methylatropine and Hypertrophy

To evaluate the role of sonography in infants with hypertrophic pyloric stenosis undergoing conservative medical treatment.. Twenty-two infants (17 male and 5 female; age range, 1-12 weeks) were clinically and sonographically considered suitable for conservative treatment and underwent follow-up during the course of the disease. Sonography was performed under a standardized protocol and included color Doppler sonography.. Fifteen infants (mean age, 9 weeks) needed surgery. They initially had a mean pyloric length of 18 mm, a diameter of 10.5 mm, and a wall thickness of 4 mm, with visible passage of food into the duodenum. These values deteriorated during follow-up (mean preoperative values: length, 20 mm; diameter, 12 mm; and wall thickness, 4.5 mm); furthermore, passage of food through the pyloric canal ceased. Seven infants (mean age, 3 weeks) were successfully treated conservatively Their initial mean pyloric measurements were slightly smaller (length, 15 mm; diameter, 10 mm; and wall thickness, 3.8 mm) and did not deteriorate during follow-up. In all of them, sonography showed improvement of passage through the pyloric canal within several days, as shown and documented by color Doppler sonography; morphologic changes persisted longer despite clinical improvement.. Sonography, including color Doppler sonography, is a valuable tool for monitoring infants with hypertrophic pyloric stenosis undergoing conservative treatment; however, initial sonograms cannot predict the further course of the disease.

Topics: Atropine Derivatives; Drug Monitoring; Female; Humans; Hypertrophy; Infant; Infant, Newborn; Male; Parasympatholytics; Prognosis; Pyloric Stenosis; Ultrasonography, Doppler, Color

Topics: Atropine Derivatives; Humans; Hypertrophy; Infant; Infant, Newborn; Male; Pyloric Stenosis; Whooping Cough