methyl methanesulfonate has been researched along with Aneuploid in 16 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " As the separation procedure may selectively retain cells containing MN, a study comparing the performance of the erythrocyte fractionation technique and standard manual smear preparation was conducted in male NMRI mice treated with a single injection of two clastogens (cyclophosphamide, 25 or 50 mg/kg, or methylmethane sulfonate, 40 or 80 mg/kg) or two aneuploidogens (colchicine, 0." | 3.69 | Comparison of separated erythrocyte preparations and manual smears of bone marrow in showing micronucleus induction by clastogens and aneuploidogens in mouse. ( Norppa, H; Vigagni, F, 1995) |
| "EMS and methotrexate modestly induced aneuploidy, while chloral hydrate and MMS failed to illicit any significant induction." | 1.31 | Simultaneous measurement of the frequencies of intrachromosomal recombination and chromosome gain using the yeast DEL assay. ( Howlett, NG; Schiestl, RH, 2000) |
| " But since it is obvious from dose-response curves where the inflection point/threshold lies, it appears that the model might be picking up some irregularities (possibly due to experimental variability in the dose-response curve at concentrations greater than the threshold)." | 1.30 | Indication for thresholds of chromosome non-disjunction versus chromosome lagging induced by spindle inhibitors in vitro in human lymphocytes. ( Elhajouji, A; Kirsch-Volders, M; Tibaldi, F, 1997) |
| "The state of aneuploidy test methodology was appraised by the U." | 1.28 | Reevaluation of the 9 compounds reported conclusive positive in yeast Saccharomyces cerevisiae aneuploidy test systems by the Gene-Tox Program using strain D61.M of Saccharomyces cerevisiae. ( Albertini, S, 1991) |
| " The test relies on a gene dosage selection system in which hyperploidy is detected by the simultaneous increase in copy number of two alleles residing on the right arm of chromosome VIII: arg4-8 and cup1S (Rockmill and Fogel." | 1.28 | The detection of mitotic and meiotic chromosome gain in the yeast Saccharomyces cerevisiae: effects of methyl benzimidazol-2-yl carbamate, methyl methanesulfonate, ethyl methanesulfonate, dimethyl sulfoxide, propionitrile and cyclophosphamide monohydrate. ( Fogel, S; Maloney, DH; Moser, SF; Piegorsch, WW; Resnick, MA; Whittaker, SG, 1990) |
| "Micronucleated cells treated with the aneuploidy-inducing agents benomyl and vinblastine sulfate contained a kinetochore-positive micronucleus 92% and 94% of the time whereas micronucleated cells treated with the clastogen methyl methanesulfonate contained a kinetochore-positive micronucleus only 11% of the time." | 1.28 | Kinetochore localization in micronucleated cytokinesis-blocked Chinese hamster ovary cells: a new and rapid assay for identifying aneuploidy-inducing agents. ( Eastmond, DA; Tucker, JD, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (37.50) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamamoto, M | 1 |
| Wakata, A | 1 |
| Aoki, Y | 1 |
| Miyamae, Y | 1 |
| Kodama, S | 1 |
| Parry, JM | 1 |
| Fowler, P | 1 |
| Quick, E | 1 |
| Parry, EM | 1 |
| Abdu, U | 1 |
| Klovstad, M | 1 |
| Butin-Israeli, V | 1 |
| Bakhrat, A | 1 |
| Schüpbach, T | 1 |
| Kim, AI | 1 |
| Aslanian, MM | 1 |
| Zimmering, S | 1 |
| Vigagni, F | 1 |
| Norppa, H | 1 |
| Elhajouji, A | 2 |
| Van Hummelen, P | 1 |
| Kirsch-Volders, M | 2 |
| Tibaldi, F | 1 |
| Howlett, NG | 1 |
| Schiestl, RH | 1 |
| Krishna, G | 1 |
| Fiedler, R | 1 |
| Theiss, JC | 1 |
| Albertini, S | 1 |
| Whittaker, SG | 1 |
| Moser, SF | 1 |
| Maloney, DH | 1 |
| Piegorsch, WW | 1 |
| Resnick, MA | 1 |
| Fogel, S | 1 |
| Eastmond, DA | 1 |
| Tucker, JD | 1 |
| Sora, S | 1 |
| Magni, GE | 1 |
| Käfer, E | 2 |
| Mayor, O | 1 |
16 other studies available for methyl methanesulfonate and Aneuploid
| Article | Year |
|---|---|
Chromosome loss caused by DNA fragmentation induced in main nuclei and micronuclei of human lymphoblastoid cells treated with colcemid.
Topics: Aneuploidy; Chromosome Deletion; Chromosomes, Human, Pair 2; Demecolcine; DNA Fragmentation; Gene Ex | 2014 |
Investigations into the biological relevance of in vitro clastogenic and aneugenic activity.
Topics: Alkylating Agents; Amsacrine; Aneuploidy; Cells, Cultured; Chromosome Aberrations; Chromosomes, Huma | 2004 |
An essential role for Drosophila hus1 in somatic and meiotic DNA damage responses.
Topics: Aneuploidy; Animals; Apoptosis; Body Patterning; Cell Cycle; Cell Cycle Proteins; DNA Damage; Drosop | 2007 |
[Effect of methylmethane sulfonate-sensitive mutations on nondisjunction and loss of sex chromosomes in Drosophila males].
Topics: Aneuploidy; Animals; Drosophila melanogaster; Drug Resistance; Female; Male; Methyl Methanesulfonate | 1983 |
Induced chromosome loss following treatment of postmeiotic cells of the Drosophila melanogaster male with MMS and DMN and matings with repair-proficient females and the repair-deficient females mei-9a and st mus302.
Topics: Aneuploidy; Animals; Cell Cycle; Dimethylnitrosamine; DNA; DNA Repair; Drosophila melanogaster; Fema | 1982 |
Comparison of separated erythrocyte preparations and manual smears of bone marrow in showing micronucleus induction by clastogens and aneuploidogens in mouse.
Topics: Aneuploidy; Animals; Bone Marrow; Bone Marrow Cells; Cell Separation; Colchicine; Cyclophosphamide; | 1995 |
Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes.
Topics: Adult; Aneuploidy; Benzimidazoles; Carbamates; Cell Division; Cell Survival; Cells, Cultured; Centro | 1995 |
Indication for thresholds of chromosome non-disjunction versus chromosome lagging induced by spindle inhibitors in vitro in human lymphocytes.
Topics: Adult; Aneuploidy; Benzimidazoles; Carbamates; Chromosomes, Human; Chromosomes, Human, Pair 1; Chrom | 1997 |
Simultaneous measurement of the frequencies of intrachromosomal recombination and chromosome gain using the yeast DEL assay.
Topics: Aneuploidy; Benomyl; Chloral Hydrate; Chromosomes, Fungal; Dactinomycin; Ethyl Methanesulfonate; Flo | 2000 |
Simultaneous analysis of chromosome damage and aneuploidy in cytokinesis-blocked V79 Chinese hamster lung cells using an antikinetochore antibody.
Topics: Aneuploidy; Animals; Cell Cycle; Cell Line; Chromosomes; Cricetinae; Cricetulus; Cytogenetics; Dose- | 1992 |
Reevaluation of the 9 compounds reported conclusive positive in yeast Saccharomyces cerevisiae aneuploidy test systems by the Gene-Tox Program using strain D61.M of Saccharomyces cerevisiae.
Topics: Acetone; Aneuploidy; Benomyl; Benzimidazoles; Biotransformation; Carbamates; Chromosomes, Fungal; Cy | 1991 |
The detection of mitotic and meiotic chromosome gain in the yeast Saccharomyces cerevisiae: effects of methyl benzimidazol-2-yl carbamate, methyl methanesulfonate, ethyl methanesulfonate, dimethyl sulfoxide, propionitrile and cyclophosphamide monohydrate.
Topics: Aneuploidy; Benzimidazoles; Carbamates; Chromosomes, Fungal; Cyclophosphamide; Dimethyl Sulfoxide; E | 1990 |
Kinetochore localization in micronucleated cytokinesis-blocked Chinese hamster ovary cells: a new and rapid assay for identifying aneuploidy-inducing agents.
Topics: Aneuploidy; Animals; Benomyl; Cell Division; Cell Line; Centromere; Chromosomes; Cricetinae; Cricetu | 1989 |
Induction of meiotic chromosomal malsegregation in yeast.
Topics: Aneuploidy; Diploidy; Meiosis; Methods; Methyl Methanesulfonate; Nondisjunction, Genetic; Saccharomy | 1988 |
MMS-induced primary aneuploidy and other genotoxic effects in mitotic cells of Aspergillus.
Topics: Aneuploidy; Aspergillus; Chloral Hydrate; Chromosome Aberrations; Crossing Over, Genetic; Diploidy; | 1988 |
Genetic analysis of DNA repair in Aspergillus: evidence for different types of MMS-sensitive hyperrec mutants.
Topics: Alleles; Aneuploidy; Aspergillus nidulans; DNA Repair; DNA, Fungal; Drug Resistance, Microbial; Epis | 1986 |