methyl methanesulfonate has been researched along with Xeroderma Pigmentosum in 16 studies
Xeroderma Pigmentosum: A rare, pigmentary, and atrophic autosomal recessive disease. It is manifested as an extreme photosensitivity to ULTRAVIOLET RAYS as the result of a deficiency in the enzyme that permits excisional repair of ultraviolet-damaged DNA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Excision repair of ultraviolet damage in the DNA of normal and xeroderma pigmentosum (Groups C, D, and variant) cells was inactivated by exposure of cells to methyl methanesulfonate immediately before irradiation independent of the presence of 0 to 10% fetal calf serum." | 7.66 | Inactivation of ultraviolet repair in normal and xeroderma pigmentosum cells by methyl methanesulfonate. ( Cleaver, JE, 1982) |
| " Two compounds from this series significantly potentiate the action of methyl methanesulfonate (MMS) and temozolamide in a bladder cancer cell line (T24)." | 3.73 | The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. ( Bailey, A; Bennani, YL; Bom, D; Boozer, S; Brunden, K; Dent, T; Gleason, E; Harrington, J; Huck, B; Leventhal, C; Murphy, S; Rundlett, S; Sherf, B; Silver, D; Tumey, LN; Wang, J, 2005) |
| "Rearrangements of chromatin structure during excision repair were examined in xeroderma pigmentosum (XP; complementation group A) human fibroblasts treated with the small-molecule alkylating agent methyl methanesulfonate (MMS)." | 3.67 | Rearrangement of nucleosome structure during excision repair in xeroderma pigmentosum (group A) human fibroblasts. ( Sidik, K; Smerdon, MJ, 1987) |
| "The value of the unscheduled DNA synthesis by exposure to combined action of damaging agents--gamma-irradiation and methyl methanesulfonate--does not exceed its value after separate actions of each particular agent in lymphocytes from healthy subjects as well as in those with Xeroderma pigmentosum in form II (XP2LE)." | 3.67 | [Unscheduled DNA synthesis in human peripheral blood lymphocytes undergoing combined exposure to gamma irradiation and methylmethane sulfonate]. ( Genter, EI; Mikhel'son, VM; Zhestianikov, VD, 1986) |
| "Excision repair of ultraviolet damage in the DNA of normal and xeroderma pigmentosum (Groups C, D, and variant) cells was inactivated by exposure of cells to methyl methanesulfonate immediately before irradiation independent of the presence of 0 to 10% fetal calf serum." | 3.66 | Inactivation of ultraviolet repair in normal and xeroderma pigmentosum cells by methyl methanesulfonate. ( Cleaver, JE, 1982) |
| " Exposure of both cell types to MMS (0-20 mM) resulted in a linear dose-response relationship for the formation of DNA alkali-labile sites (i." | 1.27 | Methylmethanesulfonate-induced DNA damage and its repair in cultured human fibroblasts: normal rates of induction and removal of alkali-labile sites in xeroderma pigmentosum (group A) cells. ( Liuzzi, M; Mirzayans, R; Paterson, MC, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (81.25) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tumey, LN | 1 |
| Bom, D | 1 |
| Huck, B | 1 |
| Gleason, E | 1 |
| Wang, J | 1 |
| Silver, D | 1 |
| Brunden, K | 1 |
| Boozer, S | 1 |
| Rundlett, S | 1 |
| Sherf, B | 1 |
| Murphy, S | 1 |
| Dent, T | 1 |
| Leventhal, C | 1 |
| Bailey, A | 1 |
| Harrington, J | 1 |
| Bennani, YL | 1 |
| Fujiwara, Y | 1 |
| Goto, K | 1 |
| Yamamoto, K | 1 |
| Ichihashi, M | 1 |
| Khachapuridze, GG | 1 |
| Mikhel'son, VM | 3 |
| Zhestianikov, VD | 3 |
| Cleaver, JE | 2 |
| Snyder, RD | 1 |
| Van Houten, B | 1 |
| Regan, JD | 1 |
| Park, SD | 1 |
| Choi, KH | 1 |
| Hong, SW | 1 |
| Gupta, PK | 1 |
| Sirover, MA | 1 |
| Carrier, F | 1 |
| Gatignol, A | 1 |
| Hollander, MC | 1 |
| Jeang, KT | 1 |
| Fornace, AJ | 1 |
| Kudrna, RD | 1 |
| Smith, J | 1 |
| Linn, S | 1 |
| Penhoet, EE | 1 |
| Higgins, NP | 1 |
| Kato, K | 1 |
| Strauss, B | 1 |
| Seetharam, S | 1 |
| Seidman, MM | 1 |
| Mirzayans, R | 1 |
| Liuzzi, M | 1 |
| Paterson, MC | 1 |
| Sidik, K | 1 |
| Smerdon, MJ | 1 |
| Thielmann, HW | 1 |
| Edler, L | 1 |
| Friemel, S | 1 |
| Genter, EI | 2 |
16 other studies available for methyl methanesulfonate and Xeroderma Pigmentosum
| Article | Year |
|---|---|
The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors.
Topics: Cell Line, Tumor; Dacarbazine; DNA Damage; Enzyme Inhibitors; Flap Endonucleases; Humans; Methyl Met | 2005 |
Roles of poly(ADP-ribose) synthesis in repair and replication in normal human, Cockayne syndrome, and xeroderma pigmentosum fibroblasts after UV irradiation.
Topics: Benzamides; Cockayne Syndrome; DNA Repair; DNA Replication; Dwarfism; Fibroblasts; Humans; In Vitro | 1983 |
[Number of chromosome aberrations induced by chemical carcinogens in the cells of patients with 2 forms of xeroderma pigmentosum].
Topics: 4-Nitroquinoline-1-oxide; Benz(a)Anthracenes; Carcinogens; Cell Cycle; Chromosome Aberrations; Human | 1980 |
Inactivation of ultraviolet repair in normal and xeroderma pigmentosum cells by methyl methanesulfonate.
Topics: Cells, Cultured; DNA; DNA Repair; Humans; Methyl Methanesulfonate; Skin Neoplasms; Ultraviolet Rays; | 1982 |
Studies on the inhibition of repair of ultraviolet- and methyl methanesulfonate-induced damage in the DNA of human fibroblasts by novobiocin.
Topics: Cell Line; DNA; DNA Repair; DNA Replication; Fibroblasts; Humans; Kinetics; Methyl Methanesulfonate; | 1982 |
Inhibition of excision-repair of ultraviolet damage in human cells by exposure to methyl methanesulfonate.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Depression, Chemical; DNA; DNA Repair; DNA Replication; | 1981 |
Cell cycle regulation of DNA repair in normal and repair deficient human cells.
Topics: Acetoxyacetylaminofluorene; Cell Cycle; Cell Line; DNA Repair; DNA Replication; Fibroblasts; Humans; | 1981 |
Induction of RNA-binding proteins in mammalian cells by DNA-damaging agents.
Topics: Animals; Cell Line; CHO Cells; Cricetinae; DNA Damage; Gamma Rays; Gene Expression Regulation; Human | 1994 |
Survival of apurinic SV40 DNA in the d-complementation group of xeroderma pigmentosum.
Topics: Cell Line; DNA Repair; DNA, Viral; Humans; Methyl Methanesulfonate; Mutagens; Simian virus 40; Skin; | 1979 |
A model for replication repair in mammalian cells.
Topics: Animals; Bromodeoxyuridine; Cell Line; Centrifugation, Density Gradient; DNA Repair; DNA Replication | 1976 |
Modulation of ultraviolet light mutational hotspots by cellular stress.
Topics: Base Sequence; Calcium; DNA Damage; DNA Repair; Humans; Ionomycin; Methyl Methanesulfonate; Molecula | 1992 |
Methylmethanesulfonate-induced DNA damage and its repair in cultured human fibroblasts: normal rates of induction and removal of alkali-labile sites in xeroderma pigmentosum (group A) cells.
Topics: Alkylating Agents; Binding Sites; Cells, Cultured; DNA; DNA Damage; DNA Repair; Fibroblasts; Humans; | 1988 |
Rearrangement of nucleosome structure during excision repair in xeroderma pigmentosum (group A) human fibroblasts.
Topics: DNA; DNA Damage; DNA Repair; Fibroblasts; Humans; Methyl Methanesulfonate; Nucleosomes; Xeroderma Pi | 1987 |
Xeroderma pigmentosum patients from Germany: repair capacity of 45 XP fibroblast strains of the Mannheim XP Collection as measured by colony-forming ability and unscheduled DNA synthesis following treatment with methyl methanesulfonate and N-methyl-N-nitr
Topics: Alkylation; Carcinogens; Cell Cycle; Colony-Forming Units Assay; DNA; DNA Repair; Fibroblasts; Human | 1986 |
[Unscheduled DNA synthesis in human peripheral blood lymphocytes undergoing combined exposure to gamma irradiation and methylmethane sulfonate].
Topics: Adult; Autoradiography; Cells, Cultured; DNA; DNA Repair; Female; Gamma Rays; Humans; Lymphocytes; M | 1986 |
[Repair of DNA damaged by methylmethane sulfonate in normal human lymphocytes and in xeroderma pigmentosum].
Topics: Cells, Cultured; DNA Repair; Humans; Lymphocytes; Methyl Methanesulfonate; Radiation, Ionizing; Ultr | 1985 |