methyl-hesperidin and Body-Weight

methyl-hesperidin has been researched along with Body-Weight* in 3 studies

Other Studies

3 other study(ies) available for methyl-hesperidin and Body-Weight

ArticleYear
Subchronic toxicity study of methyl hesperidin in mice.
    Toxicology letters, 1993, Volume: 69, Issue:1

    A subchronic toxicity study of methyl hesperidin was performed using B6C3F1 mice. The flavonoid was administered to groups of ten males and ten females in dietary levels of 0, 0.3, 0.6, 1.25, 2.5 and 5.0% for 13 weeks. No significant treatment-related differences were found in data for body weights, food and water consumption, hematology, clinical chemistry and organ weights. Furthermore, no effects of treatment were observed on gross and histopathological examination of the major organs. The present experiment thus demonstrated that methyl hesperidin exerts no obvious toxic effects in mice of either sex when administered at a level as high as 5.0% in the diet.

    Topics: Administration, Oral; Animals; Body Weight; Dose-Response Relationship, Drug; Female; Hesperidin; Kidney; Male; Mice; Organ Size

1993
Carcinogenicity study of methyl hesperidin in B6C3F1 mice.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1990, Volume: 28, Issue:9

    A long-term carcinogenicity study of methyl hesperidin, a compound of the vitamin P group, was carried out in B6C3F1 mice receiving dietary concentrations of 0, 1.25 or 5%. Administration was continued for 96 wk and then the mice were maintained on basal diet for an additional 8 wk. Growth retardation during the experiment with final changes in organ weights were observed in females given the 1.25% dose of methyl hesperidin and in both sexes receiving the 5.0% treatment. However, no biologically significant effects were evident with respect to mortality or clinical signs. Furthermore, treatment with methyl hesperidin did not result in any changes in haematology, clinical chemistry and urinalysis data. On histological examination, no significant alteration of non-neoplastic and neoplastic lesion incidence was observed in treated mice. The results thus demonstrated that methyl hesperidin lacked any carcinogenicity for B6C3F1 mice in the 96-wk feeding regimen used in this study.

    Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Female; Hesperidin; Male; Mice; Neoplasms; Organ Size; Sex Factors

1990
[Effect of methyl hesperidin on the prenatal development of rats].
    Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences, 1986, Issue:104

    Topics: Administration, Oral; Animals; Body Weight; Female; Fetus; Flavonoids; Hesperidin; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains

1986