Compounds > methyl-ethyl-ketone-peroxide

methyl-ethyl-ketone-peroxide and Chemical-and-Drug-Induced-Liver-Injury

methyl-ethyl-ketone-peroxide has been researched along with Chemical-and-Drug-Induced-Liver-Injury* in 2 studies

Other Studies

2 other study(ies) available for methyl-ethyl-ketone-peroxide and Chemical-and-Drug-Induced-Liver-Injury

Article	Year
[Caustic esophago-gastric and liver lesions caused by ingestion of a plastic resin hardener]. Gastroenterologie clinique et biologique, 1991, Volume: 15, Issue:6-7 Topics: Butanones; Chemical and Drug Induced Liver Injury; Esophagitis; Humans; Male; Middle Aged; Peroxides	1991
Peripheral zonal hepatic necrosis caused by accidental ingestion of methyl ethyl ketone peroxide. Human & experimental toxicology, 1990, Volume: 9, Issue:3 Fatal massive peripheral zonal hepatic necrosis developed in a 47-year-old man who accidentally ingested a solution of methyl ethyl ketone peroxide (MEKP) in dimethyl phthalate. Such solutions contain about 10% active oxygen. The clinical course was characterized by temporary cardiac arrest, abdominal burns, severe metabolic acidosis, rapid hepatic failure, rhabdomyolysis and respiratory insufficiency. A fatal outcome resulted 4 d afterwards from hepatic coma associated with blood coagulation disorders. Microscopical examination revealed massive periportal hepatic necrosis accompanied by atypical pseudoductular proliferation. The proliferating cells were probably of bile duct origin and exhibited atypia and mitoses. The pathogenetic mechanism may involve lipid peroxidation caused by free oxygen radicals derived from MEKP. Topics: Butanones; Chemical and Drug Induced Liver Injury; Humans; Liver; Male; Middle Aged; Necrosis; Oxygen; Peroxides	1990

Article

Year

[Caustic esophago-gastric and liver lesions caused by ingestion of a plastic resin hardener].

Gastroenterologie clinique et biologique, 1991, Volume: 15, Issue:6-7

Topics: Butanones; Chemical and Drug Induced Liver Injury; Esophagitis; Humans; Male; Middle Aged; Peroxides

1991

Peripheral zonal hepatic necrosis caused by accidental ingestion of methyl ethyl ketone peroxide.

Human & experimental toxicology, 1990, Volume: 9, Issue:3

Fatal massive peripheral zonal hepatic necrosis developed in a 47-year-old man who accidentally ingested a solution of methyl ethyl ketone peroxide (MEKP) in dimethyl phthalate. Such solutions contain about 10% active oxygen. The clinical course was characterized by temporary cardiac arrest, abdominal burns, severe metabolic acidosis, rapid hepatic failure, rhabdomyolysis and respiratory insufficiency. A fatal outcome resulted 4 d afterwards from hepatic coma associated with blood coagulation disorders. Microscopical examination revealed massive periportal hepatic necrosis accompanied by atypical pseudoductular proliferation. The proliferating cells were probably of bile duct origin and exhibited atypia and mitoses. The pathogenetic mechanism may involve lipid peroxidation caused by free oxygen radicals derived from MEKP.

Topics: Butanones; Chemical and Drug Induced Liver Injury; Humans; Liver; Male; Middle Aged; Necrosis; Oxygen; Peroxides

1990