methyl methanesulfonate has been researched along with Genome Instability in 35 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Studies on colon cancer have demonstrated that the depletion of E2F1 leads to reduced levels of homologous recombination (HR), resulting in interrupted DNA replication and the subsequent accumulation of DNA lesions." | 1.51 | E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors. ( Choi, EH; Kim, KP, 2019) |
| "Sod1 deficiency aggravates genomic instability in conjunction with the absence of Rad51 by inducing DSBs and an elevated mutation frequency." | 1.48 | Lack of superoxide dismutase in a rad51 mutant exacerbates genomic instability and oxidative stress-mediated cytotoxicity in Saccharomyces cerevisiae. ( Choi, JE; Chung, WH; Heo, SH; Kim, MJ, 2018) |
| "Thus, dFMRP maintains genome stability under genotoxic stress and regulates the G2/M DNA damage checkpoint by suppressing CycB expression." | 1.38 | Drosophila FMRP participates in the DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis. ( Bi, X; Jiang, F; Liu, W; Zhang, YQ, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (25.71) | 29.6817 |
| 2010's | 24 (68.57) | 24.3611 |
| 2020's | 2 (5.71) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, EH | 1 |
| Kim, KP | 1 |
| Feng, J | 2 |
| Islam, A | 1 |
| Bean, B | 1 |
| Sparapani, S | 1 |
| Shrivastava, M | 1 |
| Goyal, A | 1 |
| Omran, RP | 1 |
| Mallick, J | 1 |
| Whiteway, M | 1 |
| Verma, P | 1 |
| Zhou, Y | 1 |
| Cao, Z | 1 |
| Deraska, PV | 1 |
| Deb, M | 1 |
| Arai, E | 1 |
| Li, W | 1 |
| Shao, Y | 1 |
| Puentes, L | 1 |
| Li, Y | 1 |
| Patankar, S | 1 |
| Mach, RH | 1 |
| Faryabi, RB | 1 |
| Shi, J | 1 |
| Greenberg, RA | 1 |
| Segura-Wang, M | 1 |
| Onishi-Seebacher, M | 1 |
| Stütz, AM | 1 |
| Mardin, BR | 1 |
| Korbel, JO | 1 |
| Hu, LY | 1 |
| Chang, CC | 1 |
| Huang, YS | 1 |
| Chou, WC | 1 |
| Lin, YM | 1 |
| Ho, CC | 1 |
| Chen, WT | 1 |
| Shih, HM | 1 |
| Hsiung, CN | 1 |
| Wu, PE | 1 |
| Shen, CY | 1 |
| Choi, JE | 1 |
| Heo, SH | 1 |
| Kim, MJ | 1 |
| Chung, WH | 1 |
| Mara, K | 1 |
| Charlot, F | 1 |
| Guyon-Debast, A | 1 |
| Schaefer, DG | 1 |
| Collonnier, C | 1 |
| Grelon, M | 1 |
| Nogué, F | 1 |
| Nielsen, I | 1 |
| Bentsen, IB | 1 |
| Andersen, AH | 1 |
| Gasser, SM | 1 |
| Bjergbaek, L | 1 |
| Gonzalez-Huici, V | 1 |
| Szakal, B | 1 |
| Urulangodi, M | 1 |
| Psakhye, I | 1 |
| Castellucci, F | 1 |
| Menolfi, D | 1 |
| Rajakumara, E | 1 |
| Fumasoni, M | 1 |
| Bermejo, R | 1 |
| Jentsch, S | 1 |
| Branzei, D | 1 |
| Stuckey, R | 1 |
| García-Rodríguez, N | 1 |
| Aguilera, A | 1 |
| Wellinger, RE | 1 |
| de Sena-Tomás, C | 1 |
| Sutherland, JH | 1 |
| Milisavljevic, M | 1 |
| Nikolic, DB | 1 |
| Pérez-Martín, J | 1 |
| Kojic, M | 1 |
| Holloman, WK | 1 |
| Odahara, M | 1 |
| Inouye, T | 1 |
| Nishimura, Y | 1 |
| Sekine, Y | 1 |
| Zhang, J | 1 |
| Xie, S | 1 |
| Zhu, JK | 1 |
| Gong, Z | 1 |
| Willis, NA | 1 |
| Zhou, C | 1 |
| Elia, AE | 1 |
| Murray, JM | 1 |
| Carr, AM | 1 |
| Elledge, SJ | 1 |
| Rhind, N | 1 |
| Northam, MR | 1 |
| Trujillo, KM | 1 |
| Nicolella, HD | 1 |
| Neto, FR | 1 |
| Corrêa, MB | 1 |
| Lopes, DH | 1 |
| Rondon, EN | 1 |
| Dos Santos, LFR | 1 |
| de Oliveira, PF | 1 |
| Damasceno, JL | 1 |
| Acésio, NO | 1 |
| Turatti, ICC | 1 |
| Tozatti, MG | 1 |
| Cunha, WR | 1 |
| Furtado, RA | 1 |
| Tavares, DC | 1 |
| Shemesh, K | 1 |
| Sebesta, M | 1 |
| Pacesa, M | 1 |
| Sau, S | 1 |
| Bronstein, A | 1 |
| Parnas, O | 1 |
| Liefshitz, B | 1 |
| Venclovas, C | 1 |
| Krejci, L | 1 |
| Kupiec, M | 1 |
| Sagan, D | 1 |
| Müller, R | 1 |
| Kröger, C | 1 |
| Hematulin, A | 1 |
| Mörtl, S | 1 |
| Eckardt-Schupp, F | 1 |
| Zakaria, C | 1 |
| Kassahun, H | 1 |
| Yang, X | 1 |
| Labbé, JC | 1 |
| Nilsen, H | 1 |
| Ramotar, D | 1 |
| Ide, S | 1 |
| Miyazaki, T | 1 |
| Maki, H | 1 |
| Kobayashi, T | 1 |
| Suetomi, K | 1 |
| Mochizuki, M | 1 |
| Suzuki, S | 1 |
| Yamamoto, H | 1 |
| Yamamoto, K | 1 |
| Mutamba, JT | 1 |
| Svilar, D | 1 |
| Prasongtanakij, S | 1 |
| Wang, XH | 1 |
| Lin, YC | 1 |
| Dedon, PC | 1 |
| Sobol, RW | 1 |
| Engelward, BP | 1 |
| Nay, SL | 1 |
| Lee, DH | 1 |
| Bates, SE | 1 |
| O'Connor, TR | 1 |
| Rowe, LA | 1 |
| Degtyareva, N | 1 |
| Doetsch, PW | 1 |
| Madison, KE | 1 |
| Abdelmeguid, MR | 1 |
| Jones-Foster, EN | 1 |
| Nakai, H | 1 |
| Liu, W | 1 |
| Jiang, F | 1 |
| Bi, X | 1 |
| Zhang, YQ | 1 |
| Koulintchenko, M | 1 |
| Vengrova, S | 1 |
| Eydmann, T | 1 |
| Arumugam, P | 1 |
| Dalgaard, JZ | 2 |
| Banerjee, S | 1 |
| Myung, K | 1 |
| Pascucci, B | 1 |
| Russo, MT | 1 |
| Crescenzi, M | 1 |
| Bignami, M | 1 |
| Dogliotti, E | 1 |
| Sommariva, E | 1 |
| Pellny, TK | 1 |
| Karahan, N | 1 |
| Kumar, S | 1 |
| Huberman, JA | 1 |
| Paffett, KS | 1 |
| Clikeman, JA | 1 |
| Palmer, S | 1 |
| Nickoloff, JA | 1 |
| Li, J | 1 |
| Zou, C | 1 |
| Bai, Y | 1 |
| Wazer, DE | 1 |
| Band, V | 1 |
| Gao, Q | 1 |
| Yakisich, JS | 1 |
| Sandoval, PY | 1 |
| Morrison, TL | 1 |
| Kapler, GM | 1 |
| Kohzaki, M | 1 |
| Hatanaka, A | 1 |
| Sonoda, E | 1 |
| Yamazoe, M | 1 |
| Kikuchi, K | 1 |
| Vu Trung, N | 1 |
| Szüts, D | 1 |
| Sale, JE | 1 |
| Shinagawa, H | 1 |
| Watanabe, M | 1 |
| Takeda, S | 1 |
| Bailis, JM | 1 |
| Luche, DD | 1 |
| Hunter, T | 1 |
| Forsburg, SL | 1 |
35 other studies available for methyl methanesulfonate and Genome Instability
| Article | Year |
|---|---|
E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors.
Topics: Carcinogenesis; Cell Division; Colonic Neoplasms; DNA Breaks, Double-Stranded; DNA Damage; DNA Repai | 2019 |
Hof1 plays a checkpoint-related role in MMS-induced DNA damage response in
Topics: Candida albicans; Cell Cycle Checkpoints; Cell Nucleus; DNA Damage; Epistasis, Genetic; Fungal Prote | 2020 |
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells.
Topics: BRCA1 Protein; BRCA2 Protein; Cell Line, Tumor; Cell Proliferation; Chromatin; Chromatin Assembly an | 2021 |
Systematic Identification of Determinants for Single-Strand Annealing-Mediated Deletion Formation in
Topics: Camptothecin; DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Fungal; DNA, Single-Stranded; Doxor | 2017 |
SUMOylation of XRCC1 activated by poly (ADP-ribosyl)ation regulates DNA repair.
Topics: Alcohol Oxidoreductases; DNA Damage; DNA Polymerase beta; DNA Repair; DNA-Binding Proteins; Genomic | 2018 |
Lack of superoxide dismutase in a rad51 mutant exacerbates genomic instability and oxidative stress-mediated cytotoxicity in Saccharomyces cerevisiae.
Topics: 4-Nitroquinoline-1-oxide; DNA Breaks, Double-Stranded; DNA, Fungal; Gene Expression Regulation, Fung | 2018 |
POLQ plays a key role in the repair of CRISPR/Cas9-induced double-stranded breaks in the moss Physcomitrella patens.
Topics: Base Sequence; Bleomycin; Bryopsida; Cisplatin; CRISPR-Associated Protein 9; CRISPR-Cas Systems; DNA | 2019 |
A Rad53 independent function of Rad9 becomes crucial for genome maintenance in the absence of the Recq helicase Sgs1.
Topics: Cell Cycle Proteins; Checkpoint Kinase 1; Checkpoint Kinase 2; Gene Deletion; Genome, Fungal; Genomi | 2013 |
DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity.
Topics: Chromatids; Chromatin; Chromosomes, Fungal; DNA Damage; DNA Helicases; DNA Replication; DNA, Crucifo | 2014 |
Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system.
Topics: Bacterial Proteins; Camptothecin; Carcinogenesis; Cell Cycle; Cell Separation; Chromosomes; DNA; DNA | 2015 |
LAMMER kinase contributes to genome stability in Ustilago maydis.
Topics: Cell Cycle; Chromosome Segregation; Cloning, Molecular; DNA Repair; Epistasis, Genetic; Fungal Prote | 2015 |
RECA plays a dual role in the maintenance of chloroplast genome stability in Physcomitrella patens.
Topics: Bryopsida; DNA Copy Number Variations; DNA Damage; DNA Repair; Gene Knockout Techniques; Genome, Chl | 2015 |
Requirement for flap endonuclease 1 (FEN1) to maintain genomic stability and transcriptional gene silencing in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Cloning, Molecular; Flap Endonucleases; Gene Expression Regulatio | 2016 |
Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Topics: Checkpoint Kinase 2; DNA Damage; Gene Expression Regulation, Fungal; Genomic Instability; Methyl Met | 2016 |
Histone H2B mono-ubiquitylation maintains genomic integrity at stalled replication forks.
Topics: DNA Replication; DNA-Directed DNA Polymerase; Genomic Instability; Histones; Methyl Methanesulfonate | 2016 |
Toxicogenetic study of Persea americana fruit pulp oil and its effect on genomic instability.
Topics: Animals; Antibiotics, Antineoplastic; Aspartate Aminotransferases; Biological Assay; Cell Survival; | 2017 |
A structure-function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance.
Topics: Carrier Proteins; Chromatin; DNA; DNA Damage; DNA Helicases; Genomic Instability; Methyl Methanesulf | 2017 |
The DNA repair protein NBS1 influences the base excision repair pathway.
Topics: Alkylation; Cell Cycle Proteins; Cell Survival; Cells, Cultured; DNA Breaks, Double-Stranded; DNA Da | 2009 |
Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability.
Topics: Animals; Apoptosis; Bacteria; beta-Galactosidase; Blastomeres; Caenorhabditis elegans; Caenorhabditi | 2010 |
Abundance of ribosomal RNA gene copies maintains genome integrity.
Topics: Adenosine Triphosphatases; Cell Cycle Proteins; Chromatids; Chromosomal Proteins, Non-Histone; Chrom | 2010 |
Effects of Saccharomyces cerevisiae mec1, tel1, and mre11 mutations on spontaneous and methylmethane sulfonate-induced genome instability.
Topics: Endodeoxyribonucleases; Exodeoxyribonucleases; Genomic Instability; Intracellular Signaling Peptides | 2010 |
XRCC1 and base excision repair balance in response to nitric oxide.
Topics: Animals; Cell Extracts; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; DNA Repair; DNA-Binding | 2011 |
Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts.
Topics: AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; AlkB Homolog 3, Alpha-Ketoglutarate-Depen | 2012 |
Yap1: a DNA damage responder in Saccharomyces cerevisiae.
Topics: Antineoplastic Agents, Alkylating; Chromosome Aberrations; DNA Damage; DNA Repair; Dose-Response Rel | 2012 |
A new role for translation initiation factor 2 in maintaining genome integrity.
Topics: Bacteriophage mu; DNA Damage; DNA Helicases; DNA Repair; DNA Replication; Escherichia coli; Escheric | 2012 |
Drosophila FMRP participates in the DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis.
Topics: Animals; Apoptosis; Cyclin B; DNA Damage; Drosophila melanogaster; Drosophila Proteins; Fragile X Me | 2012 |
DNA polymerase α (swi7) and the flap endonuclease Fen1 (rad2) act together in the S-phase alkylation damage response in S. pombe.
Topics: Alkylating Agents; Cell Cycle Proteins; DNA Damage; DNA Polymerase I; DNA Repair; DNA-Binding Protei | 2012 |
Increased genome instability and telomere length in the elg1-deficient Saccharomyces cerevisiae mutant are regulated by S-phase checkpoints.
Topics: Base Sequence; Carrier Proteins; DNA; DNA Damage; DNA Helicases; DNA Repair; DNA Replication; DNA-Bi | 2004 |
The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells.
Topics: Animals; Chromatin; DNA Damage; DNA Polymerase beta; DNA Repair; DNA-Binding Proteins; G1 Phase; Gen | 2005 |
Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage.
Topics: Alkylation; Cell Cycle Proteins; DNA Damage; DNA-Binding Proteins; DNA, Fungal; DNA, Single-Stranded | 2005 |
Overexpression of Rad51 inhibits double-strand break-induced homologous recombination but does not affect gene conversion tract lengths.
Topics: Cell Survival; DNA Damage; DNA Helicases; DNA Repair; DNA-Binding Proteins; DNA, Fungal; Fungal Prot | 2005 |
DSS1 is required for the stability of BRCA2.
Topics: Blotting, Western; BRCA2 Protein; Breast Neoplasms; DNA Damage; Female; Genomic Instability; Humans; | 2006 |
TIF1 activates the intra-S-phase checkpoint response in the diploid micronucleus and amitotic polyploid macronucleus of Tetrahymena.
Topics: Animals; Caffeine; Chromosomes; Diploidy; DNA Damage; Gene Expression Regulation; Genomic Instabilit | 2006 |
Cooperative roles of vertebrate Fbh1 and Blm DNA helicases in avoidance of crossovers during recombination initiated by replication fork collapse.
Topics: Adenosine Triphosphatases; Animals; Camptothecin; Chickens; Cisplatin; Crossing Over, Genetic; DNA D | 2007 |
Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability.
Topics: Amino Acid Substitution; Bleomycin; Cell Cycle Proteins; Cell Survival; Checkpoint Kinase 2; DNA Dam | 2008 |