methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate has been researched along with Seizures in 45 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (37.78) | 18.7374 |
| 1990's | 15 (33.33) | 18.2507 |
| 2000's | 5 (11.11) | 29.6817 |
| 2010's | 7 (15.56) | 24.3611 |
| 2020's | 1 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Cook, JM; Cox, ED; Diaz-Arauzo, H; Harris, B; Huang, Q; Ma, C; McKernan, R; Reddy, MS; Skolnick, P | 1 |
| Atack, JR; Broughton, HB; Chambers, MS; Collinson, N; Cook, S; Dawson, GR; Hobbs, SC; MacLeod, AM; Marshall, G; Maubach, KA; Pillai, GV; Reeve, AJ | 1 |
| Culjat, M; Forcelli, PA; Huizenga, MN | 1 |
| Forcelli, PA; Gutherz, S; Kondratyev, A; Kulick, C | 1 |
| Beck, VC; Forcelli, PA; Gutherz, SB; Kulick, CV; Medvedeva, N; Soper, C | 1 |
| Contó, MB; Venditti, MA | 1 |
| Abe, K; Hasebe, N; Hosoi, R; Inoue, O; Sugiyama, E | 1 |
| Contó, MB; de Carvalho, JG; Hipólide, DC; Venditti, MA | 1 |
| Contó, MB; de Carvalho, JG; Venditti, MA | 2 |
| Benedito, MA; Contó, MB; de Carvalho, JG | 1 |
| Chaix, Y; Ferraro, TN; Lapouble, E; Martin, B | 1 |
| Little, HJ; Minchin, MC; Nutt, DJ; Taylor, SC | 1 |
| Braestrup, C; Tacke, U | 1 |
| Braestrup, C; Honoré, T; Jensen, LH; Petersen, EN | 1 |
| Jensen, MS; Lambert, JD | 1 |
| Petersen, EN | 2 |
| Braestrup, C; Honoré, T; Jensen, LH; Nielsen, M; Petersen, EN | 1 |
| Chimirri, A; De Sarro, A; De Sarro, G; Guisti, P; Lipartiti, M; Zappala, M | 1 |
| Misawa, M; Suzuki, T; Tsuda, M | 2 |
| Chimirri, A; De Sarro, A; De Sarro, G; Giusti, P; McKernan, R; Quirk, K | 1 |
| Misawa, M; Shimizu, N; Suzuki, T; Tsuda, M; Yajima, Y | 1 |
| Boehrer, A; Marescaux, C; Reibel, S; Simler, S; Vergnes, M | 1 |
| Costentin, J; Garcia de Mateos-Verchere, J; Leprince, J; Tonon, MC; Vaudry, H | 1 |
| Andersen, KE; Huusfeldt, PO; Lau, J; Lundt, BF; Petersen, H; Suzdak, PD; Swedberg, MD; Sørensen, JL | 1 |
| Corbett, R; Dunn, RW | 1 |
| Bernasconi, R; Leonhardt, T; Martin, P; Portet, C; Schmutz, M; Steulet, AF | 1 |
| Andersen, KE; Frederiksen, K; Knutsen, LJ; Nielsen, EB; Suzdak, PD; Sørensen, PO | 1 |
| Bitran, D; Kellogg, CK; Primus, RJ | 1 |
| Buck, KJ; Harris, RA; McQuilkin, SJ | 1 |
| Andersen, KE; Braestrup, C; Knutsen, LJ; Nielsen, EB; Sonnewald, U; Suzdak, PD | 1 |
| Dragunow, M | 1 |
| Abla, KA; Carney, JM; Rennert, OM; Roderick, TH; Seale, TW | 1 |
| Jensen, LH; Petersen, EN | 1 |
| Biggio, G; Corda, MG; Giorgi, O; Longoni, B | 1 |
| Chapman, AG; Cheetham, SC; Hart, GP; Meldrum, BS; Westerberg, E | 1 |
| Kulkarni, SK; Kunchandy, J | 1 |
| Little, H; Nutt, DJ | 1 |
| Duka, T; Stephens, DN | 1 |
| Little, HJ; Nutt, DJ; Taylor, SC | 1 |
| Ableitner, A; Herz, A | 1 |
| Lister, RG; Nutt, DJ | 1 |
| Carney, JM; Flux, M; Rennert, OM; Seale, TW; Skolnick, P | 1 |
3 review(s) available for methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate and Seizures
| Article | Year |
|---|---|
Chemoconvulsant-induced seizure susceptibility: toward a common genetic basis?
Topics: Animals; Carbolines; Chromosome Mapping; Chromosomes; Convulsants; GABA Agonists; Genetic Predisposition to Disease; Humans; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Pentylenetetrazole; Potassium Channels; Quantitative Trait Loci; Seizures | 2007 |
Differential pharmacological effects of benzodiazepine receptor inverse agonists.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Carbolines; Convulsants; Electroshock; Humans; Mice; Pentylenetetrazole; Rats; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
Benzodiazepine receptor ligands with positive and negative efficacy.
Topics: Acoustic Stimulation; Animals; Carbolines; Chlorides; gamma-Aminobutyric Acid; Humans; Ligands; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
42 other study(ies) available for methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate and Seizures
| Article | Year |
|---|---|
Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423)
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Carbolines; Cell Line; Cerebral Cortex; Drug Design; GABA Agonists; Humans; Male; Mice; Muscle Relaxation; Rats; Receptors, GABA-A; Recombinant Proteins; Seizures; Structure-Activity Relationship | 1998 |
Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.
Topics: Animals; Brain; Cell Line; Cognition; Female; GABA Agonists; Hippocampus; Humans; In Vitro Techniques; Ligands; Male; Maze Learning; Memory; Mice; Nootropic Agents; Oocytes; Patch-Clamp Techniques; Protein Subunits; Radioligand Assay; Rats; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Thiazoles; Thiophenes; Xenopus laevis | 2003 |
Age-dependent anticonvulsant actions of perampanel and brivaracetam in the methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) model of seizures in developing rats.
Topics: Aging; Animals; Anticonvulsants; Carbolines; Convulsants; Female; Nitriles; Pyridones; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Seizures | 2021 |
Ontogenic profile of seizures evoked by the beta-carboline DMCM (methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate) in rats.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Carbolines; Convulsants; Dose-Response Relationship, Drug; Female; Male; Rats, Sprague-Dawley; Seizures | 2014 |
Profile of anticonvulsant action of levetiracetam, tiagabine and phenobarbital against seizures evoked by DMCM (methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate) in neonatal rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Carbolines; Levetiracetam; Male; Nipecotic Acids; Phenobarbital; Piracetam; Rats; Rats, Sprague-Dawley; Seizures; Tiagabine | 2014 |
Relationship Between Susceptibility to DMCM-Induced Generalized Motor Convulsions and Low-Affinity [3H]-Ouabain Binding in Membranes in Rat Brain.
Topics: Animals; Brain; Carbolines; Disease Susceptibility; Male; Membranes; Ouabain; Rats, Wistar; Seizures; Sodium-Potassium-Exchanging ATPase; Tritium | 2016 |
Anticonvulsant effects of methyl ethyl ketone and diethyl ketone in several types of mouse seizure models.
Topics: Acetone; Animals; Anticonvulsants; Butanones; Carbolines; Disease Models, Animal; Electroshock; Kainic Acid; Male; Mice; Motor Activity; Pentanones; Pentylenetetrazole; Seizures | 2010 |
Rats with different thresholds for DMCM-induced clonic convulsions differ in the sleep-time of diazepam and [(3)H]-Ro 15-4513 binding.
Topics: Animals; Anticonvulsants; Autoradiography; Azides; Benzodiazepines; Carbolines; Convulsants; Diazepam; Differential Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Flunitrazepam; GABA Modulators; Male; Pentobarbital; Rats; Rats, Wistar; Reaction Time; Seizures; Sleep; Statistics, Nonparametric; Tritium | 2012 |
Rats with different thresholds to clonic convulsions induced by DMCM differ in the binding of [3H]-MK-801 and [3H]-ouabain in the membranes of brain regions.
Topics: Animals; Brain; Carbolines; Dizocilpine Maleate; Male; Ouabain; Radioligand Assay; Rats; Rats, Wistar; Seizures; Tritium | 2012 |
Relationship between thresholds to convulsions induced by a benzodiazepine inverse agonist and [³H]-L-glutamate binding in the membranes of brain regions.
Topics: Animals; Benzodiazepines; Brain; Carbolines; Convulsants; Disease Models, Animal; Glutamic Acid; Male; Protein Binding; Rats; Rats, Wistar; Seizures; Tritium | 2013 |
Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist.
Topics: Animals; Behavior, Animal; Benzodiazepines; Carbolines; Convulsants; Dose-Response Relationship, Drug; Male; Picrotoxin; Rats; Rats, Wistar; Seizures | 2005 |
Investigating benzodiazepine receptor function in vivo using an intravenous infusion of DMCM.
Topics: Animals; Anticonvulsants; Carbolines; Convulsants; Drug Interactions; Electroshock; Indoles; Infusions, Parenteral; Male; Mice; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Sensory Thresholds | 1984 |
A study on benzodiazepine receptor binding in audiogenic seizure-susceptible rats.
Topics: Acoustic Stimulation; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Convulsants; Diazepam; Female; Flunitrazepam; In Vitro Techniques; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1984 |
The interaction of the beta-carboline derivative DMCM with inhibitory amino acid responses on cultured mouse neurones.
Topics: Animals; Benzodiazepines; Carbolines; Central Nervous System; Culture Techniques; Evoked Potentials; gamma-Aminobutyric Acid; Indoles; Mice; Midazolam; Neural Inhibition; Neurons; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Synaptic Membranes; Synaptic Transmission | 1983 |
DMCM: a potent convulsive benzodiazepine receptor ligand.
Topics: Animals; Carbolines; Convulsants; Diazepam; Drug Interactions; Female; Indoles; Lorazepam; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Valproic Acid | 1983 |
Azirino[1, 2-d][1, 4]benzodiazepine derivatives and related 1,4-benzodiazepines as anticonvulsant agents in DBA/2 mice.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzodiazepines; Binding, Competitive; Carbolines; Cell Membrane; Cerebellum; Cerebral Cortex; Chemical Phenomena; Chemistry, Physical; Convulsants; Flumazenil; GABA Modulators; Male; Mice; Mice, Inbred DBA; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1996 |
Role of the NMDA receptor complex in DMCM-induced seizure in mice.
Topics: Animals; Carbolines; Cerebral Ventricles; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Infusions, Intravenous; Injections, Intraventricular; Injections, Spinal; Kynurenic Acid; Male; Mice; Mice, Inbred Strains; Phencyclidine; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Spinal Cord | 1997 |
Aggravation of DMCM-induced seizure by nitric oxide synthase inhibitors in mice.
Topics: Animals; Carbolines; Convulsants; Enzyme Inhibitors; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Seizures | 1997 |
Anticonvulsant activity of azirino[1,2-d][1,4]benzodiazepines and related 1,4-benzodiazepines in mice.
Topics: Animals; Anticonvulsants; Benzodiazepines; Carbolines; Cell Line; Convulsants; Flumazenil; GABA Modulators; Male; Membranes; Mice; Mice, Inbred DBA; Movement; Pentylenetetrazole; Radioligand Assay; Receptors, GABA-A; Seizures | 1997 |
Hypersusceptibility to DMCM-induced seizures during diazepam withdrawal in mice: evidence for upregulation of NMDA receptors.
Topics: Animals; Anticonvulsants; Carbolines; Cerebral Cortex; Convulsants; Diazepam; Dizocilpine Maleate; Male; Membranes; Mice; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Seizures; Spermidine; Substance Withdrawal Syndrome; Up-Regulation | 1998 |
Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA(A) receptor in rats with genetic absence epilepsy.
Topics: 3-Mercaptopropionic Acid; Animals; Bicuculline; Carbolines; Convulsants; Electroencephalography; Epilepsy, Absence; Frontal Lobe; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoniazid; Kainic Acid; Limbic System; Male; Parietal Lobe; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Mutant Strains; Rats, Wistar; Seizures; Strychnine | 2000 |
Reduction of pentylenetetrazol-induced convulsions by the octadecaneuropeptide ODN.
Topics: Acoustic Stimulation; Amino Acid Sequence; Animals; Carbolines; Convulsants; Diazepam Binding Inhibitor; Electric Stimulation; Flumazenil; Injections, Intraventricular; Male; Mice; Mice, Inbred DBA; Molecular Sequence Data; Neuropeptides; Pentylenetetrazole; Peptide Fragments; Receptors, GABA-A; Seizures | 1999 |
Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors.
Topics: Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain Chemistry; Carbolines; Convulsants; Female; gamma-Aminobutyric Acid; Mice; Neuroglia; Neurons; Neurotransmitter Uptake Inhibitors; Postural Balance; Rats; Seizures; Structure-Activity Relationship; Synaptosomes | 2001 |
Yohimbine-induced seizures involve NMDA and GABAergic transmission.
Topics: Animals; Bicuculline; Carbolines; Convulsants; Dioxanes; gamma-Aminobutyric Acid; Idazoxan; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Receptors, Adrenergic, alpha; Receptors, GABA-A; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Synaptic Transmission; Yohimbine | 1992 |
Effects of benzodiazepine receptor ligands with different intrinsic activities on seizures induced by inhibition of GAD.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Isoniazid; Male; Mice; Mice, Inbred Strains; Pyrazoles; Reaction Time; Receptors, GABA-A; Seizures | 1992 |
NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization.
Topics: Animals; Anticonvulsants; Astrocytes; Behavior, Animal; Brain; Carbolines; Cells, Cultured; Convulsants; Female; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Neurons; Nicotinic Acids; Nipecotic Acids; Oximes; Pentylenetetrazole; Rats; Seizures; Synaptosomes; Tiagabine | 1992 |
Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex.
Topics: Animals; Bicuculline; Caffeine; Carbolines; Cerebral Cortex; Chlorides; Convulsants; Diazepam; Female; GABA-A Receptor Antagonists; Male; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, GABA-A; Seizures; Strychnine; Synaptosomes | 1991 |
Modulation of gamma-aminobutyric acidA receptor-operated chloride channels by benzodiazepine inverse agonists is related to genetic differences in ethanol withdrawal seizure severity.
Topics: Animals; Benzodiazepines; Carbolines; Chloride Channels; Chlorides; Convulsants; Ethanol; Flunitrazepam; Genetic Predisposition to Disease; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Muscimol; Receptors, GABA-A; Seizures; Substance Withdrawal Syndrome | 1991 |
Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor.
Topics: Animals; Anticonvulsants; Carbolines; Clonazepam; Convulsants; Diazepam; Female; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred DBA; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Tiagabine | 1991 |
Selective protection by adenosine receptor agonists against DMCM-induced seizures.
Topics: 2-Chloroadenosine; Adenosine; Animals; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Female; Mice; Pentylenetetrazole; Phenylisopropyladenosine; Receptors, Purinergic; Seizures; Theophylline | 1991 |
Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline.
Topics: Adenosine; Aminophylline; Amygdala; Animals; Brain; Carbolines; Diazepam; Flumazenil; Kindling, Neurologic; Male; Picrotoxin; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Purinergic; Rolipram; Seizures; Theophylline; Xanthines | 1990 |
Different genes specify hyporesponsiveness to seizures induced by caffeine and the benzodiazepine inverse agonist, DMCM.
Topics: Animals; Caffeine; Carbolines; Crosses, Genetic; Disease Susceptibility; Genes; Genetics, Behavioral; Male; Mice; Mice, Inbred CBA; Mice, Inbred Strains; Mutation; Receptors, GABA-A; Seizures | 1987 |
Lorazepam and FG 7142 induce tolerance to the DMCM antagonistic effect of benzodiazepine receptor ligands.
Topics: Animals; Carbolines; Dose-Response Relationship, Drug; Drug Tolerance; Female; Lorazepam; Male; Mice; Receptors, GABA-A; Seizures | 1987 |
Decreased sensitivity to diazepam induced by chronic administration of FG 7142.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Brain; Brain Chemistry; Carbolines; Convulsants; Diazepam; Drug Interactions; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1988 |
Effects of two convulsant beta-carboline derivatives, DMCM and beta-CCM, on regional neurotransmitter amino acid levels and on in vitro D-[3H]aspartate release in rodents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Carbolines; Cerebellum; Cerebral Cortex; Convulsants; Corpus Striatum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamine; Hippocampus; Indoles; Male; Mice; Mice, Inbred DBA; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Seizures | 1985 |
On the convulsant action of DMCM and Ro 5-4864 in mice.
Topics: Adrenergic alpha-Agonists; Animals; Benzodiazepinones; Carbolines; Convulsants; Female; Male; Mice; Seizures | 1988 |
Benzodiazepine-receptor mediated convulsions in infant rats: effects of beta-carbolines.
Topics: Animals; Bicuculline; Carbolines; Convulsants; Flurazepam; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1986 |
Potentiation of the propunishment, but not the convulsant action of the beta-carboline DMCM by naltrexone.
Topics: Animals; Anxiety; Carbolines; Drug Synergism; Female; Male; Mice; Motor Activity; Naltrexone; Punishment; Receptors, GABA-A; Receptors, Opioid; Seizures | 1986 |
Selective changes in the in vivo effects of benzodiazepine receptor ligands after chemical kindling with FG 7142.
Topics: Animals; Benzodiazepines; Body Temperature; Carbolines; Flurazepam; Kindling, Neurologic; Mice; Pyrazoles; Receptors, GABA-A; Seizures | 1987 |
Changes in local cerebral glucose utilization induced by the beta-carbolines FG 7142 and DMCM reveal brain structures involved in the control of anxiety and seizure activity.
Topics: Animals; Anxiety; Autoradiography; Brain; Carbolines; Convulsants; Deoxyglucose; Flumazenil; Glucose; Male; Rats; Rats, Inbred Strains; Seizures | 1987 |
Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Bicuculline; Carbolines; Convulsants; Drug Interactions; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures | 1988 |
Coincidence of seizure susceptibility to caffeine and to the benzodiazepine inverse agonist, DMCM, in SWR and CBA inbred mice.
Topics: Animals; Caffeine; Carbolines; Convulsants; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred CBA; Mice, Inbred Strains; Seizures; Species Specificity | 1987 |