methyl methanesulfonate has been researched along with Colonic Neoplasms in 15 studies
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Studies on colon cancer have demonstrated that the depletion of E2F1 leads to reduced levels of homologous recombination (HR), resulting in interrupted DNA replication and the subsequent accumulation of DNA lesions." | 1.51 | E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors. ( Choi, EH; Kim, KP, 2019) |
| "We further showed that the colon cancer cell line expressing the wild-type APC gene was more sensitive to a DNA-methylating agent due to decreased DNA repair by long patch BER than the cell line expressing the mutant APC gene lacking the proliferating cell nuclear antigen-interacting protein-like box." | 1.33 | Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate. ( Balusu, R; Jaiswal, AS; Narayan, S, 2005) |
| "Three in 10 patients with stomach cancer and 4 in 16 patients with other cancers were sensitive to induction of SCE by methyl methanesulfonate." | 1.27 | Novel responses of peripheral lymphocytes of cancer patients to chemical induction of sister chromatid exchanges. ( Horaguchi, K; Kikuchi, J; Nakada, T; Oikawa, A; Sugawara, R; Takahashi, K; Tohda, H; Wakui, A; Yamauchi, A, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Codrich, M | 1 |
| Comelli, M | 1 |
| Malfatti, MC | 1 |
| Mio, C | 1 |
| Ayyildiz, D | 1 |
| Zhang, C | 1 |
| Kelley, MR | 1 |
| Terrosu, G | 1 |
| Pucillo, CEM | 1 |
| Tell, G | 1 |
| Choi, EH | 1 |
| Kim, KP | 1 |
| Condie, AG | 1 |
| Yan, Y | 1 |
| Gerson, SL | 1 |
| Wang, Y | 1 |
| Ravikumar, YS | 1 |
| Mahadevan, KM | 1 |
| Manjunatha, H | 1 |
| Satyanarayana, ND | 1 |
| Narayan, S | 3 |
| Jaiswal, AS | 3 |
| Balusu, R | 1 |
| Jung, HJ | 1 |
| Kim, EH | 1 |
| Mun, JY | 1 |
| Park, S | 1 |
| Smith, ML | 1 |
| Han, SS | 1 |
| Seo, YR | 1 |
| Kawamori, T | 2 |
| Tanaka, T | 2 |
| Ohnishi, M | 1 |
| Hirose, Y | 1 |
| Nakamura, Y | 1 |
| Satoh, K | 1 |
| Hara, A | 1 |
| Mori, H | 2 |
| Morishita, Y | 1 |
| Yoshimi, N | 1 |
| Kawabata, K | 1 |
| Matsunaga, K | 1 |
| Sugie, S | 1 |
| Reddy, BS | 1 |
| Lubet, R | 1 |
| Steele, V | 1 |
| Kelloff, G | 1 |
| Rao, CV | 1 |
| Sheikh, MS | 1 |
| Huang, Y | 1 |
| Fernandez-Salas, EA | 1 |
| El-Deiry, WS | 1 |
| Friess, H | 1 |
| Amundson, S | 1 |
| Yin, J | 1 |
| Meltzer, SJ | 1 |
| Holbrook, NJ | 1 |
| Fornace, AJ | 1 |
| Sevignani, C | 1 |
| Cranston, A | 1 |
| Iozzo, RV | 1 |
| Fishel, R | 1 |
| Calabretta, B | 1 |
| Bilbin, M | 1 |
| Tudek, B | 1 |
| Czeczot, H | 1 |
| Oikawa, A | 1 |
| Horaguchi, K | 1 |
| Sugawara, R | 1 |
| Kikuchi, J | 1 |
| Tohda, H | 1 |
| Takahashi, K | 1 |
| Wakui, A | 1 |
| Yamauchi, A | 1 |
| Nakada, T | 1 |
15 other studies available for methyl methanesulfonate and Colonic Neoplasms
| Article | Year |
|---|---|
Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway.
Topics: Colonic Neoplasms; DNA Damage; DNA-(Apurinic or Apyrimidinic Site) Lyase; Enzyme Inhibitors; Gene Ex | 2019 |
E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors.
Topics: Carcinogenesis; Cell Division; Colonic Neoplasms; DNA Breaks, Double-Stranded; DNA Damage; DNA Repai | 2019 |
A Fluorescent Probe to Measure DNA Damage and Repair.
Topics: Animals; Base Pairing; Base Sequence; Binding Sites; Cattle; Cell Line, Tumor; Colonic Neoplasms; DN | 2015 |
Antiproliferative, apoptotic and antimutagenic activity of isolated compounds from Polyalthia cerasoides seeds.
Topics: Antimutagenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Caco-2 Cells; Cell Proliferation | 2010 |
Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate.
Topics: Adenomatous Polyposis Coli Protein; Animals; Cell Line, Tumor; Cells, Cultured; Colonic Neoplasms; D | 2005 |
Base excision DNA repair defect in Gadd45a-deficient cells.
Topics: Animals; Cell Cycle Proteins; Colonic Neoplasms; DNA Damage; DNA Repair; Fibroblasts; Humans; Methyl | 2007 |
Chemoprevention of azoxymethane-induced colon carcinogenesis by dietary feeding of S-methyl methane thiosulfonate in male F344 rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Biogenic Polyamines; Bromodeoxyuridine; Colon; Colon | 1995 |
Regressive effects of various chemopreventive agents on azoxymethane-induced aberrant crypt foci in the rat colon.
Topics: 4-Butyrolactone; Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Carcinogens; Chemoprev | 1997 |
Chemopreventive effect of S-methylmethane thiosulfonate and sulindac administered together during the promotion/progression stages of colon carcinogenesis.
Topics: Adenocarcinoma; Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Al | 1999 |
The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma; | 1999 |
Spontaneous and mutagen-induced transformation of primary cultures of Msh2-/- p53-/- colonocytes.
Topics: Animals; Base Pair Mismatch; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Colon; | 1999 |
DNA alkylation-induced phosphorylation of p53 and activation of kinases in colon cancer cells.
Topics: Alkylation; Antineoplastic Agents, Alkylating; Blotting, Western; CDC2-CDC28 Kinases; Colonic Neopla | 2001 |
SN2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression.
Topics: Antineoplastic Agents, Alkylating; Cell Nucleus; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibito | 2002 |
Induction of aberrant crypts in the colons of rats by alkylating agents.
Topics: 1,2-Dimethylhydrazine; Aging; Alkylating Agents; Animals; Carcinogens; Colonic Neoplasms; Dimethylhy | 1992 |
Novel responses of peripheral lymphocytes of cancer patients to chemical induction of sister chromatid exchanges.
Topics: 4-Nitroquinoline-1-oxide; Aged; Carbolines; Colonic Neoplasms; Female; Humans; Lung Neoplasms; Lymph | 1986 |