methyl-triclosan and Malaria--Falciparum

methyl-triclosan has been researched along with Malaria--Falciparum* in 1 studies

Other Studies

1 other study(ies) available for methyl-triclosan and Malaria--Falciparum

ArticleYear
Novel diaryl ureas with efficacy in a mouse model of malaria.
    Bioorganic & medicinal chemistry letters, 2013, Feb-15, Volume: 23, Issue:4

    Exploration of triclosan analogs has led to novel diaryl ureas with significant potency against in vitro cultures of drug-resistant and drug-sensitive strains of the human malaria parasite Plasmodium falciparum. Compound 18 demonstrated EC(50) values of 37 and 55 nM versus in vitro cultured parasite strains and promising in vivo efficacy in a Plasmodium berghei antimalarial mouse model, with >50% survival at day 31 post-treatment when administered subcutaneously at 256 mg/kg. This series of compounds provides a chemical scaffold of novel architecture, as validated by cheminformatics analysis, to pursue antimalarial drug discovery efforts.

    Topics: Animals; Antimalarials; Benzene Derivatives; Disease Models, Animal; Drug Discovery; Malaria, Falciparum; Mice; Urea

2013