methyl-ferulate and Alzheimer-Disease

methyl-ferulate has been researched along with Alzheimer-Disease* in 1 studies

Other Studies

1 other study(ies) available for methyl-ferulate and Alzheimer-Disease

ArticleYear
The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.
    Journal of medicinal chemistry, 2016, 11-10, Volume: 59, Issue:21

    Novel multifunctional tacrines for Alzheimer's disease were obtained by Ugi-reaction between ferulic (or lipoic acid), a melatonin-like isocyanide, formaldehyde, and tacrine derivatives, according to the antioxidant additive approach in order to modulate the oxidative stress as therapeutic strategy. Compound 5c has been identified as a promising permeable agent showing excellent antioxidant properties, strong cholinesterase inhibitory activity, less hepatotoxicity than tacrine, and the best neuroprotective capacity, being able to significantly activate the Nrf2 transcriptional pathway.

    Topics: Alzheimer Disease; Antioxidants; Cell Death; Cell Survival; Cholinesterase Inhibitors; Cholinesterases; Coumaric Acids; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Melatonin; Molecular Structure; NF-E2-Related Factor 2; Structure-Activity Relationship

2016
chemdatabank.com