methyl methanesulfonate has been researched along with Ataxia Telangiectasia in 11 studies
Ataxia Telangiectasia: An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human lymphoblastoid cell lines from normal individuals and from patients with ataxia telangiectasia were either proficient or deficient in their ability to repair the mutagenic DNA adduct O6-methylguanine that is induced by methylating carcinogens." | 7.66 | Kinetics of O6-methylguanine repair in human normal and ataxia telangiectasia cell lines and correlation of repair capacity with cellular sensitivity to methylating agents. ( Becker, Y; Shiloh, Y, 1981) |
| "Human lymphoblastoid cell lines from normal individuals and from patients with ataxia telangiectasia were either proficient or deficient in their ability to repair the mutagenic DNA adduct O6-methylguanine that is induced by methylating carcinogens." | 3.66 | Kinetics of O6-methylguanine repair in human normal and ataxia telangiectasia cell lines and correlation of repair capacity with cellular sensitivity to methylating agents. ( Becker, Y; Shiloh, Y, 1981) |
| "The level of spontaneously occurring chromosome aberrations in two of these mutants differs severalfold from the level observed in wild-type V-79 cells and in V-G8, to approximately 2- and 6-fold increase in V-E5 and V-C4, respectively." | 1.28 | Ataxia-telangiectasia-like Chinese hamster V79 cell mutants with radioresistant DNA synthesis, chromosomal instability, and normal DNA strand break repair. ( Jaspers, NG; Natarajan, AT; Simons, JW; van der Schans, GP; Zdzienicka, MZ, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crimella, C | 1 |
| Cantoni, O | 1 |
| Guidarelli, A | 1 |
| Vantaggiato, C | 1 |
| Martinuzzi, A | 1 |
| Fiorani, M | 1 |
| Azzolini, C | 1 |
| Orso, G | 1 |
| Bresolin, N | 1 |
| Bassi, MT | 1 |
| Barfknecht, TR | 1 |
| Little, JB | 1 |
| Shiloh, Y | 1 |
| Becker, Y | 1 |
| Artuso, M | 1 |
| Esteve, A | 1 |
| Brésil, H | 1 |
| Vuillaume, M | 2 |
| Hall, J | 2 |
| Helbig, R | 2 |
| Gerland, E | 1 |
| Zdzienicka, MZ | 2 |
| Speit, G | 2 |
| Canman, CE | 1 |
| Wolff, AC | 1 |
| Chen, CY | 1 |
| Fornace, AJ | 1 |
| Kastan, MB | 1 |
| Stopper, H | 1 |
| Full, M | 1 |
| Jongmans, W | 1 |
| Chrzanowska, K | 1 |
| Smeets, D | 1 |
| Sperling, K | 1 |
| Hoar, DI | 1 |
| Sargent, P | 1 |
| Jaspers, NG | 1 |
| van der Schans, GP | 1 |
| Natarajan, AT | 1 |
| Simons, JW | 1 |
| Ireland, CM | 1 |
| Stewart, BW | 1 |
11 other studies available for methyl methanesulfonate and Ataxia Telangiectasia
| Article | Year |
|---|---|
A novel nonsense mutation in the APTX gene associated with delayed DNA single-strand break removal fails to enhance sensitivity to different genotoxic agents.
Topics: Apraxias; Ataxia Telangiectasia; Base Sequence; Cerebellar Ataxia; Codon, Nonsense; DNA; DNA Breaks, | 2011 |
Hypersensitivity of ataxia telangiectasia skin fibroblasts to DNA alkylating agents.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; Ataxia Telangiectasia; Cell Line; Cell Survival; Ethyl | 1982 |
Kinetics of O6-methylguanine repair in human normal and ataxia telangiectasia cell lines and correlation of repair capacity with cellular sensitivity to methylating agents.
Topics: Adolescent; Adult; Alkylating Agents; Ataxia Telangiectasia; Cell Division; Cells, Cultured; Child; | 1981 |
The role of the Ataxia telangiectasia gene in the p53, WAF1/CIP1(p21)- and GADD45-mediated response to DNA damage produced by ionising radiation.
Topics: Alkylating Agents; Antigens, Viral; Ataxia Telangiectasia; Cells, Cultured; Cyclin-Dependent Kinase | 1995 |
The pattern of mutations induced by neocarzinostatin and methyl methanesulfonate in the ataxia telangiectasia-like Chinese hamster cell line V-E5.
Topics: Animals; Ataxia Telangiectasia; Cell Cycle; Cell Line; Cell Survival; Chromatids; Chromosome Aberrat | 1995 |
The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.
Topics: Ataxia Telangiectasia; DNA Damage; G1 Phase; Humans; Methyl Methanesulfonate; Tumor Suppressor Prote | 1994 |
Micronucleus induction by neocarzinostatin and methyl methanesulfonate in ionizing radiation--sensitive Chinese hamster V79 cell mutants.
Topics: Animals; Ataxia Telangiectasia; Cells, Cultured; Cricetinae; Cricetulus; Cytochalasin B; DNA Damage; | 1997 |
Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation.
Topics: Ataxia Telangiectasia; Blotting, Northern; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; C | 1997 |
Chemical mutagen hypersensitivity in ataxia telangiectasia.
Topics: Ataxia Telangiectasia; Cell Line; Cell Survival; Dactinomycin; DNA Repair; Heterozygote; Humans; Mes | 1976 |
Ataxia-telangiectasia-like Chinese hamster V79 cell mutants with radioresistant DNA synthesis, chromosomal instability, and normal DNA strand break repair.
Topics: Animals; Ataxia Telangiectasia; Bleomycin; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cric | 1989 |
Inhibition of poly(ADP-ribose) synthesis may affect DNA repair prior to ligation.
Topics: Ataxia Telangiectasia; Cell Line; DNA Repair; Fibroblasts; Humans; Methyl Methanesulfonate; Nucleosi | 1987 |