methyl-ursolate and Urinary-Bladder-Neoplasms

methyl-ursolate has been researched along with Urinary-Bladder-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for methyl-ursolate and Urinary-Bladder-Neoplasms

Article	Year
Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. Bioorganic & medicinal chemistry letters, 2008, Apr-15, Volume: 18, Issue:8 Derivatives of oleanolic acid, ursolic acid and glycyrrhetinic acid substituted with electron-withdrawing groups at the 2-position in the A-ring which also contains a 1-en-3-one structure are potent inhibitors of cancer cell growth. In this study, we have compared the effects of several 2-substituted analogs of triterpenoid acid methyl esters derived from ursolic and glycyrrhetinic acid on proliferation of KU7 and 253JB-V bladder and Panc-1 and Panc-28 pancreatic cancer cells. The results show that the 2-cyano and 2-trifluoromethyl derivatives were the most active compounds. The glycyrrhetinic acid derivatives with the rearranged C-ring containing the 9(11)-en-12-one structure were generally more active than the corresponding 12-en-11-one isomers. However, differences in growth inhibitory IC(50) values were highly variable and dependent on the 2-substituent (CN vs CF(3)) and cancer cell context. Topics: Cell Line, Tumor; Cell Proliferation; Glycyrrhetinic Acid; Humans; Methylation; Molecular Structure; Pancreatic Neoplasms; Structure-Activity Relationship; Triterpenes; Urinary Bladder Neoplasms; Ursolic Acid	2008

Article

Year

Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives.

Bioorganic & medicinal chemistry letters, 2008, Apr-15, Volume: 18, Issue:8

Derivatives of oleanolic acid, ursolic acid and glycyrrhetinic acid substituted with electron-withdrawing groups at the 2-position in the A-ring which also contains a 1-en-3-one structure are potent inhibitors of cancer cell growth. In this study, we have compared the effects of several 2-substituted analogs of triterpenoid acid methyl esters derived from ursolic and glycyrrhetinic acid on proliferation of KU7 and 253JB-V bladder and Panc-1 and Panc-28 pancreatic cancer cells. The results show that the 2-cyano and 2-trifluoromethyl derivatives were the most active compounds. The glycyrrhetinic acid derivatives with the rearranged C-ring containing the 9(11)-en-12-one structure were generally more active than the corresponding 12-en-11-one isomers. However, differences in growth inhibitory IC(50) values were highly variable and dependent on the 2-substituent (CN vs CF(3)) and cancer cell context.

Topics: Cell Line, Tumor; Cell Proliferation; Glycyrrhetinic Acid; Humans; Methylation; Molecular Structure; Pancreatic Neoplasms; Structure-Activity Relationship; Triterpenes; Urinary Bladder Neoplasms; Ursolic Acid

2008