methyl-angolensate and Colonic-Neoplasms

methyl-angolensate has been researched along with Colonic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for methyl-angolensate and Colonic-Neoplasms

Article	Year
Xylogranin B: a potent Wnt signal inhibitory limonoid from Xylocarpus granatum. Organic letters, 2013, Dec-06, Volume: 15, Issue:23 Xylogranin B (2) was isolated from Xylocarpus granatum (Meliaceae) leaves, by use of a cell-based luciferase screening system targeting a Wnt signaling pathway. Compound 2 inhibited TCF/β-catenin transcriptional activity (IC50 48.9 nM) and exhibited strong cytotoxicity against colon cancer cell lines. Compound 2 significantly decreased β-catenin protein levels in nuclei but not in the cytosol. These results indicated that a decrease in β-catenin levels in nuclei by 2 resulted in the Wnt signal inhibitory effects of 2. Topics: beta Catenin; Colonic Neoplasms; Drug Screening Assays, Antitumor; Furans; HCT116 Cells; Humans; Limonins; Luciferases; Meliaceae; Molecular Structure; Plant Leaves; Triterpenes; Wnt Signaling Pathway	2013

Article

Year

Xylogranin B: a potent Wnt signal inhibitory limonoid from Xylocarpus granatum.

Organic letters, 2013, Dec-06, Volume: 15, Issue:23

Xylogranin B (2) was isolated from Xylocarpus granatum (Meliaceae) leaves, by use of a cell-based luciferase screening system targeting a Wnt signaling pathway. Compound 2 inhibited TCF/β-catenin transcriptional activity (IC50 48.9 nM) and exhibited strong cytotoxicity against colon cancer cell lines. Compound 2 significantly decreased β-catenin protein levels in nuclei but not in the cytosol. These results indicated that a decrease in β-catenin levels in nuclei by 2 resulted in the Wnt signal inhibitory effects of 2.

Topics: beta Catenin; Colonic Neoplasms; Drug Screening Assays, Antitumor; Furans; HCT116 Cells; Humans; Limonins; Luciferases; Meliaceae; Molecular Structure; Plant Leaves; Triterpenes; Wnt Signaling Pathway

2013