methylazoxymethanol acetate has been researched along with Dementia Praecox in 100 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (2.00) | 18.2507 |
| 2000's | 12 (12.00) | 29.6817 |
| 2010's | 63 (63.00) | 24.3611 |
| 2020's | 23 (23.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duan, J; Guo, H; Liu, J; Peng, Z; Sun, D; Tan, Q; Tang, J; Tang, Y; Wang, F; Wang, H; Wang, J; Wei, Y; Womer, FY; Xu, F; Xu, K; Yang, J; Zhang, X; Zhang, Y; Zhu, Q; Zhu, Y | 1 |
| Grace, AA; Sved, AF; Weeks, JJ | 1 |
| Cash, D; Davies, C; Gomes, FV; Grace, AA; Kiemes, A; Modinos, G; Simmons, C; Singh, N; Stone, JM; Turkheimer, F; Uliana, DL; Vernon, AC | 1 |
| An, Y; Lan, Y; Li, GY; Li, ML; Peng, Y | 1 |
| D'Addario, C; Di Bartolomeo, M; Di Martino, S; Di Marzo, V; Drago, F; Iannotti, FA; Micale, V; Piscitelli, F; Ruda-Kucerova, J; Stark, T; Wotjak, CT | 1 |
| Grace, AA; Zhu, X | 2 |
| Boley, AM; Eassa, NE; Elam, HB; Lodge, DJ; McCoy, AM; Perez, SM | 1 |
| Berta, B; Dusa, D; Gálosi, R; Kállai, V; Karádi, Z; Kertes, E; Kovács, A; László, K; Lénárd, L; Ollmann, T; Péczely, L; Tóth, A; Zagoracz, O | 1 |
| Chen, GY; Chen, L; Cheng, Y; Du, Y; Li, XS | 1 |
| Kopciuch, D; Kus, K; Murawiecka, P; Nowakowska, E; Paczkowska, A; Ratajczak, P; Słodzińska, I; Zaprutko, T | 1 |
| Gzielo, K; Holuj, M; Litwa, E; Nikiforuk, A; Popik, P; Potasiewicz, A; Socha, L | 1 |
| Babinska, Z; Bucolo, C; D'Addario, C; Di Bartolomeo, M; Di Marco, R; Di Marzo, V; Drago, F; Drazanova, E; Fedotova, J; Giurdanella, G; Iannotti, FA; Kratka, L; Mechoulam, R; Micale, V; Pekarik, V; Piscitelli, F; Platania, CBM; Ruda-Kucerova, J; Salomone, S; Starcuk, Z; Stark, T; Sulcova, A; Wotjak, CT | 1 |
| Boley, AM; Carless, MA; Donegan, JJ; Glenn, JP; Lodge, DJ | 1 |
| Babinska, Z; Hammer, T; Horska, K; Karpisek, M; Kotolova, H; Micale, V; Prochazka, J; Ruda-Kucerova, J; Stark, T | 1 |
| Bienertova-Vasku, J; Horska, K; Hruska, P; Kucera, J; Kuruczova, D; Micale, V; Ruda-Kucerova, J | 1 |
| Hu, LB; Huang, J; Ling, Y; Shen, HW; Xu, L; Zhang, XQ | 1 |
| Bilecki, W; Chmelova, M; Gawlińska, K; Latusz, J; Maćkowiak, M | 1 |
| Grace, AA; Sonnenschein, SF | 2 |
| Cabungcal, JH; Cuenod, M; Do, KQ; Grace, AA; Uliana, DL; Zhu, X | 1 |
| Bilecki, W; Chmelova, M; Maćkowiak, M; Majcher-Maślanka, I; Wawrzczak-Bargieła, A | 1 |
| Babinska, Z; Micale, V; Ruda-Kucerova, J; Stark, T | 1 |
| Gálosi, R; Kállai, J; Kállai, V; Karádi, Z; László, K; Lénárd, L; Ollmann, T; Péczely, L; Petykó, Z; Szabó, I; Tóth, A | 1 |
| Elefant, F; Gao, WJ; Gulchina, Y; Snyder, MA; Xu, SJ | 1 |
| Alsiö, J; Bussey, TJ; Dourado, T; Gamallo-Lana, B; Lei, M; Mar, AC; Nilsson, SRO; Robbins, TW; Saksida, LM | 1 |
| Gomes, FV; Grace, AA; Zhu, X | 1 |
| Gill, KM; Grace, AA; Miller, SA | 1 |
| Bator, E; Latusz, J; Maćkowiak, M; Wędzony, K | 1 |
| Bator, E; Głowacka, U; Latusz, J; Maćkowiak, M; Mudlaff, K; Radaszkiewicz, A | 1 |
| Grace, AA; Neves, GA | 1 |
| Edelson, JR; Gomes, FV; Grace, AA; Volk, DW | 1 |
| Gao, WJ; Han, G; Snyder, MA; Wang, MJ; Xing, B | 1 |
| Fenton, AA; Levy, ERJ; O'Reilly, KC; Patino, AV; Perica, MI | 1 |
| Huang, H; Huo, C; Liu, X; Ye, H; Zhao, J; Zhao, T | 1 |
| Aivaliotis, M; Chalkiadaki, K; Chatzaki, E; Kyriazidis, E; Sidiropoulou, K; Stavroulaki, V; Velli, A; Vouvoutsis, V | 1 |
| Holuj, M; Nikiforuk, A; Piotrowska, D; Popik, P; Potasiewicz, A; Wojcik, M; Zajda, K | 1 |
| Babinska, Z; Bari, M; D'Addario, C; Di Bartolomeo, M; Di Marco, R; Di Marzo, V; Drago, F; Drazanova, E; Giurdanella, G; Iannotti, FA; Maccarrone, M; Mechoulam, R; Micale, V; Pekarik, V; Piscitelli, F; Ruda-Kucerova, J; Salomone, S; Starcuk, Z; Stark, T; Sulcova, A; Wotjak, CT | 1 |
| Donegan, JJ; Lodge, DJ; Perez, SM | 1 |
| Lin, JR; Nakagawasai, O; Nemoto, W; Odaira, T; Onogi, H; Sakuma, W; Srivastava, LK; Takahashi, K; Tan-No, K | 1 |
| Donny, EC; Grace, AA; Rupprecht, LE; Sved, AF; Weeks, JJ | 1 |
| Drago, F; Drazanova, E; Kratka, L; Kuchar, M; Maryska, M; Micale, V; Ruda-Kucerova, J; Starcuk, Z; Stark, T | 1 |
| Esmaeili, B; Grace, AA | 1 |
| Lodge, DJ | 1 |
| Guo, N; Kimura, R; Osumi, N; Suto, F; Yanagawa, Y; Yoshizaki, K | 1 |
| Du, Y; Grace, AA | 3 |
| Bellaire, M; Ewing, SG; Grace, AA; Zimmerman, EC | 1 |
| Lodge, DJ; Perez, SM | 2 |
| Cook, JM; Gill, KM; Grace, AA; Poe, MM | 1 |
| Chen, L; Lodge, DJ; Perez, SM | 2 |
| Gill, KM; Grace, AA | 1 |
| Carreno, FR; Frazer, A; Lodge, DJ; Perez, SM | 1 |
| Gomes, FV; Grace, AA; Guimarães, FS | 1 |
| Bannerman, DM; Gastambide, F; Janhunen, SK; Karjalainen, M; Palmer, C; Svard, H; Taylor, AM; Tricklebank, M | 1 |
| Goda, SA; Hunt, MJ; Kasicki, S; Olszewski, M; Piasecka, J; Rejniak, K; Whittington, MA | 1 |
| Gálosi, R; Kállai, J; Kállai, V; Karádi, Z; Lénárd, L; Petykó, Z; Szabó, I; Tóth, A | 1 |
| Howe, WM; Kozak, R; Oomen, C; Tierney, PL; Young, DA | 1 |
| Kohlhaas, KL; Robb, HM; Roderwald, VA; Rueter, LE | 1 |
| Aguilar, DD; Carless, MA; Giuffrida, A; Lodge, DJ; Neary, JL; Perez, SM | 1 |
| Bator, E; Latusz, J; Maćkowiak, M; Radaszkiewicz, A; Wędzony, K | 1 |
| Giermaziak, W; Kus, K; Murawiecka, P; Nowakowska, E; Ratajczak, P; Słodzińska, I | 1 |
| Grace, AA | 1 |
| Amchova, P; Babinska, Z; Drago, F; Micale, V; Ruda-Kucerova, J; Stark, T; Sulcova, A | 1 |
| Gomes, FV; Grace, AA; Rincón-Cortés, M | 1 |
| Coman, D; de Graaf, RA; Groman, SM; Herman, P; Hyder, F; Jiang, L; Kaneko, G; Rao, J; Rich, K; Sanganahalli, BG; Taylor, JR; Wang, H | 1 |
| Fenton, AA; O'Reilly, KC; Perica, MI | 1 |
| Babinska, Z; Carlo Altamura, A; Cremaschi, L; D'Addario, C; Dell'Osso, B; Di Bartolomeo, M; Drago, F; Maccarrone, M; Micale, V; Palazzo, M; Pucci, M; Stark, T; Sulcova, A | 1 |
| Ferguson, BR; Gao, WJ; Gulchina, Y; Hu, XQ; Li, F; Li, ML; Li, YC; Monaco, SA; Xing, B | 1 |
| Bártová, E; Dekker, FJ; Dražanová, E; Kašpárek, T; Komůrková, D; Kozubek, S; Krejčí, J; Legartová, S; Mechoulam, R; Micale, V; Rudá-Kučerová, J; Seiser, C; Štark, T; Šulcová, A; Szymanski, W; Večeřa, J; Weitzer, G | 1 |
| Grace, AA; Lodge, DJ | 5 |
| Behrens, MM; Grace, AA; Lodge, DJ | 1 |
| Bellon, A; Beuvon, F; Daumas-Duport, C; Frieling, H; Jay, TM; Kebir, O; Krebs, MO; Le Pen, G; Matricon, J | 1 |
| Jay, TM; Krebs, MO; Le Pen, G | 1 |
| Cotel, MC; Edgar, DM; Jones, MW; McCarthy, AP; O'Neill, MJ; Phillips, KG; Tricklebank, M; Wafford, KA | 1 |
| Aras, S; Cook, JM; Gill, KM; Grace, AA; Lodge, DJ | 1 |
| Collingridge, GL; Cotel, MC; O'Neill, MJ; Sanderson, TM; Sher, E; Tricklebank, MD | 1 |
| Cifelli, P; Gill, KM; Grace, AA; Valenti, O | 1 |
| Bahn, S; Cheng, TM; Collingridge, GL; Fitzjohn, SM; Guest, PC; Harris, LW; Holmes, E; Hradetzky, E; Lakics, V; Malik, N; O'Neill, MJ; Rahmoune, H; Sanderson, TM; Schoeffmann, S; Sher, E; Sherwood, JL; Tricklebank, MD; Tsang, TM | 1 |
| Belujon, P; Grace, AA; Patton, MH | 2 |
| Asher, A; Lodge, DJ; Perez, SM; Shah, A | 1 |
| Lodge, DJ; Shah, A | 1 |
| Feldon, J; Jongen-Rêlo, AL; Leng, A; Lüber, M; Pothuizen, HH; Weber, L | 1 |
| Didriksen, M; Flagstad, P; Glenthøj, BY | 1 |
| Didriksen, M; Flagstad, P; Leist, M; Michael-Titus, AT; Penschuck, S | 1 |
| Geyer, MA; Ghajarnia, M; Grace, AA; Jentsch, JD; Moore, H | 1 |
| Featherstone, RE; Fletcher, PJ; Kapur, S; Nobrega, JN; Rizos, Z | 1 |
| Chessel, A; Garcia, R; Krebs, MO; Le Pen, G; Léna, I | 1 |
| Falsig, J; Geist, MA; Leist, M; Podhorna, J; Volbracht, C | 1 |
| Koch, T; Korf, J; Talamini, LM; Ter Horst, GJ | 1 |
| Aloe, L; Angelucci, F; Fiore, M; Koch, T; Korf, J; Talamini, L | 1 |
| Ellenbroek, B; Koch, T; Korf, J; Talamini, LM | 1 |
3 review(s) available for methylazoxymethanol acetate and Dementia Praecox
| Article | Year |
|---|---|
Insights on current and novel antipsychotic mechanisms from the MAM model of schizophrenia.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Hippocampus; Male; Methylazoxymethanol Acetate; Mice; Rats; Schizophrenia; Ventral Tegmental Area | 2020 |
Adolescence as a period of vulnerability and intervention in schizophrenia: Insights from the MAM model.
Topics: Adolescent; Animals; Brain; Disease Models, Animal; Dopamine; Humans; Methylazoxymethanol Acetate; Rats; Schizophrenia | 2016 |
Hippocampal dysfunction and disruption of dopamine system regulation in an animal model of schizophrenia.
Topics: Animals; Disease Models, Animal; Dopamine; Female; Gestational Age; Hippocampus; Humans; Methylazoxymethanol Acetate; Neural Pathways; Nucleic Acid Synthesis Inhibitors; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Schizophrenia; Signal Transduction | 2008 |
97 other study(ies) available for methylazoxymethanol acetate and Dementia Praecox
| Article | Year |
|---|---|
Frontal-posterior functional imbalance and aberrant function developmental patterns in schizophrenia.
Topics: Animals; Brain; Brain Mapping; Magnetic Resonance Imaging; Methylazoxymethanol Acetate; Proteomics; Rats; Schizophrenia | 2021 |
Nicotine Administration Normalizes Behavioral and Neurophysiological Perturbations in the MAM Rodent Model of Schizophrenia.
Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Hippocampus; Male; Methylazoxymethanol Acetate; Nicotine; Prepulse Inhibition; Rats; Rats, Sprague-Dawley; Schizophrenia; Self Medication; Ventral Tegmental Area | 2021 |
GABA
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Methylazoxymethanol Acetate; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2022 |
LY395756 promotes NR2B expression via activation of AKT/CREB signaling in the juvenile methylazoxymethanol mice model of schizophrenia.
Topics: Amino Acids, Dicarboxylic; Animals; Bridged Bicyclo Compounds; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Methylazoxymethanol Acetate; Mice; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Transduction | 2022 |
Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia.
Topics: Animals; Disease Models, Animal; Female; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Schizophrenia | 2022 |
Use of prepubertal environment enrichment to prevent dopamine dysregulation in a neurodevelopmental rat model of schizophrenia risk.
Topics: Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Female; Male; Methylazoxymethanol Acetate; Pregnancy; Rats; Schizophrenia | 2022 |
Congenital blindness does not protect against a schizophrenia-related phenotype in rodents.
Topics: Animals; Blindness; Corticosterone; Disease Models, Animal; Female; Male; Methylazoxymethanol Acetate; Phenotype; Rats; Rats, Sprague-Dawley; Rodentia; Schizophrenia | 2023 |
Cognitive performance of the MAM-E17 schizophrenia model rats in different age-periods.
Topics: Age Factors; Animals; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Female; Hippocampus; Male; Maze Learning; Memory, Short-Term; Methylazoxymethanol Acetate; Neurotoxins; Rats; Rats, Wistar; Reward; Schizophrenia; Sexual Maturation | 2020 |
A Network Analysis of Epigenetic and Transcriptional Regulation in a Neurodevelopmental Rat Model of Schizophrenia With Implications for Translational Research.
Topics: Adult; Animals; Disease Models, Animal; Epigenesis, Genetic; Female; Hippocampus; Humans; Male; Methylazoxymethanol Acetate; MicroRNAs; Neurodevelopmental Disorders; Neurotoxins; Prefrontal Cortex; Pregnancy; Proto-Oncogene Mas; Rats; Rats, Sprague-Dawley; RNA, Messenger; Schizophrenia; Sequence Analysis, RNA; Transcription, Genetic; Translational Research, Biomedical | 2020 |
Memory deterioration based on the tobacco smoke exposure and methylazoxymethanol acetate administration vs. aripiprazole, olanzapine and enrichment environment conditions.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Behavior, Animal; Cognition; Disease Models, Animal; Female; Male; Methylazoxymethanol Acetate; Morris Water Maze Test; Neurotoxins; Olanzapine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Schizophrenia; Spatial Memory; Tobacco Smoke Pollution; Treatment Outcome | 2020 |
Social dysfunction in the neurodevelopmental model of schizophrenia in male and female rats: Behavioural and biochemical studies.
Topics: Animals; Disease Models, Animal; Female; Male; Methylazoxymethanol Acetate; Neurotoxins; Oxytocin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Oxytocin; Schizophrenia; Schizophrenic Psychology; Social Behavior; Vocalization, Animal | 2020 |
Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment.
Topics: Animals; Antipsychotic Agents; Brain; Cannabidiol; Cerebrovascular Circulation; Disease Models, Animal; Female; Gene Expression Regulation; Haloperidol; Magnetic Resonance Imaging; Male; Methylazoxymethanol Acetate; Models, Molecular; Molecular Dynamics Simulation; Pregnancy; Prenatal Exposure Delayed Effects; Puberty; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Schizophrenia | 2020 |
Developmental alterations in the transcriptome of three distinct rodent models of schizophrenia.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Female; Gene Expression Profiling; Growth and Development; Hippocampus; Malnutrition; Methylazoxymethanol Acetate; Poly I-C; Pregnancy; Rats; Rats, Sprague-Dawley; Schizophrenia | 2020 |
Metabolic profile of methylazoxymethanol model of schizophrenia in rats and effects of three antipsychotics in long-acting formulation.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Female; Haloperidol; Lipid Metabolism; Male; Metabolome; Methylazoxymethanol Acetate; Olanzapine; Rats, Sprague-Dawley; Risperidone; Schizophrenia | 2020 |
Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: Untargeted proteomics approach in adipose tissue.
Topics: Adipose Tissue; Animals; Antipsychotic Agents; Disease Models, Animal; Female; Haloperidol; Intra-Abdominal Fat; Methylazoxymethanol Acetate; Olanzapine; Pregnancy; Prenatal Exposure Delayed Effects; Proteomics; Rats; Rats, Sprague-Dawley; Risperidone; Schizophrenia; Signal Transduction; TOR Serine-Threonine Kinases | 2021 |
Prepubertal Environmental Enrichment Prevents Dopamine Dysregulation and Hippocampal Hyperactivity in MAM Schizophrenia Model Rats.
Topics: Animals; Disease Models, Animal; Dopamine; Hippocampus; Methylazoxymethanol Acetate; Rats; Rats, Sprague-Dawley; Schizophrenia | 2021 |
Diminished excitatory synaptic transmission correlates with impaired spatial working memory in neurodevelopmental rodent models of schizophrenia.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Excitatory Postsynaptic Potentials; Female; Male; Memory, Short-Term; Methylazoxymethanol Acetate; Mice; Mice, Inbred C57BL; Neurodevelopmental Disorders; Prefrontal Cortex; Pregnancy; Pyramidal Cells; Schizophrenia; Schizophrenic Psychology; Social Isolation; Spatial Memory; Synaptic Transmission | 2021 |
Prenatal MAM treatment altered fear conditioning following social isolation: Relevance to schizophrenia.
Topics: Age Factors; Animals; Behavior, Animal; Conditioning, Classical; Fear; Female; Male; Methylazoxymethanol Acetate; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Proteome; Rats, Wistar; Schizophrenia; Social Isolation; Teratogens | 2021 |
Peripubertal mGluR2/3 Agonist Treatment Prevents Hippocampal Dysfunction and Dopamine System Hyperactivity in Adulthood in MAM Model of Schizophrenia.
Topics: Age Factors; Amino Acids; Animals; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Male; Methylazoxymethanol Acetate; Neurotoxins; Rats; Receptors, Metabotropic Glutamate; Schizophrenia; Ventral Tegmental Area | 2021 |
Thalamic reticular nucleus impairments and abnormal prefrontal control of dopamine system in a developmental model of schizophrenia: prevention by N-acetylcysteine.
Topics: Acetylcysteine; Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Methylazoxymethanol Acetate; Rats; Schizophrenia; Thalamic Nuclei | 2021 |
Inhibition of BET Proteins during Adolescence Affects Prefrontal Cortical Development: Relevance to Schizophrenia.
Topics: Adolescent; Adolescent Development; Animals; Azepines; Disease Models, Animal; Female; Gene Expression Regulation, Developmental; Humans; Long-Term Potentiation; Male; Methylazoxymethanol Acetate; Prefrontal Cortex; Proteomics; Rats; Recognition, Psychology; Schizophrenia; Sex Characteristics; Triazoles | 2021 |
Suppression of Methamphetamine Self-Administration by Ketamine Pre-treatment Is Absent in the Methylazoxymethanol (MAM) Rat Model of Schizophrenia.
Topics: Analysis of Variance; Animals; Central Nervous System Stimulants; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Ketamine; Locomotion; Methamphetamine; Methylazoxymethanol Acetate; Rats; Rats, Sprague-Dawley; Schizophrenia; Self Administration | 2017 |
The MAM-E17 schizophrenia rat model: Comprehensive behavioral analysis of pre-pubertal, pubertal and adult rats.
Topics: Aging; Animals; Anxiety; Disease Models, Animal; Exploratory Behavior; Female; Hippocampus; Male; Methylazoxymethanol Acetate; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Prepulse Inhibition; Rats, Wistar; Rotarod Performance Test; Schizophrenia; Schizophrenic Psychology | 2017 |
Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cognition Disorders; Disease Models, Animal; Epigenesis, Genetic; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Gene Expression Regulation, Developmental; In Vitro Techniques; Male; Methylazoxymethanol Acetate; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Prefrontal Cortex; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2017 |
MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs.
Topics: Animals; Attention; Cognition; Disease Models, Animal; Executive Function; Male; Methylazoxymethanol Acetate; Neurotoxins; Nootropic Agents; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Schizophrenia; Treatment Outcome | 2017 |
The methylazoxymethanol acetate rat model: molecular and epigenetic effect in the developing prefrontal cortex: An Editorial Highlight for 'Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM
Topics: Animals; Disease Models, Animal; Epigenesis, Genetic; Female; Methylazoxymethanol Acetate; Neurotoxins; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Schizophrenia | 2017 |
Impaired contextual fear-conditioning in MAM rodent model of schizophrenia.
Topics: Action Potentials; Amphetamine; Animals; Central Nervous System Stimulants; Conditioning, Classical; Disease Models, Animal; Dopaminergic Neurons; Fear; Female; Learning Disabilities; Locomotion; Male; Methylazoxymethanol Acetate; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Schizophrenia; Time Factors; Ventral Tegmental Area | 2018 |
Adolescent environmental enrichment prevents the emergence of schizophrenia-like abnormalities in a neurodevelopmental model of schizophrenia.
Topics: Animals; Disease Models, Animal; Environment; Histones; Housing, Animal; Male; Methylazoxymethanol Acetate; Prefrontal Cortex; Random Allocation; Rats, Wistar; Schizophrenia; Schizophrenic Psychology; Sexual Maturation; Site-Specific DNA-Methyltransferase (Adenine-Specific) | 2018 |
Adolescent Social Isolation Affects Schizophrenia-Like Behavior in the MAM-E17 Model of Schizophrenia.
Topics: Age Factors; Animals; Carcinogens; Disease Models, Animal; Embryo, Mammalian; Female; Gene Expression Regulation, Developmental; Glutamate Decarboxylase; Interpersonal Relations; Locomotion; Methylazoxymethanol Acetate; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Sensory Gating; Social Isolation; Statistics, Nonparametric | 2018 |
α7 Nicotinic receptor-modulating agents reverse the hyperdopaminergic tone in the MAM model of schizophrenia.
Topics: Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Basolateral Nuclear Complex; Disease Models, Animal; Dopaminergic Neurons; Hippocampus; Male; Methylazoxymethanol Acetate; Random Allocation; Rats, Sprague-Dawley; Schizophrenia; Ventral Tegmental Area | 2018 |
Altered brain cannabinoid 1 receptor mRNA expression across postnatal development in the MAM model of schizophrenia.
Topics: Animals; Brain; Disease Models, Animal; Gene Expression Regulation, Developmental; In Situ Hybridization; Male; Methylazoxymethanol Acetate; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; RNA, Messenger; Schizophrenia | 2018 |
Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β.
Topics: Amino Acids; Animals; Antipsychotic Agents; Bridged Bicyclo Compounds, Heterocyclic; Dendritic Spines; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Glycogen Synthase Kinase 3 beta; Learning Disabilities; Methylazoxymethanol Acetate; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Schizophrenia; Tissue Culture Techniques | 2018 |
Sub-circuit alterations in dorsal hippocampus structure and function after global neurodevelopmental insult.
Topics: Animals; Disease Models, Animal; Epilepsy; Female; Hippocampus; Male; Membrane Potentials; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Long-Evans; Schizophrenia; Synapses | 2018 |
Abnormalities in behaviour, histology and prefrontal cortical gene expression profiles relevant to schizophrenia in embryonic day 17 MAM-Exposed C57BL/6 mice.
Topics: Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hypertrophy; Lateral Ventricles; Male; Methylazoxymethanol Acetate; Mice; Mice, Inbred C57BL; Motor Activity; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Prepulse Inhibition; Schizophrenia; Schizophrenic Psychology; Sex Characteristics; Social Behavior; Transcriptome | 2018 |
Development of the MAM model of schizophrenia in mice: Sex similarities and differences of hippocampal and prefrontal cortical function.
Topics: Animals; Auditory Perception; Disease Models, Animal; Fear; Female; Hippocampus; Long-Term Potentiation; Male; Memory; Methylazoxymethanol Acetate; Mice; Mice, Inbred C57BL; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Prepulse Inhibition; Proteome; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Sex Characteristics | 2019 |
Evaluation of ultrasonic vocalizations in a neurodevelopmental model of schizophrenia during the early life stages of rats.
Topics: Animals; Disease Models, Animal; Female; Male; Methylazoxymethanol Acetate; Pregnancy; Rats; Schizophrenia; Social Behavior; Ultrasonics; Vocalization, Animal | 2019 |
Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia.
Topics: Amides; Animals; Arachidonic Acids; Cannabidiol; Disease Models, Animal; Endocannabinoids; Ethanolamines; Female; Glycerides; Hippocampus; Interpersonal Relations; Male; Methylazoxymethanol Acetate; Motor Activity; Oleic Acids; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Puberty; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Recognition, Psychology; RNA, Messenger; Schizophrenia | 2019 |
Effect of estrous cycle on schizophrenia-like behaviors in MAM exposed rats.
Topics: Amphetamine; Animals; Behavior, Animal; Disease Models, Animal; Estrous Cycle; Female; Hippocampus; Methylazoxymethanol Acetate; Parvalbumins; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Schizophrenia; Sensory Gating | 2019 |
Prenatal treatment with methylazoxymethanol acetate as a neurodevelopmental disruption model of schizophrenia in mice.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Behavior, Animal; Clozapine; Disease Models, Animal; Female; Haloperidol; Hippocampus; Methylazoxymethanol Acetate; Mice; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Prepulse Inhibition; Risperidone; Schizophrenia | 2019 |
Nicotine Self-administration Is Not Increased in the Methylazoxymethanol Acetate Rodent Model of Schizophrenia.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Methylazoxymethanol Acetate; Nicotine; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Schizophrenia; Self Administration; Sucrose | 2020 |
Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats.
Topics: Animals; Behavior Observation Techniques; Cerebrovascular Circulation; Circle of Willis; Disease Models, Animal; Dronabinol; Female; Hippocampus; Humans; Magnetic Resonance Angiography; Male; Methylazoxymethanol Acetate; Neurogenesis; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Schizophrenia; Sensorimotor Cortex | 2019 |
Afferent drive of medial prefrontal cortex by hippocampus and amygdala is altered in MAM-treated rats: evidence for interneuron dysfunction.
Topics: Action Potentials; Amygdala; Animals; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; Interneurons; Male; Methylazoxymethanol Acetate; Neural Inhibition; Neural Pathways; Neurotoxins; Phencyclidine; Prefrontal Cortex; Rats; Schizophrenia | 2013 |
The MAM rodent model of schizophrenia.
Topics: Animals; Brain; Clinical Protocols; Disease Models, Animal; Female; Fetal Development; Male; Methylazoxymethanol Acetate; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Schizophrenia | 2013 |
A sensitive period for GABAergic interneurons in the dentate gyrus in modulating sensorimotor gating.
Topics: Age Factors; Animals; Behavior, Animal; Critical Period, Psychological; Dendrites; Dentate Gyrus; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin-Like Kinases; Drug Interactions; Environment; GABA Agonists; GABAergic Neurons; Inhibition, Psychological; Interneurons; Intracellular Signaling Peptides and Proteins; Male; Methylazoxymethanol Acetate; Mice; Mice, Inbred C57BL; Microinjections; Microtubule-Associated Proteins; Muscimol; Neurogenesis; Neuropeptides; Prefrontal Cortex; Protein Serine-Threonine Kinases; Schizophrenia; Sensory Gating | 2013 |
Peripubertal diazepam administration prevents the emergence of dopamine system hyperresponsivity in the MAM developmental disruption model of schizophrenia.
Topics: Amphetamine; Animals; Anxiety; Central Nervous System Sensitization; Diazepam; Dopaminergic Neurons; Female; Male; Maze Learning; Methylazoxymethanol Acetate; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Schizophrenia; Ventral Tegmental Area | 2013 |
Abnormal stress responsivity in a rodent developmental disruption model of schizophrenia.
Topics: Age Factors; Animals; Corticosterone; Female; Immobility Response, Tonic; Male; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Schizophrenia; Stress, Psychological; Vocalization, Animal | 2013 |
Hippocampal interneuron transplants reverse aberrant dopamine system function and behavior in a rodent model of schizophrenia.
Topics: Action Potentials; Amphetamine; Animals; Disease Models, Animal; Dopaminergic Neurons; Female; Hippocampus; Interneurons; Male; Median Eminence; Methylazoxymethanol Acetate; Motor Activity; Rats; Schizophrenia | 2013 |
Prior antipsychotic drug treatment prevents response to novel antipsychotic agent in the methylazoxymethanol acetate model of schizophrenia.
Topics: Allosteric Regulation; Amphetamine; Animals; Antipsychotic Agents; Behavior, Animal; Diazepam; Disease Models, Animal; Dopamine; Dopamine Agents; Dopaminergic Neurons; Drug Interactions; Female; GABA Agonists; Haloperidol; Hippocampus; Imidazoles; Locomotion; Male; Methylazoxymethanol Acetate; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Schizophrenia; Sodium Chloride; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2014 |
An augmented dopamine system function is present prior to puberty in the methylazoxymethanol acetate rodent model of schizophrenia.
Topics: Action Potentials; Amphetamine; Animals; Disease Models, Animal; Dopamine; Dopamine Agents; Dopaminergic Neurons; Dose-Response Relationship, Drug; Hippocampus; Methylazoxymethanol Acetate; Motor Activity; Neural Pathways; Parvalbumins; Pedunculopontine Tegmental Nucleus; Rats, Sprague-Dawley; Schizophrenia; Sexual Maturation; Ventral Tegmental Area | 2014 |
Corresponding decrease in neuronal markers signals progressive parvalbumin neuron loss in MAM schizophrenia model.
Topics: Age Factors; Analysis of Variance; Animals; Cell Death; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Methylazoxymethanol Acetate; Neurons; Neurotoxins; Parvalbumins; Rats; Receptors, Neurokinin-1; Schizophrenia | 2014 |
Alterations in dopamine system function across the estrous cycle of the MAM rodent model of schizophrenia.
Topics: Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Estrous Cycle; Female; Humans; Male; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Sprague-Dawley; Schizophrenia; Signal Transduction; Vaginal Smears | 2014 |
Vagal nerve stimulation reverses aberrant dopamine system function in the methylazoxymethanol acetate rodent model of schizophrenia.
Topics: Action Potentials; Animals; Disease Models, Animal; Dopaminergic Neurons; Hippocampus; Humans; Male; Methylazoxymethanol Acetate; Neurotoxins; Rats; Rats, Sprague-Dawley; Schizophrenia; Treatment Outcome; Vagus Nerve Stimulation | 2014 |
Effects of pubertal cannabinoid administration on attentional set-shifting and dopaminergic hyper-responsivity in a developmental disruption model of schizophrenia.
Topics: Amphetamine; Animals; Attention; Benzoxazines; Cannabinoids; Central Nervous System Stimulants; Disease Models, Animal; Dopaminergic Neurons; Executive Function; Female; Male; Methylazoxymethanol Acetate; Morpholines; Motor Activity; Naphthalenes; Neuropsychological Tests; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Schizophrenia; Schizophrenic Psychology; Ventral Tegmental Area | 2014 |
Alterations in spatial memory and anxiety in the MAM E17 rat model of hippocampal pathology in schizophrenia.
Topics: Animals; Anxiety; Disease Models, Animal; Hippocampus; Male; Memory, Short-Term; Methylazoxymethanol Acetate; Rats; Schizophrenia; Spatial Memory | 2015 |
Aberrant high frequency oscillations recorded in the rat nucleus accumbens in the methylazoxymethanol acetate neurodevelopmental model of schizophrenia.
Topics: Animals; Antipsychotic Agents; Brain Waves; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials; Excitatory Amino Acid Antagonists; Female; Male; Methylazoxymethanol Acetate; Neurotoxins; Nucleus Accumbens; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Schizophrenia | 2015 |
[MAM-E17 schizophrenia rat model].
Topics: Animals; Behavior, Animal; Brain; Cognition; Disease Models, Animal; Frontal Lobe; Hippocampus; Limbic System; Locomotion; Methylazoxymethanol Acetate; Movement Disorders; Neurotoxins; Rats; Schizophrenia; Schizophrenic Psychology; Social Behavior | 2015 |
MAM (E17) rodent developmental model of neuropsychiatric disease: disruptions in learning and dysregulation of nucleus accumbens dopamine release, but spared executive function.
Topics: Amphetamine; Animals; Conditioning, Classical; Disease Models, Animal; Dopamine; Executive Function; Learning; Male; Methylazoxymethanol Acetate; Motivation; Nucleus Accumbens; Rats, Sprague-Dawley; Reward; Schizophrenia; Schizophrenic Psychology | 2015 |
Nicotinic modulation of auditory evoked potential electroencephalography in a rodent neurodevelopmental model of schizophrenia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Evoked Potentials, Auditory; Female; Gene Expression Regulation; Indoles; Male; Methylazoxymethanol Acetate; Neurodevelopmental Disorders; Nicotine; Pregnancy; Quinuclidines; Rats; Rats, Sprague-Dawley; Schizophrenia | 2015 |
Schizophrenia-Like Phenotype Inherited by the F2 Generation of a Gestational Disruption Model of Schizophrenia.
Topics: Animals; Disease Models, Animal; DNA Methylation; Dopaminergic Neurons; Female; Hippocampus; Male; Methylation; Methylazoxymethanol Acetate; Parvalbumins; Phenotype; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Schizophrenia; Transcription Factors; Ventral Tegmental Area | 2016 |
Valproic acid (VPA) reduces sensorimotor gating deficits and HDAC2 overexpression in the MAM animal model of schizophrenia.
Topics: Acetylation; Animals; Disease Models, Animal; Female; Gene Expression Regulation, Enzymologic; Histone Deacetylase 2; Histones; Male; Methylazoxymethanol Acetate; Prefrontal Cortex; Rats; Schizophrenia; Sensory Gating; Valproic Acid | 2015 |
Biochemical and cognitive impairments observed in animal models of schizophrenia induced by prenatal stress paradigm or methylazoxymethanol acetate administration.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Cognition Disorders; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Escape Reaction; Female; Gestational Age; Male; Maze Learning; Methylazoxymethanol Acetate; Motor Activity; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Schizophrenia | 2015 |
Dopamine System Dysregulation and the Pathophysiology of Schizophrenia: Insights From the Methylazoxymethanol Acetate Model.
Topics: Animals; Brain; Disease Models, Animal; Dopamine; Humans; Methylazoxymethanol Acetate; Neurons; Rats; Schizophrenia | 2017 |
Amygdala Hyperactivity in MAM Model of Schizophrenia is Normalized by Peripubertal Diazepam Administration.
Topics: Action Potentials; Administration, Oral; Amygdala; Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Conditioning, Psychological; Diazepam; Disease Models, Animal; Fear; Female; Hippocampus; Male; Maze Learning; Methylazoxymethanol Acetate; Neurons; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Schizophrenia | 2016 |
Reactivity to addictive drugs in the methylazoxymethanol (MAM) model of schizophrenia in male and female rats.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Disease Models, Animal; Female; Male; Methamphetamine; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Sprague-Dawley; Schizophrenia; Sex Characteristics | 2017 |
Loss of Parvalbumin in the Hippocampus of MAM Schizophrenia Model Rats Is Attenuated by Peripubertal Diazepam.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Diazepam; Disease Models, Animal; Down-Regulation; Drug Administration Schedule; Female; Gestational Age; Hippocampus; Interneurons; Methylazoxymethanol Acetate; Parvalbumins; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Schizophrenia; Schizophrenic Psychology; Sexual Maturation | 2016 |
Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model.
Topics: Animals; Behavior, Animal; Biomarkers; Brain; Decision Making; Diffusion Tensor Imaging; Disease Models, Animal; Female; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methylazoxymethanol Acetate; Multimodal Imaging; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reversal Learning; Reward; Schizophrenia; Schizophrenic Psychology | 2017 |
Memory deficits with intact cognitive control in the methylazoxymethanol acetate (MAM) exposure model of neurodevelopmental insult.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Executive Function; Female; Hippocampus; Hyperkinesis; Male; Memory Disorders; Methylazoxymethanol Acetate; Prefrontal Cortex; Pregnancy; Rats; Rats, Long-Evans; Schizophrenia; Spatial Memory | 2016 |
A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia.
Topics: Animals; Bipolar Disorder; Cohort Studies; CpG Islands; Depressive Disorder, Major; Disease Models, Animal; DNA Methylation; Endocannabinoids; Female; Gene Expression Regulation; Humans; Leukocytes, Mononuclear; Male; Methylazoxymethanol Acetate; Middle Aged; Prefrontal Cortex; Promoter Regions, Genetic; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Schizophrenia | 2017 |
Juvenile treatment with a novel mGluR2 agonist/mGluR3 antagonist compound, LY395756, reverses learning deficits and cognitive flexibility impairments in adults in a neurodevelopmental model of schizophrenia.
Topics: Amino Acids, Dicarboxylic; Animals; Brain; Bridged Bicyclo Compounds; Cognition; Cognition Disorders; Disease Models, Animal; Learning; Methylazoxymethanol Acetate; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2017 |
HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals.
Topics: Acetylation; Animals; Antipsychotic Agents; Brain; Cannabinoid Receptor Antagonists; Disease Models, Animal; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Gestational Age; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Methylazoxymethanol Acetate; Mice, Inbred C57BL; Neural Cell Adhesion Molecules; Neurogenesis; Neurons; Protein Processing, Post-Translational; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Schizophrenia; Signal Transduction; SOXB1 Transcription Factors; Time Factors | 2018 |
A loss of parvalbumin-containing interneurons is associated with diminished oscillatory activity in an animal model of schizophrenia.
Topics: Analysis of Variance; Animals; Behavior, Animal; Biological Clocks; Conditioning, Psychological; Disease Models, Animal; Electroencephalography; Evoked Potentials; Fear; Female; Glutamate Decarboxylase; Hippocampus; Interneurons; Male; Methylazoxymethanol Acetate; Neural Inhibition; Neurotoxins; Parvalbumins; Prefrontal Cortex; Pregnancy; Rats; Schizophrenia; Spectrum Analysis | 2009 |
Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophrenia.
Topics: Animals; Brain; Disease Models, Animal; Female; Hyperkinesis; Memory, Short-Term; Methylazoxymethanol Acetate; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Schizophrenia; Schizophrenic Psychology; Sensory Gating | 2009 |
Neuropathological and Reelin deficiencies in the hippocampal formation of rats exposed to MAM; differences and similarities with schizophrenia.
Topics: Animals; Brain Mapping; Cell Adhesion Molecules, Neuronal; Embryonic Development; Extracellular Matrix Proteins; Hippocampus; Humans; Mental Disorders; Methylation; Methylazoxymethanol Acetate; Nerve Tissue Proteins; Neurons; Rats; Reelin Protein; Schizophrenia; Serine Endopeptidases; Teratogens; Thalamus | 2010 |
Effect of antipsychotics on spontaneous hyperactivity and hypersensitivity to MK-801-induced hyperactivity in rats prenatally exposed to methylazoxymethanol.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dizocilpine Maleate; Female; Hyperkinesis; Methylazoxymethanol Acetate; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Schizophrenia | 2011 |
Divergent activation of ventromedial and ventrolateral dopamine systems in animal models of amphetamine sensitization and schizophrenia.
Topics: Action Potentials; Amphetamine; Animals; Central Nervous System Stimulants; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Dyskinesia, Drug-Induced; Female; Male; Methylazoxymethanol Acetate; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Schizophrenia; Ventral Tegmental Area | 2012 |
Differential effects of NMDA antagonists on high frequency and gamma EEG oscillations in a neurodevelopmental model of schizophrenia.
Topics: Animals; Biphenyl Compounds; Brain Waves; Cerebral Cortex; Cross-Over Studies; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Male; Methylazoxymethanol Acetate; Pregnancy; Propionates; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2012 |
A novel α5GABA(A)R-positive allosteric modulator reverses hyperactivation of the dopamine system in the MAM model of schizophrenia.
Topics: Allosteric Regulation; Amphetamine; Animals; Benzodiazepines; Diazepam; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Female; GABA Agonists; Hippocampus; Humans; Hyperkinesis; Imidazoles; Male; Methylazoxymethanol Acetate; Neurotoxins; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Schizophrenia; Ventral Tegmental Area | 2011 |
Alterations in hippocampal excitability, synaptic transmission and synaptic plasticity in a neurodevelopmental model of schizophrenia.
Topics: Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; Female; Hippocampus; Male; Methylazoxymethanol Acetate; Neuronal Plasticity; Organ Culture Techniques; Pregnancy; Rats; Rats, Sprague-Dawley; Schizophrenia; Synaptic Transmission | 2012 |
Antipsychotic drugs rapidly induce dopamine neuron depolarization block in a developmental rat model of schizophrenia.
Topics: Action Potentials; Animals; Animals, Newborn; Antipsychotic Agents; Cell Polarity; Disease Models, Animal; Dopamine; Female; Inhibitory Postsynaptic Potentials; Male; Methylazoxymethanol Acetate; Neural Inhibition; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Reaction Time; Schizophrenia; Ventral Tegmental Area | 2011 |
The methylazoxymethanol acetate (MAM-E17) rat model: molecular and functional effects in the hippocampus.
Topics: Animals; Disease Models, Animal; Female; Frontal Lobe; Gene Expression Regulation; Hippocampus; Humans; Male; Metabolomics; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Proteomics; Rats; Schizophrenia; Synaptic Transmission | 2012 |
Gestational methylazoxymethanol acetate administration alters proteomic and metabolomic markers of hippocampal glutamatergic transmission.
Topics: Animals; Female; Hippocampus; Humans; Male; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Schizophrenia; Synaptic Transmission | 2012 |
Aberrant dopamine D2-like receptor function in a rodent model of schizophrenia.
Topics: Alkylating Agents; Animals; Behavior, Animal; Dopamine; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Dopaminergic Neurons; Dose-Response Relationship, Drug; Female; Methylazoxymethanol Acetate; Motor Activity; Nucleus Accumbens; Quinpirole; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Dopamine D2; Receptors, Dopamine D4; Schizophrenia; Ventral Tegmental Area | 2012 |
Disruption of prefrontal cortical-hippocampal balance in a developmental model of schizophrenia: reversal by sulpiride.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Female; Hippocampus; Long-Term Potentiation; Male; Methylazoxymethanol Acetate; Prefrontal Cortex; Pregnancy; Rats; Rats, Sprague-Dawley; Schizophrenia; Sulpiride | 2013 |
Hippocampal deep brain stimulation reverses physiological and behavioural deficits in a rodent model of schizophrenia.
Topics: Action Potentials; Amphetamine; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Deep Brain Stimulation; Disease Models, Animal; Dopaminergic Neurons; Female; Hippocampus; Hyperkinesis; Male; Mental Disorders; Methylazoxymethanol Acetate; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Schizophrenia; Ventral Tegmental Area | 2013 |
Role of the prefrontal cortex in altered hippocampal-accumbens synaptic plasticity in a developmental animal model of schizophrenia.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Female; Hippocampus; Male; Methylazoxymethanol Acetate; Neural Pathways; Neuronal Plasticity; Neurons; Neurotoxins; Nucleus Accumbens; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Schizophrenia; Synapses | 2014 |
A loss of hippocampal perineuronal nets produces deficits in dopamine system function: relevance to the positive symptoms of schizophrenia.
Topics: Amphetamine; Analysis of Variance; Animals; Chondroitin ABC Lyase; Chondroitin Sulfate Proteoglycans; Disease Models, Animal; Dopamine; Hippocampus; Immunohistochemistry; Interneurons; Male; Methylazoxymethanol Acetate; Parvalbumins; Rats; Rats, Sprague-Dawley; Schizophrenia | 2013 |
The prenatal methylazoxymethanol acetate treatment: a neurodevelopmental animal model for schizophrenia?
Topics: Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Body Weight; Brain; Cognition; Disease Models, Animal; Dose-Response Relationship, Radiation; Embryo, Mammalian; Emotions; Female; Inhibition, Psychological; Male; Methylazoxymethanol Acetate; Motor Activity; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Protein Synthesis Inhibitors; Rats; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Sex Factors | 2004 |
Cognitive deficits caused by late gestational disruption of neurogenesis in rats: a preclinical model of schizophrenia.
Topics: Animals; Association Learning; Cognition Disorders; Conditioning, Operant; Disease Models, Animal; Exploratory Behavior; Female; Maze Learning; Methylazoxymethanol Acetate; Nervous System; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; Rats; Rats, Wistar; Recognition, Psychology; Reversal Learning; Schizophrenia; Swimming; Teratogens | 2005 |
Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Female; Gene Expression; Hippocampus; Immunohistochemistry; Methylazoxymethanol Acetate; Motor Activity; Neurons; Parvalbumins; Phencyclidine; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Schizophrenia; Time Factors | 2006 |
A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia.
Topics: Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Brain; Central Nervous System Stimulants; Cognition Disorders; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Gait Disorders, Neurologic; Methylazoxymethanol Acetate; Neurons; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred F344; Schizophrenia | 2006 |
Gestational methylazoxymethanol acetate treatment impairs select cognitive functions: parallels to schizophrenia.
Topics: Animals; Atrophy; Brain; Brain Damage, Chronic; Cognition Disorders; Discrimination Learning; Disease Models, Animal; Female; Learning Disabilities; Male; Methylazoxymethanol Acetate; Neuropsychological Tests; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; Rats; Reinforcement, Psychology; Schizophrenia; Teratogens | 2007 |
Alterations in prefrontal glutamatergic and noradrenergic systems following MK-801 administration in rats prenatally exposed to methylazoxymethanol at gestational day 17.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Male; Methylazoxymethanol Acetate; Microdialysis; Motor Activity; Norepinephrine; Nucleus Accumbens; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2007 |
Wide spectrum modulation by KP-544 in models relevant for neuronal survival.
Topics: Animals; Astrocytes; Cell Death; Cell Survival; Cerebellum; Cyclohexanols; Disease Models, Animal; Drug Synergism; Female; Male; Methylazoxymethanol Acetate; Nerve Growth Factor; Neurites; Neurons; Neuroprotective Agents; Neurotoxins; PC12 Cells; Pregnancy; Pyrimidines; Rats; Schizophrenia | 2007 |
Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia.
Topics: Action Potentials; Animals; Disease Models, Animal; Dopamine; Hippocampus; Male; Methylazoxymethanol Acetate; Rats; Rats, Sprague-Dawley; Schizophrenia | 2007 |
Methylazoxymethanol acetate-induced abnormalities in the entorhinal cortex of the rat; parallels with morphological findings in schizophrenia.
Topics: Animals; Disease Models, Animal; Entorhinal Cortex; Female; Frontal Lobe; Gestational Age; Gyrus Cinguli; Hippocampus; Immunohistochemistry; Isoenzymes; Male; Methylazoxymethanol Acetate; Occipital Lobe; Pregnancy; Prenatal Exposure Delayed Effects; Protein Kinase C; Rats; Rats, Wistar; Schizophrenia | 1998 |
Prenatal methylazoxymethanol acetate alters behavior and brain NGF levels in young rats: a possible correlation with the development of schizophrenia-like deficits.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Brain; Disease Models, Animal; Exploratory Behavior; Female; Methylazoxymethanol Acetate; Nerve Growth Factors; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Schizophrenia; Social Behavior; Substance P | 1999 |
Impaired sensory gating and attention in rats with developmental abnormalities of the mesocortex. Implications for schizophrenia.
Topics: Acoustic Stimulation; Animals; Attention; Cerebral Cortex; Female; Habituation, Psychophysiologic; Methylazoxymethanol Acetate; Noise; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Sensation; Sensation Disorders | 2000 |