methylamphotericin-b and Aspergillosis

methylamphotericin-b has been researched along with Aspergillosis* in 2 studies

Other Studies

2 other study(ies) available for methylamphotericin-b and Aspergillosis

Article	Year
Possible conformation of amphotericin B dimer in membrane-bound assembly as deduced from solid-state NMR. Bioorganic & medicinal chemistry, 2012, Oct-01, Volume: 20, Issue:19 Aiming for structural analysis of amphotericin B (AmB) ion-channel assemblies in membrane, a covalent dimer was synthesized between (13)C-labled AmB methyl ester and (19)F-labled AmB. The dimer showed slightly weaker but significant biological activities against fungi and red blood cells compared with those of monomeric AmB. Then the dimer was subjected to (13)C{(19)F}REDOR (Rotational-Echo Double Resonance) experiments in hydrated lipid bilayers. The obtained REDOR dephasing effects were explained by two components; a short (13)C/(19)F distance (6.9Å) accounting for 23% of the REDOR dephasing, and a longer one (14Å) comprising the rest of the dephasing. The shorter distance is likely to reflect the formation of barrel-stave ion channel. Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus niger; Dimerization; Erythrocytes; Hemolysis; Humans; Lipid Bilayers; Magnetic Resonance Spectroscopy; Molecular Conformation	2012
Leukoencephalopathy in patients treated with amphotericin B methyl ester. The Journal of infectious diseases, 1982, Volume: 146, Issue:2 Clinical and autopsy studies of 14 patients treated with amphotericin B methyl ester (AME) for focal, disseminated, and nervous system mycotic infections revealed a high incidence of progressive neurologic dysfunction (dementia, akinesia, mutism, hyperreflexia, and tremor) and diffuse white matter degeneration. All of seven patients who received greater than 9.8 g of AME intravenously developed severe neurologic and neuropathologic changes. Two of three patients given 5-7.2 g of AME developed less severe neurologic symptoms; all three had mild diffuse white matter gliosis. Four patients given less than 1.5 g of AME had no bran abnormalities except those related to coccidioidal meningitis. Thirty-one control patients who died on untreated or amphotericin B-treated coccidioidal meningitis showed no diffuse white matter abnormalities. These findings indicate that prolonged administration of AME and/or other contaminating polyenes injures human white matter. Long-term animal studies, with particular attention to nervous system histology, must precede human use of other polyene derivatives. Topics: Adolescent; Adult; Aged; Amphotericin B; Aspergillosis; Astrocytes; Brain; Brain Diseases; Child; Coccidioidomycosis; Demyelinating Diseases; Gliosis; Humans; Lung Diseases, Fungal; Middle Aged; Myelin Sheath	1982

Article

Year

Possible conformation of amphotericin B dimer in membrane-bound assembly as deduced from solid-state NMR.

Bioorganic & medicinal chemistry, 2012, Oct-01, Volume: 20, Issue:19

Aiming for structural analysis of amphotericin B (AmB) ion-channel assemblies in membrane, a covalent dimer was synthesized between (13)C-labled AmB methyl ester and (19)F-labled AmB. The dimer showed slightly weaker but significant biological activities against fungi and red blood cells compared with those of monomeric AmB. Then the dimer was subjected to (13)C{(19)F}REDOR (Rotational-Echo Double Resonance) experiments in hydrated lipid bilayers. The obtained REDOR dephasing effects were explained by two components; a short (13)C/(19)F distance (6.9Å) accounting for 23% of the REDOR dephasing, and a longer one (14Å) comprising the rest of the dephasing. The shorter distance is likely to reflect the formation of barrel-stave ion channel.

Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus niger; Dimerization; Erythrocytes; Hemolysis; Humans; Lipid Bilayers; Magnetic Resonance Spectroscopy; Molecular Conformation

2012

Leukoencephalopathy in patients treated with amphotericin B methyl ester.

The Journal of infectious diseases, 1982, Volume: 146, Issue:2

Clinical and autopsy studies of 14 patients treated with amphotericin B methyl ester (AME) for focal, disseminated, and nervous system mycotic infections revealed a high incidence of progressive neurologic dysfunction (dementia, akinesia, mutism, hyperreflexia, and tremor) and diffuse white matter degeneration. All of seven patients who received greater than 9.8 g of AME intravenously developed severe neurologic and neuropathologic changes. Two of three patients given 5-7.2 g of AME developed less severe neurologic symptoms; all three had mild diffuse white matter gliosis. Four patients given less than 1.5 g of AME had no bran abnormalities except those related to coccidioidal meningitis. Thirty-one control patients who died on untreated or amphotericin B-treated coccidioidal meningitis showed no diffuse white matter abnormalities. These findings indicate that prolonged administration of AME and/or other contaminating polyenes injures human white matter. Long-term animal studies, with particular attention to nervous system histology, must precede human use of other polyene derivatives.

Topics: Adolescent; Adult; Aged; Amphotericin B; Aspergillosis; Astrocytes; Brain; Brain Diseases; Child; Coccidioidomycosis; Demyelinating Diseases; Gliosis; Humans; Lung Diseases, Fungal; Middle Aged; Myelin Sheath

1982