methyl-caffeate and Hemorrhage

methyl-caffeate has been researched along with Hemorrhage* in 1 studies

Other Studies

1 other study(ies) available for methyl-caffeate and Hemorrhage

Article	Year
Contribution of cinnamic acid analogues in rosmarinic acid to inhibition of snake venom induced hemorrhage. Bioorganic & medicinal chemistry, 2011, Apr-01, Volume: 19, Issue:7 In our previous paper, we reported that rosmarinic acid (1) of Argusia argentea could neutralize snake venom induced hemorrhagic action. Rosmarinic acid (1) consists of two phenylpropanoids: caffeic acid (2) and 3-(3,4-dihydroxyphenyl)lactic acid (3). In this study, we investigated the structural requirements necessary for inhibition of snake venom activity through the use of compounds, which are structurally related to rosmarinic acid (1). By examining anti-hemorrhagic activity of cinnamic acid analogs against Protobothrops flavoviridis (Habu) venom, it was revealed that the presence of the E-enoic acid moiety (-CH=CH-COOH) was critical. Furthermore, among the compound tested, it was concluded that rosmarinic acid (1) (IC(50) 0.15 μM) was the most potent inhibitor against the venom. Topics: Animals; Antivenins; Caffeic Acids; Cinnamates; Crotalid Venoms; Depsides; Hemorrhage; Humans; Male; Mice; Rosmarinic Acid; Snakes; Structure-Activity Relationship	2011

Article

Year

Contribution of cinnamic acid analogues in rosmarinic acid to inhibition of snake venom induced hemorrhage.

Bioorganic & medicinal chemistry, 2011, Apr-01, Volume: 19, Issue:7

In our previous paper, we reported that rosmarinic acid (1) of Argusia argentea could neutralize snake venom induced hemorrhagic action. Rosmarinic acid (1) consists of two phenylpropanoids: caffeic acid (2) and 3-(3,4-dihydroxyphenyl)lactic acid (3). In this study, we investigated the structural requirements necessary for inhibition of snake venom activity through the use of compounds, which are structurally related to rosmarinic acid (1). By examining anti-hemorrhagic activity of cinnamic acid analogs against Protobothrops flavoviridis (Habu) venom, it was revealed that the presence of the E-enoic acid moiety (-CH=CH-COOH) was critical. Furthermore, among the compound tested, it was concluded that rosmarinic acid (1) (IC(50) 0.15 μM) was the most potent inhibitor against the venom.

Topics: Animals; Antivenins; Caffeic Acids; Cinnamates; Crotalid Venoms; Depsides; Hemorrhage; Humans; Male; Mice; Rosmarinic Acid; Snakes; Structure-Activity Relationship

2011