methyl methanesulfonate has been researched along with Sensitivity and Specificity in 29 studies
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " As the separation procedure may selectively retain cells containing MN, a study comparing the performance of the erythrocyte fractionation technique and standard manual smear preparation was conducted in male NMRI mice treated with a single injection of two clastogens (cyclophosphamide, 25 or 50 mg/kg, or methylmethane sulfonate, 40 or 80 mg/kg) or two aneuploidogens (colchicine, 0." | 3.69 | Comparison of separated erythrocyte preparations and manual smears of bone marrow in showing micronucleus induction by clastogens and aneuploidogens in mouse. ( Norppa, H; Vigagni, F, 1995) |
| "Mouse lymphoma L5178Y cells were treated with dimethyl sulphoxide (DMSO) as a standard solvent or reference agents known to induce oxidative damage (gamma irradiation and potassium bromate) or alkylation (methyl methanesulfonate, MMS; ethylnitrosurea, ENU)." | 1.33 | hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII. ( Martin, EA; O'Donovan, MR; Smith, CC, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (41.38) | 18.2507 |
| 2000's | 11 (37.93) | 29.6817 |
| 2010's | 6 (20.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elje, E | 1 |
| Hesler, M | 1 |
| Rundén-Pran, E | 1 |
| Mann, P | 1 |
| Mariussen, E | 1 |
| Wagner, S | 1 |
| Dusinska, M | 2 |
| Kohl, Y | 1 |
| Townsend, TA | 1 |
| Parrish, MC | 1 |
| Engelward, BP | 1 |
| Manjanatha, MG | 1 |
| Kimura, A | 1 |
| Miyata, A | 1 |
| Honma, M | 1 |
| Enciso, JM | 1 |
| Sánchez, O | 1 |
| López de Cerain, A | 1 |
| Azqueta, A | 1 |
| Wei, S | 1 |
| Shalhout, S | 1 |
| Ahn, YH | 1 |
| Bhagwat, AS | 1 |
| Plappert-Helbig, U | 1 |
| Guérard, M | 1 |
| Niimi, A | 1 |
| Brown, S | 1 |
| Sabbioneda, S | 1 |
| Kannouche, PL | 1 |
| Scott, A | 1 |
| Yasui, A | 1 |
| Green, CM | 1 |
| Lehmann, AR | 1 |
| Takenaka, K | 1 |
| Miki, Y | 1 |
| Kim, J | 1 |
| Matsunaga, N | 1 |
| Koyanagi, S | 1 |
| Ohdo, S | 1 |
| Valentin-Severin, I | 1 |
| Le Hegarat, L | 1 |
| Lhuguenot, JC | 1 |
| Le Bon, AM | 1 |
| Chagnon, MC | 1 |
| Rinne, M | 1 |
| Caldwell, D | 1 |
| Kelley, MR | 1 |
| Li, W | 1 |
| Tarun, M | 1 |
| Rusling, JF | 1 |
| Siddique, HR | 1 |
| Chowdhuri, DK | 1 |
| Saxena, DK | 1 |
| Dhawan, A | 2 |
| Smith, CC | 1 |
| O'Donovan, MR | 1 |
| Martin, EA | 1 |
| Vajpayee, P | 1 |
| Shanker, R | 1 |
| Vigagni, F | 1 |
| Norppa, H | 1 |
| Singh, R | 1 |
| Blättler, WA | 1 |
| Collinson, AR | 1 |
| Oberly, TJ | 1 |
| Huffman, DM | 1 |
| Scheuring, JC | 1 |
| Garriott, ML | 1 |
| Elhajouji, A | 1 |
| Santos, AP | 1 |
| Van Hummelen, P | 1 |
| Kirsch-Volders, M | 1 |
| Selden, JR | 1 |
| Dolbeare, F | 1 |
| Clair, JH | 1 |
| Nichols, WW | 1 |
| Miller, JE | 1 |
| Kleemeyer, KM | 1 |
| Hyland, RJ | 1 |
| DeLuca, JG | 1 |
| Ralph, S | 1 |
| Petras, M | 2 |
| Pandrangi, R | 1 |
| Vrzoc, M | 3 |
| Ashby, J | 1 |
| Lefevre, PA | 1 |
| Elliott, BM | 1 |
| Clapp, MJ | 1 |
| Babůrek, I | 1 |
| Stibůrková, B | 1 |
| Levy, A | 1 |
| Angelis, KJ | 2 |
| Petras, ML | 1 |
| Nakamura, J | 1 |
| Walker, VE | 1 |
| Upton, PB | 1 |
| Chiang, SY | 1 |
| Kow, YW | 1 |
| Swenberg, JA | 1 |
| Collins, AR | 1 |
| Afanassiev, V | 1 |
| Sefton, M | 1 |
| Anantachaiyong, T | 1 |
| Barker, G | 1 |
| Walmsley, R | 1 |
| Wölfl, S | 1 |
29 other studies available for methyl methanesulfonate and Sensitivity and Specificity
| Article | Year |
|---|---|
The comet assay applied to HepG2 liver spheroids.
Topics: Cell Culture Techniques; Cell Survival; Chlorpromazine; Colchicine; Comet Assay; DNA Damage; DNA, Ne | 2019 |
The development and validation of EpiComet-Chip, a modified high-throughput comet assay for the assessment of DNA methylation status.
Topics: Cell Culture Techniques; Comet Assay; DNA Damage; DNA Methylation; Epigenesis, Genetic; HeLa Cells; | 2017 |
A combination of in vitro comet assay and micronucleus test using human lymphoblastoid TK6 cells.
Topics: Cell Survival; Cells, Cultured; Comet Assay; Cross-Linking Reagents; Cytotoxins; Ethyl Methanesulfon | 2013 |
Does the duration of lysis affect the sensitivity of the in vitro alkaline comet assay?
Topics: Comet Assay; DNA Damage; DNA-Formamidopyrimidine Glycosylase; HeLa Cells; Humans; Hydrogen Peroxide; | 2015 |
A versatile new tool to quantify abasic sites in DNA and inhibit base excision repair.
Topics: Alkynes; Biotin; Cell Death; DNA; DNA Damage; DNA Mutational Analysis; DNA Repair; DNA-(Apurinic or | 2015 |
Inter-laboratory comparison of the in vivo comet assay including three image analysis systems.
Topics: Animals; Comet Assay; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Image Processing, Co | 2015 |
Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells.
Topics: Cell Cycle; Cell Line; Humans; Methyl Methanesulfonate; Proliferating Cell Nuclear Antigen; Sensitiv | 2008 |
Introduction and characterization of a polymerase-dead point mutation into the POLK gene in vertebrates.
Topics: Animals; Asparagine; Binding Sites; Cell Line; Cell Proliferation; Chickens; Clone Cells; DNA Damage | 2009 |
Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene.
Topics: Animals; Antineoplastic Agents, Alkylating; Cells, Cultured; CLOCK Proteins; DNA Damage; DNA Glycosy | 2009 |
Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Benzo(a)pyrene; Carcinoma, Hepatocellular; Comet As | 2003 |
Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells.
Topics: Adenoviridae; Alkylating Agents; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Br | 2004 |
Trace analysis of residual methyl methanesulfonate, ethyl methanesulfonate and isopropyl methanesulfonate in pharmaceuticals by capillary gas chromatography with flame ionization detection.
Topics: Chromatography, Gas; Ethyl Methanesulfonate; Mesylates; Methyl Methanesulfonate; Pharmaceutical Prep | 2004 |
Quantitative measurement of DNA adducts using neutral hydrolysis and LC-MS. Validation of genotoxicity sensors.
Topics: Chromatography, Liquid; DNA; DNA Adducts; DNA Damage; Electrochemistry; Epoxy Compounds; Guanine; Hy | 2005 |
Validation of Drosophila melanogaster as an in vivo model for genotoxicity assessment using modified alkaline Comet assay.
Topics: Alkylating Agents; Animals; Comet Assay; Cyclophosphamide; DNA Damage; Dose-Response Relationship, D | 2005 |
hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII.
Topics: Animals; Bromates; Comet Assay; Deoxyribonuclease (Pyrimidine Dimer); Dimethyl Sulfoxide; DNA Damage | 2006 |
Evaluation of the alkaline Comet assay conducted with the wetlands plant Bacopa monnieri L. as a model for ecogenotoxicity assessment.
Topics: Bacopa; Cell Nucleus; Comet Assay; DNA Damage; DNA, Plant; Dose-Response Relationship, Drug; Environ | 2006 |
Comparison of separated erythrocyte preparations and manual smears of bone marrow in showing micronucleus induction by clastogens and aneuploidogens in mouse.
Topics: Aneuploidy; Animals; Bone Marrow; Bone Marrow Cells; Cell Separation; Colchicine; Cyclophosphamide; | 1995 |
Assay for thiols based on reactivation of papain.
Topics: Animals; Binding Sites; Cysteine; Disulfides; Dithionitrobenzoic Acid; Edetic Acid; Fabaceae; Fructo | 1995 |
An evaluation of 6 chromosomal mutagens in the AS52/XPRT mutation assay utilizing suspension culture and soft agar cloning.
Topics: 2-Acetylaminofluorene; Acrylates; Aminophenols; Animals; Benzo(a)pyrene; Benzoin; Cell Line; Cloning | 1993 |
Metabolic differences between whole blood and isolated lymphocyte cultures for micronucleus (MN) induction by cyclophosphamide and benzo[a]pyrene.
Topics: Adult; Animals; Benzo(a)pyrene; Biotransformation; Blood Cells; Cells, Cultured; Cyclophosphamide; E | 1994 |
Statistical confirmation that immunofluorescent detection of DNA repair in human fibroblasts by measurement of bromodeoxyuridine incorporation is stoichiometric and sensitive.
Topics: Bromodeoxyuridine; Cells, Cultured; DNA; DNA Repair; Ethyl Methanesulfonate; Fibroblasts; Flow Cytom | 1993 |
Alkaline single-cell gel (comet) assay and genotoxicity monitoring using two species of tadpoles.
Topics: Animals; Animals, Laboratory; Bufonidae; DNA; DNA Damage; Dose-Response Relationship, Drug; Ethyl Me | 1996 |
Methyl methanesulphonate (MMS) as a resource conserving and reliable positive control agent for male rat and male mouse dominant lethal assays.
Topics: Animals; Embryo Implantation; Embryo Loss; Female; Male; Methyl Methanesulfonate; Mice; Mutagenicity | 1996 |
Tobacco cotyledons: a novel system for testing mutagenicity in plants.
Topics: Cotyledon; DNA Repair; Genes, Plant; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; | 1997 |
Comparison of DNA damage in peripheral blood and spleen lymphocytes using the single-cell gel assay.
Topics: Animals; DNA; DNA Damage; Electrophoresis, Agar Gel; Lymphocytes; Male; Methyl Methanesulfonate; Mic | 1997 |
Comparison of alkaline single cell gel (Comet) and peripheral blood micronucleus assays in detecting DNA damage caused by direct and indirect acting mutagens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Cyclophosphamide; DNA Damage; Dose-Respon | 1997 |
Highly sensitive apurinic/apyrimidinic site assay can detect spontaneous and chemically induced depurination under physiological conditions.
Topics: B-Lymphocytes; Binding Sites; Biological Assay; Cell Line; DNA; DNA Adducts; DNA Damage; Glycoprotei | 1998 |
Single cell gel electrophoresis: detection of DNA damage at different levels of sensitivity.
Topics: Buffers; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Electrophoresis, Agar Gel; Exodeoxyribonuc | 1999 |
Application of yeast cells transformed with GFP expression constructs containing the RAD54 or RNR2 promoter as a test for the genotoxic potential of chemical substances.
Topics: Biosensing Techniques; Blotting, Western; DNA Helicases; DNA Repair Enzymes; Dose-Response Relations | 2000 |