methyl methanesulfonate has been researched along with Leukemia L5178 in 16 studies
Leukemia L5178: An experimental lymphocytic leukemia of mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The dose-response relationships for in vitro mutagenicity induced by methylmethanesulfonate (MMS) or methylnitrosourea (MNU) in L5178Y mouse lymphoma (ML) cells were examined." | 1.35 | Dose-response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU. ( Bartels, MJ; Bhaskar Gollapudi, B; Fontaine, DD; McFadden, LG; Pottenger, LH; Schisler, MR; Zhang, F, 2009) |
| " For xenobiotics that generate adducts without background, the difference is even more pronounced because the dose-response curve starts at zero and the limit of detection of an increase is not affected by background variation." | 1.34 | Biological significance of DNA adducts investigated by simultaneous analysis of different endpoints of genotoxicity in L5178Y mouse lymphoma cells treated with methyl methanesulfonate. ( Brink, A; Lutz, WK; Schulz, B; Stopper, H, 2007) |
| "Mouse lymphoma L5178Y cells were treated with dimethyl sulphoxide (DMSO) as a standard solvent or reference agents known to induce oxidative damage (gamma irradiation and potassium bromate) or alkylation (methyl methanesulfonate, MMS; ethylnitrosurea, ENU)." | 1.33 | hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII. ( Martin, EA; O'Donovan, MR; Smith, CC, 2006) |
| "Methyl methanesulfonate (MMS) was used as a positive control in these studies." | 1.26 | Comparative mutagenicity of 4 DNA-intercalating agents in L5178Y mouse lymphoma cells. ( Back, KC; Rogers, AM, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (56.25) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pottenger, LH | 1 |
| Schisler, MR | 1 |
| Zhang, F | 1 |
| Bartels, MJ | 1 |
| Fontaine, DD | 1 |
| McFadden, LG | 1 |
| Bhaskar Gollapudi, B | 1 |
| Shuai, PQ | 1 |
| Zhang, LS | 3 |
| Wang, YJ | 1 |
| Smith, CC | 1 |
| O'Donovan, MR | 1 |
| Martin, EA | 1 |
| Brink, A | 1 |
| Schulz, B | 1 |
| Stopper, H | 1 |
| Lutz, WK | 1 |
| Sato, K | 7 |
| Hieda-Shiomi, N | 5 |
| Hama-Inaba, H | 3 |
| Shiomi, T | 6 |
| Rogers, AM | 1 |
| Back, KC | 1 |
| Honma, M | 2 |
| Hayashi, M | 2 |
| Suzuki, T | 2 |
| Matsuoka, A | 2 |
| Sofuni, T | 2 |
| Miyamae, Y | 1 |
| Zaizen, K | 1 |
| Ohara, K | 1 |
| Mine, Y | 1 |
| Sasaki, YF | 1 |
| Amacher, DE | 1 |
| Dunn, EM | 1 |
| Tsuji, H | 2 |
| Takahashi, E | 2 |
| Tsuji, S | 2 |
| Tobari, I | 2 |
| Ito, A | 1 |
16 other studies available for methyl methanesulfonate and Leukemia L5178
| Article | Year |
|---|---|
Dose-response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU.
Topics: Animals; DNA Adducts; Dose-Response Relationship, Drug; Leukemia L5178; Methyl Methanesulfonate; Met | 2009 |
[TK locus mutation assay: comparison of L5178Y and TK6 cell lines].
Topics: Animals; Cell Line, Tumor; Ethyl Methanesulfonate; Humans; Leukemia L5178; Lymphoma; Methyl Methanes | 2004 |
hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII.
Topics: Animals; Bromates; Comet Assay; Deoxyribonuclease (Pyrimidine Dimer); Dimethyl Sulfoxide; DNA Damage | 2006 |
Biological significance of DNA adducts investigated by simultaneous analysis of different endpoints of genotoxicity in L5178Y mouse lymphoma cells treated with methyl methanesulfonate.
Topics: Animals; Cell Line, Tumor; Chromatography, Liquid; Deoxyguanosine; DNA Adducts; DNA Breaks; DNA Meth | 2007 |
X-ray-sensitive mutant mouse cells with various sensitivities to chemical mutagens.
Topics: 4-Nitroquinoline-1-oxide; Animals; Bromodeoxyuridine; Cell Line; Leukemia L5178; Leukemia, Experimen | 1983 |
Studies on three mutagen-sensitive mutants of mouse L5178Y cells. I. Characterization of the hybrids between L5178Y and mutagen-sensitive mutants.
Topics: 4-Nitroquinoline-1-oxide; Animals; Bromodeoxyuridine; Drug Resistance; Hybrid Cells; Leukemia L5178; | 1982 |
Studies on three mutagen-sensitive mutants of mouse L5178Y cells. II. Complementation analyses between two methyl methanesulfonate-sensitive mutants and between two 4-nitroquinoline-1-oxide-sensitive mutants.
Topics: 4-Nitroquinoline-1-oxide; Animals; Drug Resistance; Genetic Complementation Test; Hybrid Cells; Leuk | 1982 |
A novel mutant of mouse lymphoma cells sensitive to alkylating agents and caffeine.
Topics: Alkylating Agents; Animals; Caffeine; Cell Survival; Ethyl Methanesulfonate; Leukemia L5178; Leukemi | 1982 |
Comparative mutagenicity of 4 DNA-intercalating agents in L5178Y mouse lymphoma cells.
Topics: Acridine Orange; Acridines; Animals; Cell Survival; Ethidium; Intercalating Agents; Leukemia L5178; | 1982 |
A comparative study of TK6 human lymphoblastoid and L5178Y mouse lymphoma cell lines in the in vitro micronucleus test.
Topics: Animals; B-Lymphocytes; Cell Line; Cell Survival; Demecolcine; Ethyl Methanesulfonate; Humans; Leuke | 1995 |
Chromosome painting analysis of spontaneous and methyl methanesulfonate-induced trifluorothymidine-resistant L5178Y cell colonies.
Topics: Animals; Antimetabolites; Drug Resistance, Neoplasm; In Situ Hybridization, Fluorescence; Leukemia L | 1996 |
Detection of DNA lesions induced by chemical mutagens by the single cell gel electrophoresis (Comet) assay. 1. Relationship between the onset of DNA damage and the characteristics of mutagens.
Topics: Animals; Bleomycin; Cross-Linking Reagents; DNA Damage; Electrophoresis; Leukemia L5178; Mercaptopur | 1997 |
Mutagenesis at the ouabain-resistance locus of 3.7.2C L5178Y cells by chromosomal mutagens.
Topics: Animals; Chromosomes; Drug Resistance; Epichlorohydrin; Hydrocarbons, Iodinated; Leukemia L5178; Met | 1985 |
Chromosomal instability in mutagen-sensitive mutants isolated from mouse lymphoma L5178Y cells. II. Abnormal induction of sister-chromatid exchanges and chromosomal aberrations by mutagens in an ionizing radiation-sensitive mutant (M10) and an alkylating
Topics: 4-Nitroquinoline-1-oxide; Animals; Caffeine; Cell Line; Cell Survival; Chromosome Aberrations; Chrom | 1987 |
Mutagen detection with a mouse line containing 3 distinct mutations conferring sensitivity.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Line; Cross-Linking Reagents; DNA Repair; Drug Resistance; L | 1987 |
Chromosomal instability in mutagen-sensitive mutants isolated from mouse lymphoma L5178Y cells. I. Five different genes participate in the formation of baseline sister-chromatid exchanges and spontaneous chromosomal aberrations.
Topics: Animals; Bromodeoxyuridine; Cell Line; Chromosome Aberrations; Chromosomes; Genes; Hybrid Cells; Leu | 1987 |