methyl methanesulfonate has been researched along with Pregnancy in 35 studies
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Intrauterine growth retardation, without an increase in gross abnormalities, was also observed in the offspring of pregnant New Zealand White rabbits dosed during the preimplantation stages of pregnancy with an "environmental cocktail" composed of ethanol, nicotine, caffeine, sodium salicylate, and dichloro-diphenyl-trichloro-ethane (DDT)." | 3.67 | Chemical exposure of embryos during the preimplantation stages of pregnancy: mortality rate and intrauterine development. ( Dames, NM; Fabro, S; McLachlan, JA, 1984) |
| "The influence of chromatin structure on the distribution of DNA repair synthesis was studied by enzymatic digestion of "repair labeled" nuclei of mouse mammary cells: "repair labeled" nuclei were isolated from pregnancy mammary tissue fragments, treated in vitro with methylmethanesulfonate (MMS) or methylnitrosourea (MNU), and pulse-labeled with 3H-thymidine in the presence of hydroxyurea in the culture medium." | 3.66 | The influence of chromatin structure on the distribution of DNA repair synthesis studied by nuclease digestion. ( Banerjee, MR; Bodell, WJ, 1979) |
| " ENU and MNU demonstrated linear dose-response curves, whereas that for EMS seemed to be supralinear over the range 0." | 1.36 | Mutagenicity of N-ethyl-N-nitrosourea, N-methyl-N-nitrosourea, methyl methanesulfonate and ethyl methanesulfonate in the developing Syrian hamster fetus. ( Donovan, P; Smith, G, 2010) |
| "Embryonic mortality and intrauterine growth retardation (IUGR) are induced by exposure of rodents to xenobiotic agents during the pregastrulation period of development." | 1.35 | Embryonic mortality and intrauterine growth retardation (IUGR) associated with placental alterations in pregnant rats treated with methyl methanesulfonate (MMS) at the peri-implantation stage. ( Hayashi, M; Kagami, H; Kobayashi, K; Kuroda, J; Kusama, H; Ono, T; Tamura, T; Yokoi, R, 2008) |
| "Intrauterine growth retardation was apparent for fetuses in groups GD5 and GD6." | 1.34 | Differential susceptibility of rat embryos to methyl methanesulfonate during the pregastrulation period. ( Kagami, H; Kobayashi, K; Kuroda, J; Kusama, H; Ono, T; Suda, S; Yokoi, R, 2007) |
| " Qualitatively, the patterns of embryo malformations reported in treated embryos paralleled those observed in in vivo studies, especially in regard to adverse effects on central nervous system and craniofacial systems." | 1.28 | In vitro developmental toxicity of five direct-acting alkylating agents in rodent embryos: structure-activity patterns. ( Faustman, EM; Gage, D; Kirby, Z; Varnum, M, 1989) |
| "The number of chromosome aberrations observed in bone marrow cells and spermatogonia, and the frequency of pre- and postimplantation foetal lethality obtained in a dominant lethal mutation assay, did not conclusively prove that the tested compounds produced a mutagenic effect." | 1.27 | Absence of genetic and cytogenetic effects in mice treated by the organophosphorus insecticide parathion, its methyl analogue, and paraoxon. ( Degraeve, N; Moutschen, J, 1984) |
| " The time of expression and dose-response relationships obtained with gamma-radiation, methyl methanesulphonate, procarbazine, mitomycin C and benzo[a]pyrene are analysed in terms of this model." | 1.26 | Short-term tests for transplacentally active carcinogens. I. Micronucleus formation in fetal and maternal mouse erythroblasts. ( Arlett, CF; Cole, J; Cole, RJ; Taylor, N, 1981) |
| "Male CD1 mice were dosed by intraperitoneal injection of 20, 40 or 80 mg of methyl methanesulphonate (MMS) per kg body weight or with the solvent, water." | 1.26 | Dominant lethal assays in male mice: evaluation of experimental design, statistical methods and the sensitivity of Charles River (CD1) mice. ( Dean, BJ; Johnstone, A, 1977) |
| "Of numerical and structural chromosome aberrations only those come into question which are able to pass the filter of several mitoses." | 1.25 | A mammalian spot test: induction of genetic alterations in pigment cells of mouse embryos with x-rays and chemical mutagens. ( Fahrig, R, 1975) |
| "These data strongly suggest that chromosome aberrations seen at the first cleavage stage are the basis of MMS-induced dominant lethality." | 1.25 | Studies on chemically induced dominant lethality. I. The cytogenetic basis of MMS-induced dominant lethality in post-meiotic male germ cells. ( Brewen, JG; Jones, KP; Payne, HS; Preston, RJ, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (74.29) | 18.7374 |
| 1990's | 3 (8.57) | 18.2507 |
| 2000's | 4 (11.43) | 29.6817 |
| 2010's | 2 (5.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yokoi, R | 2 |
| Hayashi, M | 1 |
| Tamura, T | 1 |
| Kobayashi, K | 2 |
| Kuroda, J | 2 |
| Kusama, H | 2 |
| Kagami, H | 2 |
| Ono, T | 2 |
| Gocke, E | 1 |
| Müller, L | 1 |
| Pfister, T | 1 |
| Donovan, P | 1 |
| Smith, G | 1 |
| Innocenzi, A | 1 |
| Latella, L | 1 |
| Messina, G | 1 |
| Simonatto, M | 1 |
| Marullo, F | 1 |
| Berghella, L | 1 |
| Poizat, C | 1 |
| Shu, CW | 1 |
| Wang, JY | 1 |
| Puri, PL | 1 |
| Cossu, G | 1 |
| PARTINGTON, M | 1 |
| BATEMAN, AJ | 1 |
| Suda, S | 1 |
| Jirakulsomchok, S | 1 |
| Yielding, KL | 1 |
| Cole, RJ | 3 |
| Cole, J | 3 |
| Henderson, L | 2 |
| Taylor, NA | 1 |
| Arlett, CF | 2 |
| Regan, T | 1 |
| Singh, NP | 1 |
| Turturro, A | 1 |
| Hart, RW | 1 |
| Degraeve, N | 1 |
| Moutschen, J | 1 |
| Fabro, S | 1 |
| McLachlan, JA | 1 |
| Dames, NM | 1 |
| Neuhäuser-Klaus, A | 1 |
| Aghamohammadi, Z | 1 |
| Moranelli, F | 1 |
| Lieberman, MW | 1 |
| Taylor, N | 1 |
| Schreiber, D | 2 |
| Mendel, J | 1 |
| Heiderstädt, R | 2 |
| Ashby, J | 2 |
| Lefevre, PA | 1 |
| Elliott, BM | 1 |
| Clapp, MJ | 1 |
| Tinwell, H | 1 |
| Lefevre, P | 1 |
| Williams, CV | 1 |
| Schiestl, RH | 1 |
| Aubrecht, J | 1 |
| Yap, WY | 1 |
| Kandikonda, S | 1 |
| Sidhom, S | 1 |
| Ray, KC | 1 |
| Tu, ZC | 1 |
| Grogono-Thomas, R | 1 |
| Newell, DG | 1 |
| Thompson, SA | 1 |
| Blaser, MJ | 1 |
| Fahrig, R | 1 |
| Brewen, JG | 1 |
| Payne, HS | 1 |
| Jones, KP | 1 |
| Preston, RJ | 1 |
| Bodell, WJ | 4 |
| Banerjee, MR | 3 |
| Arnold, DW | 1 |
| Kennedy, GL | 1 |
| keplinger, ML | 1 |
| Calandra, JC | 1 |
| Goldstein, LS | 1 |
| Hemsworth, BN | 1 |
| Wardhaugh, AA | 1 |
| Schneider, J | 1 |
| Warzok, R | 1 |
| Dean, BJ | 1 |
| Johnstone, A | 1 |
| Inui, N | 1 |
| Kaketomi, M | 1 |
| Nishi, Y | 1 |
| Dean, JB | 1 |
| Blair, D | 1 |
| Faustman, EM | 1 |
| Kirby, Z | 1 |
| Gage, D | 1 |
| Varnum, M | 1 |
| Doniger, J | 1 |
| Day, RS | 1 |
| DiPaolo, JA | 1 |
35 other studies available for methyl methanesulfonate and Pregnancy
| Article | Year |
|---|---|
Embryonic mortality and intrauterine growth retardation (IUGR) associated with placental alterations in pregnant rats treated with methyl methanesulfonate (MMS) at the peri-implantation stage.
Topics: Alkylating Agents; Animals; Blood Glucose; Embryo Loss; Embryonic Development; Erythrocytes; Female; | 2008 |
EMS in Viracept--initial ('traditional') assessment of risk to patients based on linear dose response relations.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents, Alkylating; Carcinogenicity Tests; Dose | 2009 |
Mutagenicity of N-ethyl-N-nitrosourea, N-methyl-N-nitrosourea, methyl methanesulfonate and ethyl methanesulfonate in the developing Syrian hamster fetus.
Topics: Animals; Cricetinae; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchang | 2010 |
An evolutionarily acquired genotoxic response discriminates MyoD from Myf5, and differentially regulates hypaxial and epaxial myogenesis.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Biological Evolution; Cell Cycle Proteins; Cell Dif | 2011 |
DOMINANT LETHAL MUTATIONS INDUCED IN MALE MICE BY METHYL METHANESULPHONATE.
Topics: Alkylating Agents; Antineoplastic Agents; Fetus; Genetics; Infertility; Male; Methyl Methanesulfonat | 1964 |
Differential susceptibility of rat embryos to methyl methanesulfonate during the pregastrulation period.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Antineoplastic Agents, Alkylating; Blast | 2007 |
DNA damage and repair in mouse embryos following treatment transplacentally with methylnitrosourea and methylmethanesulfonate.
Topics: Animals; DNA; DNA Repair; Embryo, Mammalian; Female; Liver; Methyl Methanesulfonate; Methylnitrosour | 1984 |
Short-term tests for transplacentally active carcinogens. A comparison of sister-chromatid exchange and the micronucleus test in mouse foetal liver erythroblasts.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Crossing Over, Genetic; Cyclophosphamide; Diethylnitrosamine; | 1983 |
Stage-specific induction of sister-chromatid exchanges in utero.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Crossing Over, Genetic; Female; Fetus | 1984 |
Absence of genetic and cytogenetic effects in mice treated by the organophosphorus insecticide parathion, its methyl analogue, and paraoxon.
Topics: Animals; Bone Marrow; Chromosome Aberrations; Female; Genes, Dominant; Genes, Lethal; Male; Methyl M | 1984 |
Chemical exposure of embryos during the preimplantation stages of pregnancy: mortality rate and intrauterine development.
Topics: Animals; Blastocyst; DDT; DNA; Female; Fetal Death; Fetal Growth Retardation; In Vitro Techniques; M | 1984 |
An approach towards to standardization of the mammalian spot test.
Topics: Animals; Embryo, Mammalian; Female; Genotype; Methyl Methanesulfonate; Mice; Mitomycin; Mitomycins; | 1981 |
Short-term tests for transplacentally active carcinogens. Multiple-dose regimes in the transplacental micronucleus test.
Topics: Antibiotics, Antineoplastic; Carcinogens; Cell Cycle; Female; Fetus; Humans; Liver; Maternal-Fetal E | 1982 |
Recognition of chemical carcinogen-modified DNA by a DNA-binding protein.
Topics: Acetoxyacetylaminofluorene; Carcinogens; Carrier Proteins; Chromatography, Affinity; Chromatography, | 1980 |
Short-term tests for transplacentally active carcinogens. I. Micronucleus formation in fetal and maternal mouse erythroblasts.
Topics: Animals; Carcinogens; Cell Nucleus; Dose-Response Relationship, Drug; Dose-Response Relationship, Ra | 1981 |
[Structure-activity relationships in experimental neuro-oncology (author's transl)].
Topics: Animals; Carcinogens; Ethyl Methanesulfonate; Female; Maternal-Fetal Exchange; Methyl Methanesulfona | 1981 |
Methyl methanesulphonate (MMS) as a resource conserving and reliable positive control agent for male rat and male mouse dominant lethal assays.
Topics: Animals; Embryo Implantation; Embryo Loss; Female; Male; Methyl Methanesulfonate; Mice; Mutagenicity | 1996 |
The activity of ENU, iPMS and MMS in male mouse germ cells using the Muta Mouse positive selection transgenic mutation assay.
Topics: Animals; DNA; Epididymis; Ethylnitrosourea; Female; Male; Mesylates; Methyl Methanesulfonate; Mice; | 1997 |
Polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin induce intrachromosomal recombination in vitro and in vivo.
Topics: Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cells, Cultured; Cytochrome P-450 CYP | 1997 |
Campylobacter fetus sap inversion occurs in the absence of RecA function.
Topics: Animals; Bacterial Proteins; Blotting, Southern; Campylobacter fetus; Chromosome Inversion; DNA, Bac | 2000 |
A mammalian spot test: induction of genetic alterations in pigment cells of mouse embryos with x-rays and chemical mutagens.
Topics: Animals; Chromosome Aberrations; Ethyl Methanesulfonate; Female; Genes, Recessive; Male; Maternal-Fe | 1975 |
Studies on chemically induced dominant lethality. I. The cytogenetic basis of MMS-induced dominant lethality in post-meiotic male germ cells.
Topics: Animals; Chromosome Aberrations; Dose-Response Relationship, Drug; Embryonic Development; Female; Ge | 1975 |
Reduced DNA repair in mouse satellite DNA after treatment with methylmethanesulfonate, and N-methyl-N-nitrosourea.
Topics: Animals; DNA; DNA Repair; DNA Replication; DNA, Satellite; Female; Mammary Glands, Animal; Mesylates | 1976 |
Dominant lethal studies with alkylating agents: dose-response relationships.
Topics: Alkylating Agents; Animals; Ethyl Methanesulfonate; Female; Genes, Dominant; Genes, Lethal; Male; Me | 1976 |
Methyl methanesulfonate-induced dominant lethal mutations in male mice detected in vitro.
Topics: Animals; Female; Gene Frequency; Genes, Dominant; Genes, Lethal; Infertility, Male; Male; Mesylates; | 1977 |
Nonuniform distribution of DNA repair in chromatin after treatment with methyl methanesulfonate.
Topics: Animals; Cell Nucleus; Chromatin; DNA Repair; DNA Replication; Female; Kinetics; Mammary Glands, Ani | 1977 |
Embryopathies due to spermatozoal impairment in Xenopus laevis.
Topics: Abnormalities, Drug-Induced; Animals; Busulfan; Chlorohydrins; Female; Gamma Rays; Male; Mesylates; | 1978 |
[Postnatal and transplacental carcinogenic effects of methyl methanesulphonate (MMS) and ethyl methanesulphonate (EMS) in hooded rats (author's transl)].
Topics: Age Factors; Animals; Animals, Newborn; Ethyl Methanesulfonate; Female; Mesylates; Methyl Methanesul | 1978 |
The influence of chromatin structure on the distribution of DNA repair synthesis studied by nuclease digestion.
Topics: Animals; Chromatin; DNA Repair; Female; In Vitro Techniques; Kinetics; Mammary Glands, Animal; Methy | 1979 |
DNA repair in normal and preneoplastic mammary tissues.
Topics: Animals; Bromodeoxyuridine; DNA Repair; DNA Replication; DNA, Neoplasm; Female; Hydroxyurea; In Vitr | 1978 |
Dominant lethal assays in male mice: evaluation of experimental design, statistical methods and the sensitivity of Charles River (CD1) mice.
Topics: Animals; Female; Genes, Dominant; Genes, Lethal; Male; Methods; Methyl Methanesulfonate; Mice; Pregn | 1977 |
Mutagenic effects of AF-2, a food additive, on embryonic cells of the Syrian golden hamster on transplacental application.
Topics: Acrylamides; Animals; Cell Survival; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; | 1976 |
Dominant lethal assay in female mice after oral dosing with dichlorvos or exposure to atmospheres containing dichlorovos.
Topics: Animals; Dichlorvos; Embryo Implantation; Environmental Exposure; Female; Fetal Death; Genes, Domina | 1976 |
In vitro developmental toxicity of five direct-acting alkylating agents in rodent embryos: structure-activity patterns.
Topics: Alkylating Agents; Analysis of Variance; Animals; Brain; Dose-Response Relationship, Drug; Embryo, M | 1989 |
Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agents.
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; DNA; Dose-Response Relationship, Drug; Female; | 1985 |