic hyperinnervation in the cerebral cortex of microencephalic rats does not result in muscarinic receptor down-regulation or in alteration of receptor-stimulated phosphoinositide metabolism.
Topics: Abnormalities, Drug-Induced; Acetylcholinesterase; Animals; Atropine; Brain; Cerebral Cortex; Down-Regulation; Female; Isoflurophate; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Organ Size; Phosphatidylinositols; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1992 |
Excitatory amino acid receptors in brains of rats with methylazoxymethanol-induced microencephaly.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Female; Habituation, Psychophysiologic; Kinetics; Learning; Male; Membranes; Methylazoxymethanol Acetate; Microcephaly; Organ Size; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Space Perception | 1992 |
Effects of foetal treatment with methylazoxymethanol on noradrenergic synapses in rat cerebral cortex.
Topics: Alkylating Agents; Animals; Binding, Competitive; Cerebral Cortex; Dihydroalprenolol; Female; Fetus; Isoproterenol; Ligands; Methylazoxymethanol Acetate; Mitosis; Norepinephrine; Pregnancy; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Synapses | 1992 |
Persistent innervation of the rat neocortex by basal forebrain cholinergic neurons despite the massive reduction of cortical target neurons. II. Neurochemical analysis.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Brain; Cerebral Cortex; Choline O-Acetyltransferase; Disease Models, Animal; Female; Fetus; Gestational Age; Methylazoxymethanol Acetate; Neurons; Pregnancy; Prosencephalon; Rats; Rats, Inbred Strains; Somatostatin | 1992 |
Cellular expression of somatostatin in MAM-induced microencephaly in the rat.
Topics: Animals; Brain; Brain Diseases; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; Female; Hippocampus; In Situ Hybridization; Male; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Sprague-Dawley; RNA, Messenger; Somatostatin | 1992 |
Changes in secondary structure of DNA of rat embryos following treatment with diethylnitrosamine and methylazoxymethanol acetate in vivo.
Topics: Analysis of Variance; Animals; Caffeine; Chromatography, DEAE-Cellulose; Diethylnitrosamine; DNA; DNA Damage; Embryo, Mammalian; Female; Fetal Resorption; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Mutagens; Nucleic Acid Denaturation; Pregnancy; Rats; Rats, Wistar | 1992 |
The germinative zone produces the most cortical astrocytes after neuronal migration in the developing mammalian brain.
Topics: Animals; Astrocytes; Autoradiography; Cell Differentiation; Cell Movement; Cerebral Cortex; Female; Glial Fibrillary Acidic Protein; Immunohistochemistry; Methylazoxymethanol Acetate; Mice; Neurons; Pregnancy; Staining and Labeling; Thymidine | 1992 |
Postnatal behavioral development in methylazoxymethanol-induced microcephalic rats--a behavioral teratology study.
Topics: Abnormalities, Drug-Induced; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Female; Male; Memory; Methylazoxymethanol Acetate; Microcephaly; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 1992 |
Nerve cell rearrangement in neocortical layers of MAM treated foetal mice.
Topics: Animals; Cell Division; Cell Survival; Cerebral Cortex; Female; Fetus; Gestational Age; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Mice; Microscopy, Electron; Neurons; Pregnancy; Reference Values; Synapses | 1992 |
The effects of pre-natal exposure to methylazoxymethanol acetate on microglia.
Topics: Animals; Animals, Newborn; Cell Death; Embryonic and Fetal Development; Female; Fetus; Methylazoxymethanol Acetate; Neuroglia; Pregnancy; Prenatal Exposure Delayed Effects; Prosencephalon; Rats; Rats, Wistar | 1992 |
Persistent innervation of the rat neocortex by basal forebrain cholinergic neurons despite the massive reduction of cortical target neurons. I. Morphometric analysis.
Topics: Acetylcholine; Aging; Alzheimer Disease; Animals; Cerebral Cortex; Disease Models, Animal; Female; Fetus; Gestational Age; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Male; Methylazoxymethanol Acetate; Neurons; Pregnancy; Prosencephalon; Rats; Rats, Inbred Strains | 1992 |
Effects of fetal treatment with methylazoxymethanol acetate on radial maze performance in rats.
Topics: Animals; Cerebral Cortex; Choline O-Acetyltransferase; Female; Hippocampus; Learning; Methylazoxymethanol Acetate; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains | 1991 |
Effects of prenatal exposure to methylazoxymethanol (MAM) on brain weight, hypothalamic cell number, pituitary structure, and postnatal growth in the rat.
Topics: Animals; Animals, Newborn; Body Weight; Brain; Cell Count; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Hypothalamus; Immunohistochemistry; Male; Methylazoxymethanol Acetate; Mitosis; Organ Size; Pituitary Gland; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Somatostatin | 1991 |
Treatment with methylazoxymethanol at different gestational days: two-way shuttle box avoidance and residential maze activity in rat offspring.
Topics: Alkylating Agents; Analysis of Variance; Animals; Avoidance Learning; Brain; Exploratory Behavior; Female; Gestational Age; Methylazoxymethanol Acetate; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 1991 |
Microencephaly reduces the phosphorylation of the PKC substrate B-50/GAP43 in rat cortex and hippocampus.
Topics: Animals; Brain; Cerebral Cortex; Corpus Striatum; Female; GAP-43 Protein; Hippocampus; Membrane Glycoproteins; Methylazoxymethanol Acetate; Molecular Weight; Nerve Tissue Proteins; Nucleic Acid Hybridization; Oligonucleotide Probes; Phosphoproteins; Phosphorylation; Pregnancy; Protein Kinase C; Rats; Rats, Inbred Strains; Reference Values; Synaptosomes; Thalamus | 1991 |
Early neurobehavioral disorders in the micrencephalic offspring induced by prenatal treatment with N-methyl-N-nitrosourea or methylazoxymethanol in the rat.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Female; Locomotion; Male; Methylazoxymethanol Acetate; Methylnitrosourea; Microcephaly; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Rodent Diseases; Swimming | 1991 |
Treatment with methylazoxymethanol at different gestational days: physical, reflex development and spontaneous activity in the offspring.
Topics: Animals; Brain; Female; Gestational Age; Male; Methylazoxymethanol Acetate; Motor Activity; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; Rats; Rats, Inbred Strains; Reflex | 1991 |
Morphometrical and microdensitometrical studies on peptide- and tyrosine hydroxylase-like immunoreactivities in the forebrain of rats prenatally exposed to methylazoxymethanol acetate.
Topics: Animals; Antineoplastic Agents; Azo Compounds; Female; Frontal Lobe; Methylazoxymethanol Acetate; Neuropeptides; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Tyrosine 3-Monooxygenase | 1990 |
Increased uptake sites for serotonin and dopamine with decreased S2 serotonin receptors in microencephalic rat brain.
Topics: Abnormalities, Drug-Induced; Animals; Biological Transport; Brain; Cerebral Cortex; Corpus Striatum; Dopamine; Female; Kinetics; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reference Values; Serotonin; Teratogens | 1990 |
Morphometric analysis of the development of the cortical layers and extension of the forceps major of the corpus callosum in the mouse.
Topics: Animals; Cerebral Cortex; Corpus Callosum; Female; Methylazoxymethanol Acetate; Mice; Pregnancy | 1990 |
Methylazoxymethanol (MAM)-induced brain lesion and oral dyskinesia in rats.
Topics: Animals; Azo Compounds; Behavior, Animal; Brain Diseases; Corpus Striatum; Dyskinesia, Drug-Induced; Female; Globus Pallidus; Glutamate Decarboxylase; Haloperidol; Methylazoxymethanol Acetate; Pregnancy; Rats; Substantia Nigra | 1990 |
Behavioral deficits in rats with minimal cortical hypoplasia induced by methylazoxymethanol acetate.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Azo Compounds; Brain Chemistry; Cerebral Cortex; Disease Models, Animal; Female; Learning Disabilities; Methylazoxymethanol Acetate; Microcephaly; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains | 1990 |
Patterns of transiently expressed acetylcholinesterase activity in cerebral cortex and dorsal thalamus of developing rats with cytotoxin-induced microencephaly.
Topics: Acetylcholinesterase; Animals; Azo Compounds; Cerebral Cortex; Female; Gene Expression Regulation; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Thalamus | 1990 |
Methylazoxymethanol-induced microencephaly: persistent increase of cortical somatostatin-like immunoreactivity.
Topics: Animals; Azo Compounds; Brain; Dose-Response Relationship, Drug; Female; Gestational Age; Immunohistochemistry; Male; Methylazoxymethanol Acetate; Organ Size; Peptides; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Sex Factors | 1989 |
Vascularity and cytochrome oxidase distribution in the occipital cortex in MAM Ac-induced micrencephaly.
Topics: Animals; Azo Compounds; Cerebral Cortex; Electron Transport Complex IV; Female; Histocytochemistry; Methylazoxymethanol Acetate; Microcephaly; Occipital Lobe; Pregnancy; Rats; Rats, Inbred Strains | 1987 |
Depletion of cholinergic habenulo-interpeduncular neurons by selectively timed methylazoxymethanol acetate (MAM) treatment during pregnancy.
Topics: Acetylcholinesterase; Animals; Aromatic-L-Amino-Acid Decarboxylases; Azo Compounds; Brain; Choline O-Acetyltransferase; Female; Glutamate Decarboxylase; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Neurons; Pregnancy; Rats; Rats, Inbred Strains; Reference Values; Thalamus | 1988 |
Brain changes in rats induced by prenatal injection of methylazoxymethanol.
Topics: Alkylating Agents; Animals; Azo Compounds; Body Weight; Brain; DNA; Dopamine; Dose-Response Relationship, Drug; Female; Methylazoxymethanol Acetate; Norepinephrine; Organ Size; Pregnancy; Rats; Serotonin | 1988 |
The angiogenesis of the micrencephalic rat brains caused by methylazoxymethanol acetate. III. Internal angioarchitecture of cortex.
Topics: Animals; Azo Compounds; Cerebral Cortex; Cerebrovascular Circulation; Female; Methylazoxymethanol Acetate; Microcirculation; Neurotoxins; Pregnancy; Rats; Rats, Inbred Strains; Teratogens | 1987 |
Astroglial development in microencephalic rat brain after fetal methylazoxymethanol treatment.
Topics: Animals; Astrocytes; Azo Compounds; Brain; Cerebral Cortex; Female; Gestational Age; Glial Fibrillary Acidic Protein; Hippocampus; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains | 1986 |
Prenatal exposure to methylazoxymethanol (MAM) acetate: effects on ultrasonic vocalization and locomotor activity in rat offspring.
Topics: Animals; Azo Compounds; Female; Male; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Motor Activity; Pregnancy; Rats; Rats, Inbred Strains; Sex Characteristics; Vocalization, Animal | 1987 |
[Identification of microcephaly of the rat fetus by measuring the brain length in situ].
Topics: Animals; Anthropometry; Brain; Cerebellum; Female; Fetus; Methylazoxymethanol Acetate; Microcephaly; Organ Size; Pregnancy; Rats; Rats, Inbred Strains | 1986 |
Microencephalic rats as a model for cognitive disorders.
Topics: Animals; Azo Compounds; Cognition Disorders; Disease Models, Animal; Female; Gestational Age; Learning Disabilities; Methylazoxymethanol Acetate; Microcephaly; Motor Activity; Pregnancy; Rats; Reflex | 1986 |
[Pharmacological assessment of functional alterations in the brain of rats exposed prenatally to methylazoxymethanol].
Topics: Animals; Azo Compounds; Behavior, Animal; Birth Weight; Brain; Drug Interactions; Female; Fetus; Growth; Male; Methylazoxymethanol Acetate; Organ Size; Pregnancy; Rats; Rats, Inbred Strains; Sex Factors | 1987 |
Selective attention and place navigation in rats treated prenatally with methylazoxymethanol.
Topics: Abnormalities, Drug-Induced; Animals; Attention; Azo Compounds; Brain; Cognition Disorders; Female; Inhibition, Psychological; Learning Disabilities; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Reaction Time; Space Perception | 1986 |
Direct and indirect effects on the lateral geniculate nucleus neurons of prenatal exposure to methylazoxymethanol acetate.
Topics: Age Factors; Animals; Azo Compounds; Cell Count; Cell Nucleus; Female; Geniculate Bodies; Methylazoxymethanol Acetate; Nerve Degeneration; Neurons; Occipital Lobe; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains | 1987 |
Altered morphology of dorsal lateral geniculate nucleus neurons in methylazoxymethanol acetate induced micrencephaly.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Female; Geniculate Bodies; Methylazoxymethanol Acetate; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 1987 |
[A neurochemical study of rat brain maldevelopment induced by MAM treatment at different stages of gestation].
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Azo Compounds; Brain; Brain Chemistry; Conditioning, Operant; Discrimination Learning; Female; Gestational Age; Locomotion; Methylazoxymethanol Acetate; Microcephaly; Organ Size; Phosphopyruvate Hydratase; Pregnancy; Rats; Rats, Inbred Strains; S100 Proteins | 1986 |
Impaired selective attention in methylazoxymethanol-induced microencephalic rats.
Topics: Animals; Attention; Avoidance Learning; Azo Compounds; Brain; Catecholamines; Discrimination Learning; Female; Methylazoxymethanol Acetate; Microcephaly; Motor Activity; Pregnancy; Rats; Rats, Inbred Strains; Taste | 1986 |
Selective ablation of neurons by methylazoxymethanol during pre- and postnatal brain development.
Topics: Aging; Animals; Azo Compounds; Brain; Embryonic and Fetal Development; Female; Methylazoxymethanol Acetate; Neurons; Pregnancy; Rats; Rats, Inbred Strains | 1986 |
Effect of acetyl-L-carnitine treatment on some behavioural, histochemical and histological parameters of methylazoxymethanol microencephalic rats.
Topics: Acetylcarnitine; Acetylcholinesterase; Animals; Behavior, Animal; Brain; Carnitine; Female; Histocytochemistry; Male; Methylazoxymethanol Acetate; Microcephaly; NADH Tetrazolium Reductase; Nissl Bodies; Pregnancy; Rats; Rats, Inbred Strains | 1986 |
An abnormal retinal projection to the lateral posterior nucleus in micrencephalic rats.
Topics: Abnormalities, Drug-Induced; Animals; Female; Geniculate Bodies; Methylazoxymethanol Acetate; Microcephaly; Pregnancy; Rats; Rats, Inbred Strains; Retina; Superior Colliculi; Thalamic Nuclei; Visual Pathways | 1986 |
The angiogenesis of micrencephalic rat brains caused by methylazoxymethanol acetate. I. Superficial venous system. A quantitative analysis.
Topics: Animals; Azo Compounds; Blood Vessels; Brain; Cerebral Cortex; Cerebrovascular Circulation; Cranial Sinuses; Female; Growth; Methylazoxymethanol Acetate; Microcephaly; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Skull; Veins | 1985 |
Fetal methylazoxymethanol acetate-induced lesions cause reductions in dopamine receptor-mediated catalepsy and stereotypy.
Topics: Animals; Azo Compounds; Brain; Brain Chemistry; Catalepsy; Choline O-Acetyltransferase; Depression, Chemical; Female; Fetus; Glutamate Decarboxylase; Haloperidol; Kinetics; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior | 1985 |
[Proceedings: Changes in cerebral amine content in experimental microcephaly in rats induced by methylazoxymethanol administration and their behavior changes].
Topics: Animals; Azo Compounds; Biogenic Amines; Brain Chemistry; Discrimination Learning; DNA; Female; Methylazoxymethanol Acetate; Microcephaly; Pregnancy; Rats | 1974 |